Ozurdex

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

57 FDA approvals

20 Active Studies for Ozurdex

Treatment for

Pemphigus

What is Ozurdex

DexamethasoneThe Generic name of this drug

Treatment SummaryDexamethasone, also known as MK-125, is a type of steroid used to treat a variety of conditions, including endocrine, rheumatic, and allergic diseases. It was developed in 1957 and is similar to other corticosteroids like hydrocortisone and prednisolone. Dexamethasone was approved by the FDA in 1958 and recently recommended for use in COVID-19 patients with severe respiratory symptoms. Studies have shown that Dexamethasone can reduce deaths by around one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Decadronis the brand name

image of different drug pills on a surface

Ozurdex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 57 uses which include Rosacea and Loeffler's syndrome .

Rosacea

Helps manage Rosacea

Loeffler's syndrome

Helps manage Loeffler's syndrome

Hypercalcemia

Helps manage Hypercalcemia

Brain

Helps manage Edema of the cerebrum

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Mycosis Fungoides (MF)

Helps manage Mycosis Fungoides (MF)

acquired immune hemolytic anemia

Helps manage acquired immune hemolytic anemia

Crohn Disease

Helps manage Regional Enteritis

Bursitis

Helps manage Bursitis

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Epicondylitis

Helps manage Epicondylitis

exfoliative erythroderma

Helps manage exfoliative erythroderma

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Congenital Hypoplastic Anemia

Helps manage Congenital Hypoplastic Anemia

Malignant Lymphomas

Helps manage Malignant Lymphomas

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

Optic Neuritis

Helps manage Optic Neuritis

Tuberculosis (TB)

Helps manage Tuberculosis (TB)

Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Drug Allergy

Helps manage Drug hypersensitivity reaction

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

Berylliosis

Helps manage Berylliosis

Synovitis

Helps manage Synovitis

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Pemphigus

Helps manage Pemphigus

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

Psoriasis

Helps manage severe Psoriasis

Ulcerative Colitis

Helps manage Ulcerative Colitis

Inflammation

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Cushing's Syndrome

Asthma

Helps manage Asthma

Trichinosis

Helps manage Trichinosis

Iritis

Helps manage Iritis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Iridocyclitis

Helps manage Iridocyclitis

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Acute Coryza

Helps manage acute rheumatic carditis

Choroiditis

Helps manage Choroiditis

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Chorioretinitis

Helps manage Chorioretinitis

Erythroblastopenia

Helps manage Erythroblastopenia

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Adrenocortical Hyperfunction

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

Serum Sickness

Helps manage Serum Sickness

Secondary thrombocytopenia

Helps manage Secondary thrombocytopenia

Sarcoidosis

Helps manage Sarcoidosis

Uveitis

Helps manage Uveitis

Thyroiditis

Helps manage non-suppurative Thyroiditis

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Effectiveness

How Ozurdex Affects PatientsCorticosteroids work by blocking inflammation-causing signals and promoting anti-inflammatory messages. How long these effects last depends on the type and how it's taken. Corticosteroids can be taken in much larger doses than the body would naturally produce. People taking corticosteroids should be aware that these drugs can suppress the natural hormone system, and make them more vulnerable to infections.

How Ozurdex works in the bodyCorticosteroids work to reduce inflammation. They do this by blocking blood vessels from widening, and by stopping white blood cells from travelling to sites of inflammation. When they bind to the glucocorticoid receptor, they alter gene expression and create multiple effects over time. These effects include inhibiting the breaking down of fatty acids and proteins, and promoting anti-inflammatory genes. Lower doses of corticosteroids bring about anti-inflammatory effects, while higher doses are immunosuppressive. Long-term use of high doses of corticosteroids can also alter sodium and potassium levels in the body.

When to interrupt dosage

The prescribed dosage of Ozurdex is reliant upon the diagnosed ailment, such as Pink Eye, Brain and Keloids Scars. The extent of dosage is contingent upon the procedure of delivery noted in the table beneath.

Condition

Dosage

Administration

Pemphigus

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Implant, Implant - Intravitreal, Intravitreal, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Suspension / drops, Solution, Solution - Ophthalmic, Auricular (otic), Suspension - Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Injection, Intra-articular; Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Elixir, Elixir - Oral, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Liquid - Intramuscular; Intrasynovial; Intravenous, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intrasynovial; Intravenous, Solution - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intramuscular; Intravenous, Topical, Solution / drops - Topical, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Ointment - Topical, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intramuscular; Intravenous, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Liquid - Dental, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Solution - Parenteral, Parenteral, Injection, solution - Ophthalmic, Intraocular, Injection, solution - Intraocular, Injection, suspension, Injection, suspension - Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Insert, Insert - Ophthalmic, Solution - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Perineural, Suspension / drops - Topical

Macular Edema

Chorioretinitis

Stevens-Johnson Syndrome

Iridocyclitis

Ophthalmia, Sympathetic

Iritis

Scleritis

Sarcoidosis

Inflammation

Hypercalcemia

Berylliosis

Otitis Externa

acquired immune hemolytic anemia

Infection

Loeffler's syndrome

Middle ear inflammation

Necrobiosis lipoidica diabeticorum

Uveitis

Episcleritis

Warnings

Ozurdex has nineteen contraindications and should not be amalgamated with the situations listed in the following table.Ozurdex Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

acute infectious stages of varicella

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

active ocular infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Ozurdex.

Common Ozurdex Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Ozurdex Toxicity & Overdose RiskThe most toxic dose of glucocorticoids in female mice is 6.5g/kg when taken orally and 794mg/kg when taken intravenously. Chronic high doses of glucocorticoids may cause cataracts, glaucoma, increased blood pressure, water retention, high cholesterol, ulcers, pancreatitis, muscle weakness, mood changes, mental illness, thinning skin, allergies, acne, too much body hair, weakened immune system, increased risk of infection, round face, high blood sugar, low calcium levels, low phosphate levels, and slow growth. If someone overdoses on glucocortic

image of a doctor in a lab doing drug, clinical research

Ozurdex Novel Uses: Which Conditions Have a Clinical Trial Featuring Ozurdex?

Currently, 345 active clinical trials are examining the potential of Ozurdex to address Eye Infections, Stevens-Johnson Syndrome and Chorioretinitis.

Condition

Clinical Trials

Trial Phases

Chorioretinitis

0 Actively Recruiting

anterior eye segment inflammation

0 Actively Recruiting

Necrobiosis lipoidica diabeticorum

0 Actively Recruiting

Granuloma Annulare

0 Actively Recruiting

Trichinosis

0 Actively Recruiting

ear infection-not otherwise specified caused by susceptible bacteria

0 Actively Recruiting

Pemphigus

1 Actively Recruiting

Phase 1

Keloids Scars

1 Actively Recruiting

Not Applicable

Middle ear inflammation

0 Actively Recruiting

Bullous dermatitis herpetiformis

0 Actively Recruiting

Acute Myeloid Leukemia (AML)

37 Actively Recruiting

Phase 1, Phase 2, Phase 3, Not Applicable

Bursitis

6 Actively Recruiting

Phase 4, Not Applicable

Iridocyclitis

1 Actively Recruiting

Phase 2, Phase 3

Bacterial Infections

0 Actively Recruiting

Acute Otitis Media (AOM)

3 Actively Recruiting

Not Applicable

Thyroiditis

0 Actively Recruiting

Ophthalmia, Sympathetic

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Phlyctenular keratoconjunctivitis

0 Actively Recruiting

Inflammation

172 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4

Ozurdex Reviews: What are patients saying about Ozurdex?

4.3Patient Review

11/4/2013

Ozurdex for Inflammation of Uvea of the Eye not caused by Infection

I have Pars Plantitis and this medication has done a great job at controlling the inflammation. I've also noticed that some of the floaters have cleared up and my eye pain is subsiding.

4Patient Review

10/17/2011

Ozurdex for Blockage of Central Blood Vein in Eye's Retina with Edema

I've had to get this surgery five times now, but it's helped correct my BRVO. The downside is that I may need cataract surgery because of the implant.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ozurdex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Ozurdex used to treat?

"OZURDEX® is not for people with other types of macular edema.

OZURDEX® is a prescription medicine that is an implant injected into the eye (vitreous) and used to treat adults with diabetic macular edema. It is not for people with other types of macular edema."

Answered by AI

How long do Ozurdex implants last for?

"An rod-shaped implant that is injected into the eye through a small needle-like device is used for up to six months before it needs to be replaced. This is a much more efficient method than having to use multiple eye drops every day."

Answered by AI

Does Ozurdex improve vision?

"The OZURDEX® implant is a slow-dissolving corticosteroid called dexamethasone that helps reduce inflammation in the retina. This medication helps improve visual acuity."

Answered by AI