Glumetza

Diabetic Ketoacidosis, Congestive Heart Failure, Type 1 Diabetes + 16 more

Treatment

22 FDA approvals

20 Active Studies for Glumetza

What is Glumetza

Metformin

The Generic name of this drug

Treatment Summary

Metformin is a medication used to treat type 2 diabetes. It works by lowering blood sugar levels without causing hypoglycemia (low blood sugar). Metformin also helps reduce insulin resistance and lowers fasting insulin levels, resulting in modest weight loss. It is the drug of choice for obese type 2 diabetes patients and is used by more than 120 million people around the world. Metformin was first approved in Canada in 1972 and in the United States in 1995. It comes in regular and extended-release forms.

Metformin Hydrochloride

is the brand name

image of different drug pills on a surface

Glumetza Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Metformin Hydrochloride

Metformin

2002

1263

Approved as Treatment by the FDA

Metformin, otherwise known as Metformin Hydrochloride, is approved by the FDA for 22 uses which include Heart Failure and Heart Failure .

Heart Failure

Used to treat NYHA Functional Class II-IV Heart Failure in combination with Dapagliflozin

Heart Failure

Used to treat Heart Failure in combination with Dapagliflozin

Kidney Failure

Used to treat End Stage Renal Disease (ESRD) in combination with Dapagliflozin

Type 2 Diabetes

Used to treat Type 2 Diabetes Mellitus in combination with Dapagliflozin

Chronic Kidney Disease

Used to treat Chronic Kidney Disease (CKD) in combination with Dapagliflozin

Renal Insufficiency

Used to treat decreased estimated glomerular filtration rate in combination with Dapagliflozin

Ejection fraction decreased

Used to treat Ejection fraction decreased in combination with Dapagliflozin

Type 2 Diabetes Mellitus

Used to treat Type 2 Diabetes Mellitus in combination with Dapagliflozin

Ketosis

Used to treat Diabetic Ketoacidosis in combination with Saxagliptin

Diet

Used to treat Diet in combination with Dapagliflozin

Hospitalizations

Used to treat Hospitalizations in combination with Dapagliflozin

Congestive Heart Failure

Used to treat Heart Failure in combination with Dapagliflozin

Physical Activity

Used to treat Exercise in combination with Dapagliflozin

Chronic Kidney Disease (CKD)

Used to treat Chronic Kidney Disease (CKD) in combination with Dapagliflozin

Type 1 Diabetes Mellitus

Used to treat Type 1 Diabetes Mellitus in combination with Sitagliptin

Diabetic Ketoacidosis

Used to treat Diabetic Ketoacidosis in combination with Saxagliptin

Cardiovascular Mortality

Used to treat Cardiovascular Mortality in combination with Dapagliflozin

Diabetes Mellitus

Used to treat uncontrolled diabetes in combination with Rosiglitazone

Cardiovascular Disease

Used to treat Cardiovascular Risk in combination with Dapagliflozin

Cardiovascular Diseases

Used to treat established cardiovascular disease in combination with Dapagliflozin

Heart failure

Used to treat Heart Failure in combination with Dapagliflozin

Type 1 Diabetes

Used to treat Type 1 Diabetes Mellitus in combination with Sitagliptin

Effectiveness

How Glumetza Affects Patients

Insulin is a hormone that helps control blood sugar levels. People with type 2 diabetes have trouble responding to insulin, which leads to higher blood sugar levels. Metformin helps reduce the amount of sugar the liver makes, stops sugar from being absorbed into the body, and makes it easier for the body to use insulin. Unlike other diabetes drugs, metformin doesn't cause the body to produce more insulin. In a study of people with type 2 diabetes, those taking metformin had their blood sugar levels drop an average of 59 mg/dL, compared to an average increase of 6.3 mg/dL in those taking a placebo

How Glumetza works in the body

Metformin works in several ways to lower blood sugar. It reduces the amount of glucose your liver makes, blocks glucose from being absorbed by your intestines, and increases the sensitivity of your body to insulin. Metformin is taken up by liver cells, where it blocks a key enzyme and increases the ratio of AMP to ATP. This helps activate AMPK, an enzyme that regulates glucose metabolism. AMPK then stops fat synthesis and helps fat break down in the liver, making it more sensitive to insulin. Metformin also stimulates glucose metabolism in the small intestines and increases the production of GLP-1, which helps reduce

When to interrupt dosage

The suggested amount of Glumetza is contingent upon the identified condition, including Diet, inadequate response to metformin and Diabetic Ketoacidosis. The dosage changes in accordance with the mode of delivery (e.g. Oral or Tablet - Oral) noted in the table beneath.

Condition

Dosage

Administration

Insulin Resistance

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Cardiovascular Diseases

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

inadequate response to metformin

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Renal Insufficiency

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Diabetes Mellitus

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Congestive Heart Failure

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Type 2 Diabetes

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Chronic Kidney Disease

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Diabetic Ketoacidosis

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Physical Activity

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Kidney Failure

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Diet

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Hospitalizations

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Heart Failure

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Type 1 Diabetes

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Polycystic Ovarian Syndrome

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Cardiovascular Disease

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Cardiovascular Mortality

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Ejection fraction decreased

500.0 mg, , 1000.0 mg, 750.0 mg, 850.0 mg, 250.0 mg, 500.0 mg/mL, 660.0 mg, 780.0 mg

Tablet, film coated, extended release, Oral, Tablet, film coated, extended release - Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, For suspension, extended release, For suspension, extended release - Oral, Kit - Oral

Warnings

Glumetza Contraindications

Condition

Risk Level

Notes

Liver Failure

Do Not Combine

Renal Insufficiency

Do Not Combine

Heart Arrest

Do Not Combine

Diabetic Ketoacidosis

Do Not Combine

Operative Surgery

Do Not Combine

Metabolic acidosis

Do Not Combine

Heart Failure

Do Not Combine

Renal Insufficiency

Do Not Combine

kidney function unknown

Do Not Combine

Hypovolemic Shock

Do Not Combine

serum creatinine above upper limit for age range

Do Not Combine

ethanol

Do Not Combine

Acute Coryza

Do Not Combine

Hypoxemia

Do Not Combine

Liver Failure

Do Not Combine

Acidosis, Lactic

Do Not Combine

Diabetic Ketoacidosis

Do Not Combine

Renal Insufficiency

Do Not Combine

Renal Insufficiency, Chronic

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Metformin may interact with Pulse Frequency

There are 20 known major drug interactions with Glumetza.

Common Glumetza Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The excretion of Abemaciclib can be decreased when combined with Metformin.

Procainamide

Major

The excretion of Procainamide can be decreased when combined with Metformin.

Topotecan

Major

The excretion of Topotecan can be decreased when combined with Metformin.

Abacavir

Minor

Metformin may decrease the excretion rate of Abacavir which could result in a higher serum level.

Aclidinium

Minor

Metformin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Glumetza Toxicity & Overdose Risk

The toxic dose of Metformin in rats is 1 gram/kg when given orally, 500 milligrams/kg when given through the abdomen, and 300 milligrams/kg when given through the skin. Similarly, in mice, the toxic dose is 1,450 milligrams/kg when given orally, 420 milligrams/kg when given through the abdomen, and 225 milligrams/kg when given through the skin. Metformin decreases the liver's uptake of lactate, which can lead to lactic acidosis in rare cases. Risk factors for metformin-associated lactic acidosis include kidney problems

image of a doctor in a lab doing drug, clinical research

Glumetza Novel Uses: Which Conditions Have a Clinical Trial Featuring Glumetza?

At present, 346 active clinical trials are investigating Glumetza's capacity to treat Type 2 Diabetes, Type 1 Diabetes and an inadequate response to metformin treatments.

Condition

Clinical Trials

Trial Phases

Chronic Kidney Disease

96 Actively Recruiting

Phase 1, Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1

Cardiovascular Diseases

0 Actively Recruiting

Congestive Heart Failure

187 Actively Recruiting

Not Applicable, Phase 1, Early Phase 1, Phase 2, Phase 3, Phase 4

Type 1 Diabetes

120 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Early Phase 1, Phase 1, Phase 4

Cardiovascular Disease

29 Actively Recruiting

Not Applicable, Phase 3, Phase 2

Type 2 Diabetes

182 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Kidney Failure

43 Actively Recruiting

Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Physical Activity

29 Actively Recruiting

Not Applicable, Phase 2

Insulin Resistance

0 Actively Recruiting

Renal Insufficiency

0 Actively Recruiting

Cardiovascular Mortality

0 Actively Recruiting

Ejection fraction decreased

0 Actively Recruiting

Hospitalizations

1 Actively Recruiting

Not Applicable

Diabetic Ketoacidosis

1 Actively Recruiting

Phase 1, Phase 2

Polycystic Ovarian Syndrome

7 Actively Recruiting

Not Applicable, Phase 1

inadequate response to metformin

0 Actively Recruiting

Heart Failure

0 Actively Recruiting

Diet

6 Actively Recruiting

Not Applicable, Phase 1

Diabetes Mellitus

0 Actively Recruiting

Glumetza Reviews: What are patients saying about Glumetza?

5

Patient Review

5/6/2013

Glumetza for Prevention of Type 2 Diabetes Mellitus

I took 1 500mg pill for 2 days and had the worst nausea, gas and stomach pains!!! I can't take it again. Had a similar, but less severe experience with Metformin ER.

5

Patient Review

3/19/2014

Glumetza for Prevention of Type 2 Diabetes Mellitus

Switching to gourmet metformin from regular helped me a lot with my diarrhea problem. As long as I eat minimal amounts of carbs, it works great with no side effects. If I don't get enough or the right kind of carbs, though, I have some nasty gastric issues.

5

Patient Review

10/16/2013

Glumetza for Type 2 Diabetes Mellitus

Glumetza ER has alleviated the severe diarrhea I was experiencing with base Glumetza. 1000mg twice a day (morning and night) is my current dosage.

5

Patient Review

10/29/2015

Glumetza for Type 2 Diabetes Mellitus

I was on Metformin (2 x 500 mg per day) for 4 1/2 years. Gradually, nausea and heartburn started and increased until they were unbearable. I learned about Glumetza 1000 mg and started it in April 2015; the side effects disappeared within a few days.

5

Patient Review

5/12/2016

Glumetza for Type 2 Diabetes Mellitus

Glumetza was great for my stomach, but unfortunately didn't help lower my blood sugar as much. The cost increase was also a big factor in why I had to switch back to Metformin.

4.3

Patient Review

4/21/2013

Glumetza for Type 2 Diabetes Mellitus

I was taking this medication for five weeks, but I'm quitting today because it made me too anxious.

4.3

Patient Review

8/13/2015

Glumetza for Type 2 Diabetes Mellitus

Glumetza has been the best for my stomach, but it is way too expensive. I've been spending $353/month and it just jumped to over $3000!

3.7

Patient Review

1/19/2013

Glumetza for Type 2 Diabetes Mellitus

3.7

Patient Review

8/9/2014

Glumetza for Type 2 Diabetes Mellitus

Glumetza 500XR has worked much better for me than Metformin 1000mg. I no longer experience gas or gastric issues, and my neuropathy pain has decreased significantly.

3

Patient Review

4/13/2013

Glumetza for Type 2 Diabetes Mellitus

I had a really bad experience with this drug. I was taking generic Metformin and my doctor switched me to the name brand Glumetza in an effort to stop the diarrhea I was experiencing. Once I paid $800 for a month supply and gave it a try, the diarrhea got even worse!

3

Patient Review

4/27/2013

Glumetza for Type 2 Diabetes Mellitus

I gained weight while on this medication, which was frustrating. Additionally, it didn't do much to help control my blood sugar levels. Finally, the cost of the medication was quite high.

3

Patient Review

11/14/2014

Glumetza for Type 2 Diabetes Mellitus

My blood sugar isn't as low as it used to be, but this treatment is still helpful.

2.7

Patient Review

9/14/2013

Glumetza for Type 2 Diabetes Mellitus

This medication unfortunately gave me diarrhea, itching, and blisters.

2.3

Patient Review

4/5/2013

Glumetza for Type 2 Diabetes Mellitus

This was working well for me at first, but it's not effective anymore. My blood sugar is now over 200 when I fast.

2.3

Patient Review

7/19/2013

Glumetza for Prevention of Type 2 Diabetes Mellitus

Metformin made me so sick that I couldn't keep food down. In contrast, this pill didn't have any adverse reactions for me and I actually lost 5 pounds in the first month without changing anything else. The only downside is that it's SO expensive.

2

Patient Review

12/17/2012

Glumetza for Type 2 Diabetes Mellitus

1

Patient Review

8/26/2013

Glumetza for Prevention of Type 2 Diabetes Mellitus

My insulin levels were really high when I took this medication, way higher than what the doctor wanted. The side effects were also really bad - stomach aches and diarrhea - and made me feel weak and tired.

1

Patient Review

3/8/2013

Glumetza for Type 2 Diabetes Mellitus

This drug is expensive and unfortunately ineffective for me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about glumetza

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Glumetza?

"The medication GLUMETZA, which is an extended release tablet of metformin hydrochloride, is used to help manage type 2 diabetes. This medication is not related chemically or pharmacologically to any other classes of oral antihyperglycemic agents."

Answered by AI

Why is Glumetza better than metformin?

"Compared to metformin immediate-release doses that are equal in strength, using Glumetza results in the same amount of the drug being distributed throughout the body. However, the peak plasma concentration will be 35% higher. When doses of Glumetza ranging from 500 mg to 2500 mg were given, the total drug exposure and peak plasma concentration increased, but not in proportion to the dose."

Answered by AI

Is Glumetza the same as metformin?

"Glumetza is a MOD metformin product that uses Acuform and Smartcoat, two advanced delivery systems. These delivery systems contain a substance that allows the metformin tablet to stay in the stomach for an extended period of time."

Answered by AI

What is Glumetza used for?

"The drug is used to treat patients with type 2 diabetes by controlling high blood sugar levels, which can prevent complications such as kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke."

Answered by AI

Clinical Trials for Glumetza

Image of University of Alabama at Birmingham in Birmingham, United States.

Post-Discharge Support for Type 2 Diabetes

18+
All Sexes
Birmingham, AL

This study tests whether a support program led by a nurse case manager and community health worker can help patients with type 2 diabetes manage their medications after leaving the hospital. Many patients with diabetes take multiple medications, and changes to these medications during hospital stays can cause confusion and lead to missed doses or incorrect use. This is especially common in communities with limited access to healthcare. The study uses a computer-based tool called MEDBRIDGE (MEDication BRIDGE) to identify patients who may be at higher risk for problems after discharge, such as worsening blood sugar control or return visits to the emergency department. Patients identified as high-risk will receive 3 months of support from a nurse case manager and community health worker team, who will help with medication questions, coordinate with their doctor, and provide follow-up check-ins. The main goal is to find out whether this type of support program is practical to deliver and acceptable to patients. The study will also track changes in blood sugar levels and emergency department visits. Forty-five patients will be enrolled over 6 months at the University of Alabama at Birmingham and Cooper Green Mercy Health Services in Jefferson County, Alabama.

Waitlist Available
Has No Placebo

University of Alabama at Birmingham (+1 Sites)

Seung-Yup Lee, PhD

Image of The University of Chicago in Chicago, United States.

Tegoprubart + Islet Cell Transplant for Type 1 Diabetes

18 - 70
All Sexes
Chicago, IL

Single arm- subject treated with Tegoprubart and everolimus. The purpose of this research is to gather information on the safety and effectiveness of investigational regimen containing 2 experimental components: * An investigational drug called Tegoprubart and * Human pancreatic islet cells Both Tegoprubart and human pancreatic islet cells are considered investigational because they are not approved for use in the United States by the Food and Drug Administration (FDA). Participation in this research will last about 5 years. Assess safety, tolerability, and efficacy of transplanted islet cells and immunomodulation with Tegoprubart in combination with anti-thymocyte globulin (ATG), etanercept and with everolimus in adults with brittle T1D and chronic kidney disease (stage 2-3a).

Phase 1 & 2
Recruiting

The University of Chicago

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We made a collection of clinical trials featuring Glumetza, we think they might fit your search criteria.
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Image of Institut de recherches cliniques de Montréal (IRCM) in Montreal, Canada.

Fish Oil for Type 2 Diabetes

40 - 70
All Sexes
Montreal, Canada

The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes. Some metabolic problems-such as difficulty controlling blood sugar, unhealthy particles that transport cholesterol in the blood, and poor fat tissue function-can increase the risk of type 2 diabetes. This study aims to determine whether different types of fish oil can: 1. Improve how well the body produces insulin and responds to it, 2. Improve the quality of the particles that carry "bad" cholesterol in the blood, and 3) Improve the health and function of participants' fat tissue. To answer these questions, researchers will compare the effects of two types of fish oil: EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). These will be compared with corn oil, which is used as a placebo and does not contain EPA or DHA. When included in this study, participants will: A) Take softgel capsules containing EPA, DHA, or placebo (corn oil) every day for 12 weeks, B) Keep a daily log to record when they take their study softgels, and C) Visit the research unit six times, including one and a half days before and after the intervention, to complete specialized metabolic tests that are mostly only available in research settings.

Phase 2
Waitlist Available

Institut de recherches cliniques de Montréal (IRCM)

May Faraj, P.Dt., Ph.D.

Image of Centre de recherche du CHUS in Sherbrooke, Canada.

Cold Exposure for Type 2 Diabetes

40 - 75
All Sexes
Sherbrooke, Canada

Type 2 Diabetes Mellitus (T2DM) is a widespread health condition characterized by impaired ability of the body to maintain glucose homeostasis. This impairment often leads to secondary complications, including heart disease, high blood pressure, and poor quality of life. While exercise and healthy eating are effective strategies in managing and preventing T2DM, data shows that long-term adherence to these methods are poor - especially among elderly, individuals with obesity and/or with physical limitations. This clinical study explores cold exposure with shivering as a novel strategy to improve blood sugar control and heart health. In earlier research, spending time in mildly cold environments (around 15-17°C) for a few hours a day improved insulin sensitivity of T2DM patients. Interestingly, these benefits only occurred when the cold caused mild shivering. In a recent 10-day cold acclimation study with overt shivering for minimally 1 hour/day, we observed improved glucose tolerance in participants with overweight/obesity, as well as improved fasting lipid profiles. These results indicate that when accompanied with sufficient level of muscle activation, repeated exposure to cold can beneficially affect both glucose and lipid levels - both of which are impaired in people with T2DM. In this study, we hypothesise that a 10-day cold acclimation with shivering will improve the (peripheral) insulin sensitivity of patients with T2DM, accompanied by enhanced skeletal muscle FA uptake and oxidation as assessed via the 11C palmitate uptake.

Recruiting
Has No Placebo

Centre de recherche du CHUS

Denis P. Blondin, PhD

Have you considered Glumetza clinical trials?

We made a collection of clinical trials featuring Glumetza, we think they might fit your search criteria.
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Image of Adia Med Of Winter Park in Winter Park, United States.

AdiaVita + Glutathione for Chronic Kidney Disease

18 - 80
All Sexes
Winter Park, FL

The goal of this clinical trial is to learn whether a new regenerative treatment called AdiaVita, made from umbilical cord blood-derived stem cells and exosomes combined with glutathione, is safe and can help improve kidney function in adults with chronic kidney disease (CKD). In this condition, the kidneys gradually lose their ability to filter blood as well as they should. The main questions it aims to answer are whether AdiaVita plus glutathione improves kidney function better than control treatments, as measured by blood tests for estimated glomerular filtration rate (eGFR) and creatinine levels, and whether the treatment is safe with acceptable side effects. Researchers will compare three groups. One group will receive AdiaVita plus glutathione. A second group will receive glutathione plus a placebo for AdiaVita. The third group will receive placebos for both treatments. A placebo looks like the real treatment but contains no active ingredients. This will help determine if the full treatment works better than the controls. Approximately 100 adults aged 18 to 80 with stage 2 to 4 chronic kidney disease may participate. Participants will be randomly assigned to one of the three treatment groups. They will receive monthly intravenous infusions at the clinic for the first three months and apply a skin spray twice daily at home during that period. The study lasts 12 months total for each participant, with regular visits for blood tests, physical exams, and safety monitoring. Certain participants in the control groups may switch to the active AdiaVita treatment after three months if they meet safety criteria. This is a single-blind study, meaning participants will not know which treatment they receive. Participant safety is closely monitored by the research team and an independent board throughout the study.

Phase 1
Recruiting

Adia Med Of Winter Park

Richard Edwards, DO

Image of Advanced Cardiovascular, LLC in Alexander City, United States.

NNC0487-0111 for Obesity and Heart Failure

18+
All Sexes
Alexander City, AL

This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.

Phase 3
Waitlist Available

Advanced Cardiovascular, LLC (+99 Sites)

Clinical Transparency (dept. 2834)

Novo Nordisk A/S

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