Methoxsalen

Vitiligo, Vitiligo, Psoriasis + 3 more
Treatment
19 Active Studies for Methoxsalen

What is Methoxsalen

MethoxsalenThe Generic name of this drug
Treatment SummaryPsoralen is a compound found in certain plants, including Psoralea corylifolia. When exposed to ultraviolet light, it can interact with DNA in the body and cause changes to it.
Oxsoralenis the brand name
image of different drug pills on a surface
Methoxsalen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Oxsoralen
Methoxsalen
1954
7

Effectiveness

How Methoxsalen Affects PatientsMethoxsalen prevents the body from making DNA. It also stops the body from making guanine and cytosine, two important components of DNA. When taken in large amounts, it can also stop the body from making RNA and proteins.
How Methoxsalen works in the bodyWhen activated, this drug binds to the guanine and cytosine parts of DNA, connecting them together and stopping DNA from working properly. This prevents DNA from replicating, thus inhibiting its function.

When to interrupt dosage

The measure of Methoxsalen is contingent upon the diagnosed situation, including Palliative Care, Vitiligo and Psoriasis. The dosage amount varies as per the method of delivery (e.g. Solution - Extracorporeal or Topical) identified in the table beneath.
Condition
Dosage
Administration
Vitiligo
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Vitiligo
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Psoriasis
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Lymphoma, T-Cell, Cutaneous
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
Palliative Treatment
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical
CTAGE1 protein, human
, 10.0 mg/mL, 10.0 mg, 0.02 mg/mL, 1.0 %
Topical, , Lotion, Lotion - Topical, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Injection, solution - Extracorporeal, Extracorporeal, Injection, solution, Solution - Extracorporeal, Solution, Capsule, Capsule - Oral, Liquid, Liquid - Topical

Warnings

Methoxsalen Contraindications
Condition
Risk Level
Notes
Aphakia
Do Not Combine
melanoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
Photophobia
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Methoxsalen.
Common Methoxsalen Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Methoxsalen.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Methoxsalen.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Methoxsalen.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Methoxsalen.
Bendamustine
Major
The metabolism of Bendamustine can be decreased when combined with Methoxsalen.
image of a doctor in a lab doing drug, clinical research

Methoxsalen Novel Uses: Which Conditions Have a Clinical Trial Featuring Methoxsalen?

Currently, there are 40 active studies investigating the potential of Methoxsalen to treat Lymphoma, Cutaneous T-Cell Lymphoma, Human CTAGE1 Protein and Palliative Care.
Condition
Clinical Trials
Trial Phases
Vitiligo
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Lymphoma, T-Cell, Cutaneous
0 Actively Recruiting
Vitiligo
7 Actively Recruiting
Phase 2, Phase 3, Phase 1
Palliative Treatment
1 Actively Recruiting
Not Applicable
CTAGE1 protein, human
11 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Early Phase 1, Phase 3

Methoxsalen Reviews: What are patients saying about Methoxsalen?

2Patient Review
10/7/2007
Methoxsalen for Condition Where Part of the Skin Loses Pigment
I tried this medication, and it made me feel nauseous all the time. My vitiligo got better for a little while, but then came back worse than before. It's really upsetting because now I can't stand being around people or my family.
2Patient Review
6/5/2012
Methoxsalen for Condition Where Part of the Skin Loses Pigment
No response from this treatment.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about methoxsalen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is methoxsalen natural?

"The active ingredient in UVADEX, methoxsalen, is a compound found in the plant Ammi majus. This class of compounds, called psoralens, are natural photoactive substances."

Answered by AI

What are the side effects of methoxsalen?

"The following side effects may occur: nausea, trouble sleeping, depression, nervousness, sleep problems, cold sores, headache, and dizziness."

Answered by AI

Is methoxsalen carcinogenic?

"Methoxsalen is known to cause cancer in humans based on evidence from human studies."

Answered by AI

What is methoxsalen tablet used for?

"Methoxsalen is a member of the psoralens, a group of drugs used in conjunction with ultraviolet light to treat vitiligo, a disease where patches of skin lose their pigmentation, and psoriasis, a skin disorder typified by red, scaly patches."

Answered by AI

Clinical Trials for Methoxsalen

Have you considered Methoxsalen clinical trials? We made a collection of clinical trials featuring Methoxsalen, we think they might fit your search criteria.
Have you considered Methoxsalen clinical trials? We made a collection of clinical trials featuring Methoxsalen, we think they might fit your search criteria.
Have you considered Methoxsalen clinical trials? We made a collection of clinical trials featuring Methoxsalen, we think they might fit your search criteria.
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