Penicillin G Sodium

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Penicillin G Sodium

Treatment for

Gas Gangrene

What is Penicillin G Sodium

BenzylpenicillinThe Generic name of this drug

Treatment SummaryPenicillin G (Benzylpenicillin) is a type of antibiotic used to treat bacterial infections. It is usually given intravenously or intramuscularly as it is not easily absorbed orally. Penicillin G is typically used to treat infections caused by certain gram-positive bacteria, such as Streptococcus pneumoniae, Streptococcus agalactiae and Staphylococcus. It can also be used in some cases against gram-negative bacteria such as Neisseria meningitidis and Pasteurella. Penicillin G is not usually used to treat anaerobic infections.

Bicillin L-Ais the brand name

Penicillin G Sodium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Penicillin G Sodium Affects PatientsPenicillin G is an antibiotic used to treat bacterial infections caused by certain types of bacteria. It works by preventing the bacteria from forming their cell walls, which kills them. Penicillin G is effective against both gram-positive and gram-negative bacteria, and is resistant to many types of beta-lactamases that can break down other antibiotics.

How Penicillin G Sodium works in the bodyPenicillin G works by blocking specific proteins inside the bacterial cell wall. This stops the cell from being able to build its wall, causing it to break apart and die. Penicillin G is also believed to interfere with molecules that stop autolysis, which helps the cell wall break down even further.

When to interrupt dosage

The prescribed dose of Penicillin G Sodium is contingent upon the recognized ailment, which includes rat bite fever, Haverhill fever and Actinomycosis. The amount of dosage fluctuates as per the technique of delivery (e.g. Intramuscular; Intravenous or Injection, suspension) featured in the table beneath.

Condition

Dosage

Administration

Diphtheria

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, suspension, Injection, suspension - Intramuscular, Intramuscular, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Oral, Tablet - Oral, Tablet, Suspension - Intramuscular, Suspension, Suspension - Oral, Powder, for solution - Intramuscular, Injection, solution, Injection, solution - Intravenous, Injection, powder, for solution - Intravenous

Gonorrhea

Gas Gangrene

Anthrax

Bacterial Meningitis

Pneumonia

Syphilis

Pericarditis

Endocarditis

Haverhill fever

Communicable Diseases

Sepsis

Listeriosis

Fusospirochetosis

Meningococcal Meningitis

Acute Rheumatic Fever

Botulism

Lockjaw

Empyema

Actinomycosis

Warnings

Penicillin G Sodium has one contraindication and should not be administered together with any of the conditions listed in the below table.Penicillin G Sodium Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Penicillin G Sodium.

Common Penicillin G Sodium Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Penicillin G Sodium Toxicity & Overdose RiskThe toxic dose of cephalosporin in rats is 8900 mg/kg. Taking too much can lead to seizures, a decrease in white blood cells, and other neurological reactions. If cephalosporin is taken for more than two weeks at high doses, it can also cause a drop in the number of neutrophils in the blood.

Penicillin G Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Penicillin G Sodium?

85 active clinical trials are assessing the potential of Penicillin G Sodium in treating Pneumonia, Acute Rheumatic Fever and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Diphtheria

3 Actively Recruiting

Phase 4, Phase 2, Phase 1

Listeriosis

0 Actively Recruiting

Acute Rheumatic Fever

0 Actively Recruiting

Lockjaw

2 Actively Recruiting

Phase 2

Syphilis

9 Actively Recruiting

Phase 4, Not Applicable, Phase 3, Phase 2

Endocarditis

3 Actively Recruiting

Not Applicable, Phase 4

Empyema

2 Actively Recruiting

Not Applicable

Pneumonia

62 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1, Phase 4

Gonorrhea

1 Actively Recruiting

Phase 2

Haverhill fever

0 Actively Recruiting

rat bite fever

0 Actively Recruiting

Gram-Negative Bacterial Infections

4 Actively Recruiting

Phase 2, Phase 3

Bacterial Meningitis

2 Actively Recruiting

Phase 1, Phase 2

Botulism

3 Actively Recruiting

Phase 1, Phase 3, Phase 2

Fusospirochetosis

0 Actively Recruiting

Meningococcal Meningitis

0 Actively Recruiting

Gas Gangrene

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Actinomycosis

0 Actively Recruiting

Pericarditis

2 Actively Recruiting

Phase 2, Phase 3

Penicillin G Sodium Reviews: What are patients saying about Penicillin G Sodium?

4Patient Review

6/12/2009

Penicillin G Sodium for Bacterial Pneumonia caused by Streptococcus

The needle is quite long, but it does the job. I was a bit sore afterward, but nothing too bad.

1Patient Review

10/2/2013

Penicillin G Sodium for Pus in Lungs caused by Bacteria Clostridium Perfringens

This caused me to stop breathing and cough while I was in the hospital.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about penicillin g sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is penicillin G sodium used for?

"Penicillin G sodium is an antibiotic used to treat severe infections, such as strep throat, meningitis, anthrax, pneumonia, gonorrhea, and syphilis."

Answered by AI

What does penicillin G contain?

"Penicillin G potassium is a natural penicillin. Its chemical designation is 4-Thia-1- azabicyclo[3.2. 0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, monopotassium salt, [2S-(2α, 5α, 6β)]. It is crystalline."

Answered by AI

What is penicillin G sodium salt?

"Penicillin G Sodium is the sodium salt form of benzylpenicillin, a broad-spectrum penicillin antibiotic with bactericidal activity. Benzylpenicillin sodium binds to and inactivates penicillin-binding proteins located on the bacterial cell wall."

Answered by AI

What is the difference between penicillin G potassium and penicillin G sodium?

"Penicillin G Sodium is usually given to patients who can't take Penicillin G Potassium (for example, patients with kidney problems). Most patients who need penicillin given by injection can take Penicillin G Potassium, which is not in short supply."

Answered by AI

Clinical Trials for Penicillin G Sodium

Image of Vanderbilt University Medical Center in Nashville, United States.

Have you considered Penicillin G Sodium clinical trials? We made a collection of clinical trials featuring Penicillin G Sodium, we think they might fit your search criteria.

Image of California Department of Public Health in Richmond, United States.

Botulinum Vaccine for Botulism

18 - 69

All Sexes

Richmond, CA

This trial will test safety, tolerability, and effectiveness of a botulinum vaccine in healthy participants, with a 6-month follow-up.

Phase 2

Waitlist Available

Has No Placebo

California Department of Public Health

Image of University of Utah in Salt Lake City, United States.

Antibiotic Stewardship at Discharge for Pneumonia

18+

All Sexes

Salt Lake City, UT

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Waitlist Available

Has No Placebo

University of UtahValerie M Vaughn, MD

Image of University of Michigan in Ann Arbor, United States.

Motivational Interviewing for STI Screening

18+

All Sexes

Ann Arbor, MI

This trial will investigate if gay/bi men w/ HIV are willing to collect & return bacterial STI specimens for testing when combined with live AV conferencing support, to prevent health complications & reduce transmissions.

Waitlist Available

Has No Placebo

University of MichiganAkshay Sharma, PhD

Image of Duke University in Durham, United States.

Cefiderocol for Bacterial Infections in Newborns and Infants

< 18

All Sexes

Durham, NC

This trial studies the effectiveness of cefiderocol in treating bacterial infections in newborns & babies under 3 months.

Phase 2

Recruiting

Has No Placebo

Duke University (+1 Sites)Medical DirectorShionogi

Have you considered Penicillin G Sodium clinical trials? We made a collection of clinical trials featuring Penicillin G Sodium, we think they might fit your search criteria.

T2Bacteria® Panel +1 More for Staphylococcus aureus Bacteremia

18+

All Sexes

Nashville, TN

This trial will compare the use of a rapid diagnostic test called the T2Bacteria® Panel with the standard method of using blood cultures to identify bacterial infections in patients who are suspected to have an infection

Recruiting

Has No Placebo

Vanderbilt University Medical CenterMatthew Semler, MD, MSc

Image of Columbia University Irving Medical Center in New York, United States.

mLab App Plus for HIV and Syphilis Screening

18 - 35

Male

New York, NY

This trial will test an app to help young men who have sex with men and young transgender women to self-test for HIV and syphilis, helping to reduce the high rates of diagnoses in these groups.

Recruiting

Has No Placebo

Columbia University Irving Medical Center (+1 Sites)

Verified

Image of Accellacare of Hickory in Hickory, United States.

AV7909 Vaccine Booster for Anthrax

18 - 65

All Sexes

Hickory, NC

This trial tests a new vaccine to see how safe & effective it is after booster shots 6 & 12 months later.

Accellacare of Hickory (+5 Sites)Derek Eisnor, MDRho Federal Systems Division, Inc.

Image of 235 Plain Street in Providence, United States.

Botox Injections for Thumb Arthritis

18+

All Sexes

Providence, RI

This trial will study the safety and effectiveness of Botox as a treatment for thumb joint pain/arthritis.

Have you considered Penicillin G Sodium clinical trials? We made a collection of clinical trials featuring Penicillin G Sodium, we think they might fit your search criteria.

Unbiased ResultsWe believe in providing patients with all the options.

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Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.

Penicillin G Sodium

What is Penicillin G Sodium

Effectiveness

When to interrupt dosage

Warnings

Penicillin G Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Penicillin G Sodium?

Penicillin G Sodium Reviews: What are patients saying about Penicillin G Sodium?

Patient Q&A Section about penicillin g sodium

What is penicillin G sodium used for?

What does penicillin G contain?

What is penicillin G sodium salt?

What is the difference between penicillin G potassium and penicillin G sodium?

Clinical Trials for Penicillin G Sodium

MRSA Nasal Swab for Community-acquired Pneumonia

Mobile Van Clinic for Human Immunodeficiency Virus Infection

Moxifloxacin +1 More for Community-acquired Pneumonia

Amoxicillin for Community-acquired Pneumonia

Botulinum Vaccine for Botulism

Antibiotic Stewardship at Discharge for Pneumonia

Motivational Interviewing for STI Screening

Cefiderocol for Bacterial Infections in Newborns and Infants

T2Bacteria® Panel +1 More for Staphylococcus aureus Bacteremia

mLab App Plus for HIV and Syphilis Screening

AV7909 Vaccine Booster for Anthrax

Botox Injections for Thumb Arthritis

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