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What is Menest
Esterified estrogensThe Generic name of this drug
Treatment SummaryEsterified estrogens are a combination of man-made estrogens used to treat symptoms of menopause like hot flashes, vaginal dryness, and irritation. It can also help prevent and treat osteoporosis. The main component of this medication is estrone and it contains 75-85% sodium estrone sulfate and 6-15% sodium equilin sulfate.
Menestis the brand name
Menest Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Menest
Esterified estrogens
1977
8
Approved as Treatment by the FDA
Esterified estrogens, also known as Menest, is approved by the FDA for 9 uses including Advance Directives and Hot flashes .Advance Directives
Hot flashes
Helps manage Menopause
severe menopausal vulvovaginal atrophy
Helps manage severe menopausal vulvovaginal atrophy
moderate Menopausal Vasomotor Symptoms
Helps manage moderate Menopausal Vasomotor Symptoms
Premature Menopause
Helps manage Premature Ovarian Failure (POF)
moderate Vulvovaginal atrophy
Helps manage moderate Vulvovaginal atrophy
Menopause
Helps manage severe Vasomotor Symptoms Associated With Menopause
Low Testosterone
Helps manage Hypogonadism
Metastatic Breast Cancer
Effectiveness
How Menest Affects PatientsEstrogens are hormones that help with the growth and maintenance of female reproductive organs and features. Estradiol is a major type of estrogen found in humans, and is more powerful than other types. It is the main estrogen released before menopause.
How Menest works in the bodyEstrogens help to balance the levels of hormones that stimulate the ovaries. Estrogen replacement lowers the amount of these hormones in the body, helping to keep them in the correct range.
When to interrupt dosage
The suggested amount of Menest is contingent upon the diagnosed disorder, like moderate Menopausal Vasomotor Symptoms, moderate Vulvovaginal atrophy and Menopause. The quantity of dosage is dependent upon the technique of administration, as stated in the table beneath.Condition
Dosage
Administration
Low Testosterone
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Advance Directives
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Metastatic Breast Cancer
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
severe menopausal vulvovaginal atrophy
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
moderate Vulvovaginal atrophy
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Premature Menopause
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hot flashes
, 1.25 mg, 0.625 mg, 0.3 mg, 2.5 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Menest ContraindicationsCondition
Risk Level
Notes
Neoplasms, Hormone-Dependent
Do Not Combine
suspected pregnancy
Do Not Combine
Thromboembolism
Do Not Combine
Breast
Do Not Combine
active thrombophlebitis
Do Not Combine
abnormal genital bleeding
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Breast Cancer
Do Not Combine
Common Menest Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Esterified estrogens.
Dasabuvir
Major
The risk or severity of liver enzyme elevations can be increased when Esterified estrogens is combined with Dasabuvir.
Exemestane
Major
The therapeutic efficacy of Exemestane can be decreased when used in combination with Esterified estrogens.
Ombitasvir
Major
The risk or severity of liver enzyme elevations can be increased when Esterified estrogens is combined with Ombitasvir.
Ospemifene
Major
The risk or severity of adverse effects can be increased when Esterified estrogens is combined with Ospemifene.
Menest Toxicity & Overdose RiskThe toxic dose of the drug when given by injection to rats is 325mg/kg, while the toxic dose in mice given the drug intravenously is 1740mg/kg. The toxic dose of the drug when given orally to rats is greater than 5000mg/kg.
Menest Novel Uses: Which Conditions Have a Clinical Trial Featuring Menest?
111 active clinical trials are assessing the potential of Menest to mitigate severe menopausal vulvovaginal atrophy, Metastatic Breast Cancer and Advance Directives.Condition
Clinical Trials
Trial Phases
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Menopause
0 Actively Recruiting
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Premature Menopause
1 Actively Recruiting
Phase 2
Low Testosterone
14 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Metastatic Breast Cancer
93 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Advance Directives
6 Actively Recruiting
Phase 1, Phase 2, Not Applicable
moderate Vulvovaginal atrophy
0 Actively Recruiting
Menest Reviews: What are patients saying about Menest?
5Patient Review
8/13/2009 I've liked taking this drug, but I think I need a stronger mg.
5Patient Review
2/28/2011 I had a hysterectomy that included my ovaries. After trying out other hormone replacement therapies, I finally found one that didn't give me any negative side effects. Menest has been great for me and I'm now on it eight years later!
5Patient Review
2/19/2011 I had cervical cancer when I was 32 (1986) and had everything removed. My doc put me on Menest 1.25 mg and I have been on it until June of this year. I never had problems with it. At my age now I decided to try a natural HRT.
5Patient Review
6/22/2018 I've been taking this for over 40 years, and it's really helped me. I don't have hot flashes anymore, and I just feel overall more well-rounded.
5Patient Review
5/21/20085Patient Review
12/5/20085Patient Review
12/14/20085Patient Review
10/22/2013 This medication has helped me so much by clearing up my menopause issues. I feel like a human being again because it's improved my quality of life in such a significant way.
4.7Patient Review
4/6/2010 I experienced some night sweats and bruising on my breasts. I also found myself to be a bit more irritable; however, these symptoms could very well be due to the fact that I am going through menopause.
4.3Patient Review
4/2/2009 I'm using this to help with vaginal atrophy and dryness. So far, so good!
4.3Patient Review
11/7/20084Patient Review
6/16/2014 I switched from Premarin to this medication and am finding darkening and spotting of skin on hands and arms. Otherwise I don't notice a difference. The skin discoloration is concerning, so I might switch back to Premarin.
3.7Patient Review
3/19/20082.7Patient Review
9/25/2009 I was surprised to find that this substitute medication actually made me feel better than my previous one. I take it for mood, libido, and osteoporosis prevention, among other things. I've been taking hormones for 49 years now.
Patient Q&A Section about menest
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What company makes Menest?
"The prescription medication MENEST® can be obtained by either contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com."
Answered by AI
Is Menest still on the market?
"The FDA reports that Menest (esterified estrogens; Pfizer) 2.5mg tablets have been permanently discontinued."
Answered by AI
Is Menest the same as Premarin?
"The two drugs Premarin and Menest both contain estrogen, but estrogen from two different sources. Premarin is made from the hormones of pregnant horses, while Menest is made from a combination of the hormones of pregnant horses and plant-based estrogens, including soybeans and yams."
Answered by AI
What is Menest used for?
"This medication works by supplying synthetic estrogen to the body.
This medication is a female hormone that is used by women to help reduce symptoms of menopause, such as hot flashes and vaginal dryness, caused by the body making less estrogen. This medication works by supplying synthetic estrogen to the body."
Answered by AI