Carbocaine

Vitamin B 6 Deficiency, Iron Deficiency Anemia, Nerve Block + 4 more
Treatment
3 FDA approvals
20 Active Studies for Carbocaine

What is Carbocaine

MepivacaineThe Generic name of this drug
Treatment SummaryMepivacaine is an anesthetic used to numb a specific area of the body. It is similar to bupivacaine and lidocaine and is often used for infiltration, nerve block, and epidural anesthesia. Mepivacaine is not effective when used topically and should only be used as directed.
Polocaineis the brand name
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Carbocaine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Polocaine
Mepivacaine
1984
51

Approved as Treatment by the FDA

Mepivacaine, also known as Polocaine, is approved by the FDA for 3 uses such as Local Anaesthesia therapy and lumbar epidural anesthesia therapy .
Local Anaesthesia therapy
lumbar epidural anesthesia therapy
Nerve Block

Effectiveness

How Carbocaine Affects PatientsMepivicaine is a type of drug used to numb a specific area of the body. It works quickly and can last for a while, and is sold under the names Carbocaine and Polocaine. When taken as directed, it usually has minimal effects on the heart and nervous system.
How Carbocaine works in the bodyLocal anesthetics reduce the ability of nerves to send signals. Pain sensations, temperature, touch, and body awareness are all affected in that order. Nerves with bigger diameters, better insulation, and faster conduction are affected the most.

When to interrupt dosage

The proposed dosage of Carbocaine is conditional upon the diagnosed condition, including Blood Loss Anemia, Nerve Block and Diabetic Peripheral Neuropathy (DPN). The measure of dosage varies, contingent upon the method of delivery (e.g. Injection, solution - Subcutaneous or Infiltration) as indicated in the table below.
Condition
Dosage
Administration
Local Anaesthesia therapy
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Nerve Block
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Diabetic Peripheral Neuropathy (DPN)
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
lumbar epidural anesthesia therapy
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Vitamin B 6 Deficiency
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Iron Deficiency Anemia
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Blood Loss Anemia
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous

Warnings

There are 20 known major drug interactions with Carbocaine.
Common Carbocaine Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Mepivacaine is combined with Oliceridine.
Technetium Tc-99m tilmanocept
Major
Mepivacaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
Thalidomide
Major
Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Carbocaine Toxicity & Overdose RiskOn average, it takes 18.8 mg/kg of mepivacaine to induce seizures in rhesus monkeys, with an average plasma concentration of 24.4 µg/mL. The toxic dose for mice is between 23 and 35 mg/kg when given intravenously, and 280 mg/kg when administered subcutaneously.
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Carbocaine Novel Uses: Which Conditions Have a Clinical Trial Featuring Carbocaine?

105 active clinical trials are being conducted to assess the potential of Carbocaine to treat Iron Deficiency Anemia, Diabetic Peripheral Neuropathy (DPN) and Anemia due to Blood Loss.
Condition
Clinical Trials
Trial Phases
Nerve Block
0 Actively Recruiting
Local Anaesthesia therapy
0 Actively Recruiting
Vitamin B 6 Deficiency
0 Actively Recruiting
Blood Loss Anemia
0 Actively Recruiting
Iron Deficiency Anemia
113 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1
lumbar epidural anesthesia therapy
1 Actively Recruiting
Not Applicable
Diabetic Peripheral Neuropathy (DPN)
6 Actively Recruiting
Not Applicable, Phase 2

Carbocaine Reviews: What are patients saying about Carbocaine?

5Patient Review
8/16/2012
Carbocaine for Local Anesthesia Injected to Block Nerve Transmission
4.7Patient Review
9/18/2019
Carbocaine for Injection to cause Local Loss of Feeling or Numbness
I have a reaction to anesthesia that includes epinephrine. Today, my doctor used carbocaine and it was great. I didn't feel any pain and the numbness lasted for the duration of the work.
2Patient Review
5/30/2016
Carbocaine for Local Anesthesia Injected to Block Nerve Transmission
As a cardiac patient, I have found Novacaine to be unsuitable for me as it adversely affects my heart. Carbocaine has been a much better option for me during dental procedures; I experience less pain and the numbness doesn't last as long. Most importantly, though, is that Carbocaine doesn't put my heart at risk the way Novacaine does.
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Patient Q&A Section about carbocaine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is CARBOCAINE the same as lidocaine?

"The type of local anesthetic agent most commonly used for regional or intrasynovial analgesia of the foot is Mepivacaine (Carbocaine). The authors do not use Lidocaine for regional anesthesia because it is irritating to tissues."

Answered by AI

What is CARBOCAINE used for?

"Carbocaine is a local anesthetic that is used to treat Infiltration Anesthesia and Nerve Blocks. It works by numbing the area around the nerve. Carbocaine may be used alone or with other medications."

Answered by AI

Is CARBOCAINE safe for heart patients?

"Mepivacaine should be used cautiously in patients with a history of severe disturbances of cardiac rhythm or heart block. The injections should always be made slowly with aspiration to avoid intravascular injection and therefore systemic reaction to both the local anesthetic and the vasoconstrictor."

Answered by AI

How long does CARBOCAINE last dental?

"The anesthesia will take effect within 30 to 120 seconds if injected into the maxilla, and 1 to 4 minutes if injected into the mandible. The anesthesia will last for approximately 20 minutes if injected into the maxilla, and 40 minutes if injected into the mandible."

Answered by AI

Clinical Trials for Carbocaine

Have you considered Carbocaine clinical trials? We made a collection of clinical trials featuring Carbocaine, we think they might fit your search criteria.
Have you considered Carbocaine clinical trials? We made a collection of clinical trials featuring Carbocaine, we think they might fit your search criteria.
Have you considered Carbocaine clinical trials? We made a collection of clinical trials featuring Carbocaine, we think they might fit your search criteria.