Carbocaine

Vitamin B 6 Deficiency, Iron Deficiency Anemia, Nerve Block + 4 more
Treatment
3 FDA approvals
20 Active Studies for Carbocaine

What is Carbocaine

MepivacaineThe Generic name of this drug
Treatment SummaryMepivacaine is an anesthetic used to numb a specific area of the body. It is similar to bupivacaine and lidocaine and is often used for infiltration, nerve block, and epidural anesthesia. Mepivacaine is not effective when used topically and should only be used as directed.
Polocaineis the brand name
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Carbocaine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Polocaine
Mepivacaine
1984
51

Approved as Treatment by the FDA

Mepivacaine, also known as Polocaine, is approved by the FDA for 3 uses such as Nerve Block and lumbar epidural anesthesia therapy .
Nerve Block
lumbar epidural anesthesia therapy
Local Anaesthesia therapy

Effectiveness

How Carbocaine Affects PatientsMepivicaine is a type of drug used to numb a specific area of the body. It works quickly and can last for a while, and is sold under the names Carbocaine and Polocaine. When taken as directed, it usually has minimal effects on the heart and nervous system.
How Carbocaine works in the bodyLocal anesthetics reduce the ability of nerves to send signals. Pain sensations, temperature, touch, and body awareness are all affected in that order. Nerves with bigger diameters, better insulation, and faster conduction are affected the most.

When to interrupt dosage

The proposed dosage of Carbocaine is conditional upon the diagnosed condition, including Blood Loss Anemia, Nerve Block and Diabetic Peripheral Neuropathy (DPN). The measure of dosage varies, contingent upon the method of delivery (e.g. Injection, solution - Subcutaneous or Infiltration) as indicated in the table below.
Condition
Dosage
Administration
Nerve Block
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
lumbar epidural anesthesia therapy
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Anemia
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Vitamin B 6 Deficiency
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Iron Deficiency Anemia
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Diabetic Neuropathies
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous
Local Anaesthesia therapy
30.0 mg/mL, , 20.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 1.0 %
, Dental; Infiltration, Injection, solution, Injection, solution - Dental; Infiltration, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Injection, solution - Infiltration, Infiltration, Solution, Solution - Subcutaneous, Solution - Infiltration, Liquid, Liquid - Infiltration, Epidural; Intracaudal, Solution - Epidural; Intracaudal, Liquid - Epidural; Intracaudal, Intraspinal, Liquid - Intraspinal, Dental, Injection, Injection - Dental, Injection - Infiltration, Injection - Subcutaneous

Warnings

There are 20 known major drug interactions with Carbocaine.
Common Carbocaine Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Mepivacaine is combined with Oliceridine.
Technetium Tc-99m tilmanocept
Major
Mepivacaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
Thalidomide
Major
Mepivacaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Carbocaine Toxicity & Overdose RiskOn average, it takes 18.8 mg/kg of mepivacaine to induce seizures in rhesus monkeys, with an average plasma concentration of 24.4 µg/mL. The toxic dose for mice is between 23 and 35 mg/kg when given intravenously, and 280 mg/kg when administered subcutaneously.
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Carbocaine Novel Uses: Which Conditions Have a Clinical Trial Featuring Carbocaine?

105 active clinical trials are being conducted to assess the potential of Carbocaine to treat Iron Deficiency Anemia, Diabetic Peripheral Neuropathy (DPN) and Anemia due to Blood Loss.
Condition
Clinical Trials
Trial Phases
Vitamin B 6 Deficiency
0 Actively Recruiting
lumbar epidural anesthesia therapy
0 Actively Recruiting
Local Anaesthesia therapy
0 Actively Recruiting
Diabetic Neuropathies
6 Actively Recruiting
Not Applicable, Phase 2
Anemia
0 Actively Recruiting
Iron Deficiency Anemia
20 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4
Nerve Block
0 Actively Recruiting

Carbocaine Reviews: What are patients saying about Carbocaine?

5Patient Review
8/16/2012
Carbocaine for Local Anesthesia Injected to Block Nerve Transmission
4.7Patient Review
9/18/2019
Carbocaine for Injection to cause Local Loss of Feeling or Numbness
I have a reaction to anesthesia that includes epinephrine. Today, my doctor used carbocaine and it was great. I didn't feel any pain and the numbness lasted for the duration of the work.
2Patient Review
5/30/2016
Carbocaine for Local Anesthesia Injected to Block Nerve Transmission
As a cardiac patient, I have found Novacaine to be unsuitable for me as it adversely affects my heart. Carbocaine has been a much better option for me during dental procedures; I experience less pain and the numbness doesn't last as long. Most importantly, though, is that Carbocaine doesn't put my heart at risk the way Novacaine does.
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Patient Q&A Section about carbocaine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is CARBOCAINE the same as lidocaine?

"The type of local anesthetic agent most commonly used for regional or intrasynovial analgesia of the foot is Mepivacaine (Carbocaine). The authors do not use Lidocaine for regional anesthesia because it is irritating to tissues."

Answered by AI

What is CARBOCAINE used for?

"Carbocaine is a local anesthetic that is used to treat Infiltration Anesthesia and Nerve Blocks. It works by numbing the area around the nerve. Carbocaine may be used alone or with other medications."

Answered by AI

Is CARBOCAINE safe for heart patients?

"Mepivacaine should be used cautiously in patients with a history of severe disturbances of cardiac rhythm or heart block. The injections should always be made slowly with aspiration to avoid intravascular injection and therefore systemic reaction to both the local anesthetic and the vasoconstrictor."

Answered by AI

How long does CARBOCAINE last dental?

"The anesthesia will take effect within 30 to 120 seconds if injected into the maxilla, and 1 to 4 minutes if injected into the mandible. The anesthesia will last for approximately 20 minutes if injected into the maxilla, and 40 minutes if injected into the mandible."

Answered by AI

Clinical Trials for Carbocaine

Image of University Health Network (UHN) in Toronto, Canada.

Mitapivat for Anemia

18+
All Sexes
Toronto, Canada
This is a prospective exploratory phase 2 study designed to evaluate the safety and efficacy of mitapivat in RBC membranopathies and CDAII, a rare sub type of anemia. Nine patients from Princess Margaret who are diagnosed with CDAII will be enrolled to the study. Patients will be in the trial for 57 weeks treatment weeks and a safety follow up week after 30 days from last dose. First 8 weeks will be dose escalating period followed by 48 weeks of fixed dose period. 57th week will be dose tapering week. Data collected from Princes Margaret will be incorporated to the main study conducted in EU for analysis. Overall, approximately 25 patients are expected to be enrolled: Approximately 16 patients at sites in the EU and approximately 9 patients in Canada.
Phase 2
Recruiting
University Health Network (UHN)Agios Pharmaceuticals, Inc.
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Luspatercept for Clonal Cytopenia

18+
All Sexes
New York, NY
The purpose of this clinical trial is to test how well the drug luspatercept works in improving low blood cell counts in people with clonal cytopenias of uncertain significance (CCUS). The main questions the study seeks to answer include: * How many patients experience improvements in their low blood counts (red cells, platelets, or white cells) within 24 weeks, based on specific criteria for blood conditions like myelodysplastic syndromes (MDS)? * How long these improvements last before the condition worsens or changes. * The percentage of participants showing improvements at 12, 24, and 48 weeks. * How long it takes for the condition to progress to more severe diseases like myeloid disorders. * How long red blood cell responses last and how quickly these responses are seen. * The average change in hemoglobin levels over 24 weeks. * How many patients need blood transfusions during the study and how soon transfusions are required. * Changes in participants' well-being and energy levels based on a standardized questionnaire. * Monitoring for any side effects, including progression to MDS or leukemia, heart-related issues, or sudden increases in hemoglobin. Participants will: * Receive luspatercept as an injection every three weeks. * Visit the clinic every three weeks for treatment and monitoring.
Phase 2
Recruiting
Weill Cornell Medical CollegePinkal Desai, MDBristol-Myers Squibb
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Choline for Iron Deficiency

5 - 7
All Sexes
Minneapolis, MN
BACKGROUND: Iron deficiency limits the neurodevelopmental potential of more than 200 million children each year. Iron therapy is typically started when iron deficiency anemia is first diagnosed after screening for anemia or detection of clinical symptoms of iron deficiency anemia at 12 months of age. But iron started at this time does not fully correct earlier iron-deficiency-mediated brain dysfunction, underscoring the need for low-cost, easily implementable adjunct therapies to iron to treat or prevent this dysfunction in high-risk populations. GAP Supplementation with the nutrient choline lessens damage to the hippocampus from early-life iron deficiency in pre-clinical models and improves hippocampus-mediated memory in children with Fetal Alcohol Spectrum Disorders. Choline has not been tested in children with iron deficiency anemia, despite strong pre-clinical and clinical evidence supporting a benefit to brain development. HYPOTHESIS: Infants with iron deficiency anemia who receive iron and nine months of daily choline supplements will have better scores on specific neurobehavioral tests of recognition memory than infants who receive iron and placebo. METHODS: This randomized, double-blinded, placebo-controlled clinical trial will randomize 300 6-month-old infants with iron deficiency anemia at Mulago Hospital, Kampala, Uganda, to iron plus choline or iron plus placebo to test the effect of choline on hippocampus-specific and global neurobehavioral outcomes after nine months. RESULTS: Pending IMPACT: If our hypothesis is correct, choline could be added immediately to standard-of-care treatment for iron deficiency anemia. This intervention could safely mitigate the brain dysfunction of early-life iron deficiency that is often undiagnosed until the hippocampal critical window is closing. This simple, low-cost nutrient could thus have life-long benefit for both individuals and the economic and social prosperity of entire regions.
Phase 2 & 3
Recruiting
University of MinnesotaSarah Cusick
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Iron Supplementation for Scoliosis

10 - 26
All Sexes
New York, NY
This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in adolescents undergoing scoliosis surgery. Research Question(s)/Hypothesis(es): Primary * Iron supplementation will reduce the incidence of perioperative RBC transfusion in iron deficient scoliosis patients undergoing spinal fusion. Secondary * Iron supplementation will reduce postoperative neurocognitive functional declines in iron deficient scoliosis patients undergoing spinal fusion. * Iron supplementation will improve patient-reported physical functioning in iron deficient scoliosis patients undergoing spinal fusion.
Recruiting
Paid Trial
Columbia University Medical CenterLisa D Eisler, MD
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Iron Replacement Therapy for Iron-Deficiency Anemia

16 - 60
Female
Duarte, CA
This is a trial with an observational and an interventional arm, in patients with moderate to severe anemia and control subjects. The main purposes of this study is to phenotype the scope of neurocognitive deficits from iron deficiency anemia (IDA) in adult women, determine derangements in cerebral perfusion, vascular reactivity, functional connectivity, and blood brain barrier permeability in adult-onset IDA and relate them to neurocognitive deficits, as well as determine the reversibility and durability of both the physiologic and neurocognitive derangements by iron replacement therapy. All eligible subjects will be asked to provide informed consent before participating in the study.
Phase 4
Recruiting
City of Hope Blood Donor Center (+3 Sites)John Wood, MD, PhD
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