Symbyax

Premature Ejaculation, Cataplexy, Bulimia Nervosa + 11 more
Treatment
6 FDA approvals
20 Active Studies for Symbyax

What is Symbyax

FluoxetineThe Generic name of this drug
Treatment SummaryOlanzapine is an antipsychotic drug used to treat mental health conditions. It was developed in the 1990s and is classified as a second-generation antipsychotic. It works similarly to clozapine but with a few differences. It was approved for use in the United States in 1996 and is manufactured by Eli Lilly. Olanzapine is known for its effectiveness and low risk of side effects, as well as its low risk of drug-drug interactions.
Prozacis the brand name
image of different drug pills on a surface
Symbyax Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prozac
Fluoxetine
1987
490

Approved as Treatment by the FDA

Fluoxetine, also known as Prozac, is approved by the FDA for 6 uses such as Bipolar 1 Disorder and Major depressive disorder, recurrent episode .
Bipolar 1 Disorder
Used to treat Bipolar 1 Disorder in combination with Olanzapine
Major depressive disorder, recurrent episode
Used to treat Major depressive disorder, recurrent episode in combination with Olanzapine
Premenstrual Dysphoric Disorder (PMDD)
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Olanzapine
Depression
Used to treat Depression in combination with Olanzapine
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Olanzapine

Effectiveness

How Symbyax Affects PatientsOlanzapine is used to treat symptoms of schizophrenia and bipolar disorder in adults, and manic or mixed episodes in adolescents. It works by blocking dopamine and serotonin receptors in the brain, which can help reduce hallucinations, delusions, and other disorganized thoughts and behaviors. It can also help decrease feelings of anhedonia, flat affect, alogia, avolition, and poor attention. Olanzapine has also been shown to reduce chemo-induced nausea and vomiting. In many studies, a complete response was reported in 84% of those taking the drug, with control of vomiting over 80%.
How Symbyax works in the bodyOlanzapine works by blocking certain receptors in the brain. It blocks dopamine, serotonin, and other receptors. The key action is blocking dopamine from binding to receptors in the mesolimbic pathway. This helps dampen nerve firing to reduce the symptoms of mental illnesses. Olanzapine also acts on serotonin receptors in the frontal cortex to help reduce the side effects.

When to interrupt dosage

The prescribed measure of Symbyax is contingent upon the diagnosed condition, including Schizophrenia, Bipolar Disorder and Delirium. The dosage amount shifts as per the administration technique (e.g. Kit - Intramuscular or Tablet, film coated - Oral) demonstrated in the table below.
Condition
Dosage
Administration
Premature Ejaculation
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Cataplexy
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Bulimia Nervosa
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Anorexia Nervosa
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Panic Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alcoholism
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Unipolar Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
moderate to severe symptoms
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Myoclonus
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Bipolar Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
maintenance therapy
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Obsessive-Compulsive Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Symbyax Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Symbyax.
Common Symbyax Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Fluoxetine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Fluoxetine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Fluoxetine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Fluoxetine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fluoxetine.
Symbyax Toxicity & Overdose RiskSymptoms of olanzapine overdose may include drowsiness, dilated pupils, difficulty breathing, low blood pressure, muscle twitching, and anticholinergic effects. Children may experience more serious side effects. The maximum registered dosage of olanzapine in clinical trials was 300mg and can cause drowsiness and slurred speech. Reported post-marketing symptoms include agitation, trouble speaking, fast heartbeat, and reduced consciousness. One case of death from overdosage occurred after ingesting 450mg of olanzapine. In the event of an overdose, treating the patient with oxygen, cleaning out the stomach
image of a doctor in a lab doing drug, clinical research

Symbyax Novel Uses: Which Conditions Have a Clinical Trial Featuring Symbyax?

578 active clinical trials are in progress to investigate the potential of Symbyax to ameliorate Schizophrenia, Post Traumatic Stress Disorder and Delusional Parasitosis.
Condition
Clinical Trials
Trial Phases
Unipolar Depression
51 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 3, Phase 2, Phase 1
Depression
194 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Bulimia Nervosa
0 Actively Recruiting
Alcoholism
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Anorexia Nervosa
0 Actively Recruiting
moderate to severe symptoms
0 Actively Recruiting
Bipolar Disorder
0 Actively Recruiting
Depression
337 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Panic Disorder
0 Actively Recruiting
maintenance therapy
0 Actively Recruiting
Obsessive-Compulsive Disorder
16 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Myoclonus
1 Actively Recruiting
Not Applicable
Cataplexy
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting

Symbyax Reviews: What are patients saying about Symbyax?

5Patient Review
2/17/2014
Symbyax for Major Depressive Disorder
When I started this medication, I felt very tired and dizzy. However, after about a month my body adjusted and I felt great—like a whole new person! My anxiety decreased so much that I no longer need to take anxiety medication during the day; only at night. The only side effect is some hand trembling, which hopefully won't get worse. Overall, I love this medicine because it changed my life and lifted my mood from severe depression.
5Patient Review
7/3/2013
Symbyax for Bipolar Depression
I sleep so much better now, and I even feel a little more functional during the day. That being said, I still struggle with depression and anger. It would be nice to just feel normal for once - not nauseous and anxious all the time.
5Patient Review
6/25/2013
Symbyax for Major Depressive Disorder
I wasn't warned about the potential for excessive weight gain until after I had put on about 70 pounds. If anyone has successfully tapered off this medication, I would love to hear from you about your experience.
5Patient Review
11/9/2014
Symbyax for Bipolar Depression
Symbyax has been a huge help for me in evening out my moods and reducing depression. The only downside is that it can make you sleepy, but since I take it at night that's not too big of a deal.
4.7Patient Review
6/2/2011
Symbyax for Major Depressive Disorder
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about symbyax

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Symbyax help with anxiety?

"In general, I have found symbyax to be helpful in managing my depression and anxiety. It has also helped me to sleep better."

Answered by AI

What is Symbyax used to treat?

"This medication is used to treat depression which is associated with bipolar disorder, as well as depression that has not responded to other medications. Some of the ways in which this medication can improve your condition are by helping you sleep, improve your mood, improve your concentration, and decrease nervousness."

Answered by AI

Is Symbyax a Prozac?

"Symbyax is a prescription drug that combines the antidepressant Prozac and antipsychotic Zyprexa. It is primarily used to treat bipolar depression in adults and children, but it can also be used to treat adults with depression who are resistant to other antidepressants."

Answered by AI

Does Symbyax cause weight gain?

"The medication Symbyax is a combination of the antidepressant fluoxetine and the antipsychotic olanzapine. It is associated with weight gain."

Answered by AI

Clinical Trials for Symbyax

Have you considered Symbyax clinical trials? We made a collection of clinical trials featuring Symbyax, we think they might fit your search criteria.
Have you considered Symbyax clinical trials? We made a collection of clinical trials featuring Symbyax, we think they might fit your search criteria.
Have you considered Symbyax clinical trials? We made a collection of clinical trials featuring Symbyax, we think they might fit your search criteria.
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