Detrol La

Overactive Bladder Syndrome, Urinary Incontinence, Urge

Treatment

20 Active Studies for Detrol La

What is Detrol La

Tolterodine

The Generic name of this drug

Treatment Summary

Tolterodine is a medication used to treat urinary incontinence. It targets specific types of muscle cells in the bladder and helps to reduce the symptoms of incontinence.

Detrol

is the brand name

image of different drug pills on a surface

Detrol La Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Detrol

Tolterodine

1998

78

Effectiveness

How Detrol La Affects Patients

Tolterodine is a medicine that blocks certain receptors in the body (muscarinic receptors) to help reduce symptoms of an overactive bladder. After taken orally, the drug is processed in the liver and become a metabolite responsible for the drug's effects. This metabolite specifically targets muscarinic receptors, not other receptors like calcium channels, and helps the body relax the bladder and reduce pressure. The effects of tolterodine on bladder function include increasing urine that is left in the bladder and reducing pressure.

How Detrol La works in the body

Tolterodine reduces the activity of muscles in your bladder, reducing the pressure in the bladder and improving bladder emptying. It works by blocking the effects of a neurotransmitter that would normally make the bladder muscles contract.

When to interrupt dosage

The quantity of Detrol La is contingent upon the diagnosed affliction. The amount of dosage differs, in accordance with the method of delivery (e.g. Capsule, extended release - Oral or Tablet - Oral) specified in the following table.

Condition

Dosage

Administration

Overactive Bladder Syndrome

1.0 mg, , 2.0 mg, 4.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral

Urinary Incontinence, Urge

1.0 mg, , 2.0 mg, 4.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral

Warnings

Detrol La has three contraindications, and use of it should be avoided when suffering from any of the conditions provided in the following table.

Detrol La Contraindications

Condition

Risk Level

Notes

Urinary Retention

Do Not Combine

uncontrolled narrow-angle glaucoma

Do Not Combine

Gastric Retention

Do Not Combine

There are 20 known major drug interactions with Detrol La.

Common Detrol La Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Tolterodine is combined with Aclidinium.

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Tolterodine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Tolterodine.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Tolterodine.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Tolterodine is combined with Cimetropium.

image of a doctor in a lab doing drug, clinical research

Detrol La Novel Uses: Which Conditions Have a Clinical Trial Featuring Detrol La?

42 active studies are being conducted to investigate the potential of Detrol La in providing relief from Overactive Bladder Syndrome.

Condition

Clinical Trials

Trial Phases

Urinary Incontinence, Urge

6 Actively Recruiting

Not Applicable, Phase 4

Overactive Bladder Syndrome

29 Actively Recruiting

Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2

Detrol La Reviews: What are patients saying about Detrol La?

5

Patient Review

8/10/2016

Detrol La for Overactive Bladder

This medication was extremely effective for me and helped clear up my condition quickly. The only downside is that it caused me to have a very dry mouth.

5

Patient Review

8/10/2016

Detrol La for Overactive Bladder

This medication was really effective for me and helped a lot. The only downside is that it gives me a very dry mouth.

4.7

Patient Review

9/17/2015

Detrol La for Overactive Bladder

This treatment has helped me a lot with my overactive bladder.

4.7

Patient Review

9/26/2013

Detrol La for Overactive Bladder

This didn't fully solve my problem, but it did help somewhat. I'm still leaking and wetting a diaper in the morning, but some of my symptoms have improved.

4.7

Patient Review

6/24/2013

Detrol La for Frequent Urination

I haven't seen any results yet, but I'm still hopeful.

4.7

Patient Review

9/26/2013

Detrol La for Overactive Bladder

While this medication didn't completely solve my problem, it did help to alleviate some of the symptoms.

4.7

Patient Review

6/24/2013

Detrol La for Frequent Urination

I'm still waiting to see results from this treatment, but I remain hopeful.

4.7

Patient Review

9/17/2015

Detrol La for Overactive Bladder

This treatment has been extremely effective in managing my overactive bladder. It's allowed me to live a much more normal life without having to worry about accidents.

4.3

Patient Review

10/23/2013

Detrol La for Needing to Urinate Immediately

I felt pretty tired while taking this medication, and occasionally experienced dizzy spells. That said, it was still effective for me.

4.3

Patient Review

10/23/2013

Detrol La for Needing to Urinate Immediately

I have felt tired and dizzy while taking this medication. It unfortunately has not been effective for me.

4

Patient Review

11/23/2012

Detrol La for Frequent Urination

4

Patient Review

11/23/2012

Detrol La for Frequent Urination

3.7

Patient Review

5/25/2013

Detrol La for Needing to Urinate Immediately

I found the effects of this medication to be quite unpredictable.

3.7

Patient Review

5/25/2013

Detrol La for Needing to Urinate Immediately

I found the effects of this treatment to be very unpredictable.

2.7

Patient Review

6/17/2016

Detrol La for Urine Leakage When there is a Strong Desire to Void

After learning about the potential side effects of this drug, I stopped taking it. The most worrisome possible side effect is how it affects the brain, especially relating to dementia. For the little help I noticed, it's definitely not worth the risk to me.

2.7

Patient Review

5/27/2014

Detrol La for Urine Leakage When there is a Strong Desire to Void

I experienced a lot of irritation and felt like I had a UTI while taking this medication. Cranberry tablets helped somewhat, but the symptoms were still worse than they were before I started taking the medication.

2.7

Patient Review

12/16/2014

Detrol La for Overactive Bladder

My doctor started me on Detrol La a few months ago for a kidney stone that hasn't moved in years. Recently, I've been experiencing more pain in the area around my right kidney. Could this be from the medication? The pain is even sensitive to touch now and it's getting tough to manage. So far urination isn't an issue though.

2.7

Patient Review

12/16/2014

Detrol La for Overactive Bladder

I have a kidney stone that's been stuck for over six years now. My doctor put me on Detrol about two months ago, and since then I've been having sporadic but really painful episodes in the same area. Even just touching lightly causes pain now. There haven't been any changes to my urination though.

2.7

Patient Review

5/27/2014

Detrol La for Urine Leakage When there is a Strong Desire to Void

I developed irritation and other urinary tract symptoms after starting this medication. Thankfully, cranberry tablets have helped to alleviate these issues somewhat. However, I find that the symptoms are worse when I first wake up in the morning. Overall, I feel like my condition has worsened since taking this drug.

2.7

Patient Review

6/17/2016

Detrol La for Urine Leakage When there is a Strong Desire to Void

After learning more about the potential risks, I have stopped taking Detrol LA. The most worrisome possible side effect is how it affects the brain, especially relating to dementia. For the little help I noticed, it's definitely not worth the risk to me.

2.3

Patient Review

6/3/2013

Detrol La for Overactive Bladder

I only have the urge to urinate when I'm bouncing around, and Detrol helps way more than the cheaper stuff. Although, the more I use it, the more hair I seem to be losing. Idk if it's the meds, but the drying effects of Detrol has me concerned that it could be making hair loss increase much more rapidly.

2.3

Patient Review

3/19/2014

Detrol La for Frequent Urination

An effective medication, but it's so expensive which is tough because I'm on a fixed income.

2.3

Patient Review

3/19/2014

Detrol La for Frequent Urination

An effective medication that I've been taking for a while now. The biggest downside is the cost; as a senior citizen on a fixed income, it's tough to keep up with.

2.3

Patient Review

6/3/2013

Detrol La for Overactive Bladder

I find that Detrol helps me to urinate less frequently than other, cheaper medications; however, I have noticed that the more I use it, the more hair I seem to lose. I'm not sure if this is a side effect of the medication or not, but it is something that concerns me.

2

Patient Review

9/24/2012

Detrol La for Frequent Urination

2

Patient Review

9/24/2012

Detrol La for Frequent Urination

1

Patient Review

9/24/2013

Detrol La for Frequent Urination

I had been having daytime accidents when I couldn't get to the restroom on time. Detrol has worked great for me. Now, suddenly, my copay per month went from $30 to $85 so I will have to find something else as I cannot afford this.

1

Patient Review

3/26/2014

Detrol La for Frequent Urination

I had a very severe reaction to Detrol LA and it nearly gave me a stroke.

1

Patient Review

9/24/2013

Detrol La for Frequent Urination

I was having a lot of issues with incontinence, but this drug really helped me. However, the price per month went from $30 to $85 and I just can't afford that.

1

Patient Review

3/26/2014

Detrol La for Frequent Urination

Do not take this medication if you value your health. I nearly had a stroke as a result of taking just one Detrol LA pill.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about detrol la

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Detrol LA?

"Tolterodine may also be used for purposes not listed in this medication guide.

Tolterodine is a medication used to treat overactive bladder with symptoms like urge urinary incontinence, urgency, and frequency. It is available under the brand names Detrol and Detrol LA. Tolterodine may also be used for other purposes not listed in this guide."

Answered by AI

What are the side effects of Detrol LA?

"Tell your doctor if any of the following side effects last or get worse: dry mouth, dry eyes, headache, constipation, stomach upset/pain, dizziness, drowsiness, or tiredness."

Answered by AI

Should I take Detrol in the morning or at night?

"For adults, the recommended dosage of tolterodine is 2mg in the morning and 2mg in the evening, with a 12 hour gap in between doses. For children, the usual dosage is 1-4mg per day, depending on the child's age and weight. If you are giving tolterodine to a child to stop bedwetting, the usual dose is 1mg taken at bedtime."

Answered by AI

How long does it take Detrol LA to work?

"Questions that are frequently asked about tolterodine (Detrol) include how soon the medication can start working and how long it might take to feel the full effects. It is important to continue taking the medication every day, even if there is no improvement in symptoms of OAB, to give the medication time to work to its full potential."

Answered by AI

Clinical Trials for Detrol La

Image of Stanford Medicine Department of Obstetrics & Gynecology in Palo Alto, United States.

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder

22 - 80
Female
Palo Alto, CA

The goal of this clinical trial is to learn if a vaginal radiofrequency (RF) device called MORPHEUSV works to treat overactive bladder (OAB) in women. Researchers also want to learn how safe the device is for this indication. This study will include women ages 22 to 80 who have had OAB symptoms for at least 6 months. The main questions it aims to answer are: Does the MORPHEUSV device lower the number of daily episodes of accidental urine leakage caused by urgency? Does it work better than a sham (placebo) treatment? Researchers will compare the MORPHEUSV device to a sham treatment to see how well it reduces symptoms of overactive bladder. Participants will: 1) Receive one session of either the MORPHEUSV or sham treatment. 2) Track their symptoms using a diary and questionnaires 3) Return for three to six follow-up visits over 12 months. This study is being conducted at multiple clinics in the United States.

Waitlist Available
Device

Stanford Medicine Department of Obstetrics & Gynecology (+10 Sites)

Mickey Karram, MD

InMode MD Ltd.

Have you considered Detrol La clinical trials?

We made a collection of clinical trials featuring Detrol La, we think they might fit your search criteria.
Go to Trials

Have you considered Detrol La clinical trials?

We made a collection of clinical trials featuring Detrol La, we think they might fit your search criteria.
Go to Trials
Image of Mickey Karram MD in Corona Del Mar, United States.

Nerve Ablation for Overactive Bladder

21 - 80
Female
Corona Del Mar, CA

The goal of this Safety and efficacy of transvaginal Detrusor Nerve Ablation for treatment of overactive bladder symptoms, including refractory overactive bladder The main questions it aims to answer are: •Change from baseline to the end of treatment in a 3-day diary analysis to assess the reduction of urgency incontinence episodes. \[Time Frame: 3 months\] Subjects will undergo one treatment session and be reassessed at 4 weeks post-treatment. If less than a 50% improvement is noted, a second and third treatment session will be performed at 4-week intervals. If more than a 50% improvement is noted, patients will be followed longitudinally to assess the durability of the treatment. Investigators will have the ability to initiate a second and or third treatment on an individual basis. Follow-up will occur at 3- months, 6-months and 12 months after the subject's last treatment.

Waitlist Available
Has No Placebo

Mickey Karram MD (+2 Sites)

Mickey Karram, MD

InMode MD Ltd.

Image of Cardiometabolic Research Unit in Dallas, United States.

Extended Release Torsemide for Overactive Bladder in Heart Failure

18+
All Sexes
Dallas, TX

This research study is being done to compare the effectiveness two drugs: an extended release torsemide (ERT) versus generic immediate release Torsemide (IRT) in reducing the worsening of symptoms of Overactive Bladder (OAB i.e., frequency, urgency, or urgency incontinence) in patients with chronic congestive heart failure (CHF). This study will include CHF patients who experience worsening OAB) symptoms with use of a loop diuretic. The total duration of the study is about eight weeks with a total of nine visits. There will be a screening visit that lasts one to two hours. The screening visit includes history and physical exams, blood draws, and urine analysis. If eligible for the study, participants will receive either generic torsemide or extended release torsemide for the first four weeks. Participants will do a virtual research visit on week one, two and three to submit a symptom diary and answer a questionnaire about urinary symptoms. At four weeks, history and physician exam will be done and blood will be collected. Participants will be assigned to receive either extended release torsemide (if they initially received generic torsemide) and generic torsemide (if they initially received extended release torsemide) for the next four weeks. Participants will attend virtual research visits on week five, six and seven to submit a symptom diary and answer a questionnaire about urinary symptoms. At the end of the study in week eight, they will have history and physical exams and blood draws. Some risks from the study may include side effects of torsemide like acute kidney injury, fluid/electrolyte loss, hypersensitivity reactions and reversible hearing loss/tinnitus.

Phase 2
Recruiting

Cardiometabolic Research Unit

Alvin Chandra, MD

Sarfez Pharmaceuticals, Inc.

Have you considered Detrol La clinical trials?

We made a collection of clinical trials featuring Detrol La, we think they might fit your search criteria.
Go to Trials