Crixivan

HIV
Treatment
1 FDA approval
20 Active Studies for Crixivan

What is Crixivan

IndinavirThe Generic name of this drug
Treatment SummaryA powerful medication to treat HIV infection that can be taken orally and is quickly absorbed into the body.
Crixivanis the brand name
Crixivan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Crixivan
Indinavir
1996
8

Approved as Treatment by the FDA

Indinavir, commonly known as Crixivan, is approved by the FDA for 1 uses like HIV .
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with null

Effectiveness

How Crixivan Affects PatientsIndinavir is a medication used to treat HIV-1. It works by blocking a part of HIV called protease, which is an enzyme HIV needs to survive. By preventing the enzyme from working properly, Indinavir stops HIV from forming into infectious particles. It is usually used in combination with other anti-HIV drugs to make sure the virus is completely stopped.
How Crixivan works in the bodyIndinavir stops HIV from maturing by blocking an enzyme that helps it form into a complete virus. Without this enzyme, HIV cannot form into a mature virus and cannot spread.

When to interrupt dosage

The recommended dosage of Crixivan is contingent upon the diagnosed situation. The amount of dosage fluctuates, according to the method of administration (e.g. Capsule or Oral) specified in the table below.
Condition
Dosage
Administration
HIV
300.0 mg, , 400.0 mg, 200.0 mg, 100.0 mg, 333.0 mg
Capsule, Oral, Capsule - Oral,

Warnings

Crixivan Contraindications
Condition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
There are 20 known major drug interactions with Crixivan.
Common Crixivan Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Indinavir.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Indinavir.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Indinavir.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Indinavir.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Indinavir.
Crixivan Toxicity & Overdose RiskOverdosing on this drug can lead to heart attack and chest pain.

Crixivan Novel Uses: Which Conditions Have a Clinical Trial Featuring Crixivan?

43 active clinical trials are ongoing to assess the potential of Crixivan in treating HIV (Human Immunodeficiency Virus).
Condition
Clinical Trials
Trial Phases
HIV
44 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1

Crixivan Reviews: What are patients saying about Crixivan?

5Patient Review
3/22/2010
Crixivan for HIV
I've been on this medication for over a decade and it's really helped me.
3.7Patient Review
4/5/2009
Crixivan for Prevention of HIV Infection after Exposure
I was given three different antibiotics and thirteen pills to take all at once. I came into contact with the virus again, and now I'm sure of where it came from. The doctor didn't give me any information on how to get the prescription again, so now I'm stuck.
1.7Patient Review
4/14/2009
Crixivan for HIV
Crixivan is pure poison. I took it years ago and it's still giving me lipodystrophy problems that require surgery.
1Patient Review
9/12/2011
Crixivan for Prevention of HIV Infection after Exposure
I felt incredibly nauseous after taking this medication.

Patient Q&A Section about crixivan

What is the generic name for Crixivan?

"CRIXIVAN prevents HIV from multiplying by inhibiting the protease enzyme." - Anonymous Online Contributor

Unverified Answer

Is indinavir still used?

"Newer drugs that are more convenient to take, less likely to promote virus resistance, and less toxic are replacing it." - Anonymous Online Contributor

Unverified Answer

Is Crixivan discontinued?

"Crixivan was one of the first HIV ARV medications approved by the FDA, but due to side effects and medication interactions, it has not been a first choice treatment option for many years and has been discontinued in the U.S." - Anonymous Online Contributor

Unverified Answer

What are the side effects of Crixivan?

"Possible side effects include: -Stomach pain -Nausea -Vomiting -Diarrhea -Indigestion -Heartburn -Appetite changes -Headache -Dizziness -Weakness or fatigue -Back pain -Rash -Itching -Dry skin -Altered sense of taste -Cold symptoms such as a stuffy nose, sneezing, or a sore throat" - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Crixivan

Image of 31788 Alabama CRS in Birmingham, United States.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety

Single-arm: Semaglutidefor Obesity

Birmingham, AL
18+
All Sexes
The purpose of this study is to evaluate the safety and tolerability of a drug called semaglutide and to see whether it can reduce IHTG. IHTG will be measured by magnetic resonance imaging (MRI; an MRI machine contains a powerful magnet that uses simple radio waves to take pictures of organs). Semaglutide (brand name Ozempic®) is a drug that is used to treat people who have diabetes; it also causes weight loss and may provide some protection against cardiovascular disease and diabetes. In PLWH, the use of semaglutide to reduce weight and the level of IHTG are experimental.
Phase 2
Waitlist Available
31788 Alabama CRS (+6 Sites)Kristine Erlandson, MD, MS
Have you considered Crixivan clinical trials? We made a collection of clinical trials featuring Crixivan, we think they might fit your search criteria.
Image of National Institutes of Health Clinical Center in Bethesda, United States.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety

1for HIV

Bethesda, MD
18+
All Sexes
Background: People with HIV usually take a combination of 2 or more anti-HIV drugs daily to help manage their infection. Sometimes, however, HIV becomes resistant to these drugs, and the infection cannot be treated. Untreated HIV infection can make people more vulnerable to other infections as well as some cancers. Better treatments are needed for people with drug-resistant HIV. Objective: To see if a study drug (UB-421) is effective in people with drug-resistant HIV. Eligibility: People aged 18 years and older with HIV that is resistant to anti-HIV drugs. Design: Participants will be in the study for 35 weeks. Participants will have separate screening and baseline visits within 2 months of each other. They will have a physical exam with blood and urine tests both times. On the second visit, they will undergo apheresis: Blood will be drawn from a needle in one arm. The blood will pass through a machine that separates out the white blood cells. The remaining blood will be given back through a second needle in the other arm. Participants will begin receiving the study drug 1 week after their baseline visit. UB-421 is given through a tube attached to a needle placed in a vein in the arm. They will return for UB-421 treatments every week for 26 weeks. Each visit will take 3 to 6 hours. Participants will have 2 follow-up visits 4 and 8 weeks after their last treatment with UB-421. Apheresis will be repeated at 1 of these visits.
Phase 2
Waitlist Available
National Institutes of Health Clinical CenterMohammad A Rai, M.D.
Have you considered Crixivan clinical trials? We made a collection of clinical trials featuring Crixivan, we think they might fit your search criteria.
Have you considered Crixivan clinical trials? We made a collection of clinical trials featuring Crixivan, we think they might fit your search criteria.
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