Symbyax

Premature Ejaculation, Cataplexy, Bulimia Nervosa + 11 more

Treatment

3 FDA approvals

20 Active Studies for Symbyax

Treatment for

Premature Ejaculation

What is Symbyax

FluoxetineThe Generic name of this drug

Treatment SummaryOlanzapine is an antipsychotic drug used to treat mental health conditions. It was developed in the 1990s and is classified as a second-generation antipsychotic. It works similarly to clozapine but with a few differences. It was approved for use in the United States in 1996 and is manufactured by Eli Lilly. Olanzapine is known for its effectiveness and low risk of side effects, as well as its low risk of drug-drug interactions.

Prozacis the brand name

image of different drug pills on a surface

Symbyax Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Prozac

Fluoxetine

1987

490

Approved as Treatment by the FDA

Fluoxetine, also known as Prozac, is approved by the FDA for 3 uses such as Depression and Bipolar Disorder .

Depression

Used to treat Depression in combination with Olanzapine

Bipolar Disorder

Used to treat Bipolar 1 Disorder in combination with Olanzapine

Unipolar Depression

Used to treat Major depressive disorder, recurrent episode in combination with Olanzapine

Effectiveness

How Symbyax Affects PatientsOlanzapine is used to treat symptoms of schizophrenia and bipolar disorder in adults, and manic or mixed episodes in adolescents. It works by blocking dopamine and serotonin receptors in the brain, which can help reduce hallucinations, delusions, and other disorganized thoughts and behaviors. It can also help decrease feelings of anhedonia, flat affect, alogia, avolition, and poor attention. Olanzapine has also been shown to reduce chemo-induced nausea and vomiting. In many studies, a complete response was reported in 84% of those taking the drug, with control of vomiting over 80%.

How Symbyax works in the bodyOlanzapine works by blocking certain receptors in the brain. It blocks dopamine, serotonin, and other receptors. The key action is blocking dopamine from binding to receptors in the mesolimbic pathway. This helps dampen nerve firing to reduce the symptoms of mental illnesses. Olanzapine also acts on serotonin receptors in the frontal cortex to help reduce the side effects.

When to interrupt dosage

The prescribed measure of Symbyax is contingent upon the diagnosed condition, including Schizophrenia, Bipolar Disorder and Delirium. The dosage amount shifts as per the administration technique (e.g. Kit - Intramuscular or Tablet, film coated - Oral) demonstrated in the table below.

Condition

Dosage

Administration

Unipolar Depression

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

moderate to severe symptoms

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Obsessive-Compulsive Disorder

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Myoclonus

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Anorexia Nervosa

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Depression

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Depression

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Cataplexy

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

maintenance therapy

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Premature Ejaculation

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Panic Disorder (With or Without Agoraphobia)

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Bulimia Nervosa

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Bipolar Disorder

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Alcoholism

, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg

, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Symbyax Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Symbyax.

Common Symbyax Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Fluoxetine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Fluoxetine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Fluoxetine.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Fluoxetine.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Fluoxetine.

Symbyax Toxicity & Overdose RiskSymptoms of olanzapine overdose may include drowsiness, dilated pupils, difficulty breathing, low blood pressure, muscle twitching, and anticholinergic effects. Children may experience more serious side effects. The maximum registered dosage of olanzapine in clinical trials was 300mg and can cause drowsiness and slurred speech. Reported post-marketing symptoms include agitation, trouble speaking, fast heartbeat, and reduced consciousness. One case of death from overdosage occurred after ingesting 450mg of olanzapine. In the event of an overdose, treating the patient with oxygen, cleaning out the stomach

image of a doctor in a lab doing drug, clinical research

Symbyax Novel Uses: Which Conditions Have a Clinical Trial Featuring Symbyax?

578 active clinical trials are in progress to investigate the potential of Symbyax to ameliorate Schizophrenia, Post Traumatic Stress Disorder and Delusional Parasitosis.

Condition

Clinical Trials

Trial Phases

moderate to severe symptoms

0 Actively Recruiting

maintenance therapy

0 Actively Recruiting

Depression

200 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1

Premature Ejaculation

0 Actively Recruiting

Bulimia Nervosa

15 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Early Phase 1

Unipolar Depression

50 Actively Recruiting

Not Applicable, Phase 4, Early Phase 1, Phase 2, Phase 3, Phase 1

Bipolar Disorder

1 Actively Recruiting

Phase 4

Anorexia Nervosa

0 Actively Recruiting

Panic Disorder (With or Without Agoraphobia)

0 Actively Recruiting

Depression

692 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4

Obsessive-Compulsive Disorder

17 Actively Recruiting

Not Applicable, Phase 3, Phase 2

Alcoholism

7 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Myoclonus

2 Actively Recruiting

Phase 2, Not Applicable

Cataplexy

3 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Symbyax Reviews: What are patients saying about Symbyax?

5Patient Review

2/17/2014

Symbyax for Major Depressive Disorder

When I started this medication, I felt very tired and dizzy. However, after about a month my body adjusted and I felt great—like a whole new person! My anxiety decreased so much that I no longer need to take anxiety medication during the day; only at night. The only side effect is some hand trembling, which hopefully won't get worse. Overall, I love this medicine because it changed my life and lifted my mood from severe depression.

5Patient Review

7/3/2013

Symbyax for Bipolar Depression

I sleep so much better now, and I even feel a little more functional during the day. That being said, I still struggle with depression and anger. It would be nice to just feel normal for once - not nauseous and anxious all the time.

5Patient Review

6/25/2013

Symbyax for Major Depressive Disorder

I wasn't warned about the potential for excessive weight gain until after I had put on about 70 pounds. If anyone has successfully tapered off this medication, I would love to hear from you about your experience.

5Patient Review

11/9/2014

Symbyax for Bipolar Depression

Symbyax has been a huge help for me in evening out my moods and reducing depression. The only downside is that it can make you sleepy, but since I take it at night that's not too big of a deal.

4.7Patient Review

6/2/2011

Symbyax for Major Depressive Disorder

4.3Patient Review

6/30/2011

Symbyax for Major Depressive Disorder

4.3Patient Review

8/11/2011

Symbyax for Bipolar Depression

4Patient Review

7/11/2011

Symbyax for Major Depressive Disorder

3.7Patient Review

10/3/2016

Symbyax for Bipolar Depression

This combination is an old school approach to stability. For myself, improving sleep and reducing the risk of crashes are the biggest indicators of continuing stability.

3.7Patient Review

10/1/2012

Symbyax for Bipolar Depression

I'm not sure.

3.3Patient Review

6/9/2011

Symbyax for Bipolar Depression

3Patient Review

11/4/2011

Symbyax for Bipolar Depression

My boyfriend started this medication a week ago at a dosage of 3/25mg. He is supposed to finish his supply and then increase the dosage. I have noticed a slight difference in his mood swings, but nothing significant. Does anyone know how long it will take for the full effects to be seen?

2.3Patient Review

8/20/2015

Symbyax for Bipolar Depression

I had an unfortunate reaction to the Zoloft in this medication. I felt itchy and irritable all over my body, and also found myself feeling very agitated and listless. I ended up having to go to a psychiatric triage center where they told me I was having an allergic reaction and needed to stop taking the medication immediately.

2Patient Review

5/19/2011

Symbyax for Major Depressive Disorder

1Patient Review

6/27/2011

Symbyax for Bipolar Depression

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about symbyax

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Symbyax help with anxiety?

"In general, I have found symbyax to be helpful in managing my depression and anxiety. It has also helped me to sleep better."

Answered by AI

What is Symbyax used to treat?

"This medication is used to treat depression which is associated with bipolar disorder, as well as depression that has not responded to other medications. Some of the ways in which this medication can improve your condition are by helping you sleep, improve your mood, improve your concentration, and decrease nervousness."

Answered by AI

Is Symbyax a Prozac?

"Symbyax is a prescription drug that combines the antidepressant Prozac and antipsychotic Zyprexa. It is primarily used to treat bipolar depression in adults and children, but it can also be used to treat adults with depression who are resistant to other antidepressants."

Answered by AI

Does Symbyax cause weight gain?

"The medication Symbyax is a combination of the antidepressant fluoxetine and the antipsychotic olanzapine. It is associated with weight gain."

Answered by AI

Clinical Trials for Symbyax

Image of University of California, San Francisco in San Francisco, United States.

Deep Brain Stimulation for Obsessive-Compulsive Disorder

San Francisco, CA

This trial is testing a new treatment for OCD using deep brain stimulation (DBS) guided by SEEG. The study will have three stages: brain mapping and parameter optimization, DBS surgery with stimulation

Waitlist Available

University of California, San FranciscoA Moses Lee, MD, PhD

Image of University of Southern California in Los Angeles, United States.

Heart rate variability biofeedback for Depression

Los Angeles, CA

This trial aims to study different subtypes of depression by looking at how people regulate their emotions and their physiological responses. The study involves assessing affect, regulation strategies, and physiological activity in young adults with depression

University of Southern California

Image of Toronto Western Hospital in Toronto, Canada.

Psilocybin for Depression

Toronto, Canada

This trial will test if one or two doses of psilocybin can help patients with treatment-resistant depression. It will investigate which dosing is more effective in relieving depressive symptoms and if a second

Toronto Western HospitalJoshua Rosenblat, MD, MSc

Image of Clinical Site 105 in Lauderhill, United States.

CLE-100 for Antidepressants

This trial is testing a new medication called CLE-100 (oral esketamine) for treating Major Depressive Disorder (MDD) in people who have not responded well to standard antidepressants.

Clinical Site 105 (+3 Sites)Clexio Biosciences Ltd.

Have you considered Symbyax clinical trials? We made a collection of clinical trials featuring Symbyax, we think they might fit your search criteria.

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MBCT for Breast Cancer

"This trial aims to create and test a program that can help improve mood and lessen depression symptoms."

Waitlist Available

Cleveland Clinic Department of Wellness and Preventive MedicineJacob Hill, ND

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CAPABLE Transplant for Quality of Life

This trial aims to modify a program called CAPABLE for kidney transplant patients to help them overcome barriers to getting on the transplant waitlist and to improve the health of frail patients awaiting a kidney transplant. The

Waitlist Available

Johns Hopkins School of NursingMelissa Hladek, PhD

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Intervention (videoconferencing) for Depression, Anxiety, Post-Traumatic Stress Disorder

This trial aims to develop and test a method to involve Veterans experiencing symptoms of depression, anxiety, and/or PTSD in assisting English language learners to enhance their speaking abilities through organized video calls. "This

Waitlist Available

Center for Clinical Management Research (CCMR), North Campus Research ComplexJohn D Piette, PhD

Image of Ontario Shores Centre for Mental Health Sciences in Toronto, Canada.

Accelerated Bilateral Sequential Theta Burst Stimulation for Depression

Toronto, Canada

This trial will investigate the effectiveness of a new treatment called accelerated bilateral sequential theta burst stimulation (absTBS) for older adults with treatment-resistant depression. The study will compare absTBS with a fake

Ontario Shores Centre for Mental Health SciencesAmer M. Burhan, MBChB, MSc

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Aviva for Suicidal Ideation

Colorado Springs, CO

This trial aims to test the effectiveness of a digital platform called Aviva in providing cognitive-behavioral therapy to Servicemembers who have had recent suicidal thoughts or attempts. The Aviva platform

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Psilocybin for Major Depressive Disorder

This trial aims to assess the effects of Psilocybin on adults with Major Depressive Disorder. Participants will receive either Psilocybin 25 mg, Psilocybin 5 mg,

Mountain View Clinical Research (+3 Sites)

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Psilocybin for Major Depressive Disorder

Chapel Hill, NC

"This trial aims to test how effective psilocybin-assisted therapy is in treating depression. Participants will undergo screening, receive psilocybin treatment, and attend follow-up sessions over a year.

Waitlist Available

UNC Chapel Hill Medical CenterRobert K McClure, MD

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Intermittent Theta Burst Stimulation for Alcoholism

Toronto, Canada

This trial aims to investigate a new treatment approach for alcohol use disorder (AUD) that also targets depressive symptoms. The study will use theta burst stimulation (TBS) as a form of transcranial

Centre for Addiction and Mental Health

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