Neomycin Sulfate

Pseudomonas Infections, Otitis Externa, Klebsiella + 15 more

Treatment

9 FDA approvals

15 Active Studies for Neomycin Sulfate

Treatment for

Pseudomonas Infections

What is Neomycin Sulfate

Polymyxin BThe Generic name of this drug

Treatment SummaryNeomycin is a type of antibiotic used to treat bacterial infections. It is made from the metabolic products of a certain type of bacteria. Neomycin is a complex made up of three different components, with neomycin B and C being the active ingredients. It is mainly used to treat bacterial infections in the ear, eye, and skin. Neomycin sulfate is the most common form of the drug and is available as a solution, otic suspension, and ophthalmic preparation. It is also available in over-the-counter topical products.

Polysporinis the brand name

image of different drug pills on a surface

Neomycin Sulfate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Polysporin

Polymyxin B

1951

279

Approved as Treatment by the FDA

Polymyxin B, commonly known as Polysporin, is approved by the FDA for 9 uses like Meningitis, Bacterial and Conjunctivitis .

Meningitis, Bacterial

Conjunctivitis

Used to treat Ocular Inflammation in combination with Dexamethasone

Ocular Inflammation

Used to treat Ocular Inflammation in combination with Dexamethasone

Bacterial Infections

Urinary Tract Infections

ocular bacterial infections

Used to treat ocular bacterial infections in combination with Bacitracin

Bacteremia caused by Enterobacter aerogenes

Pseudomonas Infections

Urinary Tract Infection (UTI)

Effectiveness

How Neomycin Sulfate Affects PatientsNeomycin works by blocking the production of proteins in bacteria, which stops them from growing and surviving. This effect can last for up to 72 hours after taking the drug. Additionally, neomycin helps reduce the number of bacteria in the colon that produce ammonia, which can help improve neurological symptoms in those with hepatic coma. Neomycin works on both gram-positive and gram-negative bacteria, including the common species of E. coli and Klebsiella-Enterobacter group. However, some strains of E. coli, Klebsiella, and Proteus spp. have developed resistance to neomycin

How Neomycin Sulfate works in the bodyNeomycin is an antibiotic that works by preventing bacteria from making proteins, which stops them from multiplying. It does this by binding to the bacterial ribosomes, which are responsible for making proteins, and blocking them from working correctly.

When to interrupt dosage

The proposed dose of Neomycin Sulfate is contingent upon the diagnosed disorder, such as Itching arising from Infection, Secondarily Infected Eczema and Communicable Diseases. Dosage can be found in the table below, contingent upon the technique of delivery (e.g. Suspension - Auricular (otic) or Topical).

Condition

Dosage

Administration

Meningitis caused by Haemophilus influenzae

, 100000.0 [USP'U]/mL, 5.0 [USP'U]/mg, 10.0 [USP'U]/mg, 10.0 [iU]/mg, 5.0 [iU]/mg, 200000.0 [USP'U]/mL, 10000.0 [USP'U]/mL, 1.0 [USP'U]/mg, 10000.0 units/mL, 10000.0 mL/mL, 10.0 mg/mg, 10000.0 mg/mL, 500000.0 [iU], 500000.0 [USP'U], 10.0 units/mg, 5000.0 [USP'U], 5.0 units/mg, 5.3228 [iU]/mg, 10000.0 [iU]/mL, 200000.0 [iU]/mL, 0.5 units/mg, 0.0052 mg/mg, 1.0 [iU]/mg, 16250.0 units/mL, 1500.0 units, 50.0 [iU]/mg, 0.01 mg/mg, 0.1 [USP'U]/mg, 10000.0 mg/mg, 50.0 mg, 500000.0 units, 0.77 mg/mL, 5000.0 units/mL, 15.0 [USP'U]/mg, 0.006 mg/mg, 6.0 units/mg, 6000.0 units/mL, 200000.0 units/mL, 1.0 units/mg

Ophthalmic, , Solution / drops - Ophthalmic, Topical, Ointment - Topical, Cream - Topical, Ointment - Ophthalmic, Irrigant - Irrigation, Irrigation, Suspension / drops - Auricular (otic), Auricular (otic), Solution / drops - Auricular (otic), Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Solution - Ophthalmic, Injection, powder, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Intramuscular; Intrathecal; Intravenous; Ophthalmic, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Intramuscular; Intravenous, Solution - Irrigation, Stick - Topical, Suspension - Auricular (otic), Powder - Topical, Solution - Auricular (otic), Liquid - Auricular (otic), Powder, Solution / drops, Ointment, Suspension, Cream, Kit, Injection, Injection, solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Kit - Topical, Injection, powder, for solution, Lozenge - Oral, Intramuscular; Intrathecal; Intravenous, Intramuscular; Intrathecal; Intravenous; Respiratory (inhalation); Topical, Suspension / drops, Liquid - Ophthalmic, Solution, Lozenge, Gel - Topical, Oral, Liquid, Solution - Auricular (otic); Ophthalmic, Auricular (otic); Ophthalmic, Buccal, Stick, Ointment - Ophthalmic; Topical, Lozenge - Buccal, Ophthalmic; Topical, Injection - Intramuscular; Intrathecal; Intravenous, Powder, for solution, Injection, powder, lyophilized, for solution, Solution / drops - Auricular (otic); Ophthalmic, Ointment; Swab - Topical, Injection, solution, Gel, Powder, for solution - Intramuscular; Intrathecal; Intravenous; Respiratory (inhalation); Topical, Kit - Oral; Topical, Swab - Topical, Ointment; Swab, Suspension - Topical, Oral; Topical, Liquid - Auricular (otic); Ophthalmic, Powder, for solution - Intramuscular; Intrathecal; Intravenous; Ophthalmic, Irrigant, Swab, Solution - Urethral, Urethral, Injection, powder, lyophilized, for solution - Intramuscular; Intrathecal; Intravenous, Kit - Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Irrigation; Ophthalmic; Topical, Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Topical, Kit - Ophthalmic, Kit - Ophthalmic; Topical, Ophthalmic; Respiratory (inhalation); Topical, Electro-osmosis, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Respiratory (inhalation); Topical, Kit - Electro-osmosis, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Irrigation; Oral; Respiratory (inhalation); Topical, Kit - Irrigation; Oral; Respiratory (inhalation); Topical, Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Topical, Ophthalmic; Oral; Topical, Kit - Respiratory (inhalation); Topical, Respiratory (inhalation); Topical, Oral; Respiratory (inhalation); Topical, Kit - Oral; Respiratory (inhalation); Topical, Suspension / drops - Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated

Communicable Diseases

Otitis

ocular bacterial infections

Urinary Tract Infections

Urinary Tract Infection (UTI)

Conjunctivitis

Meningitis, Bacterial

Bacteria

Otitis Externa

Klebsiella

Conjunctivitis, Bacterial

Ear Inflammation

Bacteremia caused by Enterobacter aerogenes

Conjunctivitis

Otorrhoea

Pseudomonas Infections

Urinary tract infection

Warnings

Neomycin Sulfate Contraindications

Condition

Risk Level

Notes

conjunctiva

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Neomycin Sulfate.

Common Neomycin Sulfate Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Polymyxin B.

Naxitamab

Minor

Polymyxin B may increase the neurotoxic activities of Naxitamab.

Typhoid vaccine

Minor

The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Polymyxin B.

(R)-warfarin

Moderate

The risk or severity of bleeding can be increased when Polymyxin B is combined with (R)-warfarin.

(S)-Warfarin

Moderate

The risk or severity of bleeding can be increased when Polymyxin B is combined with (S)-Warfarin.

Neomycin Sulfate Toxicity & Overdose RiskNeomycin sulfate has a low toxicity in mice, with an oral LD50 greater than 8 g/kg, a subcutaneous LD50 of 200 mg/kg in rats and 190 mg/kg in mice, and an intraperitoneal LD50 of 305 mg/kg in mice. It is unlikely to cause an overdose through oral ingestion, since it is poorly absorbed. However, it can still cause serious side effects such as nerve damage, hearing loss, and kidney damage when administered over time, especially in those with kidney impairment. Pregnant women should not take neomycin as it may cause total irreversible bilateral congen

image of a doctor in a lab doing drug, clinical research

Neomycin Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Neomycin Sulfate?

405 active clinical trials are currently underway to assess the potential of Neomycin Sulfate in alleviating Inflammation, Atopic Dermatitis and related skin conditions.

Condition

Clinical Trials

Trial Phases

Otitis

2 Actively Recruiting

Not Applicable

Urinary Tract Infections

4 Actively Recruiting

Not Applicable, Phase 4

Urinary Tract Infection (UTI)

9 Actively Recruiting

Phase 1, Phase 3, Phase 4, Not Applicable

Bacteria

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Meningitis, Bacterial

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Pseudomonas Infections

0 Actively Recruiting

ocular bacterial infections

0 Actively Recruiting

Urinary tract infection

0 Actively Recruiting

Conjunctivitis, Bacterial

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Klebsiella

0 Actively Recruiting

Ear Inflammation

0 Actively Recruiting

Meningitis caused by Haemophilus influenzae

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Otorrhoea

0 Actively Recruiting

Bacteremia caused by Enterobacter aerogenes

0 Actively Recruiting

Patient Q&A Section about neomycin sulfate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is neomycin sulfate good for skin?

"Neomycin Sulphate Cream is effective against a variety of skin infections, including boils, impetigo, and infected hair follicles. It can also be used to treat infections in small cuts or wounds on the skin."

Answered by AI

What are the side effects of neomycin sulfate?

"If you experience any of the following symptoms, please contact a doctor as soon as possible: hearing loss, clumsiness, difficulty breathing, drowsiness, decreased frequency of urination or amount of urine, increased amount of gas, increased thirst, light-colored, frothy, fatty-appearing stools."

Answered by AI

What is neomycin sulfate used for?

"Neomycin is an antibiotic that is used to treat or prevent skin infections that are caused by bacteria. It is not effective against fungal or viral infections. This medication may be prescribed for other uses. If you have any questions, please ask your doctor or pharmacist."

Answered by AI

What kind of bacteria does neomycin treat?

"Neomycin is an effective bactericidal agent against a wide variety of bacteria, including Staphylococcus aureus, and develops resistance less readily than other agents. It is also more effective against Proteus vulgaris than is polymyxin B."

Answered by AI

Clinical Trials for Neomycin Sulfate

Have you considered Neomycin Sulfate clinical trials? We made a collection of clinical trials featuring Neomycin Sulfate, we think they might fit your search criteria.

Have you considered Neomycin Sulfate clinical trials? We made a collection of clinical trials featuring Neomycin Sulfate, we think they might fit your search criteria.