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What is Probuphine
BuprenorphineThe Generic name of this drug
Treatment SummaryBuprenorphine is a medication used to treat severe pain and opioid addiction. It is sold under the brand name Suboxone and is combined with naloxone, a drug that prevents buprenorphine from being abused. Buprenorphine binds to opioid receptors, reducing pain and withdrawal symptoms for up to 36 hours with fewer side effects than other strong opioids. It also has a lower risk of overdose and respiratory depression. Buprenorphine is sometimes used in opioid agonist treatment (OAT) which replaces illicit opioids with long-acting opioids to reduce cravings and drug-seeking behaviors. OAT
Buprenexis the brand name
Probuphine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Buprenex
Buprenorphine
1985
261
Approved as Treatment by the FDA
Buprenorphine, commonly known as Buprenex, is approved by the FDA for 1 uses which include Opioid Dependence .Opioid Dependence
Used to treat Opioid Dependence in combination with Naloxone
Effectiveness
How Probuphine Affects PatientsBuprenorphine is a drug that works by blocking opioid receptors in the brain. It is used to treat pain, sedation, and changes in mood. It can cause breathing problems, constipation, low libido, and infertility. Taking it long-term can lead to adrenal insufficiency, hepatitis, and other liver issues. It can also cause orthostatic hypotension, a rise in cerebrospinal fluid pressure, and an increase in bile duct pressure.
How Probuphine works in the bodyBuprenorphine is a drug used to treat severe pain. It works by attaching to opioid receptors in the brain, but it does not activate them as strongly as other opioids like heroin and oxycodone. This means that the effects of taking buprenorphine will level off at a certain dose, which helps reduce the risk of overdose. It also means that people taking buprenorphine do not get the same intense sedation or euphoria as with more potent opioids, which can help improve quality of life. Buprenorphine is sold in combination with naloxone, an
When to interrupt dosage
The amount of Probuphine is contingent upon the diagnosed malady, including Pain, Pain and Opioid Dependence. The quantity of dosage shifts depending on the technique of administration (e.g. Tablet - Oral or Sublingual) featured in the table underneath.Condition
Dosage
Administration
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Opioid Dependence
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Warnings
Probuphine ContraindicationsCondition
Risk Level
Notes
Alcohol Withdrawal Delirium
Do Not Combine
Asthma
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Head
Do Not Combine
ethanol
Do Not Combine
Oral Mucositis
Do Not Combine
Abdomen
Do Not Combine
severe CNS depression
Do Not Combine
opioid naive
Do Not Combine
Myasthenia Gravis
Do Not Combine
Epilepsy
Do Not Combine
Hypocalcemia
Do Not Combine
Hypokalemia
Do Not Combine
Hypomagnesemia
Do Not Combine
Mental Depression
Do Not Combine
Cerebrospinal Fluid
Do Not Combine
Long QT Syndrome
Do Not Combine
Common Probuphine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Buprenorphine.
Probuphine Toxicity & Overdose RiskSigns of acute morphine overdose include constricted pupils, drowsiness, low blood pressure, slowed breathing, and in extreme cases, death.
Probuphine Novel Uses: Which Conditions Have a Clinical Trial Featuring Probuphine?
21 active studies are being conducted to evaluate the potential of Probuphine to address Opioid Dependence, Pain and Pain Management.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Opioid Dependence
14 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Pain
0 Actively Recruiting
Probuphine Reviews: What are patients saying about Probuphine?
5Patient Review
2/13/2020 I didn't experience any withdrawal symptoms, which was great. I'm feeling back to my old self again.
Patient Q&A Section about probuphine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is probuphine used for?
"The prescription drug Probuphine is used to treat opioid dependence in people aged 16 and over. Probuphine contains the active ingredient buprenorphine. Healthcare professionals now call opioid dependence 'opioid use disorder' (OUD)."
Answered by AI
What is probuphine implant?
"A probuphine implant is a small device that is placed under the skin and contains 74.2 mg of buprenorphine. It is used to treat opioid dependence in patients who have achieved and sustained prolonged clinical stability on low to moderate doses of a trasmucosal buprenorphine-containing product (i.e., doses of no more than 8 mg per day of Subutex ...)."
Answered by AI
Why was probuphine taken off the market?
"Probuphine is a subdermal implant that is meant to release buprenorphine over a long period of time. It was approved by the FDA in 2016, but was discontinued by Titan Pharmaceuticals in 2020. The pandemic likely exacerbated the already high costs associated with the implant, leading to the discontinuation of the product."
Answered by AI
Is probuphine still available?
"Titan Pharmaceuticals has announced that it will no longer be supplying Probuphine implants to patients in the United States as of October 16th, 2020. The company has stated that it will continue to provide support to patients who are already receiving treatment with the implants."
Answered by AI
Is Probuphine still available?
"Is Probuphine still available? No, the manufacturer discontinued Probuphine in October 2020."
Answered by AI
Where is Probuphine implanted?
"Probuphine is a treatment that consists of four, one-inch-long rods that are implanted under the skin on the inside of the upper arm. It requires specific training to administer because it must be surgically inserted and removed. It provides treatment for six months."
Answered by AI
Why was Probuphine taken off the market?
"The drug Probuphine was discontinued by Titan Pharmaceuticals in 2020 due to high costs. The drug was approved by the FDA in 2016, but was not used much due to the pandemic."
Answered by AI
What is Probuphine used for?
"Probuphine is a brand-name prescription drug that is used to treat opioid dependence in certain people ages 16 years and older. Probuphine contains the active drug buprenorphine."
Answered by AI