Ketoconazole
Histoplasmosis, Paracoccidioidomycosis, Chromoblastomycosis + 22 more
Treatment
4 Active Studies for Ketoconazole
Treatment for
Histoplasmosis
What is Ketoconazole
Ketoconazole
The Generic name of this drug
Treatment Summary
Cushing's Syndrome is a condition caused by excessive levels of cortisol in the body, which can cause a variety of health problems. Ketoconazole has been used to treat Cushing's Syndrome due to its ability to reduce cortisol production. However, it can cause liver damage and other side effects. Levoketoconazole is one of the components of ketoconazole, and has been found to be more effective at reducing cortisol production with fewer side effects. It was approved by the FDA in 2021 and is sold under the brand name RECORLEV by Xeris Pharmaceuticals, Inc.
Nizoral
is the brand name
Ketoconazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nizoral
Ketoconazole
1981
135
Effectiveness
How Ketoconazole Affects Patients
Levoketoconazole is a medicine used to treat Cushing's syndrome, a disorder that causes too much of the hormone cortisol in the body. When taking this drug, people may have low levels of cortisol and testosterone. It can also cause the heart to beat more slowly and lead to allergic reactions, including anaphylaxis (a severe, life-threatening reaction). Taking this drug at high doses (150-600mg twice daily) may increase the risk of these side effects.
How Ketoconazole works in the body
Cushing's Syndrome is a disorder caused by too much cortisol in the body. It can be treated by surgery, radiation, or medications targeting the different causes of the syndrome. One of these medications is ketoconazole, which stops the body from making cortisol and testosterone. Levoketoconazole is a more potent form of ketoconazole and can be used at lower dosages to achieve the same effects. It also has fewer side effects, as it doesn't inhibit the body's ability to make bile acids as much as ketoconazole does. Lastly, it has a higher potency for blocking certain enzymes that help
When to interrupt dosage
The advocated measure of Ketoconazole is contingent upon the recognized ailment. Dosage is also contingent upon the technique of administration (e.g. Aerosol, foam or Topical) outlined in the table beneath.
Condition
Dosage
Administration
Histoplasmosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Paracoccidioidomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Chromoblastomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Blastomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Coccidioidomycosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Dandruff
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
cutaneous candidiasis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Candidiasis, Vulvovaginal
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Candidiasis, Chronic Mucocutaneous
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Dermatitis, Seborrheic
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Candidiasis, Vulvovaginal
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Cushing Syndrome
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Bacterial Vaginosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Trichophyton mentagrophytes
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea cruris
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea corporis (disorder)
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Tinea Pedis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
recalcitrant Dermatophytosis
, 0.02 mg/mg, 200.0 mg, 10.0 mg/mL, 20.0 mg, 20.0 mg/mL, 2.0 %, 20.5 mg/mL
, Topical, Cream, Cream - Topical, Oral, Tablet, Tablet - Oral, Gel, Gel - Topical, Aerosol, foam, Aerosol, foam - Topical, Kit, Shampoo, Shampoo - Topical, Shampoo, suspension, Shampoo, suspension - Topical, Suspension - Oral, Suspension, Kit - Topical
Warnings
Ketoconazole Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Dysfunction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Long QT Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Long QT Syndrome
Do Not Combine
Renal Insufficiency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ketoconazole may interact with Pulse Frequency
There are 20 known major drug interactions with Ketoconazole.
Common Ketoconazole Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Ketoconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Ketoconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ketoconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ketoconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Ketoconazole.
Ketoconazole Toxicity & Overdose Risk
Taking too much levoketoconazole can lead to severe side effects including nausea, vomiting, low potassium levels, bleeding, high blood pressure, headaches, liver problems, irregular menstrual bleeding, redness of the skin, fatigue, stomach pains, joint pain, upper respiratory infections, muscle ache, irregular heartbeats, back pain, sleeping problems, and swelling in the arms and legs. Treatment should focus on relieving symptoms and supportive care. Taking activated charcoal within an hour of taking the drug may be helpful.
Ketoconazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Ketoconazole?
At the present, there are no active clinical trials assessing Ketoconazole's potential to alleviate Cushing Syndrome.
Condition
Clinical Trials
Trial Phases
Coccidioidomycosis
0 Actively Recruiting
Chromoblastomycosis
0 Actively Recruiting
Paracoccidioidomycosis
0 Actively Recruiting
Tinea corporis (disorder)
0 Actively Recruiting
Tinea corporis (disorder)
0 Actively Recruiting
Blastomycosis
0 Actively Recruiting
Candidiasis, Chronic Mucocutaneous
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
Malassezia
0 Actively Recruiting
Candidiasis, Vulvovaginal
2 Actively Recruiting
Not Applicable, Phase 3
recalcitrant Dermatophytosis
0 Actively Recruiting
Candidiasis, Systemic
0 Actively Recruiting
Cushing Syndrome
0 Actively Recruiting
Trichophyton mentagrophytes
0 Actively Recruiting
Tinea cruris
0 Actively Recruiting
Tinea Corporis caused by Trichophyton mentagrophytes
0 Actively Recruiting
Trichophyton rubrum
0 Actively Recruiting
cutaneous candidiasis
0 Actively Recruiting
Candidiasis, Vulvovaginal
0 Actively Recruiting
Bacterial Vaginosis
2 Actively Recruiting
Phase 2, Early Phase 1
Ketoconazole Reviews: What are patients saying about Ketoconazole?
4.7
Patient Review
9/4/2021
Ketoconazole for Fungal Infection of Skin
4.7
Patient Review
9/4/2021
Ketoconazole for Fungal Infection of Skin
4
Patient Review
4/17/2019
Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp
4
Patient Review
4/17/2019
Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp
4
Patient Review
6/10/2017
Ketoconazole for Fungal Infection of Skin
4
Patient Review
4/17/2019
Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp
4
Patient Review
6/10/2017
Ketoconazole for Fungal Infection of Skin
4
Patient Review
4/17/2019
Ketoconazole for Scaly Oily Skin Problem Primarily On Face and Scalp
2.7
Patient Review
7/24/2022
Ketoconazole for Fungal Infection of Skin
2.7
Patient Review
7/24/2022
Ketoconazole for Fungal Infection of Skin
2.3
Patient Review
7/5/2017
Ketoconazole for Ringworm of the Body
2.3
Patient Review
4/20/2021
Ketoconazole for Inflammation and Infection of Nail Cuticle
2.3
Patient Review
12/29/2021
Ketoconazole for Ringworm of the Beard
2.3
Patient Review
4/23/2022
Ketoconazole for Ringworm of the Beard
2.3
Patient Review
7/2/2017
Ketoconazole for Ringworm of the Body
2.3
Patient Review
7/5/2017
Ketoconazole for Ringworm of the Body
2.3
Patient Review
4/20/2021
Ketoconazole for Inflammation and Infection of Nail Cuticle
2.3
Patient Review
4/23/2022
Ketoconazole for Ringworm of the Beard
2.3
Patient Review
7/2/2017
Ketoconazole for Ringworm of the Body
2.3
Patient Review
1/1/2019
Ketoconazole for Fungal Infection of Skin
2.3
Patient Review
12/29/2021
Ketoconazole for Ringworm of the Beard
2.3
Patient Review
1/1/2019
Ketoconazole for Fungal Infection of Skin
2
Patient Review
11/23/2018
Ketoconazole for Fungal Infection of Skin
2
Patient Review
11/23/2018
Ketoconazole for Fungal Infection of Skin
1
Patient Review
1/18/2018
Ketoconazole for Athlete's Foot
1
Patient Review
12/8/2018
Ketoconazole for Athlete's Foot
1
Patient Review
4/3/2019
Ketoconazole for Ringworm of the Body
1
Patient Review
12/8/2018
Ketoconazole for Athlete's Foot
1
Patient Review
1/18/2018
Ketoconazole for Athlete's Foot
1
Patient Review
4/3/2019
Ketoconazole for Ringworm of the Body
1
Patient Review
12/8/2017
Ketoconazole for Fungal Infection of Skin
1
Patient Review
12/8/2017
Ketoconazole for Fungal Infection of Skin
Patient Q&A Section about ketoconazole
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What are the major side effects of ketoconazole?
"Acne, bleeding from sores in the mouth, blistering, crusting, irritation, itching, or reddening of the skin, cracked, dry, or scaly skin, discoloration of the fingernails or toenails, eye dryness, irritation, or swelling."
Answered by AI
What is ketoconazole used to treat?
"Ketoconazole is an antifungal medicine that is used to treat skin infections caused by a fungus (yeast). It can also prevent these infections from coming back."
Answered by AI
Is ketoconazole a steroid?
"No, ketoconazole cream is not a steroid. It is an antifungal. However, many people will be prescribed ketoconazole cream and a steroid at the same time because they can be both be used to treat similar skin conditions."
Answered by AI
How long does it take ketoconazole to work?
"If you are using ketoconazole shampoo to treat dandruff, you should see an improvement within 2 to 4 weeks. If your symptoms persist or worsen, please contact your doctor."
Answered by AI