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What is Sucralfate
SucralfateThe Generic name of this drug
Treatment SummarySucralfate is a medication used to prevent and treat a variety of gastrointestinal disorders, such as duodenal ulcers, GERD, gastritis, peptic ulcer disease, and dyspepsia. It works by protecting cells in the gastrointestinal tract from damage caused by substances like stomach acid, bile salts, alcohol, and aspirin. Sucralfate is safe and well-tolerated and comes in both tablet and suspension forms. It was approved by the FDA in 1982 for tablets and 1994 for suspension.
Carafateis the brand name
Sucralfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Carafate
Sucralfate
1981
91
Approved as Treatment by the FDA
Sucralfate, otherwise known as Carafate, is approved by the FDA for 1 uses like Duodenal Ulcer .Duodenal Ulcer
Effectiveness
How Sucralfate Affects PatientsThis drug helps heal duodenal ulcers by creating a protective barrier between the lining of the gastrointestinal tract and any harmful substances. It also accelerates the healing process by increasing the levels of growth factors and prostaglandins in the area.
How Sucralfate works in the bodySucralfate helps heal duodenal ulcers, but exactly how it works is not yet known. Studies suggest that it binds to proteins and fibrinogen on the surface of ulcers, protecting them from the harmful effects of stomach acid. It also seems to increase growth factors and prostaglandins in the tissue to promote healing. In the lab, a sucralfate-albumin film helps block hydrogen ions from entering ulcers. In humans, sucralfate also decreases pepsin activity, which can damage tissues, and it can adsorb bile salts which can cause further injury
When to interrupt dosage
The suggested dose of Sucralfate is reliant upon the diagnosed issue, for example, Healing, Mucositis and Indigestion. The measure of dosage differs, as per the technique of presentation featured in the table below.Condition
Dosage
Administration
Healing
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Curling Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Indigestion
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Heartburn
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Gastritis
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Duodenal Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Chemotherapy
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Gastric Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Peptic Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Stress Ulcers
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Mucositis
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Anti-platelet Therapy
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Cream, Cream - Topical
Warnings
Sucralfate ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sucralfate may interact with Pulse Frequency
Common Sucralfate Drug Interactions
Drug Name
Risk Level
Description
Deferasirox
Major
Sucralfate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir
Major
Sucralfate can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m oxidronate
Major
The serum concentration of Technetium Tc-99m oxidronate can be increased when it is combined with Sucralfate.
Abacavir
Minor
Sucralfate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abafungin
Minor
Sucralfate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Toxicity & Overdose RiskOverdosing on Sucralfate is rare and has not been reported in humans. Consuming too much of the drug may cause constipation and require supportive care. The drug is classified as a pregnancy Category B drug, meaning that studies in animals have not revealed any harm to the fetus - however, there have been no clinical trials in pregnant women. It is unknown whether this drug is excreted in breast milk, so caution should be taken if a lactating or nursing woman takes the drug. Tests on rodents have revealed no signs of drug-related tumors at doses up to 12 times the recommended human dose.
Sucralfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Sucralfate?
46 investigations are currently in progress to assess the potential of Sucralfate for Heartburn, Dyspepsia and Anti-platelet Agents.Condition
Clinical Trials
Trial Phases
Gastric Ulcer
1 Actively Recruiting
Phase 4
Duodenal Ulcer
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
Anti-platelet Therapy
0 Actively Recruiting
Mucositis
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Indigestion
13 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 1, Phase 4
Peptic Ulcer
2 Actively Recruiting
Not Applicable, Phase 4
Stress Ulcers
0 Actively Recruiting
Chemotherapy
2 Actively Recruiting
Not Applicable
Heartburn
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
Healing
0 Actively Recruiting
Gastritis
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Sucralfate Reviews: What are patients saying about Sucralfate?
5Patient Review
4/6/2022 If you're struggling to get a large pill down, this medication comes in liquid form. Ask your pharmacy for more information.
5Patient Review
6/6/2021 This is one of the best heartburn treatments I've ever tried.
4.7Patient Review
3/30/2022 I only started taking this medication today to help with my acid reflux, which has been really bad for a few weeks now. I'm not sure if I have ulcers or gastritis yet since I haven't seen the specialist yet, but after only two doses of this medication, I already feel so much better! It's such a relief after all these weeks of being in agony. My stomach is still burning a bit, but overall I'm feeling much better.
4.7Patient Review
2/1/2017 I had to have surgery to fix a stomach valve defect, and afterwards my reflux/GERD got worse. Omeprazole helped but my esophagus was raw. Sucralfate has solved the problem for me; however, I've developed diarrhea recently so I am stopping taking the medication temporarily to see if that solves the issue.
4.7Patient Review
9/5/2022 Super easy to use and completely effective. I would definitely recommend this to anyone who has trouble swallowing pills!
4.3Patient Review
8/3/2021 This medication has been a literal lifesaver for me. I get periodic pain in my stomach and throat that's linked to inflammation. One pill usually does the trick overnight, though they are large. You can also dissolve them in water, which is what I do.
4Patient Review
10/9/2022 I've only been taking this for two days, but I'm already careful of the aluminum content. I don't have an ulcer or pain like most people; I just get acid heartburn. I got off Prilosec because it's not good for you in the long run.
4Patient Review
6/8/2018 The pill is large, but if you cut it in half it's much easier to swallow.
3.3Patient Review
1/3/2021 I've been struggling with Burning Mouth Syndrome for over a year and a half now. I've tried other treatments that have given me some relief, but recently I switched to sucralfate and noticed significant improvement.
3Patient Review
12/12/2021 The nausea this medication caused was really tough to manage. I had no appetite and nothing sounded good. I'm glad it's over.
3Patient Review
2/18/2018 I've nearly choked to death on these pills before, and would have if my husband wasn't there to help me. I have to cut them into fourths, and even then they still stick in my throat. They have a coating that's like an aspirin, which makes them difficult to swallow. The liquid version is much more expensive, but at least it wouldn't choke me.
2.3Patient Review
4/7/2018 Although this medication is easy to take, I have experienced some very unpleasant side effects like nausea and bile in my mouth. My doctor says to take it before eating, but that hasn't alleviated the issue.
2Patient Review
11/15/2021 I have been in a lot of stomach pain for the past few days due to gastritis. I was prescribed this medication by my primary care manager, but every time I take it I feel terrible. I'm not sure why it isn't working for me, but I am doing everything else that is recommended (like staying hydrated and eating yogurt). Maybe it just takes some time?
1.7Patient Review
2/8/2021 Nausea and dizziness was so severe that I couldn't continue the treatment.
1.3Patient Review
7/19/2021 I find myself really struggling with hunger since starting this medication.
1Patient Review
6/13/2022 I was prepared to take this medication until I read about some of the more serious side effects on Wikipedia. These aren't listed under general side effects and they're pretty scary!
1Patient Review
7/8/2022 This medication made me nauseous and gave me stomach pain as soon as I took it.
1Patient Review
4/24/2021 This treatment is really hurting my stomach.
Patient Q&A Section about sucralfate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should sucralfate be taken?
"If you are taking sucralfate to prevent an ulcer from returning after it has healed, the tablets usually are taken twice a day. It is best to take sucralfate on an empty stomach, 2 hours after or 1 hour before meals. Try to take sucralfate around the same times every day."
Answered by AI
What is sucralfate used for?
"Sucralfate is a medication used to treat and prevent duodenal ulcers and other conditions. It works by forming a barrier over the ulcer, protecting it from the acid of the stomach and allowing it to heal."
Answered by AI
What is the most common side effect of sucralfate?
"The most common side effect of sucralfate is constipation. This is because the medication works by binding to ulcers to protect them from further exposure to stomach acid, bile, pepsin, and bile salts. This gives the ulcers time to heal."
Answered by AI