Nuplazid

Hallucinations, Parkinson Disease, Delusions
Treatment
4 FDA approvals
3 Active Studies for Nuplazid

What is Nuplazid

PimavanserinThe Generic name of this drug
Treatment SummaryPimavanserin, sold under the brand name Nuplazid, is a drug used to treat psychosis related to Parkinson's disease. It is different from other drugs used for this condition because it does not affect dopamine receptors, reducing the risk of side effects such as extrapyramidal symptoms. It was first approved by the FDA in 2016 and is now being studied for its potential to treat dementia-related psychosis. However, as of April 2021, it has not received FDA approval for this indication.
Nuplazidis the brand name
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Nuplazid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nuplazid
Pimavanserin
2016
3

Approved as Treatment by the FDA

Pimavanserin, otherwise known as Nuplazid, is approved by the FDA for 4 uses including Parkinson's Disease Psychosis and Parkinson Disease .
Parkinson's Disease Psychosis
Helps manage Parkinson's Disease Psychosis
Parkinson Disease
Helps manage Parkinson's Disease Psychosis
Delusions
Helps manage delusional thinking
Hallucinations
Helps manage Hallucinations

Effectiveness

How Nuplazid Affects PatientsPimavanserin works differently than other treatments to reduce hallucinations and delusions associated with Parkinson's disease. In clinical trials, the majority of patients (80.5%) reported an improvement in symptoms after taking pimavanserin. It also does not worsen motor functioning in these patients.
How Nuplazid works in the bodyPimavanserin works to treat hallucinations and delusions caused by Parkinson's Disease by affecting the balance of serotonin and dopamine in the brain. It does this by acting on serotonin 5-HT2A receptors and having limited effects on serotonin 5-HT2C receptors. Pimavanserin also does not affect muscarinic, dopaminergic, adrenergic, or histaminergic receptors, which prevents it from causing unwanted side effects.

When to interrupt dosage

The recommended measure of Nuplazid is contingent upon the diagnosed condition, such as Parkinson's Disease Psychosis, Hallucinations and Delusions. The amount of dosage is dependent on the administration technique (e.g. Tablet, coated or Capsule) provided in the table below.
Condition
Dosage
Administration
Parkinson Disease
, 17.0 mg, 10.0 mg, 34.0 mg
Oral, , Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral
Hallucinations
, 17.0 mg, 10.0 mg, 34.0 mg
Oral, , Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral
Delusions
, 17.0 mg, 10.0 mg, 34.0 mg
Oral, , Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral

Warnings

Nuplazid Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pimavanserin may interact with known hypersensitivity to the drug or any of the ingredients
There are 20 known major drug interactions with Nuplazid.
Common Nuplazid Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Minor
Pimavanserin may increase the neurotoxic activities of Amisulpride.
Amitriptylinoxide
Minor
Pimavanserin may increase the neurotoxic activities of Amitriptylinoxide.
Amperozide
Minor
Pimavanserin may increase the neurotoxic activities of Amperozide.
Aripiprazole lauroxil
Minor
Pimavanserin may increase the neurotoxic activities of Aripiprazole lauroxil.
Asenapine
Minor
Pimavanserin may increase the neurotoxic activities of Asenapine.
Nuplazid Toxicity & Overdose RiskThere is limited information available regarding the toxicity of pimavanserin. In clinical trials, nausea and vomiting have been reported as side effects. There is no known cure for an overdose of this drug, so medical professionals should begin monitoring the patient's heart and ECG immediately. If antiarrhythmic drugs are necessary, doctors should avoid those that may cause an extended QT interval, such as disopyramide, procainamide, or quinidine. It is important to note that pimavanserin stays in the bloodstream for up to 57 hours, and there may be multiple drugs involved in the overdose.
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Nuplazid Novel Uses: Which Conditions Have a Clinical Trial Featuring Nuplazid?

11 active clinical trials are presently in progress to assess the effectiveness of Nuplazid in addressing Delusions, Parkinson's Disease Psychosis and Hallucinations.
Condition
Clinical Trials
Trial Phases
Delusions
0 Actively Recruiting
Parkinson Disease
3 Actively Recruiting
Phase 4, Phase 2
Hallucinations
0 Actively Recruiting

Nuplazid Reviews: What are patients saying about Nuplazid?

5Patient Review
2/4/2017
Nuplazid for Psychosis associated with Parkinson's Disease
This medicine has been an absolute blessing. It's allowed me to spend more quality time with my dad, and the doctor was happy to prescribe it. The company does a lot of outreach to make sure we get the pills and works with the insurance, which is great.
5Patient Review
2/6/2017
Nuplazid for Psychosis associated with Parkinson's Disease
This medication did exactly what it said it would do with no negative side effects that I experienced.
4.3Patient Review
11/6/2016
Nuplazid for Psychosis associated with Parkinson's Disease
This treatment is really effective. I'm so glad I found it!
4Patient Review
11/18/2017
Nuplazid for Psychosis associated with Parkinson's Disease
I felt confused and lightheaded after taking this medication, but the hallucinations went away.
3.7Patient Review
3/29/2019
Nuplazid for Psychosis associated with Parkinson's Disease
It took a little while for this medication to start working, but when it did, I saw amazing results for two weeks. However, the hallucinations and confusion came back after that. Plus, the co-pay is really expensive. Not sure if it's worth it.
View All Reviews
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Patient Q&A Section about nuplazid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is NUPLAZID for Parkinson's?

"Nuplazid (pimavanserin) is an oral medication that has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of hallucinations and delusions associated with [Parkinson's disease](https://www.withpower.com/clinical-trials/parkinson's-disease) psychosis. People with Parkinson's disease often experience symptoms such as tremors, limb stiffness, impaired balance, and slow movement."

Answered by AI

How long does it take for NUPLAZID to work?

"If you're taking NUPLAZID to treat hallucinations and delusions related to Parkinson's disease, you may start to see improvements in as little as 4 weeks. However, it can take up to 6 weeks to feel the full effects of the medication. You shouldn't stop taking NUPLAZID without first talking to your healthcare provider."

Answered by AI

Is NUPLAZID an antipsychotic?

"It's important to note that Nuplazid has a boxed warning about people with dementia-related psychosis who are not taking antipsychotic drugs for Parkinson's disease."

Answered by AI

What is the drug NUPLAZID used for?

"The FDA approved Nuplazid in 2016 to treat visual hallucinations and delusions caused by [Parkinson's disease](https://www.withpower.com/clinical-trials/parkinson's-disease) psychosis. Parkinson's disease psychosis may be caused by the disease itself or by medications used to treat it."

Answered by AI

Clinical Trials for Nuplazid

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