Emend

Pharmacotherapy, Antiemetic Therapy, Malignant Neoplasms + 1 more
Treatment
2 Active Studies for Emend

What is Emend

AprepitantThe Generic name of this drug
Treatment SummaryAprepitant is a medication used to prevent nausea and vomiting caused by cancer chemotherapy. It works by blocking the action of the Substance P/Neurokinin 1 (NK1) receptor, stopping signals that trigger nausea and vomiting. Aprepitant has very little effect on serotonin, dopamine, and corticosteroid receptors, which are the targets of other medications used to treat chemotherapy-induced nausea and vomiting (CINV).
Emendis the brand name
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Emend Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Emend
Aprepitant
2003
22

Effectiveness

How Emend Affects PatientsAprepitant is a medication used to prevent nausea and vomiting caused by chemotherapy. It works by blocking a receptor called substance P/neurokinin 1 (NK1) and does not affect serotonin, dopamine, or corticosteroid receptors like other antiemetic medicines.
How Emend works in the bodyAprepitant is used to prevent vomiting caused by chemotherapy drugs like cisplatin. Animal and human studies have shown that this drug reaches the brain, binds to receptors there, and blocks vomiting. It also works with other drugs like ondansetron and ethasone to stop both the immediate and delayed phases of chemotherapy-induced nausea.

When to interrupt dosage

The suggested amount of Emend is contingent upon the recognized affliction, including Operative Surgery, Nausea and cancer chemotherapy. The measure of dosage varies, depending on the approach of administration (e.g. Capsule; Kit - Oral or Powder, for suspension - Oral) outlined in the table below.
Condition
Dosage
Administration
Pharmacotherapy
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral
Antiemetic Therapy
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral
Malignant Neoplasms
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral
Malignant Neoplasms
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral

Warnings

Emend has two contraindications, so it should not be utilized in combination with the issues detailed in the following table.Emend Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Emend.
Common Emend Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Aprepitant.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Aprepitant.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Aprepitant.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Aprepitant.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Aprepitant.
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Emend Novel Uses: Which Conditions Have a Clinical Trial Featuring Emend?

81 active clinical trials are currently in progress to evaluate the potential of Emend to ameliorate Operative Surgery-induced Nausea and cancer chemotherapy-related symptoms.
Condition
Clinical Trials
Trial Phases
Pharmacotherapy
2 Actively Recruiting
Phase 4, Not Applicable
Antiemetic Therapy
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting

Emend Reviews: What are patients saying about Emend?

5Patient Review
5/11/2010
Emend for Prevent Nausea and Vomiting from Cancer Chemotherapy
This drug is nothing short of miraculous. I've had to go through several surgeries due to two mastectomies and breast reconstruction, and in the past the anesthesia always made me throw up for hours despite taking Zofran and other medications. However, on my last surgery I took Emend and only felt a wave of nausea that was quickly taken care of by the Zofran.
5Patient Review
4/6/2011
Emend for Prevent Nausea and Vomiting from Cancer Chemotherapy
This medication was a lifesaver during my cancer treatment. I used it for chemotherapy and before surgery, and it really helped to ease the nausea.
5Patient Review
11/4/2010
Emend for Prevent Nausea and Vomiting from Cancer Chemotherapy
Emend has been a total Godsend. I no longer have to suffer from chemotherapy-induced nausea and vomiting for my rectal cancer treatment.
5Patient Review
4/5/2010
Emend for Prevent Nausea and Vomiting from Cancer Chemotherapy
Thank you for making this medication.
5Patient Review
11/6/2013
Emend for Prevent Nausea and Vomiting from Cancer Chemotherapy
Though this medication is expensive, I found it well worth the price. I never experienced any nausea or vomiting during my six-month treatment.
View All Reviews
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Patient Q&A Section about emend

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Emend used for?

"Aprepitant is used alongside two other medications to prevent nausea and vomiting caused by certain chemotherapy medications."

Answered by AI

How long does it take for Emend to work?

"Your doctor will tell you when to start taking this medicine. It is usual to take the first dose one hour before the start of chemotherapy. For the next two days, continue to take a dose once daily, one hour before chemotherapy if you are receiving it that day. If you are not having any chemotherapy, take the dose once daily in the morning."

Answered by AI

Can you take Emend and Zofran together?

"There is no known interaction between Emend and Zofran, but that doesn't mean there definitely isn't one. Always check with your healthcare provider if you have any concerns."

Answered by AI

What drug class is Emend?

"Emend is a prescription medicine used to relieve the symptoms of nausea and vomiting associated with chemotherapy. It may be used alone or with other medications. Emend belongs to a class of drugs called antiemetics, which are drugs that prevent or treat nausea and vomiting.NK1 receptor antagonists are a type of antiemetic."

Answered by AI

Clinical Trials for Emend

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