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What is Clinoril
SulindacThe Generic name of this drug
Treatment SummarySulindac is a type of non-steroidal anti-inflammatory drug (NSAID) used to treat acute and chronic inflammatory conditions. It is available under the brand name Clinoril and is converted by the liver into an active sulfide compound. Studies suggest that Sulindac may be less likely to cause gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. It is believed to work by reducing the production of prostaglandins in the body by blocking the COX-1 and COX-2 enzymes.
Clinorilis the brand name
Clinoril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clinoril
Sulindac
1978
55
Approved as Treatment by the FDA
Sulindac, also known as Clinoril, is approved by the FDA for 7 uses such as acute Subacromial bursitis and Tendinitis .acute Subacromial bursitis
Tendinitis
Gouty Arthritis
Rheumatoid Arthritis
Ankylosing Spondylitis
Osteoarthritis (OA)
acute supraspinatus tendinitis
Effectiveness
How Clinoril Affects PatientsSulindac is a painkiller and fever reducer that works by blocking inflammation.
How Clinoril works in the bodySulindac's effects on inflammation and fever are still unclear. It is believed that it works by blocking two enzymes, COX-1 and COX-2, which reduce prostaglandin production. It could also work by increasing blood flow, which helps the body cool down and reduce a fever.
When to interrupt dosage
The advised dosage of Clinoril is contingent upon the diagnosed condition, including Osteoarthritis (OA), Ankylosing Spondylitis and acute supraspinatus tendinitis. The measure can be found in the table below, subject to the method of delivery (e.g. Oral or Tablet).Condition
Dosage
Administration
Gouty Arthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Adenomatous Polyposis Coli
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Rheumatoid Arthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Colorectal Adenomas
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Ankylosing Spondylitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Osteoarthritis (OA)
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
acute supraspinatus tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
acute Subacromial bursitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Clinoril has three counter-indications and should not be amalgamated with the conditions presented in the following table.Clinoril ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Pulse Frequency
Do Not Combine
Common Clinoril Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Sulindac.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Sulindac.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Sulindac.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Sulindac is combined with Omacetaxine mepesuccinate.
Clinoril Toxicity & Overdose RiskThe toxic dose of Paxil in rats is 264mg/kg. If someone takes too much Paxil, they may experience confusion, unconsciousness, reduced urine production, and low blood pressure. In rare cases, death can occur as a result of an overdose.
Clinoril Novel Uses: Which Conditions Have a Clinical Trial Featuring Clinoril?
99 active clinical trials are assessing the potential of Clinoril to treat Adenomatous Polyposis Coli, Osteoarthritis (OA) and Gouty Arthritis.Condition
Clinical Trials
Trial Phases
Gouty Arthritis
1 Actively Recruiting
Phase 2, Phase 3
acute Subacromial bursitis
0 Actively Recruiting
Adenomatous Polyposis Coli
4 Actively Recruiting
Not Applicable, Phase 2, Phase 1
Ankylosing Spondylitis
2 Actively Recruiting
Phase 3, Not Applicable
Tendinitis
0 Actively Recruiting
Osteoarthritis (OA)
0 Actively Recruiting
Colorectal Adenomas
13 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
acute supraspinatus tendinitis
0 Actively Recruiting
Clinoril Reviews: What are patients saying about Clinoril?
5Patient Review
5/1/2009 I've found this medication to be one of the best options for treating my RA.
5Patient Review
3/22/2009 I've tried a lot of different medications for my pain, and none of them have worked at all. It's been really frustrating.
5Patient Review
3/12/2012 I've been taking this medication for three years to help with general joint pain. It's really effective; I only have to take it three days a week. If I forget to take it, the pain comes back pretty quickly (within a day), so it's easy to remember.
5Patient Review
2/21/2013 Sulindac has helped me a lot. I used it once for my feet and it eventually got better. Then I used it for lower back pain and still use it regularly. It enables me to have a normal, active life.
5Patient Review
9/22/2009 I took this medication for years, and it suddenly started giving me diarrhea for months. I had to stop taking it, and now I'm in a lot of pain.
5Patient Review
7/14/2011 I unfortunately haven't seen any benefits for my bursitis from this medication.
4.3Patient Review
10/13/2009 I found relief within a few days of taking this medication.
3.7Patient Review
9/2/2008 Clinoril has been working well for my fibromyalgia pain; it's better than other treatments I've tried. It does a great job of reducing soreness in muscles and joints. However, I'm concerned that I might develop stomach problems from it in the future.
3Patient Review
1/12/2014 I was recently prescribed this treatment after a trip to the ER. So far, I haven't found that it does much in terms of pain relief. The doctor said it was soft tissue damage to my neck, but it feels very inflamed in my shoulder area sometimes. This pain has even caused me to miss days where I can't get out of bed.
2.3Patient Review
2/4/2009 I've been taking this since 1987.
1.7Patient Review
4/21/2011 I was originally taking this for my frozen shoulder, but I had to switch because of digestive issues. The new medication didn't work as well and actually made physical therapy more difficult. So, I'm back on this one and just deal with the stomach problems.
1.7Patient Review
4/17/2008Patient Q&A Section about clinoril
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Clinoril same as ibuprofen?
"Clinoril and ibuprofen are two different NSAIDs that can be used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout."
Answered by AI
What are the side effects of Clinoril?
"The following are side effects that may occur: nausea, vomiting, stomach pain, indigestion, loss of appetite, diarrhea, constipation, gas, headache, dizziness, nervousness, itching, rash, or ringing in your ears."
Answered by AI
What drug category is Clinoril?
"Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) that can be used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout. Sulindac is available as either the brand-name drug Clinoril or as a generic drug."
Answered by AI