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What is Depo-Provera
Medroxyprogesterone acetateThe Generic name of this drug
Treatment SummaryMedroxyprogesterone acetate (MPA) is a hormone-based drug that was approved by the FDA in 1959. Its main purpose is to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, and osteoporosis. It can also be used to reduce pain in endometriosis, manage vasomotor symptoms in menopause, and prevent pregnancy. MPA is also used to treat endometrial and renal carcinoma in palliative care.
Medroxyprogesterone Acetateis the brand name
Depo-Provera Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Medroxyprogesterone Acetate
Medroxyprogesterone acetate
1959
139
Approved as Treatment by the FDA
Medroxyprogesterone acetate, also known as Medroxyprogesterone Acetate, is approved by the FDA for 4 uses such as Atrophic and Hot flashes .Atrophic
Used to treat Vulvo Vaginal Atrophy in combination with Conjugated estrogens
Hot flashes
Used to treat Menopause in combination with Conjugated estrogens
Vasomotor Symptoms Associated With Menopause
Used to treat Vasomotor Symptoms Associated With Menopause in combination with Conjugated estrogens
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Conjugated estrogens
Effectiveness
How Depo-Provera Affects PatientsMedroxyprogesterone acetate, or MPA, blocks hormones that help cells grow and can cause cell death in cancer cells. Depending on the form of MPA taken, its effects can last for up to a week. The drug is available in doses from 5mg daily to 1000mg a week, so it can be taken in a variety of ways. Unfortunately, long-term use of MPA can reduce bone density and lead to osteoporosis and fractures in the future - especially if taken during adolescence.
How Depo-Provera works in the bodyMedroxyprogesterone acetate (MPA) works to prevent pregnancy by stopping the release of hormones that cause ovulation. It also thins the lining of the uterus. MPA reduces estrogen receptors in the endometrium, and can induce apoptosis in some cancer cell lines. It also works to inhibit certain GABA-A receptors.
When to interrupt dosage
The prescribed dosage of Depo-Provera is contingent upon the diagnosed condition, for example Hormonal Contraception, Amenorrhea and Postmenopausal Osteoporosis. The level of dosage is contingent upon the mode of administration (e.g. Tablet - Oral or Intramuscular) stated in the table hereunder.Condition
Dosage
Administration
Pharmaceutical Preparations
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Uterine hemorrhage
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Atrophic
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Postmenopausal Osteoporosis
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Hormonal Contraception
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
hypoestrogenism
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Metastatic Renal Cell Carcinoma ( mRCC)
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Amenorrhea
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Osteoporosis
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Estrogen Replacement Therapy
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Vasomotor Symptoms Associated With Menopause
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Chronic Pain
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
conjugated estrogen
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Birth Control
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Endometriosis
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Endometrial Hyperplasia
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Endometriosis
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
metastatic Endometrial carcinoma
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Fracture
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Hot flashes
, 2.5 mg, 10.0 mg, 5.0 mg, 150.0 mg/mL, 400.0 mg/mL, 1.5 mg, 100.0 mg, 1040.0 mg/mL, 500.0 mg, 250.0 mg, 200.0 mg, 400.0 mg, 250.0 mg/mL, 50.0 mg/mL
, Oral, Tablet, Tablet - Oral, Intramuscular, Injection, suspension - Intramuscular, Injection, suspension, Tablet, sugar coated, Tablet, sugar coated - Oral, Suspension, Suspension - Intramuscular, Kit; Tablet, Kit; Tablet - Oral, Subcutaneous, Injection, suspension - Subcutaneous, Kit, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Injection, Injection - Intramuscular, Kit - Oral
Warnings
Depo-Provera ContraindicationsCondition
Risk Level
Notes
Thromboembolism
Do Not Combine
Breast
Do Not Combine
active thrombophlebitis
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
Breast
Do Not Combine
Breast Cancer
Do Not Combine
Cerebrovascular Diseases
Do Not Combine
Vascular Diseases
Do Not Combine
Thromboembolism
Do Not Combine
Liver Disease
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
suspected pregnancy
Do Not Combine
Disease
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Medroxyprogesterone Acetate may interact with Pulse Frequency
Common Depo-Provera Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Medroxyprogesterone acetate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Medroxyprogesterone acetate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Medroxyprogesterone acetate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Medroxyprogesterone acetate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Medroxyprogesterone acetate.
Depo-Provera Toxicity & Overdose RiskThe lowest toxic dose of medroxyprogesterone acetate in rats is greater than 6400mg/kg and in mice is greater than 16g/kg. Overdosing on MPA can cause symptoms such as nausea, vomiting, breast tenderness, dizziness, abdominal pain, drowsiness, fatigue, and vaginal bleeding. If someone has been given too much of a MPA depo injection, they should seek medical help immediately.
Depo-Provera Novel Uses: Which Conditions Have a Clinical Trial Featuring Depo-Provera?
406 active clinical trials are currently assessing the potential of Depo-Provera to provide Osteoporosis, Amenorrhea and Hormonal Contraception relief.Condition
Clinical Trials
Trial Phases
Osteoporosis
39 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
conjugated estrogen
0 Actively Recruiting
Vasomotor Symptoms Associated With Menopause
1 Actively Recruiting
Phase 3
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Endometriosis
1 Actively Recruiting
Phase 4
metastatic Endometrial carcinoma
0 Actively Recruiting
Endometriosis
30 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Hormonal Contraception
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Uterine hemorrhage
3 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Pharmaceutical Preparations
0 Actively Recruiting
Estrogen Replacement Therapy
0 Actively Recruiting
Amenorrhea
3 Actively Recruiting
Not Applicable, Phase 1
Fracture
0 Actively Recruiting
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Endometrial Hyperplasia
9 Actively Recruiting
Phase 2, Not Applicable
Chronic Pain
174 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Pharmaceutical Preparations
0 Actively Recruiting
Metastatic Renal Cell Carcinoma ( mRCC)
38 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable
Depo-Provera Reviews: What are patients saying about Depo-Provera?
5Patient Review
8/26/2022 This shot took some time to work for me, but it was well worth the wait. I have endometriosis and had already undergone surgery when I started this treatment. The first three months were tough with pain, bleeding, and mood swings, but after getting the second shot things really improved. Everyone is different, but don't expect this medication to fix all your problems in a month. Give it some chance to work its magic!
5Patient Review
8/21/2022 I no longer have to deal with periods, which is amazing because they used to be really painful and heavy before I started this medication. They were affecting my iron levels as well, and since I already had anemia, I had to get four infusions of iron every week for weeks on end.
4.3Patient Review
6/20/2022 I've started taking depo to help with the pain and heavy bleeding I experience during my period. So far, I'm really pleased with it. I haven't had any side effects or bleed through since starting it a few weeks ago. Fingers crossed that it continues to go well!
4.3Patient Review
9/24/2022 I've been on Depo-Provera for 11 years and, while there are some drawbacks like having to go to the doctor every 3 months and experiencing shakes, anxiety, heart palpitations, etc., I never have to worry about my period anymore. That being said, I am concerned about the bone loss that this is said to cause.
4Patient Review
10/31/2022 I started the depo shot in September of 2021, and I was on it for over a year. Unfortunately, during that time I experienced extremely heavy and painful periods. Additionally, my sex drive plummeted while I was on this medication. Thankfully, I've since switched to the pill which has been much better for me.
3Patient Review
10/17/2022 I gained a lot of weight while using this medication, but fortunately lost all of it after I stopped taking it. It was always very effective at preventing pregnancy, but the side effects were really terrible. I wouldn't recommend it to anyone.
2.7Patient Review
9/1/2022 I started the depo shot on April 21st and experienced spotting every day for the next three months. I'm now in September and still haven't gotten my period back. This birth control method really messed up my body.
2.3Patient Review
8/5/2022 I lost 20 pounds in 6 months while on the depo shot, but I started experiencing a whole host of other problems like PCOS, hair loss, anxiety, and depression. I stopped it a month ago and hope my health will improve.
2Patient Review
1/31/2022 I was on my period for almost three weeks straight, which finally stopped last night. It was an incredibly difficult and frustrating experience; I felt dizzy, bloated, had mood swings, and low self-esteem the entire time. I would never get this shot again.
1Patient Review
3/13/2022 I took the shot once and started experiencing weight gain, mood swings, and depression. My period also began about a week after taking it and I've been bleeding ever since--two periods a month, heavy and with daily spotting. If you're doubting whether or not to take this medication, trust your gut instinct.
Patient Q&A Section about depo-provera
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Depo-Provera cause weight gain?
"Depot Provera (DMPA) is a commonly used and effective form of birth control, however, most studies confirm that weight gain is a common side effect for those who use it. DMPA is more likely to cause weight gain than other methods like the pill or an IUD."
Answered by AI
How long does Depo-Provera take to work?
"If you want to be protected from pregnancy as soon as possible, you should get your first birth control shot within the first 7 days after the start of your period. If you wait longer than that, it will take a full week for the shot to become effective. To be safe, you should use a backup method of contraception, like condoms, for the first week after getting the shot."
Answered by AI
What is the most common side effect of Depo-Provera?
"The shot can also make your periods lighter, heavier, or more frequent.
The birth control shot is most commonly associated with irregular bleeding. You may experience bleeding problems for 6 to 12 months after you first begin using the shot. The shot can also make your periods lighter, heavier, or more frequent."
Answered by AI
What does Depo do to your body?
"The Depo-Provera shot affects ovulation by preventing an egg from being released from a woman's ovary. It also thickens the cervical mucus, making it difficult for sperm to reach the egg."
Answered by AI