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What is Compazine
ProchlorperazineThe Generic name of this drug
Treatment SummaryProchlorperazine, also known as Compazine, is an antipsychotic drug used to treat severe nausea and vomiting, as well as certain mental disorders. It works by blocking certain receptors in the brain, including dopamine, histamine, choline and noradrenaline. Prochlorperazine has been used for over 60 years and is still commonly used for nausea and vomiting even though newer medications are available.
Compazineis the brand name
Compazine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Compazine
Prochlorperazine
1956
162
Effectiveness
How Compazine Affects PatientsProchlorperazine is a drug used to reduce symptoms of psychosis. It also works to prevent nausea and vomiting. Prochlorperazine blocks certain receptors in the body that can cause sedation, muscle relaxation, low blood pressure, and anxiety. Compared to other drugs of its type, it causes less sedation and is less likely to lower blood pressure or interact with other drugs. One study has shown that it can also block a receptor that regulates calcium influx in cells.
How Compazine works in the bodyProchlorperazine works by blocking the dopamine type 2 receptor in the brain, which stops postsynaptic dopamine receptors from being triggered. This action can reduce nausea, vomiting, and other symptoms caused by an overstimulated dopamine system. Prochlorperazine also blocks serotonin type 3 receptors, which can help reduce nausea and vomiting when triggered.
When to interrupt dosage
The suggested measure of Compazine is contingent upon the determined condition, such as Tension Headache, Acute Coryza and Schizophrenia. The amount of dosage fluctuates, in accordance with the administration process featured in the table beneath.Condition
Dosage
Administration
Schizophrenia
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Anxiety
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Nausea
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Acute Coryza
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Tension Headache
5.0 mg, , 10.0 mg, 5.0 mg/mL, 0.5 mg, 25.0 mg, 15.0 mg, 2.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Rectal, Suppository, Suppository - Rectal, Intramuscular, Injection - Intramuscular, Solution, Solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Syrup, Syrup - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous
Warnings
Compazine ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Operative Surgery
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Comatose
Do Not Combine
Common Compazine Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Prochlorperazine may increase the antipsychotic activities of Amisulpride.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Arsenic trioxide.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Asenapine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Prochlorperazine.
Compazine Toxicity & Overdose RiskThe toxic dose of prochlorperazine in rats is 750mg/kg when taken orally. In mice, the toxic doses for intraperitoneal and subcutaneous administration are 191mg/kg and 320mg/kg respectively. Elderly patients with dementia-related psychosis taking this drug have an increased risk of death. Taking the drug for extended periods of time or at high doses can lead to involuntary and potentially irreversible muscle movements (tardive dyskinesia). Additionally, prochlorperazine can cause a potentially fatal condition called neuroleptic malignant syndrome, which is characterized by fever, rigidity of the muscles, altered
Compazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Compazine?
171 active clinical trials are underway to investigate the potential of Compazine in alleviating symptoms of Schizophrenia, Acute Coryza and Tension Headache.Condition
Clinical Trials
Trial Phases
Acute Coryza
0 Actively Recruiting
Nausea
0 Actively Recruiting
Schizophrenia
175 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Tension Headache
0 Actively Recruiting
Anxiety
0 Actively Recruiting
Compazine Reviews: What are patients saying about Compazine?
5Patient Review
2/24/2015 This is the only anti-nausea/vomiting drug that has really worked for me. I've never experienced any side effects, other than sometimes feeling tired. It's hard to tell if that's from the medication or the event itself; probably both.
5Patient Review
5/29/2017 I have to use a combination of compazine, zofran, and phenergan to control my nausea and vomiting. Compazine IV is the most effective at controlling the N/V.
5Patient Review
7/13/2018 My partner and I have both used Compazine for nausea with great success. We haven't experienced any negative side effects, which is amazing considering we've been relying on this medication to combat our IBS and GERD issues for years now.
4Patient Review
7/29/2016 I have gastroparesis and this medication usually does a great job of managing my nausea and vomiting. Sometimes I still end up throwing up, but it's been a huge help overall.
2.7Patient Review
3/7/2018 While this medication did relieve my nausea, I developed concerning side effects after taking it for some time. These included chest pain and anxiety attacks. I urge caution when taking this drug.
2.3Patient Review
7/20/2017 About an hour after taking the medication, I had a severe allergic reaction which caused my eyes to roll back into my head and muscles throughout my body to contract. It was incredibly scary and I needed to be injected with a muscle relaxer in order to bring me out of it. Needless to say, I was told never to take this medicine again.
1Patient Review
10/10/2016 Do not take this medication. I had a terrible reaction to it while undergoing chemotherapy, and ended up in the emergency room as a result.
1Patient Review
7/4/2020 I was given Compazine while pregnant, and it caused my jaw to lock shut and my eyes to roll back into my head. I ended up in the emergency room because I knew that if I didn't get help, I would choke to death. The doctor took me off the medication as soon as he realized that I was allergic.
1Patient Review
4/11/2022 I had a really terrible experience with this drug. I was extremely jittery and felt like I couldn't sleep, even though I was in a dream-like state. I went to the ER and was told to take Benadryl, but it hasn't helped at all. Does anyone have any suggestions?
1Patient Review
6/20/2016 I was told by my doctor that this medication might have some side effects, but I had no idea that it would be so dangerous. I literally almost died from liver failure while taking this drug. If you're considering it, please be sure to weigh the risks and benefits very carefully.
Patient Q&A Section about compazine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Compazine do to the brain?
"Compazine works to control nausea and vomiting and is a first-generation piperazine phenothiazine antipsychotic medication. Scientists think that phenothiazine antipsychotics may work by blocking the neurotransmitter dopamine from working in the brain."
Answered by AI
Is Zofran the same as Compazine?
"Zofran and Compazine are two different types of drugs. Zofran is a drug that works by blocking the serotonin receptor, while Compazine is an antipsychotic drug that works by decreasing the activity of certain chemicals in the brain."
Answered by AI
What is the drug Compazine used for?
"This medication works by blocking the action of a certain natural substance in the brain, which helps to reduce nausea and vomiting.
This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment) by blocking the action of a certain natural substance in the brain. Prochlorperazine belongs to a class of drugs known as phenothiazines."
Answered by AI
How does Compazine make you feel?
"or feeling confused
The possible side effects of this medication include having difficulty speaking or swallowing, stiffness or muscle spasms in your neck, tremors, or any new or unusual muscle movements you cannot control, feeling extremely drowsy or light-headed (like you might pass out), or feeling confused."
Answered by AI