Akynzeo
Treatment
2 FDA approvals
0 Active Studies for Akynzeo
What is Akynzeo
Netupitant
The Generic name of this drug
Treatment Summary
Palonosetron (brand name Aloxi) is a drug that helps prevent and treat nausea and vomiting caused by chemotherapy. It is the most effective medication of its kind to prevent delayed nausea and vomiting, which appears more than 24 hours after the first dose of chemotherapy. Palonosetron is the only drug in its class approved by the FDA for this use, and it was introduced in 2008.
Akynzeo
is the brand name
Akynzeo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Akynzeo
Netupitant
2014
2
Approved as Treatment by the FDA
Netupitant, also called Akynzeo, is approved by the FDA for 2 uses such as delayed chemotherapy-induced nausea and vomiting and acute chemotherapy-induced nausea and vomiting .
delayed chemotherapy-induced nausea and vomiting
Used to treat delayed chemotherapy-induced nausea and vomiting in combination with Palonosetron
acute chemotherapy-induced nausea and vomiting
Used to treat acute chemotherapy-induced nausea and vomiting in combination with Palonosetron
Effectiveness
How Akynzeo Affects Patients
Palonosetron is a medication used to reduce nausea and vomiting caused by chemotherapy or surgery. It works by blocking the effects of serotonin, a chemical in the body that stimulates a nerve in the brain that causes vomiting. Palonosetron is specifically designed to target serotonin 5-HT3 receptors, which are found on nerve endings in the stomach and brain. It has no effect on other receptors in the body. When chemotherapy causes damage to the stomach and intestines, it causes the release of serotonin which triggers the vomiting reflex, resulting in nausea and vomiting. Palonosetron helps to block this reflex and reduce these symptoms
How Akynzeo works in the body
Palonosetron is a drug that helps stop nausea and vomiting. It does this by blocking serotonin receptors in the brain and intestines, which in turn stops the stimulation of the vomiting center in the brain. Palonosetron also appears to be effective in preventing delayed nausea and vomiting caused by some cancer treatments. This is thought to be because the drug remains in the body for a long time, allowing it to continue to block serotonin receptors and prevent nausea and vomiting.
Warnings
There are 20 known major drug interactions with Akynzeo.
Common Akynzeo Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Netupitant.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Netupitant.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Netupitant.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Netupitant.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Netupitant.
Akynzeo Toxicity & Overdose Risk
A single injection of palonosetron at 30mg/kg was fatal for rats and mice. Signs of toxicity included convulsions, shallow breathing, paleness, blue skin, and unconsciousness.
Akynzeo Reviews: What are patients saying about Akynzeo?
5
Patient Review
6/12/2017
Akynzeo for Prevent Nausea and Vomiting from Cancer Chemotherapy
Patient Q&A Section about akynzeo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How long does Akynzeo take to work?
"The effects of Akynzeo last anywhere from 25 to 120 hours after treatment."
Answered by AI
What is Akynzeo used for?
"Akinzeo is a drug used to quell nausea and vomiting in adults with cancer who are undergoing chemotherapy treatments."
Answered by AI
How effective is Akynzeo?
"The majority of patients who took Akynzeo during highly emetogenic chemotherapy experienced no vomiting within 5 days, while 77% of patients taking palonosetron alone did not vomit."
Answered by AI