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What is Requip
RopiniroleThe Generic name of this drug
Treatment SummaryRopinirole is a medication used to treat Parkinson's disease and restless legs syndrome. It was first approved by the FDA in 1997 for the management of Parkinson's disease and in 2005 for the treatment of restless legs syndrome. In 2008, extended-release capsules of ropinirole were approved, allowing for less frequent dosing, improved compliance, and similar side effects and effectiveness as older formulations of ropinirole. This medication is manufactured by GlaxoSmithKline Pharmaceuticals and is sold under the brand name ReQuip.
Requipis the brand name
Requip Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Requip
Ropinirole
1997
379
Approved as Treatment by the FDA
Ropinirole, otherwise called Requip, is approved by the FDA for 4 uses such as Primary and Restless Legs Syndrome .Primary
Restless Legs Syndrome
Parkinson's Disease
Helps manage Parkinson's Disease (PD)
Restless Legs Syndrome
Effectiveness
How Requip Affects PatientsRopinirole is used to treat Parkinson's and restless leg syndrome. It helps by stimulating the dopamine receptors, which control movement. Taking this drug may cause low blood pressure and make it drop further when standing or sitting up quickly. It may also cause nausea, bradycardia, and syncope. Ropinirole can lower the amount of prolactin in the body at doses as small as 0.2 mg. It has no effect on the heart rate or QT interval at doses up to 4 mg per day, but it is not known if it affects these things at higher doses.
How Requip works in the bodyRopinirole is an effective medicine for Parkinson's disease and Restless Legs Syndrome. It works by targeting dopamine receptors in certain areas of the brain, primarily the D3 receptors. These receptors help control body movement, and by stimulating them, ropinirole helps reduce symptoms. This drug does not affect other receptors, such as alpha2 adrenoreceptors or serotonin-1 receptors, so it does not produce any unwanted side effects.
When to interrupt dosage
The recommended measure of Requip is based upon the diagnosed condition, including Restless Legs Syndrome, Restless Legs Syndrome and Parkinson's Disease. The dosage likewise depends upon the manner of delivery as listed in the table beneath.Condition
Dosage
Administration
Primary
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson's Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Requip ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ropinirole may interact with Pulse Frequency
Common Requip Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Acebutolol.
Aliskiren
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Aliskiren.
Ambrisentan
Minor
Ropinirole may increase the hypotensive activities of Ambrisentan.
Amifostine
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amifostine.
Amiloride
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amiloride.
Requip Toxicity & Overdose RiskOverdosing on Ropinirole may cause agitation, chest pain, confusion, drowsiness, unusual facial movements, grogginess, increased jerky motions, dizziness or lightheadedness when standing, nausea, and vomiting. In animal studies, there was an increase in testicular tumors in rats and benign uterine polyps in mice at higher doses. Ropinirole was not found to be mutagenic or clastogenic. In female rats, ropinirole disrupted implantation at high doses. Pregnant women should not take Ropinirole due to the potential for adverse effects on the developing fetus
Requip Novel Uses: Which Conditions Have a Clinical Trial Featuring Requip?
51 active clinical trials are presently being conducted to assess the potential of Requip in alleviating Restless Legs Syndrome, Parkinson Disease and other Restless Legs Syndrome-related afflictions.Condition
Clinical Trials
Trial Phases
Parkinson Disease
7 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Restless Legs Syndrome
0 Actively Recruiting
Primary
0 Actively Recruiting
Restless Legs Syndrome
0 Actively Recruiting
Requip Reviews: What are patients saying about Requip?
5Patient Review
12/31/2014 My restless legs were affecting me any time of the day and night. I could not sit still in business meetings, go out to dinner, go to the movies, or sleep at night. I occasionally had symptoms in my arms, also. I started with small doses of Requip, but now take 4mg time release in the morning and 1 mg before bed.
5Patient Review
3/31/2016 Requip has been a game-changer for me and my sleep patterns. I no longer have to dread going to bed, knowing that it'll be another restless night of pain.
5Patient Review
7/27/2016 I no longer suffer from debilitating leg and ankle cramps since I started this medication.
4Patient Review
6/9/2014 At first, I didn't mind the nausea and stomach pain because this drug seemed to be effective in alleviating my RLS symptoms. However, as time has gone on, the symptoms have gotten worse and now they're even affecting me while driving. I feel like the medicine made the problem more unbearable than it was to start with.
4Patient Review
4/29/2017 I've had RLS for many years now, and it's mostly a nightly occurrence. This medication help me get through the evening without too much discomfort. The only downside is that I sometimes feel sleepy and have chest tension.
4Patient Review
7/17/2014 This treatment does a good job, but I have experienced severe diarrhea as a side effect.
3.7Patient Review
2/3/2016 This drug does help with RLS, but it also makes me very sleepy. After taking it, I'm out like a light within two hours. However, my leg twitches have stopped while sleeping. It's not something I can take during the day though.
2.7Patient Review
4/13/2022 I had to stop taking ropinerole because it started causing me severe stomach pain, nausea, and sometimes vomiting. I tried upping the dosage, but that only made things worse. I've had a CT scan and everything looks normal, so I don't know what the issue is. But I just can't take it anymore.
1.7Patient Review
1/1/2016 I've been taking the medication for a while now, and it doesn't seem to be as effective. I'm constantly tired, my joints hurt, and I have a cough that just won't go away. Not sure if it's related to the meds or not, but I'm going to try something else soon.
1Patient Review
11/11/2015 While this drug did help me with my RLS, I developed sores on my vulva after only a week of use. Once I stopped taking the medication, they cleared up immediately. I'm not sure if it was the 2mg dosage or what, but I'll be asking my doctor to prescribe something else.
1Patient Review
10/9/2017 I was prescribed Requip for my RLS, but it made the condition worse and almost killed me. I experienced serious side effects like muscle tremors and dehydration, which landed me in the ER. Do not take this medication!
Patient Q&A Section about requip
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Requip help with anxiety?
"The text states that ropinirole not only helps with motor symptoms, but also with anxiety and depression. The changes in mood and anxiety are linked to changes in sleep patterns."
Answered by AI
Is Requip a pain pill?
"Requip is a medication used to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. It is also used to treat restless legs syndrome."
Answered by AI
What is the drug Requip used for?
"This medication is used to treat Parkinson's disease either by itself or combined with other medications. It can help improve your ability to move, reduce tremors, stiffness, slow movement, and lack of balance. It can also reduce the number of times you can't move ("on-off syndrome")."
Answered by AI
Is Requip a muscle relaxer?
"Requip is a medication used to treat symptoms of Parkinson's disease and restless legs syndrome. It is a dopamine agonist and is available in generic form."
Answered by AI