Declomycin

Yaws, Plague, Psittacosis + 23 more

Treatment

25 FDA approvals

20 Active Studies for Declomycin

Treatment for

Yaws

What is Declomycin

DemeclocyclineThe Generic name of this drug

Treatment SummaryChlortetracycline is an antibiotic that is similar to tetracycline, but stays in the body for longer periods of time. This allows it to keep a constant, effective level of medication in the blood.

Demeclocycline Hydrochlorideis the brand name

image of different drug pills on a surface

Declomycin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Demeclocycline Hydrochloride

Demeclocycline

2004

30

Approved as Treatment by the FDA

Demeclocycline, commonly known as Demeclocycline Hydrochloride, is approved by the FDA for 25 uses including Disease and Respiratory Tract Infections .

Disease

Respiratory Tract Infections

Chlamydia trachomatis

Skin Infections caused by Staphylococcus Aureus

Tularemia

Actinomycosis

Severe Acne Vulgaris

Gram-Negative Bacterial Infections

Campylobacter Infection

CMC-CDI

Plague

Rickettsia Infections

Conjunctivitis caused by chlamydia

Chlamydia Infections

Brucellosis

Used to treat Brucellosis in combination with Streptomycin

Necrotizing ulcerative gingivostomatitis

Bartonellosis

Listeriosis

Urinary Tract Infection

Amebic colitis

Psittacosis

Yaws

Sexually Transmitted Infections (STIs)

Relapsing fever caused by Borrelia recurrentis

Anthrax

Effectiveness

How Declomycin Affects PatientsDemeclocycline is an antibiotic used to treat a variety of illnesses caused by bacteria, including Rocky Mountain spotted fever, typhus fever, Q fever, chancroid, and brucellosis. It works by stopping the growth of bacteria and staying in the body for a long time. It does not directly kill the bacteria, but prevents it from reproducing.

How Declomycin works in the bodyDemeclocycline works by inhibiting protein production in cells. It binds to ribosomes, which are responsible for making proteins, and blocks the assembly of amino acids into proteins. This process is reversible, meaning that the effect can be reversed with time. Demeclocycline is also sometimes used to treat a condition called Syndrome of Inappropriate Antidiuretic Hormone (SIADH). It is thought to do this by blocking the binding of antidiuretic hormone to its receptor.

When to interrupt dosage

The quantity of Declomycin is contingent upon the diagnosed disorder, including Chlamydia trachomatis, Psittacosis and Respiratory Tract Infections. The measure of dosage is contingent upon the method of administration described in the accompanying table.

Condition

Dosage

Administration

Urinary Tract Infection

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Actinomycosis

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Rickettsia Infections

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Amebic colitis

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Necrotizing ulcerative gingivostomatitis

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Conjunctivitis caused by chlamydia

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Relapsing fever caused by Borrelia recurrentis

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Yaws

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Chlamydia Infections

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Bartonellosis

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Plague

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Tularemia

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Skin Infections caused by Staphylococcus Aureus

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Anthrax

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Campylobacter Infection

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Gram-Negative Bacterial Infections

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Sexually Transmitted Infections (STIs)

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Disease

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Brucellosis

150.0 mg, , 300.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule

Warnings

There are 20 known major drug interactions with Declomycin.

Common Declomycin Drug Interactions

Drug Name

Risk Level

Description

Amdinocillin

Major

The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Demeclocycline.

Amoxicillin

Major

The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Demeclocycline.

Ampicillin

Major

The therapeutic efficacy of Ampicillin can be decreased when used in combination with Demeclocycline.

Aspoxicillin

Major

The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Demeclocycline.

Azidocillin

Major

The therapeutic efficacy of Azidocillin can be decreased when used in combination with Demeclocycline.

Declomycin Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 2372 mg/kg.

image of a doctor in a lab doing drug, clinical research

Declomycin Novel Uses: Which Conditions Have a Clinical Trial Featuring Declomycin?

43 active studies are presently evaluating the potential of Declomycin in providing relief from Chlamydia trachomatis, Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) and Necrotizing ulcerative gingivostomatitis.

Condition

Clinical Trials

Trial Phases

Conjunctivitis caused by chlamydia

0 Actively Recruiting

Brucellosis

0 Actively Recruiting

Respiratory Tract Infections

1 Actively Recruiting

Phase 2

Campylobacter Infection

1 Actively Recruiting

Phase 1

Bartonellosis

0 Actively Recruiting

Severe Acne Vulgaris

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Rickettsia Infections

0 Actively Recruiting

Amebic colitis

0 Actively Recruiting

Yaws

0 Actively Recruiting

Sexually Transmitted Infections (STIs)

8 Actively Recruiting

Phase 4, Not Applicable

Psittacosis

0 Actively Recruiting

Necrotizing ulcerative gingivostomatitis

0 Actively Recruiting

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

0 Actively Recruiting

CMC-CDI

4 Actively Recruiting

Not Applicable, Phase 3, Phase 2

Plague

0 Actively Recruiting

Tularemia

0 Actively Recruiting

Skin Infections caused by Staphylococcus Aureus

0 Actively Recruiting

Relapsing fever caused by Borrelia recurrentis

0 Actively Recruiting

Listeriosis

0 Actively Recruiting

Patient Q&A Section about declomycin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Demeclocycline used for?

"Demeclocycline can be used to treat infections caused by different kinds of bacteria. These include infections of the lungs and other respiratory tract infections, certain skin infections, certain infections of the reproductive system, and certain other infections that are spread by ticks, lice, mites, or infected animals."

Answered by AI

What is another name for Demeclocycline?

"Demeclocycline is an antibiotic derived from a mutant strain of Streptomyces aureofaciens. It is used to treat infections caused by bacteria."

Answered by AI

Why is Declomycin used for Siadh?

"Demeclocycline, an antibiotic that belongs to a group of drugs known as tetracyclines, works by inhibiting the activation of adenylyl cyclase after AVP binds to the V2R in the kidney. This therapy is used to treat SIADH, a condition characterized by the body's inability to regulate the level of fluid in the blood."

Answered by AI

What is Declomycin used for?

"It will not work for virus infections (such as common cold, flu).

This medication is used to treat a wide variety of bacterial infections, including those that cause acne. It is a tetracycline antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for virus infections (such as common cold, flu)."

Answered by AI

Clinical Trials for Declomycin

Image of Queen Elizabeth II Health Sciences Centre in Halifax, Canada.

Chlamydia trachomatis and Neisseria gonorrhea self-swab(s) and/or urine collection for Gonorrhea

Halifax, Canada

This trial aims to test a new project in Nova Scotia where pharmacists will help manage and treat Chlamydia and Gonorrhea infections. These infections are becoming more common in Canada, but many

Waitlist Available

Queen Elizabeth II Health Sciences Centre

Image of University of Illinois Chicago in Chicago, United States.

Floreciendo for Sexually Transmitted Diseases

This trial aims to test a sexual and reproductive health workshop called Floreciendo for Latina teenagers and their female caregivers. The study will use a pilot optimization trial approach to determine the best ways to deliver the

Waitlist Available

University of Illinois Chicago

Image of Harborview Medical Center in Seattle, United States.

Mobile Van Clinic for Human Immunodeficiency Virus Infection

This trial will set up a pop-up clinic in a van near areas where women who inject drugs gather in north Seattle. The clinic will offer HIV prevention medication, opioid use disorder medication, and testing for

Harborview Medical CenterMaria Corcorran, MD, MPH

Image of University of Utah in Salt Lake City, United States.

Antibiotic Stewardship at Discharge for Pneumonia

Salt Lake City, UT

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Waitlist Available

University of UtahValerie M Vaughn, MD

Have you considered Declomycin clinical trials? We made a collection of clinical trials featuring Declomycin, we think they might fit your search criteria.

Explore trials for Declomycin

Image of Duke University in Durham, United States.

Cefiderocol for Bacterial Infections in Newborns and Infants

This trial studies the effectiveness of cefiderocol in treating bacterial infections in newborns & babies under 3 months.

Duke University (+1 Sites)Medical DirectorShionogi

Image of Medical facility in Miami, United States.

Tebipenem Pivoxil Hydrobromide +1 More for Urinary Tract Infection

This trial aims to compare how well an oral medication called TBP-PI-HBr works against a standard intravenous medication called imipenem-cilastatin in treating urinary tract or abdominal infections

Medical facilityKamal Hamed, MDGlaxoSmithKline

Image of Child Trends in Bethesda, United States.

SafeSpace App Intervention for Sexually Transmitted Infections

This trial will measure the impacts of using an app to promote sexual and reproductive health & wellbeing among young people assigned female/intersex.

Child TrendsRiley Steiner, PhD

Image of Accellacare of Hickory in Hickory, United States.

AV7909 Vaccine Booster for Anthrax

This trial tests a new vaccine to see how safe & effective it is after booster shots 6 & 12 months later.

Accellacare of Hickory (+5 Sites)Derek Eisnor, MDRho Federal Systems Division, Inc.

Have you considered Declomycin clinical trials? We made a collection of clinical trials featuring Declomycin, we think they might fit your search criteria.

Explore trials for Declomycin

Image of RTI International in Durham, United States.

Virtual Support Group for PrEP Use in HIV Prevention

This trial tests a modified mobile health program to reduce alcohol use, sexual risk and increase PrEP use among 500 HIV-negative African American women.

Waitlist Available

RTI InternationalFelicia A Browne, ScD, MPH

Image of Magee Women's Hospital of UPMC in Pittsburgh, United States.

Culture-Directed vs Empiric Antibiotics for Urinary Tract Infections

This trial will assess if a culture-based or empiric antibiotic strategy is best for treating UTI symptoms in older women, and their ability to follow the study plan.

Magee Women's Hospital of UPMC

Image of Florida International University in Miami, United States.

Digital Prevention Program for HIV/STI Risk Reduction in Couples

This trial tests an online program to reduce HIV/STI risk among male couples in long-term relationships.

Waitlist Available

Florida International University (+1 Sites)Jason W Mitchell, PhD

Image of Northwestern University in Chicago, United States.

Relationship Education Program for HIV Prevention

This trial tests a program to help gay, bisexual, queer, transgender, and non-binary people reduce their risk of HIV infection, by using online surveys & testing for Chlamydia and Gonorrhea and at-home point-of-care HIV testing. Participants randomized into one of two conditions & monitored for 2 yrs. Participation is remote.

Northwestern UniversityMichael E Newcomb, Ph.D

Have you considered Declomycin clinical trials? We made a collection of clinical trials featuring Declomycin, we think they might fit your search criteria.

Explore trials for Declomycin

Unbiased ResultsWe believe in providing patients with all the options.

Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.

Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.

Back to top

Terms of Service Privacy Policy Security