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What is Lupkynis
VoclosporinThe Generic name of this drug
Treatment SummaryLupus nephritis (LN) is a type of kidney disease that affects people with systemic lupus erythematosus (SLE). It can lead to end-stage kidney failure, which is fatal. To help improve clinical outcomes in patients with LN, an immunosuppressant drug called voclosporin (brand name Lupkynis) was developed and approved by the FDA in 2021. Voclosporin has been shown to be more effective than other calcineurin-inhibitor drugs, as it has a more stable pharmacokinetic and pharmacodynamic relationship, a higher potency
Lupkynisis the brand name
Lupkynis Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lupkynis
Voclosporin
2021
1
Effectiveness
How Lupkynis Affects PatientsVoclosporin works by blocking a protein called calcineurin, which stops the body from making certain proteins that can cause inflammation. It is used to treat lupus nephritis and helps prevent kidney damage.
How Lupkynis works in the bodyVoclospoprin is an analog of cyclosporine A, which works by blocking the release of a chemical called IL-2. This chemical helps the body create T-cells, which are part of the immune response. By blocking the production of IL-2, voclosporin stops the body from making T-cells, which reduces inflammation and treats kidney glomerulonephritis, a condition associated with systemic lupus erythematosus. Voclospoprin works by binding to a protein called cyclophilin, which then stops the activity of another protein called calcineurin.
When to interrupt dosage
The suggested measure of Lupkynis is conditioned on the determined ailment. The portion of dosage is contingent upon the technique of delivery (e.g. Capsule or Oral) specified in the following table.Condition
Dosage
Administration
Lupus Nephritis
, 7.9 mg
Capsule, Oral, , Capsule - Oral
Immunosuppression
, 7.9 mg
Capsule, Oral, , Capsule - Oral
Warnings
Lupkynis has two contraindications and should be avoided while experiencing the circumstances delineated in the table below.Lupkynis ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Voclosporin may interact with Pulse Frequency
Common Lupkynis Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Voclosporin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Acteoside
Major
The risk or severity of adverse effects can be increased when Voclosporin is combined with Acteoside.
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Voclosporin.
Baricitinib
Major
The risk or severity of adverse effects can be increased when Voclosporin is combined with Baricitinib.
Begelomab
Major
The risk or severity of adverse effects can be increased when Voclosporin is combined with Begelomab.
Lupkynis Toxicity & Overdose RiskThe toxic dose of voclosporin is unknown, but an overdose can cause symptoms such as headaches, nausea and vomiting, infections, rapid heartbeat, hives, tiredness, and tremors. This drug can also increase levels of urea nitrogen, creatinine, and alanine aminotransferase in the blood. There is no cure for an overdose of voclosporin, so treatment should focus on providing supportive care and monitoring levels of urea nitrogen, creatinine, eGFR, and alanine aminotransferase. If you think you or someone else has overdosed on
Lupkynis Novel Uses: Which Conditions Have a Clinical Trial Featuring Lupkynis?
Currently, 26 active trials are investigating the potential of Lupkynis to act as an Immunosuppressant.Condition
Clinical Trials
Trial Phases
Lupus Nephritis
21 Actively Recruiting
Phase 4, Phase 3, Phase 2, Phase 1
Immunosuppression
6 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Lupkynis Reviews: What are patients saying about Lupkynis?
4.7Patient Review
10/14/2022 I saw a significant reduction in the amount of protein in my urine within just one month of taking this medication. The only downside is the potential for experiencing some side effects.
Patient Q&A Section about lupkynis
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long can you take Lupkynis?
"If the patient does not show any improvement after 24 weeks of treatment, it may be necessary to discontinue LUPKYNIS. There is not enough evidence to say definitively whether the medication is effective or safe for use after one year."
Answered by AI
Is Lupkynis available?
"The autoimmune disease systemic lupus erythematosus (SLE) is one of the most serious and common complications. LUPKYNIS is now available to patients in the United States (U.S.)."
Answered by AI
What is Lupkynis for?
"LUPKYNIS is the first FDA-approved oral treatment specifically for lupus nephritis. LUPKYNIS stops the attack of lupus nephritis, while protecting the kidneys from damage caused by this serious disease. In clinical trials, LUPKYNIS helped control lupus nephritis with low-dose steroids."
Answered by AI
How is Lupkynis administered?
"The capsules should be swallowed whole and should not be opened, crushed, or divided. The medicine should be taken on an empty stomach and as close to a 12-hour schedule as possible, with a minimum of 8 hours between doses."
Answered by AI