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What is Actoplus Met
PioglitazoneThe Generic name of this drug
Treatment SummaryPioglitazone is a medication used to treat type 2 diabetes. It is usually taken alongside diet, exercise, and other diabetes medications. Pioglitazone works by increasing the body's sensitivity to insulin and allowing for increased uptake of glucose from the blood. It belongs to a class of medications called thiazolidinediones, which also includes rosiglitazone and troglitazone. Although it is effective in treating type 2 diabetes, it has been linked to several adverse effects and warnings, including an increased risk of heart failure and bladder cancer. Therefore, newer and safer alternatives are now available for patients
Actosis the brand name
Actoplus Met Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actos
Pioglitazone
1999
257
Effectiveness
How Actoplus Met Affects PatientsPioglitazone helps the body better respond to insulin, which improves the way the body processes sugar. This drug can help lower blood glucose, insulin, and HbA1c levels in people with type 2 diabetes. However, it can also cause fluid retention, which can lead to heart failure, so it should be avoided in patients at risk of developing heart failure. Additionally, taking pioglitazone may increase the risk of developing bladder cancer, so it should not be used in patients with active bladder cancer and should be used with caution in those with a history of bladder cancer.
How Actoplus Met works in the bodyPioglitazone helps your body process sugar and fat. It works by activating a protein called peroxisome proliferator-activated receptor gamma (PPARγ). This protein helps your body use insulin more effectively, which lowers your blood sugar levels. It also reduces the amount of sugar your liver produces, improving the insulin resistance associated with type 2 diabetes mellitus.
When to interrupt dosage
The recommended dosage of Actoplus Met is contingent upon the identified malady, including Diet, Physical Activity and Type 2 Diabetes. Dosage likewise is contingent upon the delivery approach (e.g. Tablet, film coated or Tablet, film coated - Oral) featured in the table beneath.Condition
Dosage
Administration
Type 2 Diabetes
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diabetic Neuropathy
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diet
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Type 2 Diabetes
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Physical Activity
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Warnings
Actoplus Met ContraindicationsCondition
Risk Level
Notes
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
uninvestigated macroscopic hematuria
Do Not Combine
Urinary Bladder
Do Not Combine
Urinary Bladder
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pioglitazone may interact with Pulse Frequency
Common Actoplus Met Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Pioglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Pioglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Pioglitazone.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Pioglitazone.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Pioglitazone.
Actoplus Met Toxicity & Overdose RiskIn mice, the lowest toxic dose of pioglitazone was found to be 24mg/kg for 4 days, and in rats the lowest toxic dose was 3mg/kg for 6 days. In one case, a patient took an overdose of pioglitazone, 120mg daily for 4 days followed by 180mg daily for 7 days, without reporting any negative symptoms. If someone takes an overdose of pioglitazone, medical attention should be sought and the patient should be monitored for any symptoms.
Actoplus Met Novel Uses: Which Conditions Have a Clinical Trial Featuring Actoplus Met?
300 active trials are presently underway to analyze the potential of Actoplus Met in managing Type 2 Diabetes, controlling Type 2 Diabetes and promoting Physical Activity.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
92 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diabetic Neuropathy
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Diet
5 Actively Recruiting
Not Applicable
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Actoplus Met Reviews: What are patients saying about Actoplus Met?
5Patient Review
4/25/2010 I was on steroids and developed diabetes. My doctor put me on Actoplus and my sugar levels have been normal for the past 4 months. I'm now off of steroids, but why do I still have to take this medication?
5Patient Review
12/31/20095Patient Review
1/14/2010 I had really severe diarrhea, but my sugar levels were totally fine.
4.7Patient Review
5/30/2013 No issues thus far.
4.3Patient Review
10/20/2010 This medication has been effective in controlling my symptoms and keeping my A1C levels in check. However, I have occasionally experienced an upset stomach and diarrhea. Overall, though, it has been a helpful medication that I have been taking for over a year now.
4.3Patient Review
3/17/2010 This medication is really easy to use, which I appreciate.
4.3Patient Review
9/10/2011 Following my doctor's recommendation.
4Patient Review
7/8/2010 This medicine has been great for my blood sugar levels, but I've been feeling really nauseous lately and tonight I started throwing up. Does anyone else have this problem?
3.7Patient Review
9/14/2010 I am a senior citizen and I've found that this is the best medication to control my blood sugar. However, it's quite expensive and I can't afford it at $218 a pop. If there's any way you could help me out, I would really appreciate it as I'm struggling to pay for all of my medications. Thank you.
3.7Patient Review
1/13/20103.3Patient Review
11/27/20093Patient Review
2/26/2010 I was originally worried about my sugar levels, but after getting checked out at the ER, I found out that this treatment really helped lower it down within a few weeks.
3Patient Review
8/24/2011 This medication did a fair job of managing my blood sugar levels. However, I started having other symptoms almost immediately after starting to take it. These included weight gain, swollen feet and fatigue. I felt much better when I wasn't taking the medication and lost weight and had more energy. But my blood sugar numbers were high and out of control.
3Patient Review
5/30/2015 This medication unfortunately had some really unpleasant side effects for me. It made it so that I was constantly hungry, gave me diarrhea, and just generally made me feel terrible.
3Patient Review
10/26/2010 I've been taking this medication for a few months now and it has helped to regulate my sugar levels. However, I've recently started having issues with pain in my joints, particularly my hips, which is impacting my ability to walk. I'm hoping to lose weight so that I can get off the medication, but the jitteriness makes it difficult to exercise.
2.3Patient Review
2/10/2013 I took Actosplus for a few years and experienced some serious side effects, like my leg breaking. I also gained weight (17 pounds), and had trouble breathing. I finally stopped taking it after my leg broke.
1.3Patient Review
10/12/2013 Absolutely horrible experience. Gained 45 pounds, felt pain in my liver constantly, and my A1c was out of control. I felt terrible all the time - digestive problems and diarrhea nonstop. As soon as I went off the medication, I lost weight and felt 100% better. My doctor insisted I go back on it and now I feel horrible again.
Patient Q&A Section about actoplus met
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Actoplus Met used for?
"Actoplus Met contains two oral diabetes medicines, metformin and pioglitazone, which work together to help control blood sugar levels. It is most effective when used in conjunction with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections."
Answered by AI
Is Actoplus Met XR discontinued?
"The product ActoPlus Met XR has been discontinued and is no longer available in the United States. However, if the FDA has approved generic versions of this product, there may be generic equivalents available."
Answered by AI
What is the generic name for Actoplus Met?
"The medication known as Actos can also be referred to by its generic name, pioglitazone. A generic drug is an identical copy of the active drug found in a brand-name medication."
Answered by AI
What type of drug is Actoplus Met?
"Type 2 diabetes Mellitus is a condition that can be treated with the medication Actoplus MET. This medication may be used by itself or in combination with other drugs. Actoplus MET is classified as a Biguanides/Thiazolidinediones drug, which is a type of Antidiabetic medication. The safety and effectiveness of this drug has not been studied in children."
Answered by AI