Cubicin

Communicable Diseases, Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia), Bacterial Endocarditis

Treatment

2 FDA approvals

0 Active Studies for Cubicin

Treatment for

Communicable Diseases

What is Cubicin

Daptomycin

The Generic name of this drug

Treatment Summary

Daptomycin is an antibiotic used to treat various bacterial infections, including those caused by Methicillin-sensitive and -resistant Staphylococcus aureus (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE). It was first discovered in the 1980s and was licensed by Cubist Pharmaceuticals in 1997. Daptomycin was approved by the FDA in 2003 and is marketed under the name CUBICIN®. It is a cyclic lipopeptide made up of 13 amino acids, including some non-standard and D-amino acids. A once-

Cubicin

is the brand name

image of different drug pills on a surface

Cubicin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cubicin

Daptomycin

2003

Approved as Treatment by the FDA

Daptomycin, otherwise known as Cubicin, is approved by the FDA for 2 uses such as Complicated Skin and Skin Structure Infection and Communicable Diseases .

Complicated Skin and Skin Structure Infection

Communicable Diseases

Effectiveness

How Cubicin Affects Patients

Daptomycin is a type of antibiotic made by a soil microbe. It is mainly used to treat infections caused by certain types of bacteria, including Staphylococcus aureus and Clostridioides difficile. It works by killing the bacteria that cause the infection. While it is generally safe to use, there are some side effects and risks associated with taking daptomycin. These include muscle problems, an increased risk of developing resistance to the antibiotic, and an increased risk of developing severe hypersensitivity reactions. It is not recommended for use in patients under one year of age due to potential serious side effects

How Cubicin works in the body

Daptomycin works by binding to the cell membrane and altering its structure. It binds to calcium, which helps it attach to the cell membrane, particularly in areas where there is a lot of phosphatidylglycerol. This binding alters the fluidity of the membrane, which prevents enzymes that make up the cell wall from working properly. It can also disrupt the cell's ability to divide, which leads to its death. In some cases, it causes an imbalance of potassium and other ions in the cell, leading to a loss of energy and nutrients. All of these effects result in the death of the cell.

When to interrupt dosage

The recommended measure of Cubicin depends on the diagnosed situation, such as Communicable Diseases, Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia) and Bacterial Endocarditis. The dose differs in accordance with the delivery approach (e.g. Powder, for solution - Intravenous or Injection, powder, lyophilized, for solution - Intravenous) presented in the following table.

Condition

Dosage

Administration

Communicable Diseases

500.0 mg, , 50.0 mg/mL, 350.0 mg/mL, 350.0 mg, 35.0 mg/mL, 50.0 mg/mg

, Powder, for solution, Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection - Intravenous, Injection, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution - Intravenous, Solution

Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)

500.0 mg, , 50.0 mg/mL, 350.0 mg/mL, 350.0 mg, 35.0 mg/mL, 50.0 mg/mg

Bacterial Endocarditis

500.0 mg, , 50.0 mg/mL, 350.0 mg/mL, 350.0 mg, 35.0 mg/mL, 50.0 mg/mg

Warnings

Cubicin Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Daptomycin may interact with Pulse Frequency

There are 20 known major drug interactions with Cubicin.

Common Cubicin Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Daptomycin.

Abacavir

Minor

Daptomycin may decrease the excretion rate of Abacavir which could result in a higher serum level.

Acetaminophen

Minor

Daptomycin may decrease the excretion rate of Acetaminophen which could result in a higher serum level.

Aclidinium

Minor

Daptomycin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Daptomycin may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Cubicin Toxicity & Overdose Risk

Overdosing on daptomycin may cause a variety of serious side effects, including muscle pain, breakdown of muscle tissue, neurological symptoms, allergic pneumonia, kidney inflammation, and other symptoms such as vomiting, diarrhea, abdominal pain, headache, dizziness, fever, sweating, and itchiness. Treatment for daptomycin overdose should focus on providing supportive care, and dialysis may be used to remove some of the drug from the body. However, this method is not very effective as only around 15% of a dose can be removed over four hours of hemodialysis.

image of a doctor in a lab doing drug, clinical research

Cubicin Novel Uses: Which Conditions Have a Clinical Trial Featuring Cubicin?

No active trials are currently underway to investigate the potential of Cubicin in providing relief for Bacterial Endocarditis, Communicable Diseases and Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia).

Condition

Clinical Trials

Trial Phases

Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Bacterial Endocarditis

0 Actively Recruiting

Cubicin Reviews: What are patients saying about Cubicin?

Patient Review

8/8/2011

Cubicin for Blood Infection caused by Staphylococcus Aureus Bacteria

Within two weeks of being on Cubicin IV, my bloodwork showed that the infection was gone. I had a slight headache after taking it the first few days, but that passed and I haven't had any other side effects since.

4.7

Patient Review

7/31/2011

Cubicin for Blood Infection caused by Staphylococcus Aureus Bacteria

I've been receiving cubicin for three weeks now and have three more scheduled. I'm experiencing some pretty severe side effects, like insomnia and fatigue. Also, my ability to regulate body temperature has gone out the window--I'll be hot one minute and then cold the next, often accompanied by cold sweats.

4.7

Patient Review

11/6/2016

Cubicin for Complicated Skin Infection due to Staphyloccus Aureus Bacteria

I've been using this medication for six weeks now, and I've experienced three main side effects. Two of them – slight diarrhea and an itchy scrotum – don't really bother me. The third one is hair loss, which I have never found mentioned in my research on the drug. Every morning, I'm shocked at how thin my once-lush hair has become. Hopefully it'll grow back soon.

4.7

Patient Review

9/30/2010

Cubicin for Blood Infection caused by Staphylococcus Aureus Bacteria

I have two more weeks of IV therapy, but I've been having issues with strange dreams and insomnia. Has anyone else experienced this side effect?

Patient Review

11/3/2010

Cubicin for Blood Infection caused by Staphylococcus Aureus Bacteria

I've been struggling with yeast infections and, as a result, nausea and diarrhea. I'm really exhausted all the time, and my muscles are constantly sore. This has been going on for three weeks now, with three more to go. Last year, I was on this medication for five weeks and don't remember feeling this terrible.

Patient Review

7/3/2011

Cubicin for Blood Infection caused by Staphylococcus Aureus Bacteria

I'm experiencing some of the side effects, like chest pain and headaches. They're pretty bad, and they also give me anxiety. I feel really weak since starting this medication, too.

Patient Review

2/13/2012

Cubicin for Diabetic with Foot Infection due to a Specific Bacteria

I'm currently on my fourth week of IV treatment. I have experienced many side effects including headaches, diarrhea, fever and chills, increased muscle and back pain, weakness, breathing problems. Even with all of this, I am healing well and quicker than with Vancomyicin. The side effects with both are bad; however, it is a small price to pay for keeping my foot.

Patient Review

8/14/2012

Cubicin for Complicated Skin Infection by Streptococcus Agalactiae

I was on I.V. Cubicin for a week and felt really tired, dizzy, and nauseous the entire time. Additionally, I had strange dreams that were quite vivid. That said, the infection from the spider bite cleared up very well.

3.7

Patient Review

8/6/2011

Cubicin for Blood Infection caused by Staphylococcus Aureus Bacteria

My 17-year-old daughter is receiving Cubicin I.V. at home for the next month or so. She's been experiencing a lot of the side effects--nausea/vomiting, muscle/joint pain, fatigue--but one that's not mentioned is hair loss. It's coming out in clumps. Has anyone else had this issue? The drug is effective, but it takes a toll on the body.

2.7

Patient Review

12/19/2015

Cubicin for Blood Infection caused by Staphylococcus Aureus Bacteria

Unfortunately, this medicine caused me a great deal of pain and discomfort. Severe stomach cramping, diarrhea, and leg pain made it so that I could barely eat or walk.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cubicin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of antibiotic is Cubicin?

"Cubicin is an antibiotic that is used to fight bacteria in the body. Cubicin is used to treat bacterial infections of the skin and underlying tissues, as well as infections that have entered the bloodstream. Cubicin is particularly effective in treating complicated infections, including MRSA or "super bug" infections."

Answered by AI

What is another name for Cubicin?

"Daptomycin (Cubicin) is an injectable antibiotic that is used to treat serious bacterial infections of the skin and underlying tissues. This antibiotic is usually used to treat complicated and serious infections because it is a strong antibiotic."

Answered by AI

What drug class is Cubicin?

"Cubicin is a prescription medicine used to treat the symptoms of Staphylococcus Aureus Bacteremia, Complicated Skin and Skin Structure Infections. Cubicin belongs to a class of drugs called Lipopeptides. Cubicin may be used alone or with other medications."

Answered by AI

What is the drug Cubicin used for?

"This is an antibiotic used to treat bacterial infections. It works by halting the growth of bacteria. This medication is not recommended for children younger than 12 months because of the potential for serious side effects."

Answered by AI