What is Symbyax
OlanzapineThe Generic name of this drug
Treatment SummaryOlanzapine is an antipsychotic drug used to treat mental health conditions. It was developed in the 1990s and is classified as a second-generation antipsychotic. It works similarly to clozapine but with a few differences. It was approved for use in the United States in 1996 and is manufactured by Eli Lilly. Olanzapine is known for its effectiveness and low risk of side effects, as well as its low risk of drug-drug interactions.
Zyprexais the brand name
Symbyax Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyprexa
Olanzapine
1996
546
Approved as Treatment by the FDA
Olanzapine, otherwise known as Zyprexa, is approved by the FDA for 4 uses which include Unipolar Depression and Bipolar Disorder .Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Fluoxetine
Bipolar Disorder
Used to treat Bipolar Disorder With Manic or Mixed Episodes in combination with Lithium cation
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Fluoxetine
Mental Depression
Used to treat Acute Depressive Episode in combination with Fluoxetine
Effectiveness
How Symbyax Affects PatientsOlanzapine is used to treat symptoms of schizophrenia and bipolar disorder in adults, and manic or mixed episodes in adolescents. It works by blocking dopamine and serotonin receptors in the brain, which can help reduce hallucinations, delusions, and other disorganized thoughts and behaviors. It can also help decrease feelings of anhedonia, flat affect, alogia, avolition, and poor attention. Olanzapine has also been shown to reduce chemo-induced nausea and vomiting. In many studies, a complete response was reported in 84% of those taking the drug, with control of vomiting over 80%.
How Symbyax works in the bodyOlanzapine works by blocking certain receptors in the brain. It blocks dopamine, serotonin, and other receptors. The key action is blocking dopamine from binding to receptors in the mesolimbic pathway. This helps dampen nerve firing to reduce the symptoms of mental illnesses. Olanzapine also acts on serotonin receptors in the frontal cortex to help reduce the side effects.
When to interrupt dosage
The prescribed measure of Symbyax is contingent upon the diagnosed condition, including Schizophrenia, Bipolar Disorder and Delirium. The dosage amount shifts as per the administration technique (e.g. Kit - Intramuscular or Tablet, film coated - Oral) demonstrated in the table below.Condition
Dosage
Administration
Gilles de la Tourette's Syndrome
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Acute Agitation
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Schizophrenia
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Delirium
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Bipolar Disorder
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Bipolar Disorder
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Schizophrenia
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Mental Depression
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Alzheimer's Disease
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Post Traumatic Stress Disorder
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Bipolar Disorder
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Acute Coryza
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Unipolar Depression
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Delusional Parasitosis
, 12.0 mg, 6.0 mg, 3.0 mg, 2.5 mg, 10.0 mg, 20.0 mg, 5.0 mg, 15.0 mg, 10.0 mg/mL, 7.5 mg, 210.0 mg, 300.0 mg, 405.0 mg, 210.0 mg/mL, 405.0 mg/mL, 300.0 mg/mL
Kit - Intramuscular, Tablet, film coated - Oral, Injection, powder, for suspension, extended release - Intramuscular, , Oral, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Intramuscular, Tablet, Powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Tablet, film coated, Capsule, Kit, Tablet, orally disintegrating, Tablet - Oral, Capsule - Oral, Tablet, coated, Injection, powder, for solution, Powder, for solution - Intramuscular, Tablet, orally disintegrating - Oral, Injection, powder, for solution - Intramuscular, Injection, powder, lyophilized, for solution
Warnings
There are 20 known major drug interactions with Symbyax.Common Symbyax Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Olanzapine.
Acepromazine
Major
Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Olanzapine is combined with Aclidinium.
Alfuzosin
Major
Olanzapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Olanzapine may increase the antipsychotic activities of Amisulpride.
Symbyax Toxicity & Overdose RiskSymptoms of olanzapine overdose may include drowsiness, dilated pupils, difficulty breathing, low blood pressure, muscle twitching, and anticholinergic effects. Children may experience more serious side effects. The maximum registered dosage of olanzapine in clinical trials was 300mg and can cause drowsiness and slurred speech. Reported post-marketing symptoms include agitation, trouble speaking, fast heartbeat, and reduced consciousness. One case of death from overdosage occurred after ingesting 450mg of olanzapine. In the event of an overdose, treating the patient with oxygen, cleaning out the stomach
Symbyax Novel Uses: Which Conditions Have a Clinical Trial Featuring Symbyax?
578 active clinical trials are in progress to investigate the potential of Symbyax to ameliorate Schizophrenia, Post Traumatic Stress Disorder and Delusional Parasitosis.Condition
Clinical Trials
Trial Phases
Schizophrenia
182 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Post Traumatic Stress Disorder
243 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 3
Delusional Parasitosis
0 Actively Recruiting
Mental Depression
3 Actively Recruiting
Not Applicable, Phase 2
Gilles de la Tourette's Syndrome
0 Actively Recruiting
Alzheimer's Disease
40 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Acute Coryza
1 Actively Recruiting
Not Applicable
Bipolar Disorder
1 Actively Recruiting
Phase 4
Unipolar Depression
53 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 3, Phase 1
Delirium
39 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Acute Agitation
0 Actively Recruiting
Bipolar Disorder
0 Actively Recruiting
Bipolar Disorder
0 Actively Recruiting
Schizophrenia
34 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4
Symbyax Reviews: What are patients saying about Symbyax?
5Patient Review
2/17/2014 When I started this medication, I felt very tired and dizzy. However, after about a month my body adjusted and I felt great—like a whole new person! My anxiety decreased so much that I no longer need to take anxiety medication during the day; only at night. The only side effect is some hand trembling, which hopefully won't get worse. Overall, I love this medicine because it changed my life and lifted my mood from severe depression.
5Patient Review
7/3/2013 I sleep so much better now, and I even feel a little more functional during the day. That being said, I still struggle with depression and anger. It would be nice to just feel normal for once - not nauseous and anxious all the time.
5Patient Review
6/25/2013 I wasn't warned about the potential for excessive weight gain until after I had put on about 70 pounds. If anyone has successfully tapered off this medication, I would love to hear from you about your experience.
5Patient Review
11/9/2014 Symbyax has been a huge help for me in evening out my moods and reducing depression. The only downside is that it can make you sleepy, but since I take it at night that's not too big of a deal.
4.7Patient Review
6/2/20114.3Patient Review
6/30/20114.3Patient Review
8/11/20114Patient Review
7/11/20113.7Patient Review
10/3/2016 This combination is an old school approach to stability. For myself, improving sleep and reducing the risk of crashes are the biggest indicators of continuing stability.
3.7Patient Review
10/1/2012 I'm not sure.
3.3Patient Review
6/9/20113Patient Review
11/4/2011 My boyfriend started this medication a week ago at a dosage of 3/25mg. He is supposed to finish his supply and then increase the dosage. I have noticed a slight difference in his mood swings, but nothing significant. Does anyone know how long it will take for the full effects to be seen?
2.3Patient Review
8/20/2015 I had an unfortunate reaction to the Zoloft in this medication. I felt itchy and irritable all over my body, and also found myself feeling very agitated and listless. I ended up having to go to a psychiatric triage center where they told me I was having an allergic reaction and needed to stop taking the medication immediately.
2Patient Review
5/19/20111Patient Review
6/27/2011Patient Q&A Section about symbyax
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Symbyax help with anxiety?
"In general, I have found symbyax to be helpful in managing my depression and anxiety. It has also helped me to sleep better."
Answered by AI
What is Symbyax used to treat?
"This medication is used to treat depression which is associated with bipolar disorder, as well as depression that has not responded to other medications. Some of the ways in which this medication can improve your condition are by helping you sleep, improve your mood, improve your concentration, and decrease nervousness."
Answered by AI
Is Symbyax a Prozac?
"Symbyax is a prescription drug that combines the antidepressant Prozac and antipsychotic Zyprexa. It is primarily used to treat bipolar depression in adults and children, but it can also be used to treat adults with depression who are resistant to other antidepressants."
Answered by AI
Does Symbyax cause weight gain?
"The medication Symbyax is a combination of the antidepressant fluoxetine and the antipsychotic olanzapine. It is associated with weight gain."
Answered by AI