Combipres

Swollen feet or ankles, Chronic Kidney Disease (CKD), Congestive Heart Failure + 5 more
Treatment
20 Active Studies for Combipres

What is Combipres

ChlorthalidoneThe Generic name of this drug
Treatment SummaryChlorthalidone is a medication used to treat high blood pressure and reduce swelling caused by conditions like heart failure and kidney disease. It works by preventing your kidneys from absorbing water, which helps lower blood pressure and reduce swelling. It is usually the first choice of treatment for high blood pressure and has been proven to lower the risk of strokes, heart attacks, and other cardiovascular issues. Chlorthalidone also has other benefits, such as decreasing platelet aggregation and promoting angiogenesis, which may help reduce cardiovascular risk.
Chlorthalidoneis the brand name
Combipres Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Chlorthalidone
Chlorthalidone
1981
193

Effectiveness

How Combipres works in the bodyChlorthalidone helps lower blood pressure by limiting the reabsorption of sodium and chloride in the kidneys. This reduces the amount of fluid in the body, thus reducing the pressure in the blood vessels. Chlorthalidone also prevents platelets from sticking together, reduces permeability in blood vessels, and encourages the growth of new blood vessels. All of these effects contribute to a reduction in overall cardiovascular risk.

When to interrupt dosage

The encouraged dose of Combipres is contingent upon the diagnosed condition, for example Cirrhosis, likely necessitating multiple antihypertensive drugs, and Edema. The amount of dosage is dependent upon the technique of delivery specified in the table underneath.
Condition
Dosage
Administration
Hypertensive disease
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Swollen feet or ankles
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Chronic Kidney Disease (CKD)
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
multiple antihypertensive drugs likely required
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
not adequately controlled with monotherapy
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Cirrhosis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Nephrolithiasis
, 25.0 mg, 50.0 mg, 15.0 mg, 12.5 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Combipres Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
allergic reaction to sulfonamide derivatives
Do Not Combine
There are 20 known major drug interactions with Combipres.
Common Combipres Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Chlorthalidone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Chlorthalidone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Hexamethonium.
Lithium carbonate
Major
Chlorthalidone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.

Combipres Novel Uses: Which Conditions Have a Clinical Trial Featuring Combipres?

641 active trials are currently being conducted to assess the potential of Combipres to ameliorate Kidney Disease, Cirrhosis and Hypertensive Disease.
Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
31 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
not adequately controlled with monotherapy
0 Actively Recruiting
Cirrhosis
53 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
Congestive Heart Failure
185 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
multiple antihypertensive drugs likely required
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Swollen feet or ankles
6 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Nephrolithiasis
0 Actively Recruiting

Patient Q&A Section about combipres

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the side effects of clonidine?

"Anxiety, skin problems like blisters, burns, dryness, or flaking, chest pain, confusion, decreased urine output, large neck veins, a fast or irregular heartbeat, and feeling unwell."

Answered by AI

Does clonidine lower potassium?

"Clonidine and chlorthalidone may cause a loss of potassium from your body. To help prevent this, your doctor may want you to eat or drink foods that have a high potassium content (for example, orange or other citrus fruit juices), or take a potassium supplement"

Answered by AI

Does clonidine make you pee?

"This medicine may cause you to feel unusually tired when you first start taking it. You may also notice an increase in how much urine you produce, or how often you need to urinate."

Answered by AI

Does clonidine dehydrate you?

"Thus, it is very important that you follow a low-salt diet and take this medication exactly as directed by your healthcare professional.

The side effects of this medication are usually not serious. However, the chlorthalidone in it can cause dehydration and a loss of salt and minerals if you do not follow a low-salt diet and take the medication as directed."

Answered by AI

Clinical Trials for Combipres

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Combipres clinical trials? We made a collection of clinical trials featuring Combipres, we think they might fit your search criteria.Go to Trials
Image of Cedars-Sinai Medical Center in Los Angeles, United States.

AI-Enabled Identification for Fatty Liver Disease

18+
All Sexes
Los Angeles, CA
The goal of this prospective, multicenter, open-label, blinded end-point pragmatic study is to evaluate an artificial intelligence (AI)-augmented echocardiography screening approach for early detection of metabolic dysfunction associated steatotic liver disease (MASLD) and/or cirrhosis, in patients undergoing routine transthoracic echocardiograms (TTEs). The main question it aims to answer is to: 1. Evaluate notification responsiveness and rates of confirmatory testing for patients identified as high risk for having liver disease to determine whether optimized notifications increase timely confirmatory testing and treatment initiation versus standard of care assessment. 2. Compare time to diagnosis, treatment uptake, and clinical outcomes (hospitalizations, incident ASCVD, mortality) between cohorts identified as high risk by the AI algorithm and comparison groups to determine whether AI guided screening shortens time to diagnosis and increases appropriate treatment.
Waitlist Available
Has No Placebo
Cedars-Sinai Medical Center (+3 Sites)
Image of Los Angeles General Medical Center in Los Angeles, United States.

Supportive Management for Heart Failure and Methamphetamine Addiction

18+
All Sexes
Los Angeles, CA
Heart failure (HF) affects over 6 million people in the US and is a major cause of both hospital admissions and death. HF has many causes and contributing factors. One of the most aggressive forms of HF is associated with methamphetamine abuse, which has become its own epidemic in the US over the past twenty years. People who use methamphetamine tend to develop HF at a much younger age, with more severe disease and more serious consequences. A recent analysis using nationwide data, methamphetamine use doubled the risk of death or hospitalizations compared to non-users in patients with HF. Thus, methamphetamine users with HF represent a very high-risk group of patients from a healthcare perspective. HF may be reversible in some patients who use methamphetamine if patients can achieve 1) abstain from further methamphetamine use and 2) consistently take all the medications that can improve HF. These two goals are very difficult to achieve in practice, as the care of both methamphetamine addiction and HF requires specialized medical expertise and intensive regular follow up of patients. In general, achievement of one goal is not possible without the other. Patients who use methamphetamine have poor adherence to medical follow-up and therapies, and abstinence from methamphetamine is difficult to maintain. This is further complicated because the current model of HF care does not incorporate treatment for methamphetamine use. The current study proposes to launch a multidisciplinary clinic that treats both HF and methamphetamine use disorder at the same time. The HF care will be led by a cardiologist while the methamphetamine use treatment will be led by a psychiatric clinical pharmacist trained in addiction medicine. State-of-the-art HF care will include optimization of four pillar HF medications. Methamphetamine use treatment will include counseling and incentivized abstinence known as contingency management (CM). The investigators will manage the patients in the clinic for 6 months total. The investigators are interested in demonstrating that this integrated clinic model will result in improved delivery of care for these patients by reporting the rates of successful abstinence from methamphetamine, improved optimization of the four HF medications, and enhanced patient reported quality of life over the 6 months of follow up. The investigators will also collect data on the costs associated with providing this level of care and estimate a range of potential cost-savings.
Waitlist Available
Has No Placebo
Los Angeles General Medical Center (+1 Sites)Tien Ng, PharmD
Have you considered Combipres clinical trials? We made a collection of clinical trials featuring Combipres, we think they might fit your search criteria.Go to Trials
Image of Cleveland Clinic Avon Hospital in Avon, United States.

Wake and Weigh for Heart Failure

18+
All Sexes
Avon, OH
Ongoing self-care for heart failure is essential to avoid complications and hospitalization. Supportive strategies are needed; however, patients with heart failure may find many interventions complicated and overwhelming. The purpose of this pilot study is to implement a simple weight tracking tool (Wake and Weigh) to affect self-care and quality of life in a population of older adults with heart failure. This will be a randomized controlled pilot trial to test the methods to be used in a larger randomized controlled trial. The Self-care in Heart Failure Index and Kansas City Cardiomyopathy Questionnaire surveys will be given at admission and four weeks after discharge. The Wake and Weigh tool is designed to help patients track weight in the hospital and following discharge. Feasibility endpoints will be summarized descriptively.
Recruiting
Has No Placebo
Cleveland Clinic Avon Hospital
Have you considered Combipres clinical trials? We made a collection of clinical trials featuring Combipres, we think they might fit your search criteria.Go to Trials
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