Adipex-P

Caloric Restriction, Obesity, Type 2 Diabetes + 6 more

Treatment

3 FDA approvals

20 Active Studies for Adipex-P

What is Adipex-P

Phentermine

The Generic name of this drug

Treatment Summary

Phentermine is a medication used to treat obesity. It was first introduced in 1959 and became popular in 1960. It is a chemical relative of amphetamine, but is not known to be addictive and has been classified as a drug with low abuse potential. Phentermine was approved for short-term weight management in 1959, but it was later discontinued after reports of abnormal valve growth in nearly 30% of consumers. In 2012, phentermine was approved alone and in combination with topiramate for a new weight loss treatment that requires lower doses of phentermine.

Ionamin

is the brand name

image of different drug pills on a surface

Adipex-P Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ionamin

Phentermine

1959

298

Approved as Treatment by the FDA

Phentermine, also known as Ionamin, is approved by the FDA for 3 uses including Obesity and Comorbidity .

Obesity

Used to treat Obesity in combination with Topiramate

Comorbidity

Used to treat one related comorbidity in combination with Topiramate

Regime of weight reduction

Effectiveness

How Adipex-P Affects Patients

Phentermine is a drug used to help with weight loss. It works by reducing appetite and increasing resting energy expenditure. Studies have shown that people taking phentermine lose an average of 3.6 kg over 2-24 weeks, and can maintain the weight loss after treatment is stopped. Unlike other amphetamines, phentermine does not cause any stimulation, elevated blood pressure, or other side effects.

How Adipex-P works in the body

Phentermine works by releasing a chemical called noradrenaline in the brain. This chemical stimulates certain receptors in the body, creating a "fight-or-flight" response which suppresses the hunger signal. It also weakly inhibits a chemical called monoamine oxidase, though this doesn't have a major effect.

When to interrupt dosage

The prescribed dose of Adipex-P is contingent upon the diagnosed condition, including Regime of weight reduction, Hyperlipidemia and Type 2 Diabetes. The quantity of dosage is dependent upon the technique of delivery (e.g. Oral or Tablet) as stated in the table below.

Condition

Dosage

Administration

Obesity

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Caloric Restriction

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Type 2 Diabetes

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Hypertensive disease

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

High Cholesterol

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Regime of weight reduction

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Chronic Weight Management therapy

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

increase in physical activity

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Comorbidity

, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg

Oral, , Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet - Oral, Tablet, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating

Warnings

Adipex-P Contraindications

Condition

Risk Level

Notes

Hyperthyroidism

Do Not Combine

concomitant use or 14 days after discontinuation

Do Not Combine

Agitation

Do Not Combine

Drug abuse

Do Not Combine

Cardiovascular Diseases

Do Not Combine

Open-angle glaucoma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Phentermine may interact with Pulse Frequency

There are 20 known major drug interactions with Adipex-P.

Common Adipex-P Drug Interactions

Drug Name

Risk Level

Description

Iobenguane

Major

Phentermine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.

Methylene blue

Major

Phentermine may increase the serotonergic activities of Methylene blue.

Mirtazapine

Major

Phentermine may increase the serotonergic activities of Mirtazapine.

1-benzylimidazole

Minor

The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Phentermine.

4-Methoxyamphetamine

Minor

The risk or severity of hypertension can be increased when Phentermine is combined with 4-Methoxyamphetamine.

Adipex-P Toxicity & Overdose Risk

The most toxic dose of phentermine in rats is 151mg/kg. Signs of acute overdose include restlessness, tremors, confusion, hallucinations, fatigue, depression, rapid heart rate, irregular heartbeat, high or low blood pressure, nausea, vomiting, diarrhea, and abdominal cramps. Long-term overdosage may lead to skin problems, difficulty sleeping, irritability, hyperactivity, and personality changes. There is no evidence that phentermine is carcinogenic or mutagenic.

image of a doctor in a lab doing drug, clinical research

Adipex-P Novel Uses: Which Conditions Have a Clinical Trial Featuring Adipex-P?

104 active trials are currently underway to determine the efficacy of Adipex-P for Type 2 Diabetes, Weight Loss Regimes and other Related Diseases.

Condition

Clinical Trials

Trial Phases

Type 2 Diabetes

98 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Obesity

0 Actively Recruiting

Hypertensive disease

0 Actively Recruiting

Comorbidity

0 Actively Recruiting

High Cholesterol

19 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Early Phase 1

Caloric Restriction

0 Actively Recruiting

Regime of weight reduction

0 Actively Recruiting

increase in physical activity

0 Actively Recruiting

Chronic Weight Management therapy

0 Actively Recruiting

Adipex-P Reviews: What are patients saying about Adipex-P?

5

Patient Review

4/26/2019

Adipex-P for Weight Loss Management for an Obese Person

I started this treatment when I was 18 years old, and it really helped me lose weight. I didn't have any major side effects, other than feeling thirsty and my heart rate being pretty fast at times. Unfortunately, I gained the weight back after a year of college. But I'm starting the treatment again now and am hopeful that I'll be able to lose the weight and keep it off this time around.

5

Patient Review

1/21/2020

Adipex-P for Overweight

Adipex has been a godsend. It completely suppressed my appetite and helped me lose 46lbs in just two months. I'm excited to see how much more weight I can lose now that I've started taking it again.

5

Patient Review

5/18/2021

Adipex-P for Overweight

I took this years ago and it was very effective. I went from 193 pounds to 119 pounds within several months while following a 1200 calorie diet and doing short workouts 2-3 days per week. I was able to keep the weight off for 8 years by halving the dose and taking the pill every 2-3 days for 30 days.

5

Patient Review

7/28/2021

Adipex-P for Overweight

I've been doing this meditation for about a month now, and I've already lost 21 pounds! When I first started, I had some side effects, but they went away after a little while. I'm really hoping to lose another 128 pounds, but even if I don't, I'm still happy with the progress I've made so far.

5

Patient Review

1/31/2022

Adipex-P for Weight Loss Management for Overweight Person with BMI 27 to 29 and Weight-Related Comorbidity

This medication was incredibly effective for me. I started at 238lbs and after three weeks of taking it, I had already lost 20lbs. However, I would not recommend taking it later than 8am as it will make it hard to sleep at night. Other than that, I've been really happy with the results and am currently on my second round.

5

Patient Review

5/12/2022

Adipex-P for Overweight

So far, I'm really happy with Adipex. In just one week, I lost nine pounds.

4.7

Patient Review

11/11/2019

Adipex-P for Overweight

Adipex is a popular weight loss drug that people regularly buy. You'll find many online sources that claim to sell the drug or drugs of a similar kind. It is very effective for weight loss.

4.7

Patient Review

1/9/2022

Adipex-P for Adjunct Treatment of Obesity in a Comprehensive Weight Reduction Regimen

I started this medication to lose weight because my extra weight was causing knee and foot pain. I started at 176lbs and after 2 1/2 months I am at 156. I have lost 20lbs with this medication along with daily exercise and nutrition. I have no thyroid and had not been able to lose weight before. The down side of this medication has been dry mouth, constipation, insomnia at first, and feeling like I have had too much caffeine; however, the pros far outweigh the cons in my opinion!

4

Patient Review

11/10/2022

Adipex-P for Weight Loss Management for Overweight Person with BMI 27 to 29 and Weight-Related Comorbidity

Adipex was a great help to me when I lost 110 pounds. Now, years later, I've kept the weight off and even lost more. However, my doctor had a problem with how long I took it for, so I stopped taking it for a few months. Starting again to make it a better experience.

2

Patient Review

10/9/2021

Adipex-P for Weight Gain

I would not recommend this treatment if you want to see any long-term weight loss. I gained all the weight back that I lost plus more after just three months off the medication.

1.7

Patient Review

9/18/2019

Adipex-P for Weight Loss Management for an Obese Person

This pill helped me to lose weight by decreasing my appetite, but it's been difficult to exercise in the heat this summer. In 10 weeks, I've lost 10lbs while drinking a lot of water and sticking to a diet. I'm also taking Lipo BC which is supposed to help burn fat, but I haven't seen any results from that yet. Any suggestions?
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about adipex-p

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Adipex-P the same as phentermine?

"There are two different forms of phentermine that are available as brand-name drugs: Adipex-P and Lomaira. Both of these drugs contain phentermine as the active ingredient, but they come in different strengths. Adipex-P is available as a 37.5 mg tablet or capsule."

Answered by AI

What drug class is Adipex-P?

"Adipex-P is a prescription medicine that is used to treat the symptoms of obesity. It may be used alone or with other medications. Adipex-P belongs to a class of drugs that are called CNS Stimulants, Anorectics; Stimulants; Sympathomimetics."

Answered by AI

How long does adipex take to lose weight?

"When taking phentermine, the average weight loss is 3% of your body weight after 3 months, and 5-7% after 6 months. Some people reported even more weight loss."

Answered by AI

Clinical Trials for Adipex-P

Image of Cleveland Clinic Foundation in Cleveland, United States.

Capsule Endoscopy for Bariatric Surgery Candidates

18+
All Sexes
Cleveland, OH

The goal of this clinical trial is to test if a swallowable camera capsule can safely examine the upper digestive tract in people preparing for weight loss surgery. The camera capsule (called NaviCam® Xpress™ Stomach System) is controlled by magnets from outside the body and doesn't require sedation, unlike traditional endoscopy. The main questions it aims to answer are: Can the camera capsule be safely used in people with a body mass index (BMI) greater than 38? Can doctors successfully control and move the camera capsule to see the necessary areas of the stomach and esophagus? Researchers will evaluate 30 participants who are preparing for weight loss surgery. Participants will: Swallow the camera capsule with water after not eating or drinking since midnight Have their upper digestive tract examined while the doctor controls the capsule from outside their body Complete a brief satisfaction survey about their experience Be followed up with a phone call 2-3 weeks after the procedure This study could help determine if the camera capsule is a good alternative to traditional endoscopy for people preparing for weight loss surgery, potentially avoiding the need for sedation.

Waitlist Available
Has No Placebo

Cleveland Clinic Foundation

Jerry Dang, MD, PhD

AnX Robotica Corp.

Image of University of Southern California in Los Angeles, United States.

Antibiotics for Diabetes with Bone Fractures

18+
All Sexes
Los Angeles, CA

The goal of this clinical trial is to learn if taking an antibiotic pill for 7 days after surgery reduces the risk of wound infection in adults with poorly controlled diabetes who have surgery to fix a broken bone in the leg, ankle, or foot. It will also learn about the safety of the extended antibiotic course. The main questions it aims to answer are: Does a 7-day antibiotic course after surgery lower the rate of wound infection within 90 days? What medical problems do participants have when taking the extended antibiotic course? Researchers will compare a 7-day course of an oral antibiotic (cefadroxil) to standard care (no additional antibiotics after surgery) to see if the extended course reduces infections. Participants will: Take an antibiotic pill or receive standard care for 7 days after surgery Receive a phone call from the study team about 1 week after surgery Visit the clinic at 3 weeks, 6 weeks, and 3 months after surgery for checkups

Phase 4
Recruiting

University of Southern California (+2 Sites)

Image of University of Missouri-Kansas City in Kansas City, United States.

Enhanced Diabetes Prevention Program for Prediabetes

18+
All Sexes
Kansas City, MO

The goal of this clinical trial is to learn if an enhanced, culturally, socially, and structurally tailored Diabetes Prevention Program (E-DPP) can improve weight loss and related diabetes risk factors in African American adults with prediabetes living in low-income, socially vulnerable communities. The main questions it aims to answer are: * Does the enhanced DPP (E-DPP) lead to greater percent weight loss at 6 and 12 months compared to the standard culturally tailored DPP (S-DPP)? * How do social determinants (e.g., food insecurity, stigma, access to resources) influence weight loss and engagement in lifestyle behaviors? Researchers will compare a standard culturally tailored DPP (S-DPP) to an enhanced DPP (E-DPP) to see if improving access to healthy food, physical activity, and community resources increases weight loss and improves diabetes-related outcomes. Participants will 1. Attend DPP sessions delivered in community settings (e.g., churches) 2. Receive lifestyle education focused on diet, physical activity, and weight loss 3. Engage in physical activity (including in-class exercise sessions \[E-DPP only\] and community-based options) 4. Receive support for healthy eating, including food deliveries (\[E-DPP only\]), food selection guidance, and referrals to food assistance programs 5. Receive information and support for accessing community resources for food and physical activity

Waitlist Available
Has No Placebo

University of Missouri-Kansas City

Jenifer E Jenifer, PhD

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Image of Kaiser Permenante Northern California in Pleasant Hill, United States.

Messaging Strategies for Cardiovascular Disease

18+
All Sexes
Pleasant Hill, CA

The goal of the ADHERE-ASCVD study is to evaluate and optimize patient-facing messaging strategies to improve statin refill and adherence among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes. The main questions it aims to answer are: 1. Do different outreach methods (such as text messages, secure portal messages, or email) increase short-term statin refill compared to usual care? 2. Among patients who do not initially refill their prescription, does changing the outreach method improve refill rates? The team with operational partners will evaluate the comparitive effectivessness of multiple messaging strategies delivered through existing health system communication channels, including SMS (text messaging), secure patient portal messages, non-secure email, and usual care (no additional outreach). Participants * Receive an initial outreach message encouraging statin refill (or usual care) Be monitored for statin refill within 14 days * Potentially receive a second outreach message using the same or a different communication method if they do not initially refill their prescription * Have their medication refill patterns tracked over time, including longer-term adherence outcomes

Waitlist Available
Has No Placebo

Kaiser Permenante Northern California

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Pharmacist-led Care for Diabetes

18+
All Sexes
Edmonton, Canada

As of 2024, nine percent of Albertans are living with Type 2 diabetes, which increases their risk for cardiovascular disease, stroke, blindness, and kidney failure. Unfortunately, less than half of patients have controlled Type 2 diabetes. We are well aware of the factors which lead to worsening diabetes, but need to give people more support to help them manage their diabetes. Pharmacists are respected health care professionals who are often easier to see that doctors and can help people with diabetes to stay as healthy as possible. This research project aims to see whether a pharmacist service can help improve diabetes management in people with type 2 diabetes compared to usual care from their family physician or nurse practitionner. The potential impact of this project is to empower people with type 2 diabetes to understand their condition, it's management, and to achieve target blood sugar levels, which will ultimately reduce the risk of diabetes-related complications.

Recruiting
Has No Placebo

University of Alberta

Ross Tsuyuki, BScPharm, PharmD, MSc

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