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What is Dipentum
OlsalazineThe Generic name of this drug
Treatment SummaryOlsalazine is a medication used to reduce inflammation in the intestines. It is derived from salicylic acid and is converted by bacteria in the colon into mesalamine, which works to reduce inflammation in patients with inflammatory bowel disease and ulcerative colitis.
Dipentumis the brand name
Dipentum Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dipentum
Olsalazine
1990
5
Approved as Treatment by the FDA
Olsalazine, also known as Dipentum, is approved by the FDA for 1 uses which include Ulcerative Colitis .Ulcerative Colitis
Helps manage Ulcerative Colitis
Effectiveness
How Dipentum Affects PatientsOlsalazine is a drug used to treat Inflammatory Bowel Disease and Ulcerative Colitis, both of which cause inflammation, frequent diarrhea, rectal bleeding, and abdominal pain. Olsalazine works by delivering a special form of a medicine (mesalazine or 5-aminosalicylic acid) to the large intestine, where it can reduce the inflammation and symptoms.
How Dipentum works in the bodyOlsalazine is taken orally and is turned into mesalamine, which helps treat ulcerative colitis. The exact way it works is still unknown, but it seems to work on the site of the inflammation, not throughout the body. Mesalamine may help reduce inflammation by blocking a type of enzyme that produces substances that can cause inflammation.
When to interrupt dosage
The prescribed dosage of Dipentum is contingent upon the diagnosed condition. The amount of dosage varies, as per the method of delivery (e.g. Capsule, gelatin coated or Oral) indicated in the table beneath.Condition
Dosage
Administration
Ulcerative Colitis
, 250.0 mg
Oral, , Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, Capsule - Oral
Warnings
There are 20 known major drug interactions with Dipentum.Common Dipentum Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Olsalazine.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Olsalazine.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Olsalazine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Olsalazine is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Olsalazine is combined with Omacetaxine mepesuccinate.
Dipentum Toxicity & Overdose RiskTests have found that giving mice, rats, and dogs a single oral dose of up to 5g/kg, and 2g/kg respectively, is not lethal.
Dipentum Novel Uses: Which Conditions Have a Clinical Trial Featuring Dipentum?
96 active trials are being conducted to assess the efficacy of Dipentum in treating Ulcerative Colitis.Condition
Clinical Trials
Trial Phases
Ulcerative Colitis
98 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4, Early Phase 1
Dipentum Reviews: What are patients saying about Dipentum?
5Patient Review
6/29/2010 Dipentum has been by far the best medication I've tried for my ulcerative colitis. It doesn't have any of the nasty side effects that other medications did, and it's helped me more than anything else I've tried.
5Patient Review
12/31/2008 This drug has been a life saver for me. I've been taking it for over 12 years to manage my colitis, and it's worked wonders. I was able to get off of steroids thanks to this medication, and I haven't had any flareups since starting it.
5Patient Review
4/11/2011 I've been using this medicine for over a decade and it's worked great, but the price has increased three-fold in the last year. If anyone else has experienced this, please let me know.
5Patient Review
11/18/2015 I've been taking this drug for almost 30 years and it has done wonders for me. However, in the last year or so, the price has skyrocketed. I used to be able to get a three-month supply for $100, but now it costs me nearly $300. And if I didn't have insurance, it would cost me $1,500 per month! I know that other people are experiencing similar problems, and I hope that somebody comes out with a generic soon.
5Patient Review
6/22/2015 This medication has been absolutely integral in managing my Ulcerative Colitis. I was shocked and disappointed to learn that the manufacturer has discontinued it; hopefully there will be a replacement available soon.
5Patient Review
12/20/2013 This treatment is amazing! I have rectal bleeding with burning pain and bloating and abdominal distention, but when I take Dipentum, I get relief almost immediately. It's my go-to whenever I have a flare-up, and it always does the job for me.
5Patient Review
7/14/2018 I've been using this medication for over 30 years now and I can say with certainty that it's never given me any problems. In contrast, I have experienced negative side effects from other medications.
5Patient Review
1/26/2010 Dipentum has been a game changer for me. I've been taking it regularly for 18 years with minimal side effects.
5Patient Review
7/19/2008 I've been on this medication for about fifteen years and, in my opinion, it's been working great.
5Patient Review
8/5/2008 I've been on dipentum for 11 years and have never experienced any negative side effects. I also had a stroke last year, but that hasn't stopped me from continuing to use this medication with great results.
4.3Patient Review
9/30/2009 This treatment has done wonders for my chronic diarrhea and cramping. The only downside is the cost--$250 a month without insurance coverage
Patient Q&A Section about dipentum
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Dipentum an anti-inflammatory?
"Dipentum is an aminosalicylate, a type of anti-inflammatory drug. It is believed to work by decreasing the production of prostaglandins, which regulates inflammation in the body. This, in turn, decreases inflammation in the intestines, allowing them to heal and preventing flare-ups."
Answered by AI
What is Dipentum used for?
"Dipentum is a drug that is used to treat ulcerative colitis. It is a salicylate anti-inflammatory drug."
Answered by AI
Is Dipentum available?
"Dipentum is not currently available in the United States. Note: There may be illegal online pharmacies selling a generic version of Dipentum. These medications may be counterfeit and potentially unsafe."
Answered by AI
What drug class is Dipentum?
"Dipentum is a 5-Aminosalicylic Acid Derivative."
Answered by AI