Your session is about to expire
What is Emend
AprepitantThe Generic name of this drug
Treatment SummaryAprepitant is a medication used to prevent nausea and vomiting caused by cancer chemotherapy. It works by blocking the action of the Substance P/Neurokinin 1 (NK1) receptor, stopping signals that trigger nausea and vomiting. Aprepitant has very little effect on serotonin, dopamine, and corticosteroid receptors, which are the targets of other medications used to treat chemotherapy-induced nausea and vomiting (CINV).
Emendis the brand name
Emend Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Emend
Aprepitant
2003
22
Effectiveness
How Emend Affects PatientsAprepitant is a medication used to prevent nausea and vomiting caused by chemotherapy. It works by blocking a receptor called substance P/neurokinin 1 (NK1) and does not affect serotonin, dopamine, or corticosteroid receptors like other antiemetic medicines.
How Emend works in the bodyAprepitant is used to prevent vomiting caused by chemotherapy drugs like cisplatin. Animal and human studies have shown that this drug reaches the brain, binds to receptors there, and blocks vomiting. It also works with other drugs like ondansetron and ethasone to stop both the immediate and delayed phases of chemotherapy-induced nausea.
When to interrupt dosage
The suggested amount of Emend is contingent upon the recognized affliction, including Operative Surgery, Nausea and cancer chemotherapy. The measure of dosage varies, depending on the approach of administration (e.g. Capsule; Kit - Oral or Powder, for suspension - Oral) outlined in the table below.Condition
Dosage
Administration
Malignant Neoplasms
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral
Malignant Neoplasms
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral
Pharmacotherapy
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral
Antiemetic Therapy
40.0 mg, , 80.0 mg, 125.0 mg, 165.0 mg, 13.0 mg/mL, 205.0 mg
, Oral, Capsule, Capsule - Oral, Kit, Capsule; Kit, Capsule; Kit - Oral, Powder, for suspension, Powder, for suspension - Oral, Intravenous, Injection, emulsion, Injection, emulsion - Intravenous, Kit - Oral
Warnings
Emend has two contraindications, so it should not be utilized in combination with the issues detailed in the following table.Emend ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Emend Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Aprepitant.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Aprepitant.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Aprepitant.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Aprepitant.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Aprepitant.
Emend Novel Uses: Which Conditions Have a Clinical Trial Featuring Emend?
81 active clinical trials are currently in progress to evaluate the potential of Emend to ameliorate Operative Surgery-induced Nausea and cancer chemotherapy-related symptoms.Condition
Clinical Trials
Trial Phases
Pharmacotherapy
1 Actively Recruiting
Phase 4
Malignant Neoplasms
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Antiemetic Therapy
0 Actively Recruiting
Emend Reviews: What are patients saying about Emend?
5Patient Review
5/11/2010 This drug is nothing short of miraculous. I've had to go through several surgeries due to two mastectomies and breast reconstruction, and in the past the anesthesia always made me throw up for hours despite taking Zofran and other medications. However, on my last surgery I took Emend and only felt a wave of nausea that was quickly taken care of by the Zofran.
5Patient Review
4/6/2011 This medication was a lifesaver during my cancer treatment. I used it for chemotherapy and before surgery, and it really helped to ease the nausea.
5Patient Review
11/4/2010 Emend has been a total Godsend. I no longer have to suffer from chemotherapy-induced nausea and vomiting for my rectal cancer treatment.
5Patient Review
4/5/2010 Thank you for making this medication.
5Patient Review
11/6/2013 Though this medication is expensive, I found it well worth the price. I never experienced any nausea or vomiting during my six-month treatment.
5Patient Review
5/20/2013 I haven't had any negative side effects since taking this medication, which is great.
5Patient Review
6/17/2014 Emend was an absolute life-saver for me during my chemotherapy. I tried Phenergan and Zofran prior with little to no relief, but Emend completely took away the nausea and allowed me to get through my treatments.
5Patient Review
11/19/2013 Zolfram on its own only partially worked for me in terms of reducing nausea and delaying vomiting. However, when I combined it with this treatment, it was much more effective.
5Patient Review
6/3/2015 I have really severe PONV after anesthesia, but this time I was given Emend and didn't experience any nausea. It worked great for me!
5Patient Review
1/8/2014 Emend has been an absolute godsend. I haven't been able to keep food down for years, but this medication finally gave me relief.
5Patient Review
5/11/20095Patient Review
2/5/2011 I'm a one year breast cancer survivor, and I can attest that Emend was extremely helpful for me. Usually, after treatment on Wednesday, I was able to go back to work on Thursday and then rest over the weekend. Without Emend, there's no way I could have kept up with that schedule--I never once had to use my backup Zofran, either.
5Patient Review
3/16/2016 This drug has made all the difference for my daughter's cancer. She's going through chemo again, and this time around we're seeing much better results than before. I'm so thankful that this medication exists.
5Patient Review
7/23/2015 I am so grateful that this medication was prescribed to me by my oncologist. It has been extremely helpful.
4.7Patient Review
5/15/2009 Emend has been working well for me in conjunction with adriamycin/cytoxan. I only feel mildly queasy every now and then, which is a drastic improvement.
4.3Patient Review
4/29/20094Patient Review
9/5/2012 I'm sorry, I haven't had a chance to use this treatment yet. I'll update my review after I've tried it out.
3.7Patient Review
2/10/2011 My husband had his first round of chemo today for bladder cancer. It was Cisplatin/Gemzar. Th Emend worked great. No nausea at all.
1Patient Review
12/18/2020 I had a severe allergic reaction to Emend, which was given to me intravenously before chemotherapy. I experienced chest tightness and intense pain in my lower back. My blood pressure spiked dangerously high as a result. If you're prone to allergies, be very careful with this medication.
1Patient Review
1/21/2020 I unfortunately had a severe allergic reaction to Emend and had to be switched to Compazine. The new medication made me very tired.
Patient Q&A Section about emend
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Emend used for?
"Aprepitant is used alongside two other medications to prevent nausea and vomiting caused by certain chemotherapy medications."
Answered by AI
How long does it take for Emend to work?
"Your doctor will tell you when to start taking this medicine. It is usual to take the first dose one hour before the start of chemotherapy. For the next two days, continue to take a dose once daily, one hour before chemotherapy if you are receiving it that day. If you are not having any chemotherapy, take the dose once daily in the morning."
Answered by AI
Can you take Emend and Zofran together?
"There is no known interaction between Emend and Zofran, but that doesn't mean there definitely isn't one. Always check with your healthcare provider if you have any concerns."
Answered by AI
What drug class is Emend?
"Emend is a prescription medicine used to relieve the symptoms of nausea and vomiting associated with chemotherapy. It may be used alone or with other medications. Emend belongs to a class of drugs called antiemetics, which are drugs that prevent or treat nausea and vomiting.NK1 receptor antagonists are a type of antiemetic."
Answered by AI