Fosrenol

Hyperphosphataemia, Kidney Failure
Treatment
2 FDA approvals
20 Active Studies for Fosrenol

What is Fosrenol

Lanthanum carbonateThe Generic name of this drug
Treatment SummaryLanthanum carbonate, also known as Fosrenol, is a medication used to lower high phosphate levels in people with chronic kidney disease. It is a large pill that should be chewed and taken with meals to help bind to the phosphate in food and stop it from being absorbed by the intestine. Sometimes people forget to chew the pill and have experienced severe choking as a result.
Fosrenolis the brand name
image of different drug pills on a surface
Fosrenol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fosrenol
Lanthanum carbonate
2004
24

Approved as Treatment by the FDA

Lanthanum carbonate, otherwise known as Fosrenol, is approved by the FDA for 2 uses like Kidney Failure and Hyperphosphataemia .
Kidney Failure
Hyperphosphataemia

Effectiveness

How Fosrenol Affects PatientsLaboratory tests have shown that lanthanum can effectively bind phosphate at a range of acidity levels found in the human body (pH 3-7). When tested in a simulated stomach environment, lanthanum was able to bind up to 97% of the available phosphate when it was present in double the amount of phosphate. Bile acids do not affect the phosphate binding ability of lanthanum. To work properly, lanthanum must be taken with or right after meals.
How Fosrenol works in the bodyLanthanum carbonate helps to reduce the amount of phosphate absorbed by the body. It does this by forming a complex with the phosphate that cannot be absorbed by the body. This complex then passes through the digestive system, preventing it from entering the bloodstream. As a result, the amount of both phosphate and calcium phosphate in the body is reduced.

When to interrupt dosage

The measure of Fosrenol is dependent upon the established condition. The amount of dosage is contingent upon the technique of delivery indicated in the table beneath.
Condition
Dosage
Administration
Hyperphosphataemia
500.0 mg, 750.0 mg, 1000.0 mg, , 250.0 mg, 0.025 mL/mL
, Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Topical, Gel, Gel - Topical
Kidney Failure
500.0 mg, 750.0 mg, 1000.0 mg, , 250.0 mg, 0.025 mL/mL
, Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, Powder - Oral, Topical, Gel, Gel - Topical

Warnings

Fosrenol has three contraindications. It should not be employed if any of the conditions in the table below are present.Fosrenol Contraindications
Condition
Risk Level
Notes
ileus and fecal impaction
Do Not Combine
Pulse Frequency
Do Not Combine
Intestinal Obstruction
Do Not Combine
There are 20 known major drug interactions with Fosrenol.
Common Fosrenol Drug Interactions
Drug Name
Risk Level
Description
Atorvastatin
Minor
The absorption of Atorvastatin can be decreased when combined with Lanthanum carbonate.
Cerivastatin
Minor
The absorption of Cerivastatin can be decreased when combined with Lanthanum carbonate.
Fluvastatin
Minor
The absorption of Fluvastatin can be decreased when combined with Lanthanum carbonate.
Halofantrine
Minor
Lanthanum carbonate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lovastatin
Minor
The absorption of Lovastatin can be decreased when combined with Lanthanum carbonate.
Fosrenol Toxicity & Overdose RiskCommon symptoms of lanthanum carbonate overdose include headache, nausea, and vomiting. Animal testing has shown that this drug is not toxic when given orally, even in large doses (up to 2000mg/kg). No deaths or other adverse effects have been observed in mice, rats, or dogs after single oral doses.

Fosrenol Novel Uses: Which Conditions Have a Clinical Trial Featuring Fosrenol?

55 active studies are currently being conducted to assess the effectiveness of Fosrenol in reducing Hyperphosphataemia.
Condition
Clinical Trials
Trial Phases
Hyperphosphataemia
0 Actively Recruiting
Kidney Failure
45 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Fosrenol Reviews: What are patients saying about Fosrenol?

5Patient Review
5/16/2013
Fosrenol for Renal Osteodystrophy with Hyperphosphatemia
I find that grinding the tablets into a powder makes them much easier to take and improves the taste. I actually enjoy the sweetness of the powder.
5Patient Review
6/21/2012
Fosrenol for High Amount of Phosphate in the Blood
As a home hemodialysis patient, my phosphorus levels were through the roof. 11.0 to be exact. But after my nutritionist suggested I try Fosrenol (2 500mg chewable tablets with meals and snacks), it lowered my phosphorus all the way down to 3.5; which is well within the normal range of 3.5-5.5. Not only that, but this product tastes like tums! And I have experienced zero stomach problems or nausea from taking it regularly.
5Patient Review
1/17/2009
Fosrenol for High Amount of Phosphate in the Blood
I'm on dialysis for end stage renal failure, and this product has been great for keeping my phosphorus levels in check. I chew one 1000mg tablet after every meal and snack, and it's really helped me out.
5Patient Review
7/30/2009
Fosrenol for High Amount of Phosphate in the Blood
I've had a great experience with this medication. It's easy to chew and I stay in range on my report card. Some of the other comments mention having trouble with upset stomach and nausea, but that improved for me within two months.
5Patient Review
10/5/2007
Fosrenol for Renal Osteodystrophy with Hyperphosphatemia
This medication was easy to take and had a pleasant taste.
View All Reviews
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Patient Q&A Section about fosrenol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of medication is Fosrenol?

"FOSRENOL works by binding phosphate in the gut so that it isn't absorbed into the body, reducing serum phosphate levels."

Answered by AI

When should I take Fosrenol?

"Fosrenol should be taken with food to avoid nausea and vomiting. The tablets must be chewed completely and not swallowed whole. To aid with chewing, the tablets may be crushed."

Answered by AI

Is there a generic for Fosrenol?

"Lanthanum, the generic version of the drug Fosrenol, may be much cheaper than the brand version of the drug."

Answered by AI

What is Fosrenol used for?

"Fosrenol prevents the body from absorbing phosphate by bind to it in the gastrointestinal tract, which then allows it to be removed from the body through the feces. This medication is used to treat patients with end stage renal disease who have high phosphate levels in their blood, which can lead to problems with calcium absorption and other serious medical problems."

Answered by AI

Clinical Trials for Fosrenol

Have you considered Fosrenol clinical trials? We made a collection of clinical trials featuring Fosrenol, we think they might fit your search criteria.
Have you considered Fosrenol clinical trials? We made a collection of clinical trials featuring Fosrenol, we think they might fit your search criteria.
Have you considered Fosrenol clinical trials? We made a collection of clinical trials featuring Fosrenol, we think they might fit your search criteria.
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