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What is Complera
Tenofovir disoproxilThe Generic name of this drug
Treatment SummaryRilpivirine is a medication used to treat HIV-1 infections in people who have not received prior treatment. It is an NNRTI (non-nucleoside reverse transcriptase inhibitor) drug that works by blocking the action of an enzyme involved in the replication of the virus. It is highly effective and has a low risk of causing resistance compared to other NNRTI drugs. It was approved by the FDA in 2011 and is now available as a two-drug regimen with dolutegravir (Juluca) or cabotegravir (Cabenuva).
Vireadis the brand name
Complera Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viread
Tenofovir disoproxil
2001
154
Effectiveness
How Complera Affects PatientsRilpivirine is a medication used to treat HIV-1 infection. It can be taken as an oral tablet daily or as an intramuscular injection monthly. Patients should talk to their doctor about the potential risks, such as allergic reactions, liver damage, depression, and changes in body fat.
How Complera works in the bodyRilpivirine is a medicine that works by blocking HIV-1 replication, or the production of new virus cells. It does this by binding to a protein called reverse transcriptase, which is involved in the replication process. This binding stops the production of new virus cells, and helps to prevent the virus from mutating and becoming resistant to treatment.
When to interrupt dosage
The prescribed measure of Complera is contingent upon the recognized condition, such as weight of no less than 35 kg, HIV-1 RNA Not Exceeding 100,000 copies/mL and HIV (Human Immunodeficiency Virus). The amount of dosage is contingent upon the mode of administration (e.g. Tablet, film coated - Oral or Tablet - Oral) as delineated in the table beneath.Condition
Dosage
Administration
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Chronic Hepatitis B Infection
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
virologically-suppressed
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
weight at least 35 kg
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
weigh >40 kg
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Antiretroviral Therapy
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Warnings
Complera has fifteen counter-indications. It should not be employed in coordination with the conditions given in the following table.There are 20 known major drug interactions with Complera.Common Complera Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Tenofovir disoproxil is combined with Neomycin.
Tenofovir
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir alafenamide.
Abacavir
Minor
Tenofovir disoproxil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetaminophen
Minor
Tenofovir disoproxil may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Complera Toxicity & Overdose RiskIf you have overdosed on this drug, call a poison control center immediately. Those with an overdose should receive supportive treatments and be monitored for changes in their heartbeat. Dialysis is not likely to remove much of the drug from the bloodstream, as it is tightly bound to proteins.
Complera Novel Uses: Which Conditions Have a Clinical Trial Featuring Complera?
43 active clinical trials are currently investigating the potential of Complera to provide therapeutic benefits for individuals with a weight of at least 35 kg, HIV (Human Immunodeficiency Virus) and HIV-1 RNA Levels Less Than or Equal to 100,000 copies/mL.Condition
Clinical Trials
Trial Phases
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
HIV
0 Actively Recruiting
virologically-suppressed
0 Actively Recruiting
weight at least 35 kg
0 Actively Recruiting
HIV
41 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
weigh >40 kg
0 Actively Recruiting
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
0 Actively Recruiting
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Complera Reviews: What are patients saying about Complera?
5Patient Review
4/9/2012 I switched to this new medication from another because of the side effects I experienced with the other drug. After only four days on this new medication, I've already noticed vast improvements in my sleep and mood. Additionally, I don't get that "hungover" feeling if I take it a bit later at night.
5Patient Review
4/10/2014 Though I've been on this medication for a while now, I recently noticed that my memory has gotten worse and it's hard to concentrate. I'm not sure if it has anything to do with the drug as it's not a very common side effect, but I thought I should mention it.
5Patient Review
12/6/2012 I was able to reduce my pill intake from seven per day down to just one thanks to this treatment. My liver enzymes are slightly elevated, but my doctor is monitoring the situation closely. So far, so good!
5Patient Review
7/8/2013 I saw a decrease in my viral load from 76294 to 1197 within 30 days. Just be sure you take it with a hearty meal; I experienced some discomfort when I took it on an empty stomach.
5Patient Review
11/11/2013 I had some intense gastrointestinal side effects when I first started this treatment, but they eventually subsided. My partner also started the treatment at the same time and didn't experience any problems whatsoever. It's been eight months now and we're both undetectable!
5Patient Review
4/26/2015 This drug has been incredibly effective for me. In just one month, my viral load went from 25000 to 150 and my cd4 from 636 to 1150. I didn't experience any side effects, but one thing to note is that it does make you very hungry.
5Patient Review
4/22/2012 I experienced no negative side effects from this drug, and I would highly recommend it to others.
5Patient Review
10/31/2012 I saw really great results within one week of using Complera. My CD-4 count went from 385 to 850 and I felt normalized again.
5Patient Review
10/29/2013 I was one of the first people to start taking this drug, and it's been working great for me. I take six pills a day and have had no problems with undetectability or side effects (aside from the occasional night sweat).
4.7Patient Review
7/23/2012 My feet are numb and I sweat excessively, but I'm managing. There are definitely more annoying things in life.
4.7Patient Review
5/2/2012 The only issues I had were three days of insomnia, but that's it!
4.3Patient Review
7/1/2014 I've been taking this treatment for over three years now, and it's been easy to keep up with the one pill a day. My lab results have shown that the virus is undetectable, and if I manage my stress levels, my CD4 count increases. However, I haven't been able to reach the 500 goal mark yet. The side effects are almost nonexistent; my liver and kidneys haven't suffered any damage, and I rarely get colds or flu. Of course, part of keeping up my health is maintaining a healthy lifestyle.
4.3Patient Review
3/3/2014 This is the only medication I've been taking since being diagnosed with HIV in 2012, and it's been working well for me. I did gain a little weight when I first started taking it because the pill has to be taken with a big meal, but I've since cut down on the size of my meals. I'm due to see the doctor next month and will let them know how things are going then.
4.3Patient Review
6/26/2013 Insomnia was a huge problem for me, but this treatment really helped.
4.3Patient Review
8/7/2014 So far, this has been like a miracle controlling the diarreah. While I still have it somehow it is much more under control. I work and this helps. Previously I was taking eight pills a day.
4Patient Review
2/3/2014 I've been on Atripla for a while now, but I started having some bad dreams recently. My doctor said to try this treatment and see if it helped. So far, so good! I'll update in a month.
3.3Patient Review
5/31/2013 I developed a serious skin reaction about seven weeks into treatment, so I had to stop using the drug. It was working well up until that point though, and my CD4 levels were improving.
3Patient Review
2/23/2014 After being on Atripla for two years, I switched to Complera. Unfortunately, I experienced many of the same symptoms, plus some additional ones. These include but are not limited to: severe insomnia, fatigue, hitching, dehydration, stomach cramps, acid reflux, sore joints, swelling, dry eyes, memory loss, poor concentration and heart palpitations. On a good week, I maybe have one or two days where I can sleep properly.
2.3Patient Review
9/29/2013 I unfortunately had a really negative reaction to this medication. I saw drastic and unwelcome changes in my weight, sleeping patterns, skin, and overall mood. Additionally, I experienced pain all over my body which made it difficult to function normally.
Patient Q&A Section about complera
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What drugs are in Complera?
"You should ask your healthcare provider if COMPLERA is the right medication for you. COMPLERA is a combination of emtricitabine, rilpivirine, and tenofovir disoproxil fumarate, and it comes in the form of a pill. View the Patient Information leaflet for more information, including important warnings."
Answered by AI
What is Complera used to treat?
"This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life.
This product contains 3 different medications: emtricitabine, rilpivirine, and tenofovir. These medications are used to help control HIV infection by decreasing the amount of HIV in the body. This lowers the individual's chances of developing HIV complications (such as new infections or cancer) and improves quality of life."
Answered by AI
What is the generic name for Complera?
"TENOFOVIR DISOPROXIL FUMARATE is the brand name for tenofovir DF, a nucleotide reverse transcriptase inhibitor.
COMPLERA is a fixed-dose combination tablet containing emtricitabine and rilpivirine hydrochloride, two synthetic nucleoside analogs of cytidine, and tenofovir DF, a nucleotide reverse transcriptase inhibitor."
Answered by AI