Cyklokapron

Hyperfibrinolysis, Hemorrhage, Angioedemas, Hereditary + 3 more

Treatment

14 Active Studies for Cyklokapron

What is Cyklokapron

Tranexamic acid

The Generic name of this drug

Treatment Summary

Tranexamic acid is a medication that helps to reduce bleeding. It is a synthetic form of lysine, and is more effective than other similar drugs. It was first patented in 1957 and approved for use in the United States in 1986.

Cyklokapron

is the brand name

Cyklokapron Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cyklokapron

Tranexamic acid

1986

57

Effectiveness

How Cyklokapron Affects Patients

Tranexamic acid is a medication used to reduce bleeding. It works by stopping the breakdown of blood clots, which helps to stop bleeding. It is used to treat hereditary angioedema, a condition that causes swelling. In some cases, tranexamic acid can cause convulsions or increased excitability in patients. Therefore, those with a history of seizures should have their EEG monitored when taking this drug.

How Cyklokapron works in the body

Tranexamic acid works by stopping the breakdown of blood clots. It does this by attaching to the same sites on blood clots that would normally cause them to dissolve. By occupying these sites, it prevents the clot from breaking down and stops bleeding.

When to interrupt dosage

The advised dosage of Cyklokapron is contingent upon the diagnosed condition, including Tooth Extractions, Angioedemas, Hereditary and Hemophilia. The amount also deviates as per the mode of delivery (e.g. Cream - Topical or Injection, solution - Intravenous) outlined in the table beneath.

Condition

Dosage

Administration

Hyperfibrinolysis

100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical

Hemorrhage

100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical

Angioedemas, Hereditary

100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical

Hemophilia A

100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical

Menorrhagia

100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical

Tooth Extractions

100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical

Warnings

Cyklokapron Contraindications

Condition

Risk Level

Notes

NF1 gene

Do Not Combine

Thrombosis

Do Not Combine

Thromboembolism

Do Not Combine

Pulse Frequency

Do Not Combine

Subarachnoid Hemorrhage

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Tranexamic Acid may interact with Pulse Frequency

There are 20 known major drug interactions with Cyklokapron.

Common Cyklokapron Drug Interactions

Drug Name

Risk Level

Description

Albutrepenonacog alfa

Major

Tranexamic acid may increase the thrombogenic activities of Albutrepenonacog alfa.

Aminocaproic acid

Major

Tranexamic acid may increase the thrombogenic activities of Aminocaproic acid.

Aminomethylbenzoic acid

Major

Tranexamic acid may increase the thrombogenic activities of Aminomethylbenzoic acid.

Andexanet alfa

Major

Tranexamic acid may increase the thrombogenic activities of Andexanet alfa.

Anti-inhibitor coagulant complex

Major

Tranexamic acid may increase the thrombogenic activities of Anti-inhibitor coagulant complex.

Cyklokapron Toxicity & Overdose Risk

Too much tranexamic acid can cause severe stomach issues, low blood pressure, blood clots, vision problems, seizures, changes in mental state, and skin rashes.

Cyklokapron Novel Uses: Which Conditions Have a Clinical Trial Featuring Cyklokapron?

34 active trials are in progress to assess the potential of Cyklokapron in managing Hemophilia, Hemorrhage and Hereditary Angioedemas.

Condition

Clinical Trials

Trial Phases

Hemorrhage

0 Actively Recruiting

Tooth Extractions

3 Actively Recruiting

Not Applicable, Early Phase 1

Hyperfibrinolysis

0 Actively Recruiting

Angioedemas, Hereditary

12 Actively Recruiting

Phase 3, Phase 1, Phase 2, Phase 4

Menorrhagia

0 Actively Recruiting

Hemophilia A

0 Actively Recruiting

Cyklokapron Reviews: What are patients saying about Cyklokapron?

5

Patient Review

10/4/2019

Cyklokapron for Abnormally Long or Heavy Periods

This treatment completely changed my life for the better. I used to have heavy cycles that would last for years, and it became so bad that I was anemic and had to sleep with pads on my bed. But since using this treatment, I haven't had any issues at all! My period has become shorter and lighter, and I couldn't be happier.

5

Patient Review

7/9/2022

Cyklokapron for Abnormally Long or Heavy Periods

I've been really impressed with this treatment. I was experiencing heavy flows for two years straight and nothing seemed to help. But this has definitely made a difference.

5

Patient Review

5/18/2022

Cyklokapron for Abnormally Long or Heavy Periods

So, I've only been taking this for a month. But as a 45-year-old woman who has always had really heavy and painful periods, let me say: 650mg three times per day during my period for three days has resulted in a significant decrease of bleeding and clots. The only adverse effect I noticed was some minor headaches.

5

Patient Review

9/27/2021

Cyklokapron for Abnormally Long or Heavy Periods

I have fibroids and my periods cause my anemia. So far I have seen a decrease in the amount of time I have had my periods since taking this medication, as well as the menstrual pain and swelling that occurs.

5

Patient Review

5/18/2022

Cyklokapron for Abnormally Long or Heavy Periods

I tried this medication for the first time last month and it was incredibly effective. I'm a 45-year-old woman who has always had heavy, painful periods. This medication helped to reduce both the bleeding and clotting within the first day of my period. The only adverse effect I experienced was minor headaches.

5

Patient Review

7/9/2022

Cyklokapron for Abnormally Long or Heavy Periods

I've been dealing with heavy flows for the past two years as I approach menopause. This treatment really helped me cut down on my flow without any negative side effects. My iron levels have also doubled, which is a relief.

5

Patient Review

10/4/2019

Cyklokapron for Abnormally Long or Heavy Periods

This treatment completely changed my life for the better. I used to have heavy periods that caused me a lot of problems, but this medication has really helped to lessen the flow and duration of my period.

5

Patient Review

9/27/2021

Cyklokapron for Abnormally Long or Heavy Periods

This medication has helped to lessen the duration, pain, and swelling of my periods caused by fibroids.

4.7

Patient Review

7/17/2022

Cyklokapron for Abnormally Long or Heavy Periods

I found that this medication significantly lightened my period flow on the second day of taking it.

4.7

Patient Review

7/17/2022

Cyklokapron for Abnormally Long or Heavy Periods

I experienced a significant decrease in the heaviness of my period flow by the second day of taking this medication, which was great.

4.3

Patient Review

12/7/2020

Cyklokapron for Abnormally Long or Heavy Periods

My gynecologist prescribed this to me as a last resort for my heavy period bleeding, and it worked very quickly (within 4 hours). I've had no issues with side effects, which is great.

4.3

Patient Review

12/7/2020

Cyklokapron for Abnormally Long or Heavy Periods

My doctor prescribed this to me as a last resort for my heavy period bleeding, and I'm really glad we tried it. It kicked in within just a few hours, and I haven't had any issues with side effects.

4

Patient Review

5/21/2022

Cyklokapron for Abnormally Long or Heavy Periods

Endometriosis is a tough condition, but this medication has given me my life back. It's not perfect, but it helps immensely.

4

Patient Review

1/20/2022

Cyklokapron for Abnormally Long or Heavy Periods

I had no issues when I took one pill, but as directed by my doctor, I took two pills three times a day. After doing this once, I felt dizzy and out of sorts with a rapid heartbeat. Needless to say, I'm scared to take it again.

4

Patient Review

1/20/2022

Cyklokapron for Abnormally Long or Heavy Periods

I had success with this treatment, but only when I took one pill at a time. As directed, I was supposed to take two pills three times per day; however, after doing so just once, I felt dizzy and my heart rate increased rapidly. Needless to say, I was scared to take it again.

4

Patient Review

5/21/2022

Cyklokapron for Abnormally Long or Heavy Periods

Endometriosis is a debilitating condition, but this medication has given me my life back. I can now work and function like a normal person during my period instead of being confined to bed for days on end.

2.3

Patient Review

6/6/2022

Cyklokapron for Abnormally Long or Heavy Periods

I had some bad side effects after taking the recommended dosage. I felt like I was going to die in the middle of the night-- it was hard to breathe and my chest felt tight. I also experienced panic attacks, so I won't be continuing with this medication.

2.3

Patient Review

6/6/2022

Cyklokapron for Abnormally Long or Heavy Periods

I took two milligrams and didn't feel any effects the first time. The second time, I woke up in the middle of the night feeling like I was going to die. It was hard to breathe and my chest felt tight. I also had panic attacks, so I won't be taking this medication anymore.

1.7

Patient Review

4/23/2022

Cyklokapron for Abnormally Long or Heavy Periods

Though it does lighten my periods, I Break out in cystic acne and spot for a couple weeks every time I take this medication.

1.7

Patient Review

4/23/2022

Cyklokapron for Abnormally Long or Heavy Periods

Though it does what it advertises in terms of lightening my flow, I consistently get cystic acne and spotting for longer than usual when I take this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cyklokapron

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of medication is CYKLOKAPRON?

"Cyklokapron is a man-made form of lysine, an amino acid, used to prevent bleeding in people with hemophilia who need dental procedures. Cyklokapron is typically given just before the dental procedure and daily for up to eight days afterward."

Answered by AI

How long does it take for CYKLOKAPRON to work?

"The medicine will not have its full effect for up to 24 hours. Tranexamic acid is typically only used for a short time to treat bleeding. For heavy periods, it is usually taken for four days, or for seven days to treat other types of bleeding that does not stop on its own."

Answered by AI

Is CYKLOKAPRON a blood thinner?

"Tranexamic acid reduces the amount of blood loss and is used to control unwanted bleeding. Side-effects are usually minor and rare."

Answered by AI

What is CYKLOKAPRON used for?

"This medication is used to prevent and reduce bleeding from a tooth extraction in people with hemophilia, a bleeding disorder."

Answered by AI

Clinical Trials for Cyklokapron

Image of University of Texas Health Science Center at San Antonio School of Dentistry in San Antonio, United States.

OsteoGen for Tooth Extractions

18 - 89
All Sexes
San Antonio, TX

After the removal of a tooth, a bone graft is often placed in the socket to try to keep the volume of bone that was there when the tooth was present so that the bone does not "shrink". The bone graft is sometimes kept in place with a small piece of material over the top of the tooth socket and with stitches. This procedure is called "Ridge Preservation". Many different materials are used for ridge preservation including bone allografts (bone grafts derived from a human tissue donor), bone xenografts (bone grafts derived from species other than humans, such as cows and pigs), and synthetic materials that are similar in structure to bone (such as calcium apatite). The bone allograft and the calcium apatite product used in this study are Food and Drug Administration (FDA) approved. This study will compare the two methods used to see how much new bone formation there is inside the tooth socket at about 16 weeks of healing after ridge preservation with a calcium apatite/collagen sponge versus an allograft.

Recruiting
Has No Placebo

University of Texas Health Science Center at San Antonio School of Dentistry

Brian Mealey, DDS, MS

Have you considered Cyklokapron clinical trials?

We made a collection of clinical trials featuring Cyklokapron, we think they might fit your search criteria.
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Image of University of Kentucky in Lexington, United States.

Alternatives to Opioids for Pain After Tooth Extraction

12 - 25
All Sexes
Lexington, KY

The goal of this clinical trial is to test a three-item intervention in oral surgeons who remove teeth. The main questions it aims to answer are: * Can the intervention reduce opioid prescriptions to adolescents and young adults after tooth removal? * Do oral surgeons' beliefs about the intervention and opioid prescribing change? * Do patients that report using opioids after tooth removal have different experiences than patients that do not? Oral surgeon participants will: * Attend a 1-hour education session with a trained pharmacist * Receive patient instructions and blister packs of pain medicine to give to patients * Complete 2 surveys about feasibility and appropriateness Patient participants will complete a survey about pain and medication use after having a tooth removed. Researchers will compare the intervention to usual care to see if it reduces opioid prescribing.

Waitlist Available
Has No Placebo

University of Kentucky

Marcia V Rojas Ramirez, DDS

Have you considered Cyklokapron clinical trials?

We made a collection of clinical trials featuring Cyklokapron, we think they might fit your search criteria.
Go to Trials