Ketoconazole

Histoplasmosis, Paracoccidioidomycosis, Chromoblastomycosis + 22 more

Treatment

4 Active Studies for Ketoconazole

What is Ketoconazole

Ketoconazole

The Generic name of this drug

Treatment Summary

Cushing's Syndrome is a condition caused by excessive levels of cortisol in the body, which can cause a variety of health problems. Ketoconazole has been used to treat Cushing's Syndrome due to its ability to reduce cortisol production. However, it can cause liver damage and other side effects. Levoketoconazole is one of the components of ketoconazole, and has been found to be more effective at reducing cortisol production with fewer side effects. It was approved by the FDA in 2021 and is sold under the brand name RECORLEV by Xeris Pharmaceuticals, Inc.

Nizoral

is the brand name

image of different drug pills on a surface

Ketoconazole Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nizoral

Ketoconazole

1981

135

Effectiveness

How Ketoconazole Affects Patients

Levoketoconazole is a medicine used to treat Cushing's syndrome, a disorder that causes too much of the hormone cortisol in the body. When taking this drug, people may have low levels of cortisol and testosterone. It can also cause the heart to beat more slowly and lead to allergic reactions, including anaphylaxis (a severe, life-threatening reaction). Taking this drug at high doses (150-600mg twice daily) may increase the risk of these side effects.

How Ketoconazole works in the body

Cushing's Syndrome is a disorder caused by too much cortisol in the body. It can be treated by surgery, radiation, or medications targeting the different causes of the syndrome. One of these medications is ketoconazole, which stops the body from making cortisol and testosterone. Levoketoconazole is a more potent form of ketoconazole and can be used at lower dosages to achieve the same effects. It also has fewer side effects, as it doesn't inhibit the body's ability to make bile acids as much as ketoconazole does. Lastly, it has a higher potency for blocking certain enzymes that help

When to interrupt dosage

The advocated measure of Ketoconazole is contingent upon the recognized ailment. Dosage is also contingent upon the technique of administration (e.g. Aerosol, foam or Topical) outlined in the table beneath.

Condition

Dosage

Administration

Histoplasmosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Paracoccidioidomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Chromoblastomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Blastomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Coccidioidomycosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Dandruff

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

cutaneous candidiasis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Candidiasis, Chronic Mucocutaneous

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Dermatitis, Seborrheic

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Cushing Syndrome

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Bacterial Vaginosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Trichophyton mentagrophytes

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea cruris

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea Pedis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea Pedis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea corporis (disorder)

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Tinea Pedis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

recalcitrant Dermatophytosis

, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL

, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical

Warnings

Ketoconazole Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

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Pulse Frequency

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Do Not Combine

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Do Not Combine

Liver Dysfunction

Do Not Combine

Pulse Frequency

Do Not Combine

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Do Not Combine

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Do Not Combine

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Do Not Combine

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Do Not Combine

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Do Not Combine

Long QT Syndrome

Do Not Combine

Pulse Frequency

Do Not Combine

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Do Not Combine

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Do Not Combine

Long QT Syndrome

Do Not Combine

Renal Insufficiency

Do Not Combine

Pulse Frequency

Do Not Combine

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Do Not Combine

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Do Not Combine

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Do Not Combine

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Pulse Frequency

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Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Ketoconazole may interact with Pulse Frequency

There are 20 known major drug interactions with Ketoconazole.

Common Ketoconazole Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Ketoconazole.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Ketoconazole.

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ketoconazole.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ketoconazole.

5-androstenedione

Major

The metabolism of 5-androstenedione can be decreased when combined with Ketoconazole.

Ketoconazole Toxicity & Overdose Risk

Taking too much levoketoconazole can lead to severe side effects including nausea, vomiting, low potassium levels, bleeding, high blood pressure, headaches, liver problems, irregular menstrual bleeding, redness of the skin, fatigue, stomach pains, joint pain, upper respiratory infections, muscle ache, irregular heartbeats, back pain, sleeping problems, and swelling in the arms and legs. Treatment should focus on relieving symptoms and supportive care. Taking activated charcoal within an hour of taking the drug may be helpful.

image of a doctor in a lab doing drug, clinical research

Ketoconazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Ketoconazole?

At the present, there are no active clinical trials assessing Ketoconazole's potential to alleviate Cushing Syndrome.

Condition

Clinical Trials

Trial Phases

Coccidioidomycosis

0 Actively Recruiting

Chromoblastomycosis

0 Actively Recruiting

Paracoccidioidomycosis

0 Actively Recruiting

Tinea corporis (disorder)

0 Actively Recruiting

Tinea corporis (disorder)

0 Actively Recruiting

Blastomycosis

0 Actively Recruiting

Candidiasis, Chronic Mucocutaneous

0 Actively Recruiting

Tinea Pedis

0 Actively Recruiting

Malassezia

0 Actively Recruiting

Candidiasis, Vulvovaginal

2 Actively Recruiting

Not Applicable, Phase 3

recalcitrant Dermatophytosis

0 Actively Recruiting

Candidiasis, Systemic

0 Actively Recruiting

Cushing Syndrome

0 Actively Recruiting

Trichophyton mentagrophytes

0 Actively Recruiting

Tinea cruris

0 Actively Recruiting

Tinea Corporis caused by Trichophyton mentagrophytes

0 Actively Recruiting

Trichophyton rubrum

0 Actively Recruiting

cutaneous candidiasis

0 Actively Recruiting

Candidiasis, Vulvovaginal

0 Actively Recruiting

Bacterial Vaginosis

2 Actively Recruiting

Phase 2, Early Phase 1

Ketoconazole Reviews: What are patients saying about Ketoconazole?

4.7

Patient Review

9/4/2021

Ketoconazole for Fungal Infection of Skin

After a few days, you'll start to see major improvements in your skin condition--this was something I experienced firsthand.

4.7

Patient Review

9/4/2021

Ketoconazole for Fungal Infection of Skin

You may have to wait a few days, but the improvement in your skin condition will be very noticeable. That's based on my own experience.

4

Patient Review

4/17/2019

Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp

Out of all the shampoos I've tried, this one is really effective for my chronic dandruff.

4

Patient Review

4/17/2019

Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp

Out of all the shampoos I've tried, this is one of the only ones that has helped my difficult dandruff.

4

Patient Review

6/10/2017

Ketoconazole for Fungal Infection of Skin

I haven't had the problem in over a year since starting this treatment.

4

Patient Review

4/17/2019

Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp

I've tried a lot of different shampoos for my dandruff, and this is one of the few that has actually worked.

4

Patient Review

6/10/2017

Ketoconazole for Fungal Infection of Skin

I haven't had the issue in over a year, so I'm confident that this treatment worked for me.

4

Patient Review

4/17/2019

Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp

This is one of the few shampoos that is effective for the stubborn dandruff I have had for many years. Prescription Selsun shampoo was also helpful. Shampoo with both 2% sulfur and salicylic were helpful in past.

2.7

Patient Review

7/24/2022

Ketoconazole for Fungal Infection of Skin

I didn't see any effect from this treatment, even after completing the whole bottle.

2.7

Patient Review

7/24/2022

Ketoconazole for Fungal Infection of Skin

I didn't see any change after using this whole bottle as directed to treat my yeast infection of the scalp.

2.3

Patient Review

7/5/2017

Ketoconazole for Ringworm of the Body

I found that this medicine unfortunately made my ringworm worse.

2.3

Patient Review

4/20/2021

Ketoconazole for Inflammation and Infection of Nail Cuticle

Applied this treatment to my feet for six months with no results. My toes are still just as distended and thickened, making it difficult to find shoes that fit properly.

2.3

Patient Review

12/29/2021

Ketoconazole for Ringworm of the Beard

I've been fighting a losing battle against tinea cruris/corpus for over two months. My GP prescribed K2%, but all it's done is cause redness, skin discoloration, and itching! I'm now also dealing with an increased area in my arm pits which seems to be growing, not slowing. I'm going to try using K2 on one side and nystatin on the other side, alternating every day. My groin and penis look red and inflamed from this—I really hope this treatment plan works better than the last one.

2.3

Patient Review

4/23/2022

Ketoconazole for Ringworm of the Beard

The options for this treatment really suck! I was misdiagnosed by a cvs doctor and ended up wasting $65.

2.3

Patient Review

7/2/2017

Ketoconazole for Ringworm of the Body

My ringworm got worse after using this treatment. Avoid it if you can.

2.3

Patient Review

7/5/2017

Ketoconazole for Ringworm of the Body

Unfortunately, this medication caused my ringworm to spread and worsen. I cannot in good faith recommend it to others.

2.3

Patient Review

4/20/2021

Ketoconazole for Inflammation and Infection of Nail Cuticle

My mom used this treatment for six months with no change. Her toes still catch on socks and her shoes don't fit properly because of the thickening and distension of her toes.

2.3

Patient Review

4/23/2022

Ketoconazole for Ringworm of the Beard

I was very disappointed with this treatment. I was misdiagnosed by the cvs doctor and ended up wasting $65 on a lotion that did nothing more than what a generic body lotion would have done.

2.3

Patient Review

7/2/2017

Ketoconazole for Ringworm of the Body

This actually made my ringworm worse and it got significantly larger. I would not recommend this to anyone.

2.3

Patient Review

1/1/2019

Ketoconazole for Fungal Infection of Skin

The PA instructed me to use this cream once a day for three weeks. Unfortunately, it made my rash much worse.

2.3

Patient Review

12/29/2021

Ketoconazole for Ringworm of the Beard

I've been dealing with a serious case of athlete's foot for over two months now. My doctor prescribed me K2%, but it only seemed to make the redness and skin discoloration worse, and there was still a lot of itching! I'm going to try using K2 on one side and nystatin on the other side. Hopefully that will help. My groin and penis are still red from this and it hasn't healed yet.

2.3

Patient Review

1/1/2019

Ketoconazole for Fungal Infection of Skin

The PA told me to use this cream once a day for three weeks, but it made my rash much worse. Avoid at all costs!

2

Patient Review

11/23/2018

Ketoconazole for Fungal Infection of Skin

I was prescribed this cream for an infection on my face. I would recommend you test it somewhere else before using it on your face like I did. After two applications, my face was burning and looked swollen and red. Two days later and there is still some swelling.

2

Patient Review

11/23/2018

Ketoconazole for Fungal Infection of Skin

I got this cream for an infection on my face. Definitely test it out somewhere else before using it on your face like I did. After two applications, my face was burning and looked terrible. Still waiting for the swelling to go down days later.

1

Patient Review

1/18/2018

Ketoconazole for Athlete's Foot

This caused a severe rash on the top of both my feet. Even after discontinuing use, the discoloration and discomfort persisted for over a week. I'm currently seeing a dermatologist to help address the issues this medication caused.

1

Patient Review

12/8/2018

Ketoconazole for Athlete's Foot

I would not recommend this cream. I had athlete's foot on only one foot, but applied the cream to both since the other was getting better from using natural coconut oil. Unfortunately, after just a few applications of this cream, both feet got worse.

1

Patient Review

4/3/2019

Ketoconazole for Ringworm of the Body

I had two dime-sized ringworm infections. I went to the doctor and they prescribed me with Ketoconazole. They are now both quarter-sized, but they're itchy as hell. This treatment was not effective at all!

1

Patient Review

12/8/2018

Ketoconazole for Athlete's Foot

I would not recommend this cream, as it made my athlete's foot worse. I only used it a few times before seeing negative results.

1

Patient Review

1/18/2018

Ketoconazole for Athlete's Foot

Not only did this medication not work for me, but it also caused a severe rash on both of my feet. The discoloration from the rash is still present even though I stopped using the product over a week ago. I'm currently seeing a dermatologist to try and fix the mess that this treatment caused.

1

Patient Review

4/3/2019

Ketoconazole for Ringworm of the Body

I had two dime-sized ringworm infections and was prescribed Ketoconazole by my doctor. They are now both quarter-sized, but the itchiness is unbearable. I don't recommend this medication to anyone.

1

Patient Review

12/8/2017

Ketoconazole for Fungal Infection of Skin

After just one application, I was covered in hives and my face and neck started swelling up. It got so bad that I had trouble swallowing and developed a headache.

1

Patient Review

12/8/2017

Ketoconazole for Fungal Infection of Skin

Applied this once and it caused giant hives all over my neck and face, as well as severe swelling on my neck, face, back of neck, and ear. One blotch in front of throat made it difficult to swallow and gave me a headache too.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ketoconazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the major side effects of ketoconazole?

"Acne, bleeding from sores in the mouth, blistering, crusting, irritation, itching, or reddening of the skin, cracked, dry, or scaly skin, discoloration of the fingernails or toenails, eye dryness, irritation, or swelling."

Answered by AI

What is ketoconazole used to treat?

"Ketoconazole is an antifungal medicine that is used to treat skin infections caused by a fungus (yeast). It can also prevent these infections from coming back."

Answered by AI

Is ketoconazole a steroid?

"No, ketoconazole cream is not a steroid. It is an antifungal. However, many people will be prescribed ketoconazole cream and a steroid at the same time because they can be both be used to treat similar skin conditions."

Answered by AI

How long does it take ketoconazole to work?

"If you are using ketoconazole shampoo to treat dandruff, you should see an improvement within 2 to 4 weeks. If your symptoms persist or worsen, please contact your doctor."

Answered by AI

Clinical Trials for Ketoconazole

Image of University of Minnesota in Minneapolis, United States.

LAmB and Posaconazole for Histoplasmosis

18+
All Sexes
Minneapolis, MN

The purpose of the study is threefold: 1. Assess the safety and efficacy of a single high-dose intravenous (LAmB 10mg/kg) compared to the SOC daily dosing (3mg/kg) of the same medication for induction therapy in moderate to severe histoplasmosis. 2. Assess the safety and efficacy of oral posaconazole 300mg delayed-release tablets three times daily for two days then once daily for consolidation therapy compared to SOC oral itraconazole 200 mg capsules three times daily for three days then twice daily in moderate to severe histoplasmosis 3. Assess the safety and efficacy of 6 months of consolidation therapy compared to the SOC 12 months of consolidation therapy in persons with HIV on appropriate antiretroviral therapy.

Phase 3
Waitlist Available

University of Minnesota

Nathan Bahr, MD

Image of Rush University Medical Center in Chicago, United States.

Menstrual Cups for Vaginal Infections

15 - 35
Female
Chicago, IL

HIV remains a global pandemic with 37 million infected. In western Kenya, 16% of women in the general population and 29% of the poorest women have HIV. The HIV and sexually transmitted infection (STI) epidemics overlap with broader reproductive health concerns. Menstrual hygiene management is a big problem in low- and middle-income countries and a lack of menstrual products negatively impacts women's work-life. This comes from cultural taboos, stigma, and discrimination, promoting secrecy around menstruation, high cost of menstrual products, use of traditional materials (e.g. rags, cotton wool, etc.) causing leakage and odor, and lack of water and safe hygiene facilities. Menstrual cups designed for use during sex may help women prevent Bacterial vaginosis (BV) and STIs through hygienic period practices, and may help them avoid bad practices in an attempt to maintain vaginal dryness. The goal of this interventional trial is to test the impact of menstrual cups on vaginal microbiome, BV, and STIs of poor women at high risk for STIs and HIV. We predict to see 25% less BV, our primary outcome, over one year. This trial aims to learn more about the safety of the intervention, and understand what is needed to fully implement the program.

Phase 2
Waitlist Available

Rush University Medical Center