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What is Intermezzo
ZolpidemThe Generic name of this drug
Treatment SummaryZolpidem, also known as Ambien, is a sleep-aid drug that was approved by the FDA in 1992. It helps people with insomnia fall asleep faster, sleep longer and wake up fewer times during the night. Zolpidem is generally safe to take as long as it is taken according to the manufacturer's instructions. It also improves sleep quality in people with chronic insomnia and can have a mild muscle-relaxing effect. Studies have found that zolpidem can help restore brain function for people in a vegetative state following a brain injury.
Ambienis the brand name
Intermezzo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ambien
Zolpidem
1993
361
Effectiveness
How Intermezzo Affects PatientsThis drug has a sedative effect and can cause sleepiness, reduced alertness, drowsiness, dizziness, and other changes in how your body moves. It is recommended to take the lowest dose possible (5mg for women and 5-10mg for men) immediately before bedtime and make sure you have 7-8 hours of sleep to allow the drug to take full effect. Zolpidem can reduce the time it takes to fall asleep and helps maintain deep sleep. However, there may be issues with memory or psychomotor performance the day after taking this drug, especially if you take more than the recommended dose.
How Intermezzo works in the bodyZolpidem is a drug used to induce sleep. It has a different chemical structure than other drugs that produce a hypnotic effect. It works by attaching to certain parts of the GABA receptor in the brain. It binds to the alpha 1, 2, and 3 subunits of the GABA receptor specifically, which is found mainly in certain parts of the brain like the sensorimotor cortex and substantia nigra. This binding helps promote deep sleep while limiting the muscle-relaxing and anticonvulsant effects of the drug.
When to interrupt dosage
The suggested dosage of Intermezzo is contingent upon the diagnosed state. The dose can be found in the table below, subject to the delivery approach (e.g. Tablet, film coated - Oral or Tablet - Sublingual).Condition
Dosage
Administration
Insomnia
, 6.25 mg, 12.5 mg, 10.0 mg, 5.0 mg, 3.5 mg, 1.75 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Spray, metered, Spray, metered - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Sublingual, Tablet - Sublingual, Tablet, extended release, Tablet, extended release - Oral, Kit, Kit - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual
Warnings
Intermezzo ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Zolpidem may interact with Pulse Frequency
Common Intermezzo Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Zolpidem.
Azelastine
Major
Zolpidem may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Zolpidem.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Zolpidem is combined with Deutetrabenazine.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Zolpidem.
Intermezzo Toxicity & Overdose RiskThe toxic dose of zolpidem in male rats is 695mg/kg. Symptoms of an overdose include confusion, difficulty breathing, and coma, while suddenly stopping zolpidem can lead to withdrawal effects similar to other sedative drugs. In animal studies, zolpidem had no effect on fertility and caused kidney tumors in a few rats. Zolpidem is a pregnancy category C drug, as not enough studies have been done to determine its safety for pregnant women. Up to 0.019% of zolpidem can be transferred to a nursing infant through breast milk, so caution should be used when taking z
Intermezzo Novel Uses: Which Conditions Have a Clinical Trial Featuring Intermezzo?
82 active clinical trials are underway to analyze the potential of Intermezzo in treating Insomnia.Condition
Clinical Trials
Trial Phases
Insomnia
93 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Intermezzo Reviews: What are patients saying about Intermezzo?
5Patient Review
4/22/2013 I took this drug once and felt its effects very strongly. I was able to drift off to sleep easily without feeling drowsy beforehand.
4.7Patient Review
8/17/2015 I've been struggling with insomnia for a long time, and this medication has really helped me to get my life back on track. I feel more rested when I wake up, and I have more energy throughout the day. This has made a huge difference in my quality of life.
Patient Q&A Section about intermezzo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How do you use intermezzo in a sentence?
"You won't be able to play the Intermezzo Giocoso unless you practise for at least 30 minutes a day. After the intermezzo was finished, he was surrounded by beautiful Japanese women in kimonos."
Answered by AI
Is Cafe an intermezzo in German?
"There, he discovered the grand cafes and became enchanted with their Old World elegance and charm.
Café Intermezzo has been around for over 40 years and is known for its grand cafes that are reminiscent of Old World Europe."
Answered by AI
What are some examples of intermezzo?
"Many of the most celebrated intermezzi come from operas of the verismo period, including Mascagni's Cavalleria rusticana and L'amico Fritz, Leoncavallo's Pagliacci, Puccini's Manon Lescaut and Suor Angelica, Giordano's Fedora, and Cilea's Adriana Lecouvreur. The intermezzo from Massenet's Thais is especially well-known and became known as the ..."
Answered by AI
What does intermezzo mean?
"1: A brief musical performance between the main sections of a longer work. 2a: A musical section coming between the large sections of a longer musical work, such as an opera. b: A short, independent instrumental piece. 3: A short period of time devoted to an activity that is not the main focus of attention."
Answered by AI