Omeprazole Magnesium

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 14 more

Treatment

5 FDA approvals

18 Active Studies for Omeprazole Magnesium

What is Omeprazole Magnesium

Esomeprazole

The Generic name of this drug

Treatment Summary

Esomeprazole, sold under the brand name Nexium, is a medication used to treat gastroesophageal reflux disease (GERD), peptic ulcer disease, and other disorders related to too much stomach acid. It is a proton pump inhibitor (PPI) and works by blocking the production of stomach acid. Esomeprazole is usually prescribed with other antibiotics to help treat _H. pylori_ infections. It is generally safe and effective, but long-term use can lead to some side effects such as an increased risk of bacterial infections and reduced absorption of certain vitamins and minerals. Rapid

Nexium

is the brand name

image of different drug pills on a surface

Omeprazole Magnesium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nexium

Esomeprazole

2001

347

Approved as Treatment by the FDA

Esomeprazole, otherwise called Nexium, is approved by the FDA for 5 uses including Heartburn and Heartburn .

Heartburn

Heartburn

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Gastro-esophageal Reflux Disease (GERD)

Helps manage Gastro-esophageal Reflux Disease (GERD)

Heartburn

Helps manage Gastro-esophageal Reflux Disease (GERD)

Effectiveness

How Omeprazole Magnesium Affects Patients

Esomeprazole is a drug that stops stomach acid from being released. It is used to treat GERD, heal damage to the esophagus, and to prevent ulcers in the stomach. It works by blocking the enzyme (H+/K+ ATPase) on the stomach wall that is responsible for producing acid. Esomeprazole is similar to another antacid, [DB00338], but does not have the same side effects. Taking esomeprazole long-term can lead to some risks, including increased risk of bacterial infections, difficulty absorbing certain vitamins, low magnesium levels, and

How Omeprazole Magnesium works in the body

Esomeprazole works by blocking the enzyme that produces stomach acid. This enzyme, called the (H+, K+)-ATPase, is found on the surface of stomach cells. When esomeprazole binds to it, it stops the enzyme from creating acid. This effect lasts longer than 24 hours, and new enzyme needs to be produced for acid production to resume.

When to interrupt dosage

The suggested dosage of Omeprazole Magnesium is contingent upon the diagnosed condition, including Curling Ulcer, Hemorrhage and Critical Illness. The quantity of dosage fluctuates as per the approach of administration (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) outlined in the table beneath.

Condition

Dosage

Administration

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stomach Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

antibacterial therapy

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Zollinger-Ellison Syndrome

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Curling Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

maintenance of healing Erosive esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Gastric ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Erosive Esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Critical Illness

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Helicobacter Pylori Infection

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

prophylaxis of Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Omeprazole Magnesium has a single contraindication and should not be employed when one is suffering from any of the conditions outlined in the table below.

Omeprazole Magnesium Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Omeprazole Magnesium.

Common Omeprazole Magnesium Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.

Atazanavir

Major

Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Esomeprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.

Infigratinib

Major

The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.

Omeprazole Magnesium Toxicity & Overdose Risk

Taking too much of this drug may cause blurry vision, confusion, drowsiness, thirst, redness in the face, headache, stomach upset, an unusually fast heart rate, and excessive sweating.

image of a doctor in a lab doing drug, clinical research

Omeprazole Magnesium Novel Uses: Which Conditions Have a Clinical Trial Featuring Omeprazole Magnesium?

Currently, 26 active trials are examining the potential of Omeprazole Magnesium in treating prior gastric or duodenal ulcer, Stomach Ulcer and Peptic Ulcer Disorders.

Condition

Clinical Trials

Trial Phases

Hemorrhage

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Gastric ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Stomach Ulcer

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Stress Ulcers

0 Actively Recruiting

maintenance of healing Erosive esophagitis

0 Actively Recruiting

Peptic Ulcer

0 Actively Recruiting

Critical Illness

0 Actively Recruiting

Hemorrhage

0 Actively Recruiting

Heartburn

12 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Peptic Ulcer

0 Actively Recruiting

prophylaxis of Stress Ulcers

0 Actively Recruiting

Omeprazole Magnesium Reviews: What are patients saying about Omeprazole Magnesium?

5

Patient Review

8/23/2013

Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus

I was taking one 20ml tablet a day and it didn't seem to be doing much. I then started taking two pills each day, one in the morning and one at night. However, after a couple of weeks on this higher dosage, I started experiencing some pain on the left side of my back. Once I stopped taking the pills, the pain went away.

5

Patient Review

12/25/2013

Omeprazole Magnesium for Treatment to Prevent Heartburn

I take this medication first thing in the morning and it really does help reduce or eliminate my heartburn symptoms. I've been taking it for years and would recommend it to others.

5

Patient Review

3/16/2011

Omeprazole Magnesium for Stress Ulcer Prevention

5

Patient Review

11/20/2011

Omeprazole Magnesium for Treatment to Prevent Heartburn

5

Patient Review

4/18/2013

Omeprazole Magnesium for Heartburn

I've been on a lot of different medications for my heartburn, and none of them have really worked. I'm disappointed that after two years, I'm still not any better.

5

Patient Review

1/15/2017

Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus

Though it doesn't work in the same way as Nexium, this drug was highly effective for me. I really enjoyed taking it!

4.7

Patient Review

7/28/2011

Omeprazole Magnesium for Conditions of Excess Stomach Acid Secretion

4.7

Patient Review

6/11/2012

Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus

4.7

Patient Review

7/28/2014

Omeprazole Magnesium for Heartburn

This medication is very effective and very affordable.

4.3

Patient Review

6/6/2018

Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication has been a total game-changer for me and my acid reflux. I never forget to take it because it's such an easy pill to remember, and since starting it I haven't had any issues at all.

4.3

Patient Review

2/16/2020

Omeprazole Magnesium for Treatment to Prevent Heartburn

I've used this for 12 years and, for a long time, still battled with reflux. I finally discovered that the key is to take a lower dose than what is typically prescribed. Now, I haven't had any problems in over two years.

3.7

Patient Review

10/4/2012

Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus

I was taking anti-inflammatory drugs but developed stomach pains. This medication worked well for me.

3.7

Patient Review

10/25/2016

Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus

The medication worked but after taking it for just over a year, I started having hand tremors Went thru tests, including an MRI. After renewing my prescription, I read the insert more carefully. Seems it lowers the magnesium levels, which caused my problem, plus heart palpatations, rashes, & more. I've stopped the medication & will start Mg supplementation.

3.7

Patient Review

4/28/2013

Omeprazole Magnesium for Heartburn

I've taken omeprazole before and found it very easy to use. I didn't experience any negative effects, even after using it for more than two weeks straight.

3.7

Patient Review

4/6/2011

Omeprazole Magnesium for Condition in which Stomach Acid is Pushed Into the Esophagus

3.3

Patient Review

2/2/2015

Omeprazole Magnesium for Inflammation of the Stomach Lining caused by H. Pylori

I wonder how this medication will affect the absorption of methotrexate. I noticed that on this site, it says that methotrexate is a drug with interactions?

1

Patient Review

1/3/2013

Omeprazole Magnesium for Heartburn

While this medication was successful in reducing stomach acid, I began experiencing anxiety, tachycardia, and hypertension. After getting a full cardiac workup (which came back negative), I stopped taking the drug and my symptoms immediately disappeared.

1

Patient Review

4/23/2012

Omeprazole Magnesium for Ulcer of Duodenum caused by Bacteria Helicobacter Pylori

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about omeprazole magnesium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does omeprazole cause low magnesium?

"The majority of reports of low magnesium levels have been linked to extended use of omeprazole at standard doses (20-40mg daily). after discontinuing the medication, magnesium levels returned to normal."

Answered by AI

Is omeprazole the same as omeprazole magnesium?

"Omeprazole Magnesium is a generic drug, also known by its brand name, First-Omeprazole."

Answered by AI

Does magnesium interact with omeprazole?

"There are no known interactions between Chelated Magnesium and omeprazole, but this does not mean that interactions can't exist. Always check with your healthcare provider."

Answered by AI

What does omeprazole magnesium do?

"This medication works by decreasing the amount of acid your stomach makes, relieving symptoms such as heartburn, difficulty swallowing, and cough. It also helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus."

Answered by AI

Clinical Trials for Omeprazole Magnesium

Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA

Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.

Waitlist Available
Has No Placebo

University of California, Irvine - UCI Medical Center

Jason Samarasena, MD, MBA

Image of Del Sol Research Management, LLC in Tucson, United States.

Linaprazan Glurate vs Lansoprazole for Acid Reflux

18 - 80
All Sexes
Tucson, AZ

The goal of this clinical trial is to find out how well linaprazan glurate can heal erosive esophagitis (EE) caused by gastroesophageal reflux disease (GERD), compared to lansoprazole, a commonly used medication. Researchers will also evaluate whether linaprazan glurate: * Reduces heartburn symptoms more effectively than lansoprazole * Is safe and well tolerated, based on physical exams, blood tests, and vital signs (heart rate, blood pressure, temperature, and breathing rate) * Causes any side effects during treatment * Has different effects depending on how much of the drug is in the blood * Works differently depending on participants' genes Participants must be between 18 to 80 years old and have EE due to GERD confirmed by an endoscopy. Participants cannot join if they have an active Helicobacter pylori (HP) infection or were treated for HP in the past 6 weeks or have taken antibiotics or bismuth-containing drugs in the past 6 weeks. The study is a randomized, double-blind, active comparator-controlled trial lasting up to 4 months. Randomized means that participants are assigned by chance (like flipping a coin) to one of the treatment groups and double-blind means neither the participants nor the study team will know which treatment is given. Participants will be placed into one of three groups (about 167 people in each group): * Linaprazan glurate 50 mg twice a day * Linaprazan glurate 50 mg once a day * Lansoprazole 30 mg once a day Everyone will take 2 tablets and 1 capsule by mouth daily for 8 weeks. Some tablets or capsules will be placebos (look like medicine but contain no active drug). Participants will: * Undergo an endoscopy in the beginning and after 4 weeks of treatment * If healing is not observed, another endoscopy may be done at 8 weeks * During the procedure, doctors will use a thin, flexible tube with a camera to look at the esophagus and take small tissue samples (biopsies) * Have blood and urine tests at clinic visits to check overall health * Receive electrocardiograms (ECGs) to monitor heart function * Complete daily questionnaires on an electronic device about symptoms and experiences

Phase 3
Waitlist Available

Del Sol Research Management, LLC (+24 Sites)

Cinclus Pharma Holding AB

Have you considered Omeprazole Magnesium clinical trials?

We made a collection of clinical trials featuring Omeprazole Magnesium, we think they might fit your search criteria.
Go to Trials
Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting
Has No Placebo

Brigham and Women's Hospital

Christopher C Thompson, MD

Erbe Elektromedizin GmbH

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Mesh vs Pledgets for Hernia Repair

18+
All Sexes
Cleveland, OH

The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: * Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. * Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms

Recruiting
Has No Placebo

Cleveland Clinic Center for Abdominal Core Health

David M Krpata, MD

Have you considered Omeprazole Magnesium clinical trials?

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Have you considered Omeprazole Magnesium clinical trials?

We made a collection of clinical trials featuring Omeprazole Magnesium, we think they might fit your search criteria.
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