Revia

Pruritus, Caloric Restriction, Obesity + 8 more
Treatment
7 FDA approvals
6 Active Studies for Revia

What is Revia

NaltrexoneThe Generic name of this drug
Treatment SummaryNaltrexone is a drug derived from noroxymorphone and is used to block the effects of narcotics and alcohol. It is more potent and longer lasting than naloxone, which makes it a good treatment for heroin addiction. Naltrexone has been approved by the FDA to treat alcohol dependence.
Naltrexone Hydrochlorideis the brand name
image of different drug pills on a surface
Revia Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Naltrexone Hydrochloride
Naltrexone
1998
59

Approved as Treatment by the FDA

Naltrexone, otherwise known as Naltrexone Hydrochloride, is approved by the FDA for 7 uses including Opioid-Related Disorders and Alcohol Dependency .
Opioid-Related Disorders
Helps manage Opioid Dependence
Alcohol Dependency
Helps manage Alcohol Dependency
Opioid Dependence
Helps manage Opioid Dependence
Therapeutic procedure
Used to treat inadequate alternative treatment options in combination with Morphine
Alcoholism
Helps manage Alcohol Dependency
Pain
Used to treat Severe Pain in combination with Morphine
Opiate Substitution Treatment
Used to treat requiring long-term opioid treatment in combination with Morphine

Effectiveness

How Revia Affects PatientsNaltrexone is a drug that blocks the effects of opioids in the body and is used to treat alcohol dependence. It stops the body from feeling the effects of opioids taken externally and blocks physical dependence on them. When taken with opioids, it can cause withdrawal symptoms in those who are physically dependent on them.
How Revia works in the bodyNaltrexone is a drug that blocks the effects of opioids in the brain. It does this by attaching itself to opioid receptors, which prevents other molecules, like endorphins, from binding to them. This stops the effects opioids have on the body, like pain relief, miosis, and respiratory depression. The major metabolite of naltrexone, 6-β-naltrexol, also has opioid blocking activity. It is unclear how it works to help treat alcoholism.

When to interrupt dosage

The serving of Revia is contingent upon the diagnosed problem, including Opioid Dependence, a reduced-calorie diet, and BMI >27 kg/m2. The measure of dosage diverges as per the method of delivery shown in the accompanying table.
Condition
Dosage
Administration
Comorbidity
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Chronic Weight Management therapy
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Pruritus
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Caloric Restriction
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Opioid-Related Disorders
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Increased physical activity levels
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Obesity
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Pain
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Alcoholism
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Opiate Substitution Treatment
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular
Therapeutic procedure
, 50.0 mg, 0.8 mg, 1.2 mg, 2.0 mg, 4.0 mg, 2.4 mg, 3.2 mg, 8.0 mg, 4.8 mg, 3.6 mg, 7.2 mg, 9.6 mg, 380.0 mg, 200.0 mg, 380.0 mg/mL, 90.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Subcutaneous, Implant, Implant - Subcutaneous, Intramuscular, Kit - Intramuscular

Warnings

Revia Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Withdrawal syndrome
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
There are 20 known major drug interactions with Revia.
Common Revia Drug Interactions
Drug Name
Risk Level
Description
Eluxadoline
Major
The risk or severity of constipation can be increased when Naltrexone is combined with Eluxadoline.
Methylene blue
Major
Naltrexone may increase the serotonergic activities of Methylene blue.
Methylnaltrexone
Major
Naltrexone may increase the opioid antagonism activities of Methylnaltrexone.
Mirtazapine
Major
Naltrexone may increase the serotonergic activities of Mirtazapine.
Naloxegol
Major
Naltrexone may increase the opioid antagonism activities of Naloxegol.
Revia Toxicity & Overdose RiskAnimals have a toxic dose of naltrexone between 1100-1550mg/kg for mice, 1450mg/kg for rats, and 1490mg/kg for guinea pigs. Taking very high doses of naltrexone (generally more than 1000mg/kg) can cause drooling, reduced energy levels, tremors, and seizures.
image of a doctor in a lab doing drug, clinical research

Revia Novel Uses: Which Conditions Have a Clinical Trial Featuring Revia?

Currently, 30 active studies are being conducted to assess the effectiveness of Revia in conjunction with a reduced-calorie diet, Pruritus alleviation and increased physical activity.
Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Comorbidity
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Increased physical activity levels
0 Actively Recruiting
Opioid-Related Disorders
0 Actively Recruiting
Opiate Substitution Treatment
0 Actively Recruiting
Obesity
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Alcoholism
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3

Revia Reviews: What are patients saying about Revia?

5Patient Review
2/21/2014
Revia for Prevention of Opiate Drug Abuse
I'm so glad I found this medication! It's been a month and it's working great for me with no side effects. I was using opiates and heroin before, but this pill has been a miracle for me.
5Patient Review
3/23/2009
Revia for Prevention of Opiate Drug Abuse
5Patient Review
1/11/2010
Revia for Prevention of Opiate Drug Abuse
I would like to learn more about this medication.
4.7Patient Review
1/13/2010
Revia for Habit of Drinking Too Much Alcohol
My fiance was an opiate addict for 3 years. He went to rehab and they gave him revia, which caused withdrawal symptoms for the first few days. But he tough it out and now he's been clean for a year! He's made so much progress and is the man I fell in love with again.
4.7Patient Review
5/13/2009
Revia for Prevention of Opiate Drug Abuse
I felt pretty bad after taking this, with diarrhea and still feeling cravings for Lortab.
View All Reviews
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Patient Q&A Section about revia

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between ReVia and Vivitrol?

"The only form of naltrexone that is FDA-approved for treating opioid use disorder is the injectable form, Vivitrol. Naltrexone in any form will block the effects of opioid drugs. Taking naltrexone reduces your tolerance to opioids."

Answered by AI

What is the meaning of ReVia?

"This drug blocks the action of opiates, which are drugs used to treat pain. It may be used to treat intravenous opiate addiction or alcohol dependence."

Answered by AI

How does naltrexone make you feel?

"Naltrexone works by blocking the parts of the brain that are associated with pleasure from alcohol and drugs. By doing this, it makes it easier to stop drinking."

Answered by AI

How do you use ReVia?

"This medicine is taken by mouth, with or without food. The usual dose is 50 mg per day. You may be monitored by a health care professional when taking this medicine."

Answered by AI

Clinical Trials for Revia

Have you considered Revia clinical trials? We made a collection of clinical trials featuring Revia, we think they might fit your search criteria.
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