<p>Prescription medication Avinza is used to treat symptoms of both acute and <a href="https://www.withpower.com/clinical-trials/chronic-pain">chronic pain</a>. It can be used alone or in conjunction with other medications and belongs to a class of drugs called Opioid Analgesics.</p>

Avinza

Chronic Pain, Pain, Therapeutic procedure

Treatment

3 FDA approvals

0 Active Studies for Avinza

Treatment for

Chronic Pain

What is Avinza

Morphine

The Generic name of this drug

Treatment Summary

Morphine is a powerful pain reliever derived from poppy seeds. It is still widely used today, but is limited due to a high risk of addiction and abuse. There are also several other opioids that are similar to morphine, such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone. Morphine was officially approved by the FDA in 1941.

Morphine Sulfate

is the brand name

image of different drug pills on a surface

Avinza Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Morphine Sulfate

Morphine

1971

459

Approved as Treatment by the FDA

Morphine, also known as Morphine Sulfate, is approved by the FDA for 3 uses including Pain, Chronic and Chronic Pain .

Pain, Chronic

Helps manage Pain, Chronic

Chronic Pain

Helps manage Pain, Chronic

Pain

Effectiveness

How Avinza Affects Patients

Morphine works by blocking pain signals from reaching the brain. It usually takes 6-30 minutes after being taken for it to take effect. Taking too much morphine and other opioids may cause changes in how the brain works. Additionally, the strength of morphine’s effect is different in men and women. For men, 76ng/mL of morphine is needed for the desired effect, while in women it only takes 22ng/mL. Morphine-6-glucuronide is much less effective than morphine, with only 22% of the potency.

How Avinza works in the body

Morphine-6-glucuronide is the main cause of morphine's effects. It binds to two types of opioid receptors in the brain, the mu and kappa receptors. These receptors are responsible for morphine's effect on the pleasure centers of the brain, as well as its ability to modify breathing and create addiction.

When to interrupt dosage

The suggested measure of Avinza is contingent upon the diagnosed condition, including Therapeutic procedure, Pain and Chronic Pain. The amount of dosage deviates, in light of the administration strategy outlined in the table beneath.

Condition

Dosage

Administration

Therapeutic procedure

10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL

Oral, Solution - Oral, Capsule, extended release, Capsule, extended release - Oral, , Injection, solution, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Solution, Rectal, Suppository - Rectal, Suppository, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Injection, solution - Intravenous, Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution - Epidural; Intravenous; Subcutaneous, Suppository, extended release, Suppository, extended release - Rectal, Syrup, Syrup - Oral, Injection, Injection - Intravenous, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Epidural; Intrathecal; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Tincture, Tincture - Oral, Liquid - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Parenteral, Injection - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intrathecal; Intravenous, Solution / drops, Solution / drops - Oral, Epidural, Solution - Epidural, Solution - Intramuscular; Intravenous; Subcutaneous, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Solution - Intravenous, Liquid - Intravenous, Intramuscular, Injection - Intramuscular, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex, Injection, lipid complex - Epidural, Solution - Parenteral, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid

Pain

Chronic Pain

Warnings

Avinza Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Morphine may interact with Pulse Frequency

Pulse Frequency

Do Not Combine

Mental Depression

Do Not Combine

Asthma

Do Not Combine

Gastrointestinal obstruction

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Avinza.

Common Avinza Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Morphine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Morphine.

Eluxadoline

Major

The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Morphine.

Avinza Toxicity & Overdose Risk

The toxic dose for males and females is 0.78µg/mL and 0.98µg/mL respectively. Symptoms of an overdose can include shallow breathing, drowsiness, limp muscles, cold and clammy skin, constricted pupils, and dilated pupils. In severe cases, overdose could cause fluid in the lungs, slow heart rate, low blood pressure, heart attack, and death. Treatment of overdose should include oxygen, medications to increase blood pressure, and naloxone to reverse the effects of the drug.

Avinza Novel Uses: Which Conditions Have a Clinical Trial Featuring Avinza?

24 ongoing research trials are examining the potential of Avinza to facilitate Therapeutic procedures, Pain Relief and Chronic Pain Management.

Condition

Clinical Trials

Trial Phases

Pain

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Chronic Pain

0 Actively Recruiting

Avinza Reviews: What are patients saying about Avinza?

Patient Review

9/30/2011

Avinza for Chronic Pain with Narcotic Drug Tolerance

Even though this treatment is working well, I find that I sometimes need to take a supplemental pain medication like Vicodin.

Patient Review

3/9/2013

Avinza for Chronic Pain

Originally, this medication was effective in treating my nerve pain. However, it caused new problems with joint and muscle pain all over my body. I felt exhausted and cranky all the time. It took a long time for my doctor to understand that these were side effects of the medication, but eventually we switch ed to Exalgo and I feel so much better now.

Patient Review

1/29/2014

Avinza for Severe Pain with Opioid Tolerance

This drug has been a game-changer for me. I was barely able to work 5 or 6 hours a day before starting this medication, and now I'm back to working full time plus. My quality of life has improved dramatically, as well as my family's.

Patient Review

11/1/2013

Avinza for Chronic Pain with Narcotic Drug Tolerance

I was in a lot of pain from my surgery and Avinza was the only thing that really helped.

Patient Review

1/12/2015

Avinza for Chronic Pain

I've been dealing with chronic pain for more than a decade, and Avinza has really helped me to make it tolerable. I do have to use a laxative as well, but that's such a small inconvenience compared to how effective this medication is.

4.7

Patient Review

8/23/2011

Avinza for Chronic Pain

4.3

Patient Review

9/10/2012

Avinza for Severe Pain with Opioid Tolerance

Avinza is very expensive, and you have to take it once a day. It does help with pain, but like any narcotic, tolerance develops over time. I've had the daily dosage increased four times in 16 years. The best thing I can say about Avinza is that it keeps me functioning and on my feet; without it, I probably wouldn't be working. That said, I still have quite a lot of pain and am not at all comfortable.

Patient Review

9/24/2011

Avinza for Chronic Pain with Narcotic Drug Tolerance

I have a spinal cord injury and two diskectomies (cervical) in which the last one left me with some residual paralysis on my right side, constant burning and terrible pain. Avinza really helps to take the edge off of the pain.

3.7

Patient Review

3/24/2012

Avinza for Chronic Pain with Narcotic Drug Tolerance

I was starting to get used to the dosage I was on, and didn't want to increase it.

3.7

Patient Review

6/3/2011

Avinza for Chronic Pain

3.7

Patient Review

7/9/2011

Avinza for Chronic Pain

3.3

Patient Review

7/25/2013

Avinza for Chronic Pain with Narcotic Drug Tolerance

Avinza has been a game-changer for me in terms of managing my chronic pain.

Patient Review

3/25/2012

Avinza for Chronic Pain

While this treatment does help to some degree, I find that it doesn't do much for nerve pain. I've never had back surgery, but it was recommended to me.

Patient Review

3/5/2012

Avinza for Neuropathic Pain

I suffer from chronic pain and this treatment didn't help as much as I had hoped.

Patient Review

3/27/2014

Avinza for Chronic Pain

I've been taking this for five years and, because it's long-acting, I haven't had to adjust the dosage.

Patient Review

2/3/2013

Avinza for Chronic Pain with Narcotic Drug Tolerance

Morphine has been effective in reducing my chronic back pain.

2.3

Patient Review

6/2/2015

Avinza for Chronic Pain with Narcotic Drug Tolerance

The effects of this medication were too short-lived for my liking. I didn't appreciate how strong it was at the beginning only to have it wear off after a few hours.

Patient Review

1/23/2012

Avinza for Severe Pain with Opioid Tolerance

This treatment lessens some of the pain caused by ddD and fibromyalgia.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about avinza

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Ultram?

"If you're looking for pain relief, you may want to learn more about tramadol (Ultram). Tramadol is a generic prescription drug that's used to treat severe pain in adults. It's an opioid, a powerful type of pain reliever."

Answered by AI

Is avinza an OTC?

"Prescription medication Avinza is used to treat symptoms of both acute and chronic pain. It can be used alone or in conjunction with other medications and belongs to a class of drugs called Opioid Analgesics."

Answered by AI