Requip

Parkinson Disease, Parkinson's Disease, Primary + 2 more
Treatment
7 FDA approvals
20 Active Studies for Requip

What is Requip

RopiniroleThe Generic name of this drug
Treatment SummaryRopinirole is a medication used to treat Parkinson's disease and restless legs syndrome. It was first approved by the FDA in 1997 for the management of Parkinson's disease and in 2005 for the treatment of restless legs syndrome. In 2008, extended-release capsules of ropinirole were approved, allowing for less frequent dosing, improved compliance, and similar side effects and effectiveness as older formulations of ropinirole. This medication is manufactured by GlaxoSmithKline Pharmaceuticals and is sold under the brand name ReQuip.
Requipis the brand name
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Requip Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Requip
Ropinirole
1997
379

Approved as Treatment by the FDA

Ropinirole, otherwise called Requip, is approved by the FDA for 7 uses such as Moderate restless legs syndrome (RLS) and Parkinson's Disease (PD) .
Moderate restless legs syndrome (RLS)
Parkinson's Disease (PD)
Helps manage Parkinson's Disease (PD)
Severe restless legs syndrome (RLS)
Primary
Restless Legs Syndrome
Restless Legs Syndrome
Parkinson's Disease
Helps manage Parkinson's Disease (PD)

Effectiveness

How Requip Affects PatientsRopinirole is used to treat Parkinson's and restless leg syndrome. It helps by stimulating the dopamine receptors, which control movement. Taking this drug may cause low blood pressure and make it drop further when standing or sitting up quickly. It may also cause nausea, bradycardia, and syncope. Ropinirole can lower the amount of prolactin in the body at doses as small as 0.2 mg. It has no effect on the heart rate or QT interval at doses up to 4 mg per day, but it is not known if it affects these things at higher doses.
How Requip works in the bodyRopinirole is an effective medicine for Parkinson's disease and Restless Legs Syndrome. It works by targeting dopamine receptors in certain areas of the brain, primarily the D3 receptors. These receptors help control body movement, and by stimulating them, ropinirole helps reduce symptoms. This drug does not affect other receptors, such as alpha2 adrenoreceptors or serotonin-1 receptors, so it does not produce any unwanted side effects.

When to interrupt dosage

The recommended measure of Requip is based upon the diagnosed condition, including Restless Legs Syndrome, Restless Legs Syndrome and Parkinson's Disease. The dosage likewise depends upon the manner of delivery as listed in the table beneath.
Condition
Dosage
Administration
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson's Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Primary
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Requip Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ropinirole may interact with Pulse Frequency
There are 20 known major drug interactions with Requip.
Common Requip Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Acebutolol.
Aliskiren
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Aliskiren.
Ambrisentan
Minor
Ropinirole may increase the hypotensive activities of Ambrisentan.
Amifostine
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amifostine.
Amiloride
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amiloride.
Requip Toxicity & Overdose RiskOverdosing on Ropinirole may cause agitation, chest pain, confusion, drowsiness, unusual facial movements, grogginess, increased jerky motions, dizziness or lightheadedness when standing, nausea, and vomiting. In animal studies, there was an increase in testicular tumors in rats and benign uterine polyps in mice at higher doses. Ropinirole was not found to be mutagenic or clastogenic. In female rats, ropinirole disrupted implantation at high doses. Pregnant women should not take Ropinirole due to the potential for adverse effects on the developing fetus
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Requip Novel Uses: Which Conditions Have a Clinical Trial Featuring Requip?

51 active clinical trials are presently being conducted to assess the potential of Requip in alleviating Restless Legs Syndrome, Parkinson Disease and other Restless Legs Syndrome-related afflictions.
Condition
Clinical Trials
Trial Phases
Parkinson Disease
7 Actively Recruiting
Early Phase 1, Phase 2, Not Applicable
Restless Legs Syndrome
0 Actively Recruiting
Primary
0 Actively Recruiting
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Restless Legs Syndrome
0 Actively Recruiting

Requip Reviews: What are patients saying about Requip?

5Patient Review
12/31/2014
Requip for Extreme Discomfort in Calves when Sitting or Lying Down
My restless legs were affecting me any time of the day and night. I could not sit still in business meetings, go out to dinner, go to the movies, or sleep at night. I occasionally had symptoms in my arms, also. I started with small doses of Requip, but now take 4mg time release in the morning and 1 mg before bed.
5Patient Review
3/31/2016
Requip for Extreme Discomfort in Calves when Sitting or Lying Down
Requip has been a game-changer for me and my sleep patterns. I no longer have to dread going to bed, knowing that it'll be another restless night of pain.
5Patient Review
7/27/2016
Requip for Extreme Discomfort in Calves when Sitting or Lying Down
I no longer suffer from debilitating leg and ankle cramps since I started this medication.
4Patient Review
6/9/2014
Requip for Extreme Discomfort in Calves when Sitting or Lying Down
At first, I didn't mind the nausea and stomach pain because this drug seemed to be effective in alleviating my RLS symptoms. However, as time has gone on, the symptoms have gotten worse and now they're even affecting me while driving. I feel like the medicine made the problem more unbearable than it was to start with.
4Patient Review
4/29/2017
Requip for Extreme Discomfort in Calves when Sitting or Lying Down
I've had RLS for many years now, and it's mostly a nightly occurrence. This medication help me get through the evening without too much discomfort. The only downside is that I sometimes feel sleepy and have chest tension.
View All Reviews
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Patient Q&A Section about requip

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Requip help with anxiety?

"The text states that ropinirole not only helps with motor symptoms, but also with anxiety and depression. The changes in mood and anxiety are linked to changes in sleep patterns."

Answered by AI

Is Requip a pain pill?

"Requip is a medication used to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. It is also used to treat restless legs syndrome."

Answered by AI

What is the drug Requip used for?

"This medication is used to treat Parkinson's disease either by itself or combined with other medications. It can help improve your ability to move, reduce tremors, stiffness, slow movement, and lack of balance. It can also reduce the number of times you can't move ("on-off syndrome")."

Answered by AI

Is Requip a muscle relaxer?

"Requip is a medication used to treat symptoms of Parkinson's disease and restless legs syndrome. It is a dopamine agonist and is available in generic form."

Answered by AI

Clinical Trials for Requip

Have you considered Requip clinical trials? We made a collection of clinical trials featuring Requip, we think they might fit your search criteria.
Have you considered Requip clinical trials? We made a collection of clinical trials featuring Requip, we think they might fit your search criteria.
Have you considered Requip clinical trials? We made a collection of clinical trials featuring Requip, we think they might fit your search criteria.
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