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What is Adipex-P
PhentermineThe Generic name of this drug
Treatment SummaryPhentermine is a medication used to treat obesity. It was first introduced in 1959 and became popular in 1960. It is a chemical relative of amphetamine, but is not known to be addictive and has been classified as a drug with low abuse potential. Phentermine was approved for short-term weight management in 1959, but it was later discontinued after reports of abnormal valve growth in nearly 30% of consumers. In 2012, phentermine was approved alone and in combination with topiramate for a new weight loss treatment that requires lower doses of phentermine.
Ionaminis the brand name
Adipex-P Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ionamin
Phentermine
1959
298
Approved as Treatment by the FDA
Phentermine, also known as Ionamin, is approved by the FDA for 2 uses including Regime of weight reduction and Comorbidity .Regime of weight reduction
Comorbidity
Used to treat one related comorbidity in combination with Topiramate
Effectiveness
How Adipex-P Affects PatientsPhentermine is a drug used to help with weight loss. It works by reducing appetite and increasing resting energy expenditure. Studies have shown that people taking phentermine lose an average of 3.6 kg over 2-24 weeks, and can maintain the weight loss after treatment is stopped. Unlike other amphetamines, phentermine does not cause any stimulation, elevated blood pressure, or other side effects.
How Adipex-P works in the bodyPhentermine works by releasing a chemical called noradrenaline in the brain. This chemical stimulates certain receptors in the body, creating a "fight-or-flight" response which suppresses the hunger signal. It also weakly inhibits a chemical called monoamine oxidase, though this doesn't have a major effect.
When to interrupt dosage
The prescribed dose of Adipex-P is contingent upon the diagnosed condition, including Regime of weight reduction, Hyperlipidemia and Type 2 Diabetes. The quantity of dosage is dependent upon the technique of delivery (e.g. Oral or Tablet) as stated in the table below.Condition
Dosage
Administration
increase in physical activity
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Type 2 Diabetes
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
High Cholesterol
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Regime of weight reduction
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Comorbidity
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Caloric Restriction
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Hypertensive disease
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
BMI >27 kg/m2
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Chronic Weight Management therapy
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Warnings
Adipex-P ContraindicationsCondition
Risk Level
Notes
Hyperthyroidism
Do Not Combine
concomitant use or 14 days after discontinuation
Do Not Combine
Agitation
Do Not Combine
Drug abuse
Do Not Combine
Cardiovascular Diseases
Do Not Combine
Open-angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Phentermine may interact with Pulse Frequency
Common Adipex-P Drug Interactions
Drug Name
Risk Level
Description
Iobenguane
Major
Phentermine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylene blue
Major
Phentermine may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Phentermine may increase the serotonergic activities of Mirtazapine.
1-benzylimidazole
Minor
The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Phentermine.
4-Methoxyamphetamine
Minor
The risk or severity of hypertension can be increased when Phentermine is combined with 4-Methoxyamphetamine.
Adipex-P Toxicity & Overdose RiskThe most toxic dose of phentermine in rats is 151mg/kg. Signs of acute overdose include restlessness, tremors, confusion, hallucinations, fatigue, depression, rapid heart rate, irregular heartbeat, high or low blood pressure, nausea, vomiting, diarrhea, and abdominal cramps. Long-term overdosage may lead to skin problems, difficulty sleeping, irritability, hyperactivity, and personality changes. There is no evidence that phentermine is carcinogenic or mutagenic.
Adipex-P Novel Uses: Which Conditions Have a Clinical Trial Featuring Adipex-P?
104 active trials are currently underway to determine the efficacy of Adipex-P for Type 2 Diabetes, Weight Loss Regimes and other Related Diseases.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
93 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Regime of weight reduction
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
High Cholesterol
20 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4, Early Phase 1
BMI >27 kg/m2
0 Actively Recruiting
increase in physical activity
0 Actively Recruiting
Comorbidity
0 Actively Recruiting
Adipex-P Reviews: What are patients saying about Adipex-P?
5Patient Review
4/26/2019 I started this treatment when I was 18 years old, and it really helped me lose weight. I didn't have any major side effects, other than feeling thirsty and my heart rate being pretty fast at times. Unfortunately, I gained the weight back after a year of college. But I'm starting the treatment again now and am hopeful that I'll be able to lose the weight and keep it off this time around.
5Patient Review
1/21/2020 Adipex has been a godsend. It completely suppressed my appetite and helped me lose 46lbs in just two months. I'm excited to see how much more weight I can lose now that I've started taking it again.
5Patient Review
5/18/2021 I took this years ago and it was very effective. I went from 193 pounds to 119 pounds within several months while following a 1200 calorie diet and doing short workouts 2-3 days per week. I was able to keep the weight off for 8 years by halving the dose and taking the pill every 2-3 days for 30 days.
5Patient Review
7/28/2021 I've been doing this meditation for about a month now, and I've already lost 21 pounds! When I first started, I had some side effects, but they went away after a little while. I'm really hoping to lose another 128 pounds, but even if I don't, I'm still happy with the progress I've made so far.
5Patient Review
1/31/2022 This medication was incredibly effective for me. I started at 238lbs and after three weeks of taking it, I had already lost 20lbs. However, I would not recommend taking it later than 8am as it will make it hard to sleep at night. Other than that, I've been really happy with the results and am currently on my second round.
5Patient Review
5/12/2022 So far, I'm really happy with Adipex. In just one week, I lost nine pounds.
4.7Patient Review
11/11/2019 Adipex is a popular weight loss drug that people regularly buy. You'll find many online sources that claim to sell the drug or drugs of a similar kind. It is very effective for weight loss.
4.7Patient Review
1/9/2022 I started this medication to lose weight because my extra weight was causing knee and foot pain. I started at 176lbs and after 2 1/2 months I am at 156. I have lost 20lbs with this medication along with daily exercise and nutrition. I have no thyroid and had not been able to lose weight before. The down side of this medication has been dry mouth, constipation, insomnia at first, and feeling like I have had too much caffeine; however, the pros far outweigh the cons in my opinion!
4Patient Review
11/10/2022 Adipex was a great help to me when I lost 110 pounds. Now, years later, I've kept the weight off and even lost more. However, my doctor had a problem with how long I took it for, so I stopped taking it for a few months. Starting again to make it a better experience.
2Patient Review
10/9/2021 I would not recommend this treatment if you want to see any long-term weight loss. I gained all the weight back that I lost plus more after just three months off the medication.
1.7Patient Review
9/18/2019 This pill helped me to lose weight by decreasing my appetite, but it's been difficult to exercise in the heat this summer. In 10 weeks, I've lost 10lbs while drinking a lot of water and sticking to a diet. I'm also taking Lipo BC which is supposed to help burn fat, but I haven't seen any results from that yet. Any suggestions?
Patient Q&A Section about adipex-p
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Adipex-P the same as phentermine?
"There are two different forms of phentermine that are available as brand-name drugs: Adipex-P and Lomaira. Both of these drugs contain phentermine as the active ingredient, but they come in different strengths. Adipex-P is available as a 37.5 mg tablet or capsule."
Answered by AI
What drug class is Adipex-P?
"Adipex-P is a prescription medicine that is used to treat the symptoms of obesity. It may be used alone or with other medications. Adipex-P belongs to a class of drugs that are called CNS Stimulants, Anorectics; Stimulants; Sympathomimetics."
Answered by AI
How long does adipex take to lose weight?
"When taking phentermine, the average weight loss is 3% of your body weight after 3 months, and 5-7% after 6 months. Some people reported even more weight loss."
Answered by AI