Aristada

Schizophrenia
Treatment
1 FDA approval
20 Active Studies for Aristada

What is Aristada

Aripiprazole lauroxilThe Generic name of this drug
Treatment SummaryAripiprazole lauroxil is a medication used to treat schizophrenia in adults. It works by reducing the activity of certain receptors in the brain that are linked to schizophrenia. It was approved by the FDA in 2015 and can be given as an injection or in combination with an oral dose of aripiprazole. Aripiprazole lauroxil has been found to be effective and safe, and can reduce the frequency of dosing to improve patient adherence.
Aristadais the brand name
image of different drug pills on a surface
Aristada Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aristada
Aripiprazole lauroxil
2015
5

Approved as Treatment by the FDA

Aripiprazole lauroxil, otherwise known as Aristada, is approved by the FDA for 1 uses like Schizophrenia .
Schizophrenia
Used to treat Schizophrenia in combination with Aripiprazole

Effectiveness

How Aristada Affects PatientsAripiprazole is a drug that helps to improve the symptoms of schizophrenia and works by affecting the dopamine-related pathways in the body. It has been shown to have little impact on sexual function or breast milk production.
How Aristada works in the bodyAripiprazole works on dopamine and serotonin receptors in the brain to reduce the symptoms of schizophrenia. It acts as a partial agonist at dopamine and serotonin receptors in the limbic system, reducing the positive symptoms. It also acts as a functional antagonist in the mesolimbic dopamine pathway, which helps reduce the intensity of these symptoms. At serotonin receptors, it functions as an antagonist, decreasing negative symptoms and cognitive impairment. Aripiprazole also blocks alpha-1 adrenergic receptors, which can lead to low blood pressure, and histamine H1 receptors, which can cause drowsiness.

When to interrupt dosage

The dosage of Aristada is subject to the perceived affliction. The amount of dosage is contingent upon the method of delivery noted in the table below.
Condition
Dosage
Administration
Schizophrenia
, 441.0 mg/mL, 662.0 mg/mL, 882.0 mg/mL, 1064.0 mg/mL, 675.0 mg/mL
, Intramuscular, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular

Warnings

Aristada Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Aristada.
Common Aristada Drug Interactions
Drug Name
Risk Level
Description
Alfuzosin
Major
Aripiprazole lauroxil may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Aripiprazole lauroxil may increase the antipsychotic activities of Amisulpride.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Aripiprazole lauroxil.
Azelastine
Major
Aripiprazole lauroxil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Aripiprazole lauroxil.
Aristada Toxicity & Overdose RiskTests have found that the lethal dose of aripiprazole in rats is greater than 60mg. For female and male rats, the oral lethal dose was 705mg/kg and 965mg/kg respectively. The maximum recommended daily dose of aripiprazole is 1260mg, but an overdose of this can cause vomiting, drowsiness, trembling, acidosis, aggression, increased liver enzymes, irregular heartbeat, confusion, seizures, low potassium levels, loss of consciousness, abnormal electrical activity in the heart, aspiration pneumonia, stopped breathing, prolonged QRS complex, prolonged QT interval, and rapid heartbeat. A
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Aristada Novel Uses: Which Conditions Have a Clinical Trial Featuring Aristada?

At present, 170 active studies are investigating the potential of Aristada to treat Schizophrenia.
Condition
Clinical Trials
Trial Phases
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1

Aristada Reviews: What are patients saying about Aristada?

4.3Patient Review
10/25/2017
Aristada for Schizophrenia
This is the most effective medication I've found for my auditory hallucinations. It's not a cure, but it definitely makes them more manageable and less disruptive to my life.
1Patient Review
5/14/2022
Aristada for Schizophrenia
If you're experiencing a severe allergic reaction to this drug, Benadryl may help lessen the symptoms. You can either ask your doctor for an IV or get a shot of it intramuscularly. If you still have to stay on the injection and are allergic to aripiprazole lauroxil, Benadryl and Claritin may be of benefit to you.
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Patient Q&A Section about aristada

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Aristada an antipsychotic?

"Both Aristada and Abilify Maintena are antipsychotic drugs."

Answered by AI

How often is Aristada injection given?

"The recommended dose of ARISTADA is 441 mg, 662 mg, or 882 mg administered monthly, 882 mg dose every 6 weeks, or 1064 mg dose every 2 months."

Answered by AI

What is the drug Aristada used for?

"It helps you to think more clearly and positively about yourself, feel less nervous, and take a more active part in everyday life. Aripiprazole belongs to a class of drugs called atypical antipsychotics.

Extended-release aripiprazole injection is used as a treatment for schizophrenia, a mental/mood disorder. The medication can help patients by decreasing hallucinations and increasing concentration levels. It also allows the individual to think more clearly, feel less nervous, and take a more active role in everyday life. Aripiprazole belongs to a class of drugs known as atypical antipsychotics."

Answered by AI

What is the difference between Aristada and Abilify?

"Aristada is currently only FDA-approved to treat schizophrenia, but Abilify Maintena is approved to treat both bipolar I disorder and schizophrenia. Abilify Maintena is typically given as a monthly injection, while Aristada can be given as infrequently as every two months."

Answered by AI

Clinical Trials for Aristada

Have you considered Aristada clinical trials? We made a collection of clinical trials featuring Aristada, we think they might fit your search criteria.
Have you considered Aristada clinical trials? We made a collection of clinical trials featuring Aristada, we think they might fit your search criteria.
Have you considered Aristada clinical trials? We made a collection of clinical trials featuring Aristada, we think they might fit your search criteria.