Exercise for Non-Alcoholic Fatty Liver Disease

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Non-Alcoholic Fatty Liver DiseaseExercise - Behavioral
Eligibility
18 - 69
All Sexes
What conditions do you have?
Select

Study Summary

This trial found that a single session of high-intensity interval training (HIIT) improved liver fat and insulin sensitivity in those with NAFLD.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 17 Secondary · Reporting Duration: 16 weeks

16 weeks
Adiponectin
Body mass index
Change in liver fat
Change in stiffness of the liver
Enhance liver fibrosis (ELF) test
Fibroblast Growth Factor (FGF) 21
Hemoglobin A1c
Hip/waist circumference
Insulin
Interleukin-6
Liver ATP
Liver glycogen
Non-Alcoholic Fatty Liver Disease (NAFLD) Fibrosis Score
ProC3
TIMP-1
c-reactive protein
change in body composition
change in cholesterol and triglycerides levels (dyslipidemia)

Trial Safety

Safety Progress

1 of 3

Trial Design

3 Treatment Groups

Standard of Care
1 of 3
Exercise Arm 1
1 of 3
Exercise Arm 2
1 of 3

Active Control

Experimental Treatment

45 Total Participants · 3 Treatment Groups

Primary Treatment: Exercise · No Placebo Group · N/A

Exercise Arm 1
Behavioral
Experimental Group · 1 Intervention: Exercise · Intervention Types: Behavioral
Exercise Arm 2
Behavioral
Experimental Group · 1 Intervention: Exercise · Intervention Types: Behavioral
Standard of CareNoIntervention Group · 1 Intervention: Standard of Care · Intervention Types:
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise
2016
Completed Phase 1
~760

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 16 weeks

Who is running the clinical trial?

Milton S. Hershey Medical CenterLead Sponsor
461 Previous Clinical Trials
2,784,536 Total Patients Enrolled
Jonathan G StinePrincipal InvestigatorMilton S. Hershey Medical Center

Eligibility Criteria

Age 18 - 69 · All Participants · 5 Total Inclusion Criteria

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Who else is applying?

What state do they live in?
Pennsylvania100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Penn State Hershey Medical Center100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%