Navelbine

Uterine Cervical Neoplasms, Monotherapy, Metastatic Breast Cancer + 4 more

Treatment

4 FDA approvals

20 Active Studies for Navelbine

Treatment for

Uterine Cervical Neoplasms

What is Navelbine

VinorelbineThe Generic name of this drug

Treatment SummaryVinorelbine is a chemotherapy drug used to treat breast cancer and non-small cell lung cancer (NSCLC). It was approved by the FDA in the 1990s specifically for NSCLC. Vinorelbine belongs to a group of drugs known as vinca alkaloids, which have been found to improve survival rates in patients with advanced NSCLC. However, treatment with vinorelbine can cause serious side effects. A study was done that showed that genetic mutations can affect how quickly the body clears vinorelbine, with some patients clearing the drug up to 4.3 times faster than others

Vinorelbineis the brand name

Navelbine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Vinorelbine

2003

Approved as Treatment by the FDA

Vinorelbine, otherwise called Vinorelbine, is approved by the FDA for 4 uses which include Metastatic Non-Small Cell Lung Cancer and Carcinoma, Non-Small-Cell Lung .

Metastatic Non-Small Cell Lung Cancer

Used to treat Metastatic Non-Small Cell Lung Cancer in combination with Cisplatin

Carcinoma, Non-Small-Cell Lung

Used to treat Locally Advanced Non-Small Cell Lung Cancer in combination with Cisplatin

Previously Untreated

Used to treat Previously Untreated in combination with Cisplatin

Malignant Neoplasms

Used to treat Metastatic Non-Small Cell Lung Cancer in combination with Cisplatin

Effectiveness

How Navelbine Affects PatientsVinorelbine is a medication used to fight tumors. It belongs to a group of drugs called vinca-alkaloids, which stop cancer cells from dividing by preventing them from forming the structures needed for cell division.

How Navelbine works in the bodyVinorelbine tartrate is a special type of vinca alkaloid that works to fight cancer. It does this by inhibiting the process of cell division, by attaching to the microtubule proteins in the cell. This prevents cells from dividing and reproducing, resulting in cell death. Vinorelbine also works to activate certain tumor suppressor genes, like p53, and deactivate certain cancer-promoting proteins. It also affects metabolism, respiration, and other essential cell functions. All of these effects together lead to the death of cancerous cells.

When to interrupt dosage

The dosage of Navelbine is contingent upon the diagnosed issue, including Monotherapy, Soft Tissue Sarcoma and Malignant Neoplasms. The quantity of dosage is further dependent upon the administration approach (e.g. Solution - Intravenous or Solution) elucidated in the accompanying table.

Condition

Dosage

Administration

Uterine Cervical Neoplasms

, 10.0 mg/mL, 50.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous

Monotherapy

, 10.0 mg/mL, 50.0 mg/mL

Carcinoma, Non-Small-Cell Lung

, 10.0 mg/mL, 50.0 mg/mL

Malignant Neoplasms

, 10.0 mg/mL, 50.0 mg/mL

Soft Tissue Sarcoma

, 10.0 mg/mL, 50.0 mg/mL

Previously Untreated

, 10.0 mg/mL, 50.0 mg/mL

Metastatic Breast Cancer

, 10.0 mg/mL, 50.0 mg/mL

Warnings

There are 20 known major drug interactions with Navelbine.

Common Navelbine Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Vinorelbine is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Vinorelbine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abetimus

Major

The risk or severity of adverse effects can be increased when Vinorelbine is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Vinorelbine is combined with Acteoside.

Aldosterone

Major

The risk or severity of adverse effects can be increased when Vinorelbine is combined with Aldosterone.

Navelbine Toxicity & Overdose RiskVinorelbine has been linked to a variety of potential side effects, including decreased white blood cell count, infections, anemia, tingling or numbness in the extremities, hair loss, difficulty breathing, nausea, constipation, vomiting, diarrhea, fatigue, abdominal pain, chest pain, jaw pain, muscle aches, joint aches, headaches, difficulty swallowing, skin rash, bleeding in the bladder, and abnormal production of a hormone. It may also affect the chromosomes in the body. These side effects vary in severity and some may be life-threatening.

image of a doctor in a lab doing drug, clinical research

Navelbine Novel Uses: Which Conditions Have a Clinical Trial Featuring Navelbine?

155 active studies are being conducted to assess the potential of Navelbine as a Monotherapy, Previously Untreated and Soft Tissue Sarcoma Treatment.

Condition

Clinical Trials

Trial Phases

Metastatic Breast Cancer

1 Actively Recruiting

Phase 1, Phase 2

Carcinoma, Non-Small-Cell Lung

11 Actively Recruiting

Phase 3, Phase 2, Early Phase 1, Not Applicable

Monotherapy

1 Actively Recruiting

Phase 1, Phase 2

Malignant Neoplasms

4 Actively Recruiting

Phase 1, Phase 2

Uterine Cervical Neoplasms

0 Actively Recruiting

Previously Untreated

0 Actively Recruiting

Soft Tissue Sarcoma

59 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Navelbine Reviews: What are patients saying about Navelbine?

5Patient Review

10/23/2013

Navelbine for Breast Cancer that has Spread to Another Part of the Body

Navelbine was fantastic for my bone and soft tissue cancer in my neck. I had weekly treatments for six months with very minimal side effects-- just some leg fatigue at the six month mark. I stopped taking it because of the leg pain, but if my current treatment stops working, I can go back on Navelbine. Right now, my cancer is stable.

5Patient Review

7/20/2013

Navelbine for Breast Cancer that has Spread to Another Part of the Body

Navelbine was really the first treatment that helped me. I had bone mets from breast cancer and the pain was unbearable. But after beginning this medication, I felt so much better almost immediately!

5Patient Review

7/8/2009

Navelbine for Cancer of the Uterus

My mom has been battling lung cancer for over 10 years and we've tried a lot of different treatments. This is one of the last options, but it's working really well for her. She doesn't have many side effects and is able to live a normal life including going shopping and exercising twice a week!

5Patient Review

1/22/2009

Navelbine for Breast Cancer that has Spread to Another Part of the Body

I've been taking this medication for almost four years, and it's been working great! The only downside is the side effects, but they're manageable.

4.7Patient Review

6/24/2013

Navelbine for Breast Cancer that has Spread to Another Part of the Body

I'm currently on my fifth cycle of this medication, and the biggest complaint I have is the fatigue. The nausea is easily dealt with a zofran/ativan combo, but the fatigue has been tough to manage. However, it's worth it because this medication has kept my cancer from growing (it's stable).

View All Reviews

Patient Q&A Section about navelbine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How often is Navelbine given?

"The dosage of NAVELBINE should be 30 mg/m2 given as an IV either as an injection or an infusion over 6-10 minutes. This should be done once a week in combination with cisplatin 120 mg/m2 given on days 1 and 29. This process should be repeated every 6 weeks."

Answered by AI

How effective is Navelbine?

"A phase 2 clinical trial that is studying the effectiveness of navelbine (vinorelbine) as a single-agent first-line treatment is showing a partial response rate of 24%, a stable disease rate of 55% with 21% of patients experiencing disease progression during treatment. This means that out of 100 patients treated with this drug, 24% saw their cancer shrink, 55% saw their cancer stay the same, and 21% saw their cancer grow."

Answered by AI

Does Navelbine cause neuropathy?

"The most common adverse reactions to NAVELBINE when used as a single agent include low white blood cell count, low neutrophil count, low hemoglobin, increased AST, nausea, vomiting, constipation, fatigue, reaction at the injection site, and peripheral neuropathy."

Answered by AI

What is Navelbine used to treat?

"Vinorelbine is a chemotherapy drug used for the treatment of breast cancer. Navelbine is the brand name for this drug."

Answered by AI

Clinical Trials for Navelbine

Have you considered Navelbine clinical trials? We made a collection of clinical trials featuring Navelbine, we think they might fit your search criteria.

Have you considered Navelbine clinical trials? We made a collection of clinical trials featuring Navelbine, we think they might fit your search criteria.