Sudafed 12 Hour

Sneezing, Chronic Pain, Catarrh + 31 more

Treatment

1 FDA approval

20 Active Studies for Sudafed 12 Hour

Treatment for

Sneezing

What is Sudafed 12 Hour

Pseudoephedrine

The Generic name of this drug

Treatment Summary

Pseudoephedrine is a drug that is closely related to Ephedrine, another drug derived from the ephedra plant. It has been used in Eastern medicine for centuries and was first studied in the West in 1889. Pseudoephedrine has a milder effect on the nervous system than Ephedrine, and its decongestant effect was first demonstrated in dogs in 1927.

Nasal Decongestant Maximum Strength

is the brand name

Sudafed 12 Hour Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nasal Decongestant Maximum Strength

Pseudoephedrine

1981

547

Approved as Treatment by the FDA

Pseudoephedrine, also known as Nasal Decongestant Maximum Strength, is approved by the FDA for 1 uses including Nasal Congestion .

Nasal Congestion

Effectiveness

How Sudafed 12 Hour Affects Patients

Pseudoephedrine is a decongestant that works by narrowing the blood vessels, leading to a decongestant effect. Its effects last for a short period of time, unless it is taken as an extended release product. Taking pseudoephedrine can lead to stimulation of the central nervous system, so patients should be aware of this risk.

How Sudafed 12 Hour works in the body

Pseudoephedrine works on the body by stimulating certain receptors and blocking others. Specifically, it stimulates alpha adrenergic receptors and blocks norepinephrine, dopamine, and serotonin transporters. These effects lead to increased blood pressure and heart rate, as well as constriction of the blood vessels. It is used as a decongestant and to treat priapism. Pseudoephedrine also partially activates the anococcygeal muscle, and inhibits some proteins like NF-kappa-B, NFAT, and AP-1.

When to interrupt dosage

The proposed dose of Sudafed 12 Hour is contingent upon the determined condition, including Upper Respiratory Tract Infection, Airway secretion clearance therapy and Coughing. The measure also relies upon the delivery approach (e.g. Tablet, extended release or Oral) expressed in the table beneath.

Condition

Dosage

Administration

Catarrh

60.0 mg, , 120.0 mg, 240.0 mg, 30.0 mg, 6.0 mg/mL, 3.0 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 60.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 40.0 mg, 50.0 mg/mL, 14.998 mg/mL, 15.001 mg/mL, 0.3 mg/mg, 0.15 mg/mg, 7.5 mg/mL, 25.0 mg, 45.0 mg/mL, 15.0 mg, 7.5 mg, 9.38 mg/mL, 20.0 mg, 45.0 mg, 4.0 mg/mL, 80.0 mg, 4.5 mg/mL, 22.5 mg/mL, 14.999 mg/mL, 9.0 mg/mL, 8.0 mg/mL, 12.5 mg/mL, 25.0 mg/mL, 180.0 mg, 0.6 mg/mg, 75.0 mg/mL, 0.06 mg/mg, 0.006 mg/mg

Oral, Powder, for solution - Oral, , Powder, for solution, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated, Liquid - Oral, Tablet, coated - Oral, Liquid, Tablet, Tablet - Oral, Solution, Solution - Oral, Syrup - Oral, Syrup, Elixir, Elixir - Oral, Solution / drops, Solution / drops - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Oral, Pill, Pill - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Powder - Oral, Capsule, extended release - Oral, Capsule, extended release, Powder, Tablet, chewable, Tablet, chewable - Oral, Kit; Tablet - Oral, Tablet; Tablet, extended release - Oral, Tablet; Tablet, extended release, Kit; Tablet, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Capsule; Kit, Capsule; Kit - Oral, Kit; Powder - Oral, Kit; Powder, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Kit; Powder, for solution - Oral, Kit; Powder, for solution, Kit, Kit - Oral, Solution / drops - Nasal, Nasal, Tablet, for suspension - Oral, Tablet, for suspension

Priapism

Migraine

Bronchitis

Fever

Upper respiratory tract signs and symptoms

Influenza

Rhinitis, Allergic

Sneezing

Acute Bronchitis

Chronic Pain

Throat irritation

Sinusitis

Upper respiratory tract congestion

Rhinorrhea

Sinus Congestion

Coughing

Pharyngitis

Common Cold

Hypersensitivity

Warnings

Sudafed 12 Hour has five contraindications and should not be ingested when exhibiting any of the issues featured in the following table.

Sudafed 12 Hour Contraindications

Condition

Risk Level

Notes

Coronary Artery Disease

Do Not Combine

Hypertension

Do Not Combine

Urinary Retention

Do Not Combine

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Pseudoephedrine may interact with Pulse Frequency

There are 20 known major drug interactions with Sudafed 12 Hour.

Common Sudafed 12 Hour Drug Interactions

Drug Name

Risk Level

Description

Iobenguane

Major

Pseudoephedrine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.

Methylene blue

Major

Pseudoephedrine may increase the serotonergic activities of Methylene blue.

Mirtazapine

Major

Pseudoephedrine may increase the serotonergic activities of Mirtazapine.

1-benzylimidazole

Minor

The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Pseudoephedrine.

4-Methoxyamphetamine

Minor

The risk or severity of hypertension can be increased when Pseudoephedrine is combined with 4-Methoxyamphetamine.

Sudafed 12 Hour Toxicity & Overdose Risk

The toxic dose of pseudoephedrine in rats is 2206mg/kg and 726mg/kg in mice. Overdosing on pseudoephedrine can cause symptoms such as dizziness, headache, nausea, vomiting, increased heart rate, chest pain, difficulty urinating, muscle weakness, anxiety, restlessness, insomnia, confusion, abnormal heart rhythms, collapse of the circulatory system, seizures, unconsciousness, and difficulty breathing. Treatment for overdose includes relieving symptoms and removing any unabsorbed drug.

image of a doctor in a lab doing drug, clinical research

Sudafed 12 Hour Novel Uses: Which Conditions Have a Clinical Trial Featuring Sudafed 12 Hour?

270 active trials are being conducted to assess the efficacy of Sudafed 12 Hour in remedying Allergy, Migraine and Ocular conditions.

Condition

Clinical Trials

Trial Phases

Chronic Pain

130 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1

Sinus Congestion

0 Actively Recruiting

Throat irritation

0 Actively Recruiting

Hypersensitivity

1 Actively Recruiting

Phase 4

Acute Bronchitis

7 Actively Recruiting

Phase 4, Not Applicable, Phase 3, Early Phase 1

Sneezing

0 Actively Recruiting

Migraine

13 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Pharyngitis

0 Actively Recruiting

Bronchitis

0 Actively Recruiting

Sinusitis

2 Actively Recruiting

Not Applicable

Influenza

29 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3

Hay Fever

0 Actively Recruiting

Rhinorrhea

0 Actively Recruiting

Seasonal Allergies

0 Actively Recruiting

Fever

2 Actively Recruiting

Not Applicable, Phase 4

Perennial Allergy

0 Actively Recruiting

Coughing

0 Actively Recruiting

Common Cold

0 Actively Recruiting

Eye

0 Actively Recruiting

Coughing

0 Actively Recruiting

Sudafed 12 Hour Reviews: What are patients saying about Sudafed 12 Hour?

Patient Review

12/30/2009

Sudafed 12 Hour for Stuffy Nose

Sudafed 12 hour is great at clearing up congestion, but unfortunately it also keeps me awake all night. I end up only sleeping 1-2 hours per night when I take this medication.

Patient Review

12/22/2013

Sudafed 12 Hour for Ear Congestion

I had a lot of pressure and pain in my ear from congestion, but after taking this medication I could feel it start to work within 15-30 minutes. It cleared up my ear for 12 hours and also took care of the congestion in my nose.

Patient Review

10/1/2016

Sudafed 12 Hour for Stuffy Nose

First time taking and I'm impressed with how it's cleared me up after only 1 dose. Definitely recommend.

Patient Review

4/4/2011

Sudafed 12 Hour for Stuffy Nose

This treatment was incredibly effective at reducing my sinus pain and congestion. I felt relief within 15 minutes, and it lasted for around 12 hours.

Patient Review

7/12/2012

Sudafed 12 Hour for Ear Congestion

I'm currently pregnant and was struggling with a lot of fluid buildup and severe allergies. My doctor recommended this treatment to me, and it worked wonders! It relieved the pressure in my ears within an hour, and my headache completely disappeared. I would highly recommend this to anyone else dealing with similar issues.

4.7

Patient Review

9/18/2007

Sudafed 12 Hour for Ear Congestion

Sudafed has been amazing for me during long flights. The sinus pressure can be unbearable without it, and Sudafed really helps alleviate that issue.

4.7

Patient Review

9/25/2015

Sudafed 12 Hour for Runny Nose

Sudafed is great for me. I take one every morning and it really helps to keep my nose from running all day long. The only time it doesn't work well enough is if I'm doing a lot of outdoor activities.

4.7

Patient Review

2/26/2009

Sudafed 12 Hour for Ear Congestion

This medication quickly cleared up my sinuses and as a result, I can hear much better now. The only downside is that it seemed to cause an increase in the production of large, dry boogers.

4.3

Patient Review

6/24/2009

Sudafed 12 Hour for Ear Congestion

The CVS generic version of Sudafed 12-hour has helped me a lot with my ear congestion and post-nasal drip. However, I have also experienced some unpleasant side effects related to the tightening of my prostate, such as reduced urine flow, inability to empty bladder, and intense ejaculation. Additionally, I sometimes feel jumpy and have less of an appetite when taking this medication.

4.3

Patient Review

9/7/2008

Sudafed 12 Hour for Stuffy Nose

This really helps me when I have a stuffed nose.

Patient Review

11/10/2012

Sudafed 12 Hour for Stuffy Nose

This was a good treatment for me.

3.7

Patient Review

4/24/2009

Sudafed 12 Hour for Runny Nose

The medication did provide some relief, though it made it hard to sleep. I also noticed issues with urination and ejaculation that were strange and not entirely pleasant. However, the cold symptoms went away, so on balance it was worth it.

2.3

Patient Review

6/21/2020

Sudafed 12 Hour for Stuffy Nose

Even after using this product for nearly a month, I'm still struggling with a stuffed nose that makes it hard to sleep.

1.3

Patient Review

3/28/2014

Sudafed 12 Hour for Runny Nose

The effectiveness of this medication only lasts for the first five hours. After that, it's like you never took it in the first place.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sudafed 12 hour

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can you take Sudafed 12 hour before bed?

"To help you sleep better, take your last dose of pseudoephedrine a few hours before going to bed. If you have any questions, talk to your doctor. Only take this medicine as directed."

Answered by AI

How often can I buy 12 hour Sudafed?

"There are laws throughout the nation that restrict and limit the sale of pseudoephedrine by pharmacies. All products containing pseudoephedrine must be secured and only sold from behind a sales counter. The maximum amount that can be legally purchased is 3.6 grams per day (approximately a 15-day supply) or 9 grams in a 30-day period."

Answered by AI

Is Sudafed 12 the same as 24 hour?

"This medication contains pseudoephedrine HCl, a nasal decongestant, and provides relief from symptoms for up to 24 hours. Adults and children 12 years and over should take one whole tablet with water every 24 hours."

Answered by AI

What is the difference between Sudafed PE and Sudafed 12 Hour?

"The majority of patients and healthcare providers agree that Sudafed (pseudoephedrine) is more effective at treating congestion than its counterpart Sudafed PE (phenylephrine). This is most likely due to the fact that the intestines only absorb around 38% of the amount of Sudafed PE in one tablet, whereas Sudafed is 100% absorbed."

Answered by AI

Clinical Trials for Sudafed 12 Hour

Image of UCI Health Susan Samueli Integrative Health Institute in Irvine, United States.

Biofield Therapy for Cancer

18+

All Sexes

Irvine, CA

Cancer treatment with immunotherapy is often associated with symptoms such as fatigue, pain, and emotional distress, which may affect patients' daily functioning and quality of life. Additional supportive care approaches are being studied to better understand their potential role in supporting these symptoms. The purpose of this study is to learn whether a biofield therapy, called Reiki may help to support adults with cancer who are receiving immunotherapy and currently struggling with fatigue. Reiki is a non-invasive complementary therapy delivered by a trained practitioner who places their hands lightly near the body. It is intended to promote relaxation and support general well-being. Reiki is used as a supportive practice and is not considered a medical treatment or replacement for standard care. The secondary goal of this study is to evaluate the feasibility of delivering Reiki in this clinical setting. This includes examining recruitment, retention, adherence to study procedures, and overall participant engagement. Lastly, the third aim is to explore participants' experiences with Reiki through guided interviews. Participants enrolled in this study will first be asked to participate in a one-hour, one-on-one interview about their experiences with cancer treatment, their symptoms, and their thoughts about integrative care practices such as Reiki. After the interview, they will be randomly assigned to one of two groups: Immediate Reiki Group: If participants are assigned to this group, they will receive six weekly, in-person 30-minute Usui Reiki sessions from a Reiki master at the Susan Samueli Integrative Health Institute. Before and after each session, participants will complete questionnaires about fatigue, pain, and stress. At the first and final sessions, a small blood sample will be collected to measure inflammatory biomarkers, and Electroencephalogram (EEG) hyperscanning will be conducted to measure brain activity and connectivity between the participant and the practitioner. Four weeks after the final session, they will complete the questionnaires again, followed by a short satisfaction survey about their experience. Waitlist Group: If they are assigned to the waitlist group, they will first complete a 6-week observation period that includes brief weekly fatigue questionnaires and two in-person 30-minute sessions with EEG measurements at Week 1 and Week 6. This will be followed by a 4-week period with no sessions, after which they will complete questionnaires about fatigue, pain, and psychological distress. Participants will then begin the same six weekly, in-person 30-minute sessions described above. As with the Immediate Group, they will complete questionnaires before and after each session. At the first and final sessions, a small blood sample will be collected and EEG hyperscanning will be conducted. At the end of the study, participants will also complete a short satisfaction survey about their experience. The investigators hypothesize that participants receiving Reiki will report improvements in symptoms and well-being compared to those not yet receiving Reiki, and that the intervention will be feasible to implement and acceptable to participants.

Recruiting

Has No Placebo

UCI Health Susan Samueli Integrative Health Institute (+1 Sites)