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What is Permax
PergolideThe Generic name of this drug
Treatment SummaryPergolide is a medication used to treat symptoms of Parkinson’s Disease. It works by stimulating the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was initially approved in 1982 and used as an add-on medication with levodopa/carbidopa, but was later found to increase the risk of cardiac valvulopathy and was removed from the US and Canadian markets in 2007. Today, it is mainly used for veterinary purposes.
Pergolide Mesylateis the brand name
Permax Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pergolide Mesylate
Pergolide
2002
9
Approved as Treatment by the FDA
Pergolide, also known as Pergolide Mesylate, is approved by the FDA for 1 uses such as Parkinson's Disease .Parkinson's Disease
Used to treat Parkinson's Disease (PD) in combination with Carbidopa
Effectiveness
How Permax Affects PatientsPergolide works by stimulating certain parts of the brain to improve symptoms of movement disorders. It affects five types of dopamine receptors, namely D1, D2, D3, D4, and D5. The D2 and D3 receptors are particularly important for treating Parkinson's, as they help reduce symptoms like slow movements, tremors, and stiffness. It can also help protect the brain from long-term dopamine loss. However, it can also cause hallucinations and other mental side effects due to its action on the mesolimbic pathway. Pergolide also affects the tuberoinfundibular pathway, reducing
How Permax works in the bodyThe dopamine D2 receptor is a protein found in cells that helps control certain functions. When activated, it can reduce the amount of calcium that flows into cells, as well as the activity of certain proteins. This can reduce the release of hormones from the pituitary gland and help improve coordination in people with movement disorders. Activating this receptor also blocks certain chemical signals from cells, which may help reduce inflammation and other effects.
When to interrupt dosage
The prescribed amount of Permax is contingent upon the diagnosed condition. The dosage likewise varies as per the technique of delivery (e.g. Oral or Tablet) outlined in the table beneath.Condition
Dosage
Administration
Parkinson's Disease
, 0.05 mg, 0.25 mg, 1.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Permax has two contraindications, so it should not be taken while dealing with the conditions recorded in the following table.Permax ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pergolide may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Pergolide may interact with Pulse Frequency
Common Permax Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Pergolide may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Pergolide may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Pergolide may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Pergolide may increase the hypertensive and vasoconstricting activities of Abediterol.
Adrafinil
Major
Pergolide may increase the hypertensive and vasoconstricting activities of Adrafinil.
Permax Toxicity & Overdose RiskThe toxic dose of this drug in rats is 15mg/kg. Overdosing may cause nausea, vomiting, seizures, low blood pressure, and increased activity of the central nervous system.
Permax Novel Uses: Which Conditions Have a Clinical Trial Featuring Permax?
45 active trials are in progress to assess Permax's potential to alleviate symptoms of Parkinson's Disease.Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Permax Reviews: What are patients saying about Permax?
5Patient Review
10/2/2007 I was very disappointed that this drug was pulled off the market. I had been taking it for 10 years with no signs of heart valve problems.
Patient Q&A Section about permax
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What was pergolide used for in humans?
"Treatments for Parkinson's disease other than Pergolide are often preferred because Pergolide is associated with a small risk of fibrotic reactions."
Answered by AI
What is Permax used for?
"Permax is a drug used to treat the symptoms of Parkinson's disease, such as stiffness, tremors, spasms, and poor muscle control. It is often used in combination with other medications."
Answered by AI
What is pergolide used for?
"Pergolide is a dopamine receptor agonist that is used to treat Parkinson's disease in some countries. It is typically taken in pill form."
Answered by AI
Why was pergolide taken off the market?
"The FDA today announced that manufacturers of the drug pergolide will be voluntarily removing it from the market due to the risk of serious damage to patients' heart valves."
Answered by AI