Omeprazole Magnesium

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 14 more
Treatment
5 FDA approvals
15 Active Studies for Omeprazole Magnesium

What is Omeprazole Magnesium

EsomeprazoleThe Generic name of this drug
Treatment SummaryEsomeprazole, sold under the brand name Nexium, is a medication used to treat gastroesophageal reflux disease (GERD), peptic ulcer disease, and other disorders related to too much stomach acid. It is a proton pump inhibitor (PPI) and works by blocking the production of stomach acid. Esomeprazole is usually prescribed with other antibiotics to help treat _H. pylori_ infections. It is generally safe and effective, but long-term use can lead to some side effects such as an increased risk of bacterial infections and reduced absorption of certain vitamins and minerals. Rapid
Nexiumis the brand name
image of different drug pills on a surface
Omeprazole Magnesium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexium
Esomeprazole
2001
347

Approved as Treatment by the FDA

Esomeprazole, otherwise called Nexium, is approved by the FDA for 5 uses including Heartburn and Heartburn .
Heartburn
Heartburn
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Gastro-esophageal Reflux Disease (GERD)
Helps manage Gastro-esophageal Reflux Disease (GERD)
Heartburn
Helps manage Gastro-esophageal Reflux Disease (GERD)

Effectiveness

How Omeprazole Magnesium Affects PatientsEsomeprazole is a drug that stops stomach acid from being released. It is used to treat GERD, heal damage to the esophagus, and to prevent ulcers in the stomach. It works by blocking the enzyme (H+/K+ ATPase) on the stomach wall that is responsible for producing acid. Esomeprazole is similar to another antacid, [DB00338], but does not have the same side effects. Taking esomeprazole long-term can lead to some risks, including increased risk of bacterial infections, difficulty absorbing certain vitamins, low magnesium levels, and
How Omeprazole Magnesium works in the bodyEsomeprazole works by blocking the enzyme that produces stomach acid. This enzyme, called the (H+, K+)-ATPase, is found on the surface of stomach cells. When esomeprazole binds to it, it stops the enzyme from creating acid. This effect lasts longer than 24 hours, and new enzyme needs to be produced for acid production to resume.

When to interrupt dosage

The suggested dosage of Omeprazole Magnesium is contingent upon the diagnosed condition, including Curling Ulcer, Hemorrhage and Critical Illness. The quantity of dosage fluctuates as per the approach of administration (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) outlined in the table beneath.
Condition
Dosage
Administration
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
antibacterial therapy
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Zollinger-Ellison Syndrome
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Curling Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Peptic Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
maintenance of healing Erosive esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Gastric ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Peptic Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Erosive Esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Critical Illness
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Helicobacter Pylori Infection
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
prophylaxis of Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Stomach Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

Omeprazole Magnesium has a single contraindication and should not be employed when one is suffering from any of the conditions outlined in the table below.Omeprazole Magnesium Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Omeprazole Magnesium.
Common Omeprazole Magnesium Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.
Atazanavir
Major
Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Esomeprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.
Omeprazole Magnesium Toxicity & Overdose RiskTaking too much of this drug may cause blurry vision, confusion, drowsiness, thirst, redness in the face, headache, stomach upset, an unusually fast heart rate, and excessive sweating.
image of a doctor in a lab doing drug, clinical research

Omeprazole Magnesium Novel Uses: Which Conditions Have a Clinical Trial Featuring Omeprazole Magnesium?

Currently, 26 active trials are examining the potential of Omeprazole Magnesium in treating prior gastric or duodenal ulcer, Stomach Ulcer and Peptic Ulcer Disorders.
Condition
Clinical Trials
Trial Phases
Hemorrhage
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
Gastric ulcer
0 Actively Recruiting
Helicobacter Pylori Infection
1 Actively Recruiting
Not Applicable
Stomach Ulcer
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Stress Ulcers
0 Actively Recruiting
maintenance of healing Erosive esophagitis
0 Actively Recruiting
Peptic Ulcer
0 Actively Recruiting
Critical Illness
0 Actively Recruiting
Hemorrhage
0 Actively Recruiting
Heartburn
12 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Phase 4
Peptic Ulcer
0 Actively Recruiting
prophylaxis of Stress Ulcers
0 Actively Recruiting

Omeprazole Magnesium Reviews: What are patients saying about Omeprazole Magnesium?

5Patient Review
8/23/2013
Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus
I was taking one 20ml tablet a day and it didn't seem to be doing much. I then started taking two pills each day, one in the morning and one at night. However, after a couple of weeks on this higher dosage, I started experiencing some pain on the left side of my back. Once I stopped taking the pills, the pain went away.
5Patient Review
12/25/2013
Omeprazole Magnesium for Treatment to Prevent Heartburn
I take this medication first thing in the morning and it really does help reduce or eliminate my heartburn symptoms. I've been taking it for years and would recommend it to others.
5Patient Review
3/16/2011
Omeprazole Magnesium for Stress Ulcer Prevention
5Patient Review
11/20/2011
Omeprazole Magnesium for Treatment to Prevent Heartburn
5Patient Review
4/18/2013
Omeprazole Magnesium for Heartburn
I've been on a lot of different medications for my heartburn, and none of them have really worked. I'm disappointed that after two years, I'm still not any better.
View All Reviews
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Patient Q&A Section about omeprazole magnesium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does omeprazole cause low magnesium?

"The majority of reports of low magnesium levels have been linked to extended use of omeprazole at standard doses (20-40mg daily). after discontinuing the medication, magnesium levels returned to normal."

Answered by AI

Is omeprazole the same as omeprazole magnesium?

"Omeprazole Magnesium is a generic drug, also known by its brand name, First-Omeprazole."

Answered by AI

Does magnesium interact with omeprazole?

"There are no known interactions between Chelated Magnesium and omeprazole, but this does not mean that interactions can't exist. Always check with your healthcare provider."

Answered by AI

What does omeprazole magnesium do?

"This medication works by decreasing the amount of acid your stomach makes, relieving symptoms such as heartburn, difficulty swallowing, and cough. It also helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus."

Answered by AI

Clinical Trials for Omeprazole Magnesium

Have you considered Omeprazole Magnesium clinical trials? We made a collection of clinical trials featuring Omeprazole Magnesium, we think they might fit your search criteria.
Have you considered Omeprazole Magnesium clinical trials? We made a collection of clinical trials featuring Omeprazole Magnesium, we think they might fit your search criteria.
Have you considered Omeprazole Magnesium clinical trials? We made a collection of clinical trials featuring Omeprazole Magnesium, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
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