Prolensa

Eye Pain, Cataract Surgery, Conjunctivitis

Treatment

5 FDA approvals

3 Active Studies for Prolensa

What is Prolensa

Bromfenac

The Generic name of this drug

Treatment Summary

Bromfenac is an eye medication used to reduce pain and inflammation. It belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Ophthalmic NSAIDs are often used to manage ocular pain and inflammation after surgery and have a long track record of being safe and effective.

Xibrom

is the brand name

image of different drug pills on a surface

Prolensa Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Xibrom

Bromfenac

2005

19

Approved as Treatment by the FDA

Bromfenac, otherwise called Xibrom, is approved by the FDA for 5 uses including Conjunctivitis and Ocular Inflammation .

Conjunctivitis

Ocular Inflammation

Eye

Helps manage Eye Pain

Eye Pain

Helps manage Eye Pain

Cataract Surgery

Helps manage Cataract Surgery

Effectiveness

How Prolensa Affects Patients

Bromfenac ophthalmic solution is an eye drop that helps reduce inflammation. It is a non-steroidal anti-inflammatory drug (NSAID) and should be used as directed.

How Prolensa works in the body

The way this drug works is by stopping the body from making prostaglandins. Prostaglandins can cause inflammation in the eyes. In animal studies, they have been linked to increased eye pressure, increased blood flow, and increased permeability of the blood vessels in the eye. The drug blocks the substances that make prostaglandins, so less of them are made and the inflammation is reduced.

When to interrupt dosage

The prescribed amount of Prolensa is contingent upon the diagnosed condition, including Cataract Surgery, Eye Pain and Ocular Inflammation. The degree of dosage is contingent upon the delivery technique (e.g. Solution / drops - Ophthalmic or Solution / drops), as mentioned in the table underneath.

Condition

Dosage

Administration

Cataract Surgery

, 0.9 mg/mL, 1.035 mg/mL, 0.07 %, 0.7 mg/mL, 0.76 mg/mL, 0.75 mg/mL

, Solution / drops - Ophthalmic, Ophthalmic, Solution / drops, Solution - Ophthalmic, Solution, Suspension / drops - Ophthalmic, Suspension / drops

Eye Pain

, 0.9 mg/mL, 1.035 mg/mL, 0.07 %, 0.7 mg/mL, 0.76 mg/mL, 0.75 mg/mL

, Solution / drops - Ophthalmic, Ophthalmic, Solution / drops, Solution - Ophthalmic, Solution, Suspension / drops - Ophthalmic, Suspension / drops

Conjunctivitis

, 0.9 mg/mL, 1.035 mg/mL, 0.07 %, 0.7 mg/mL, 0.76 mg/mL, 0.75 mg/mL

, Solution / drops - Ophthalmic, Ophthalmic, Solution / drops, Solution - Ophthalmic, Solution, Suspension / drops - Ophthalmic, Suspension / drops

Warnings

Prolensa Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Prolensa.

Common Prolensa Drug Interactions

Drug Name

Risk Level

Description

Valproic acid

Minor

The protein binding of Valproic acid can be decreased when combined with Bromfenac.

Aceclofenac

Moderate

The risk or severity of adverse effects can be increased when Bromfenac is combined with Aceclofenac.

Acemetacin

Moderate

The risk or severity of adverse effects can be increased when Bromfenac is combined with Acemetacin.

Acetylsalicylic acid

Moderate

The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Bromfenac.

Alclofenac

Moderate

The risk or severity of adverse effects can be increased when Bromfenac is combined with Alclofenac.

image of a doctor in a lab doing drug, clinical research

Prolensa Novel Uses: Which Conditions Have a Clinical Trial Featuring Prolensa?

Seven active clinical trials are currently evaluating Prolensa as a potential treatment for Cataract Surgery, Ocular Pain and Inflammation.

Condition

Clinical Trials

Trial Phases

Eye Pain

0 Actively Recruiting

Cataract Surgery

3 Actively Recruiting

Not Applicable

Conjunctivitis

0 Actively Recruiting

Prolensa Reviews: What are patients saying about Prolensa?

5

Patient Review

12/10/2013

Prolensa for Inflammation of the Eye Following Surgery

I had surgery and used this treatment. I experienced no problems whatsoever. Thank you!

5

Patient Review

6/21/2014

Prolensa for Inflammation of the Eye Following Surgery

Though this drug is effective, it's also very costly.

4.3

Patient Review

2/23/2018

Prolensa for Postoperative Pain in Eye

Though it is very expensive, this medication does what it's supposed to do. I have yet to find a generic brand that works as well.

3.7

Patient Review

1/24/2017

Prolensa for Inflammation of the Eye Following Surgery

I developed pain in both eyes after cataract surgery. My doctor recommended adding Durezol to my Prolensa routine. However, this only made my eyes more red, itchy, light sensitive, blurred, and twitching. They also became very dry. The post-operative effects have been a nightmare.

3.7

Patient Review

6/5/2021

Prolensa for Inflammation of the Eye Following Surgery

The usual dosage on the box suggests using for 14 days, however I found that 0.6 ml was enough for me and only needed it for ten days after my cataract surgery. Unfortunately, because I ran out over the weekend, I wasn't able to get a prescription from my doctor until Monday.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about prolensa

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic drug for PROLENSA?

"Use one drop of generic bromfenac (0.09% strength) in the affected eye once a day."

Answered by AI

What is the drug PROLENSA used for?

"PROLENSA is a drug that helps to reduce inflammation and eye pain in patients who have recently had surgery to remove cataracts."

Answered by AI

How long should PROLENSA be used?

"Before cataract surgery, use one drop of Prolensa™ in the affected eye once a day. On the day of surgery, use one drop of Prolensa™ and one drop of Bromday®. For two weeks after surgery, use one drop of Prolensa™ once a day."

Answered by AI

Is PROLENSA a steroid?

"Prolensa is an eye medication used to treat swelling and pain caused by cataract surgery. It is a non-steroidal anti-inflammatory drug (NSAID). Prolensa may also be used for other purposes not listed in this guide."

Answered by AI

Clinical Trials for Prolensa

Image of Byers Eye Institute in Palo Alto, United States.

LLM-Based Education for Cataract Surgery

18+
All Sexes
Palo Alto, CA

Patients with cataracts disease need to choose what type of artificial lens will go into their eye prior to surgery date. Some lenses are standard and are usually covered by insurance. Other "premium" lenses have various benefits such as reducing the need for glasses but usually require out-of-pocket costs. The combined busy outpatient clinic and complexity of artificial lens choices in the ever-changing world of cataract surgery tends to lead patients confused about their available lens options. There is an abundance of educational material present in premium lenses, however these are limited by accessibility and are standardized at single educational levels. Therefore in the present study, we want to test whether giving patients a short LLM powered AI-guided explanation from Custom GPT from OpenAI of lens options prior to their consultation with their doctor can improve visit efficiency, physician explanation and patient understanding of lens options. We will compare two groups: standard of care versus standard of care plus AI education. The LLM in this study is intended to provide supplemental information about premium intraocular lens(IOLs) options to study participants, and is no means supposed to replace a health care professional in the diagnosis, cure, treatment, and/or mitigation of disease. Study is analogous to giving a verified health pamphlet to a patient for them to view and learn different IOL options, in other words, facilitating patient understanding of their options. The LLM will be trained by several health care professionals and MD specialists to provide sufficient instructions. Sources will include verified online resources and MD information. The investigators hope to learn if a large language model-based educational tool can improve visit efficiency, physician explanation and patient understanding of intraocular lens options. New knowledge of this study could guide how cataract counseling is delivered in the future and may help clinics spend more time on individualized questions instead of repeating generic information.

Waitlist Available
Has No Placebo

Byers Eye Institute

Robert T Chang, MD

Image of University of California, San Francisco in San Francisco, United States.

Vision Centers for Eye Care

Any Age
All Sexes
San Francisco, CA

The goal of this clinical trial is to evaluate the effect of vision centers on access to eye care and eye health outcomes in South Asia. The main questions it aims to answer are: 1. Do vision centers increase visits to eyecare centers? 2. Do vision centers increase spectacle ownership and wearing? 3. Do vision centers improve visual acuity of the population? Researchers will compare outcomes in communities randomized to have a vision center is established with communities randomized to delay establishment of a vision center. Outcomes will be assessed through population-based surveys at baseline and after two years as well as through hospital records collected throughout the study period.

Waitlist Available
Has No Placebo

University of California, San Francisco

Kieran O'Brien, PhD, MPH