Dotarem

MRI

Treatment

1 FDA approval

17 Active Studies for Dotarem

Treatment for

MRI

What is Dotarem

Gadoteric acidThe Generic name of this drug

Treatment SummaryGadoteric acid (also known as Dotarem) is a medical imaging agent used in MRI scans. It contains the organic acid DOTA and gadolinium (Gd3+), which react to magnetic fields. This reaction creates a brighter signal in the MRI scan, allowing doctors to detect and visualize areas of the brain, spine, and associated tissues with disrupted blood-brain barriers or abnormal vascularity. Gadoteric acid is approved for use in adults and children aged two years and older.

Dotaremis the brand name

Dotarem Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Dotarem

Gadoteric acid

2013

Approved as Treatment by the FDA

Gadoteric acid, also known as Dotarem, is approved by the FDA for 1 uses including MRI .

MRI

Effectiveness

How Dotarem Affects PatientsGadoterate changes the way protons act in MRI scans, and produces images with clear contrast. It works on most MRI machines (from 0.2 to 1.5 Tesla). Gadoterate does not enter the brain normally, so it does not show up on healthy brain tissue or on cysts and scars. However, if the brain's natural protection is damaged or if there is unusual blood flow in the area, then gadoterate can enter and show up in scans of tumors, abscesses, and strokes.

How Dotarem works in the bodyGadoterate is a molecule that becomes magnetic when placed in a magnetic field. This magnetism increases the signal intensity of nearby tissues, making them appear brighter on MRI scans. Gadoterate shortens the time it takes for these tissues to return to their resting state in a magnetic field, making them easier to detect.

When to interrupt dosage

The encouraged dose of Dotarem is contingent upon the diagnosed disorder. The amount of dosage varies, in accordance with the delivery system (e.g. Injection - Intravenous or Solution - Intravenous) featured in the table below.

Condition

Dosage

Administration

MRI

, 376.9 mg/mL

, Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous

Warnings

There are 20 known major drug interactions with Dotarem.

Common Dotarem Drug Interactions

Drug Name

Risk Level

Description

Technetium Tc-99m oxidronate

Major

Gadoteric acid may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.

Acrivastine

Minor

Gadoteric acid may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Gadoteric acid may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Almasilate

Minor

Gadoteric acid may decrease the excretion rate of Almasilate which could result in a higher serum level.

Antihemophilic factor (recombinant), PEGylated

Minor

Gadoteric acid may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.

Dotarem Toxicity & Overdose RiskCommon reactions to Gadolinium-Based Contrast Agents (GBCAs) include nausea, headaches, discomfort or pain at the injection site, feeling cold or a burning sensation at the injection site. Patients with poor kidney function may develop Nephrogenic Systemic Fibrosis.

Dotarem Novel Uses: Which Conditions Have a Clinical Trial Featuring Dotarem?

Ten active trials are currently underway to assess the potential of Dotarem in Magnetic Resonance Imaging (MRI) Scanning.

Condition

Clinical Trials

Trial Phases

MRI

17 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Patient Q&A Section about dotarem

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Dotarem FDA approved?

"Guerbet LLC USA announced that the U.S. Food and Drug Administration approved Dotarem (gadoterate meglumine) for intravenous use with magnetic resonance imaging in pediatric patients under two years of age, including term neonates, to detect and visualize areas with disrupted blood brain barrier."

Answered by AI

What are the side effects of Dotarem?

"I’m feeling really sick. I’ve got a headache and I’m feeling nauseous. I’m also feeling really cold and I’ve got a rash. I’m really sleepy and I’m feeling really tired. I’m also feeling really dizzy and I’m vomiting."

Answered by AI

Is Dotarem safer than gadolinium?

"Gadolinium contrast injections have been used successfully in hundreds of millions of patients over the last three decades. They are safe, not radioactive, and are different (and better) than the contrast agents used for a CT scan. The U.S. Food and Drug Administration has approved Dotarem as safe for use in MRI scans."

Answered by AI

What is Dotarem used for?

"DOTAREM is a gadolinium-based contrast agent that is injected intravenously and is indicated for use with magnetic resonance imaging (MRI) in brain, spine, and associated tissues in adult and pediatric patients, including term neonates, to detect and visualize areas with disruption of the blood brain barrier or abnormal vascularity."

Answered by AI