Avinza

Chronic Pain, Pain, Therapeutic procedure
Treatment
2 FDA approvals
20 Active Studies for Avinza

What is Avinza

MorphineThe Generic name of this drug
Treatment SummaryMorphine is a powerful pain reliever derived from poppy seeds. It is still widely used today, but is limited due to a high risk of addiction and abuse. There are also several other opioids that are similar to morphine, such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone. Morphine was officially approved by the FDA in 1941.
Morphine Sulfateis the brand name
image of different drug pills on a surface
Avinza Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Morphine Sulfate
Morphine
1971
459

Approved as Treatment by the FDA

Morphine, also known as Morphine Sulfate, is approved by the FDA for 2 uses including Chronic Pain and Pain .
Chronic Pain
Helps manage Pain, Chronic
Pain

Effectiveness

How Avinza Affects PatientsMorphine works by blocking pain signals from reaching the brain. It usually takes 6-30 minutes after being taken for it to take effect. Taking too much morphine and other opioids may cause changes in how the brain works. Additionally, the strength of morphine’s effect is different in men and women. For men, 76ng/mL of morphine is needed for the desired effect, while in women it only takes 22ng/mL. Morphine-6-glucuronide is much less effective than morphine, with only 22% of the potency.
How Avinza works in the bodyMorphine-6-glucuronide is the main cause of morphine's effects. It binds to two types of opioid receptors in the brain, the mu and kappa receptors. These receptors are responsible for morphine's effect on the pleasure centers of the brain, as well as its ability to modify breathing and create addiction.

When to interrupt dosage

The suggested measure of Avinza is contingent upon the diagnosed condition, including Therapeutic procedure, Pain and Chronic Pain. The amount of dosage deviates, in light of the administration strategy outlined in the table beneath.
Condition
Dosage
Administration
Chronic Pain
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid
Pain
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid
Therapeutic procedure
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid

Warnings

Avinza Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Mental Depression
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Morphine may interact with Pulse Frequency
There are 20 known major drug interactions with Avinza.
Common Avinza Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Morphine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Morphine.
Eluxadoline
Major
The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Morphine.
Avinza Toxicity & Overdose RiskThe toxic dose for males and females is 0.78µg/mL and 0.98µg/mL respectively. Symptoms of an overdose can include shallow breathing, drowsiness, limp muscles, cold and clammy skin, constricted pupils, and dilated pupils. In severe cases, overdose could cause fluid in the lungs, slow heart rate, low blood pressure, heart attack, and death. Treatment of overdose should include oxygen, medications to increase blood pressure, and naloxone to reverse the effects of the drug.

Avinza Novel Uses: Which Conditions Have a Clinical Trial Featuring Avinza?

24 ongoing research trials are examining the potential of Avinza to facilitate Therapeutic procedures, Pain Relief and Chronic Pain Management.
Condition
Clinical Trials
Trial Phases
Chronic Pain
32 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Therapeutic procedure
0 Actively Recruiting
Pain
0 Actively Recruiting

Avinza Reviews: What are patients saying about Avinza?

5Patient Review
9/30/2011
Avinza for Chronic Pain with Narcotic Drug Tolerance
Even though this treatment is working well, I find that I sometimes need to take a supplemental pain medication like Vicodin.
5Patient Review
3/9/2013
Avinza for Chronic Pain
Originally, this medication was effective in treating my nerve pain. However, it caused new problems with joint and muscle pain all over my body. I felt exhausted and cranky all the time. It took a long time for my doctor to understand that these were side effects of the medication, but eventually we switch ed to Exalgo and I feel so much better now.
5Patient Review
1/29/2014
Avinza for Severe Pain with Opioid Tolerance
This drug has been a game-changer for me. I was barely able to work 5 or 6 hours a day before starting this medication, and now I'm back to working full time plus. My quality of life has improved dramatically, as well as my family's.
5Patient Review
11/1/2013
Avinza for Chronic Pain with Narcotic Drug Tolerance
I was in a lot of pain from my surgery and Avinza was the only thing that really helped.
5Patient Review
1/12/2015
Avinza for Chronic Pain
I've been dealing with chronic pain for more than a decade, and Avinza has really helped me to make it tolerable. I do have to use a laxative as well, but that's such a small inconvenience compared to how effective this medication is.
4.7Patient Review
8/23/2011
Avinza for Chronic Pain
4.3Patient Review
9/10/2012
Avinza for Severe Pain with Opioid Tolerance
Avinza is very expensive, and you have to take it once a day. It does help with pain, but like any narcotic, tolerance develops over time. I've had the daily dosage increased four times in 16 years. The best thing I can say about Avinza is that it keeps me functioning and on my feet; without it, I probably wouldn't be working. That said, I still have quite a lot of pain and am not at all comfortable.
4Patient Review
9/24/2011
Avinza for Chronic Pain with Narcotic Drug Tolerance
I have a spinal cord injury and two diskectomies (cervical) in which the last one left me with some residual paralysis on my right side, constant burning and terrible pain. Avinza really helps to take the edge off of the pain.
3.7Patient Review
3/24/2012
Avinza for Chronic Pain with Narcotic Drug Tolerance
I was starting to get used to the dosage I was on, and didn't want to increase it.
3.7Patient Review
6/3/2011
Avinza for Chronic Pain
3.7Patient Review
7/9/2011
Avinza for Chronic Pain
3.3Patient Review
7/25/2013
Avinza for Chronic Pain with Narcotic Drug Tolerance
Avinza has been a game-changer for me in terms of managing my chronic pain.
3Patient Review
3/25/2012
Avinza for Chronic Pain
While this treatment does help to some degree, I find that it doesn't do much for nerve pain. I've never had back surgery, but it was recommended to me.
3Patient Review
3/5/2012
Avinza for Neuropathic Pain
I suffer from chronic pain and this treatment didn't help as much as I had hoped.
3Patient Review
3/27/2014
Avinza for Chronic Pain
I've been taking this for five years and, because it's long-acting, I haven't had to adjust the dosage.
3Patient Review
2/3/2013
Avinza for Chronic Pain with Narcotic Drug Tolerance
Morphine has been effective in reducing my chronic back pain.
2.3Patient Review
6/2/2015
Avinza for Chronic Pain with Narcotic Drug Tolerance
The effects of this medication were too short-lived for my liking. I didn't appreciate how strong it was at the beginning only to have it wear off after a few hours.
2Patient Review
1/23/2012
Avinza for Severe Pain with Opioid Tolerance
This treatment lessens some of the pain caused by ddD and fibromyalgia.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about avinza

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Ultram?

"If you're looking for pain relief, you may want to learn more about tramadol (Ultram). Tramadol is a generic prescription drug that's used to treat severe pain in adults. It's an opioid, a powerful type of pain reliever."

Answered by AI

Is avinza an OTC?

"Prescription medication Avinza is used to treat symptoms of both acute and chronic pain. It can be used alone or in conjunction with other medications and belongs to a class of drugs called Opioid Analgesics."

Answered by AI

What class is Actiq?

"Actiq is a type of drug known as an opioid analgesic, which is a class of drugs that includes anilidopiperidines."

Answered by AI

Clinical Trials for Avinza

Have you considered Avinza clinical trials? We made a collection of clinical trials featuring Avinza, we think they might fit your search criteria.
Have you considered Avinza clinical trials? We made a collection of clinical trials featuring Avinza, we think they might fit your search criteria.
Have you considered Avinza clinical trials? We made a collection of clinical trials featuring Avinza, we think they might fit your search criteria.