Actoplus Met

Type 2 Diabetes, Diabetic Neuropathy, Physical Activity + 2 more
Treatment
20 Active Studies for Actoplus Met

What is Actoplus Met

PioglitazoneThe Generic name of this drug
Treatment SummaryPioglitazone is a medication used to treat type 2 diabetes. It is usually taken alongside diet, exercise, and other diabetes medications. Pioglitazone works by increasing the body's sensitivity to insulin and allowing for increased uptake of glucose from the blood. It belongs to a class of medications called thiazolidinediones, which also includes rosiglitazone and troglitazone. Although it is effective in treating type 2 diabetes, it has been linked to several adverse effects and warnings, including an increased risk of heart failure and bladder cancer. Therefore, newer and safer alternatives are now available for patients
Actosis the brand name
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Actoplus Met Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actos
Pioglitazone
1999
257

Effectiveness

How Actoplus Met Affects PatientsPioglitazone helps the body better respond to insulin, which improves the way the body processes sugar. This drug can help lower blood glucose, insulin, and HbA1c levels in people with type 2 diabetes. However, it can also cause fluid retention, which can lead to heart failure, so it should be avoided in patients at risk of developing heart failure. Additionally, taking pioglitazone may increase the risk of developing bladder cancer, so it should not be used in patients with active bladder cancer and should be used with caution in those with a history of bladder cancer.
How Actoplus Met works in the bodyPioglitazone helps your body process sugar and fat. It works by activating a protein called peroxisome proliferator-activated receptor gamma (PPARγ). This protein helps your body use insulin more effectively, which lowers your blood sugar levels. It also reduces the amount of sugar your liver produces, improving the insulin resistance associated with type 2 diabetes mellitus.

When to interrupt dosage

The recommended dosage of Actoplus Met is contingent upon the identified malady, including Diet, Physical Activity and Type 2 Diabetes. Dosage likewise is contingent upon the delivery approach (e.g. Tablet, film coated or Tablet, film coated - Oral) featured in the table beneath.
Condition
Dosage
Administration
Type 2 Diabetes
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diabetic Neuropathy
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Type 2 Diabetes
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Physical Activity
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diet
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique

Warnings

Actoplus Met Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
uninvestigated macroscopic hematuria
Do Not Combine
Urinary Bladder
Do Not Combine
Urinary Bladder
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pioglitazone may interact with Pulse Frequency
There are 20 known major drug interactions with Actoplus Met.
Common Actoplus Met Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Pioglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Pioglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Pioglitazone.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Pioglitazone.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Pioglitazone.
Actoplus Met Toxicity & Overdose RiskIn mice, the lowest toxic dose of pioglitazone was found to be 24mg/kg for 4 days, and in rats the lowest toxic dose was 3mg/kg for 6 days. In one case, a patient took an overdose of pioglitazone, 120mg daily for 4 days followed by 180mg daily for 7 days, without reporting any negative symptoms. If someone takes an overdose of pioglitazone, medical attention should be sought and the patient should be monitored for any symptoms.
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Actoplus Met Novel Uses: Which Conditions Have a Clinical Trial Featuring Actoplus Met?

300 active trials are presently underway to analyze the potential of Actoplus Met in managing Type 2 Diabetes, controlling Type 2 Diabetes and promoting Physical Activity.
Condition
Clinical Trials
Trial Phases
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Type 2 Diabetes
174 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diabetic Neuropathy
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Type 2 Diabetes
89 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Actoplus Met Reviews: What are patients saying about Actoplus Met?

5Patient Review
4/25/2010
Actoplus Met for Type 2 Diabetes Mellitus
I was on steroids and developed diabetes. My doctor put me on Actoplus and my sugar levels have been normal for the past 4 months. I'm now off of steroids, but why do I still have to take this medication?
5Patient Review
12/31/2009
Actoplus Met for Type 2 Diabetes Mellitus
5Patient Review
1/14/2010
Actoplus Met for Type 2 Diabetes Mellitus
I had really severe diarrhea, but my sugar levels were totally fine.
4.7Patient Review
5/30/2013
Actoplus Met for Type 2 Diabetes Mellitus
No issues thus far.
4.3Patient Review
10/20/2010
Actoplus Met for Type 2 Diabetes Mellitus
This medication has been effective in controlling my symptoms and keeping my A1C levels in check. However, I have occasionally experienced an upset stomach and diarrhea. Overall, though, it has been a helpful medication that I have been taking for over a year now.
View All Reviews
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Patient Q&A Section about actoplus met

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Actoplus Met used for?

"Actoplus Met contains two oral diabetes medicines, metformin and pioglitazone, which work together to help control blood sugar levels. It is most effective when used in conjunction with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections."

Answered by AI

Is Actoplus Met XR discontinued?

"The product ActoPlus Met XR has been discontinued and is no longer available in the United States. However, if the FDA has approved generic versions of this product, there may be generic equivalents available."

Answered by AI

What is the generic name for Actoplus Met?

"The medication known as Actos can also be referred to by its generic name, pioglitazone. A generic drug is an identical copy of the active drug found in a brand-name medication."

Answered by AI

What type of drug is Actoplus Met?

"Type 2 diabetes Mellitus is a condition that can be treated with the medication Actoplus MET. This medication may be used by itself or in combination with other drugs. Actoplus MET is classified as a Biguanides/Thiazolidinediones drug, which is a type of Antidiabetic medication. The safety and effectiveness of this drug has not been studied in children."

Answered by AI

Clinical Trials for Actoplus Met

Have you considered Actoplus Met clinical trials? We made a collection of clinical trials featuring Actoplus Met, we think they might fit your search criteria.
Have you considered Actoplus Met clinical trials? We made a collection of clinical trials featuring Actoplus Met, we think they might fit your search criteria.
Have you considered Actoplus Met clinical trials? We made a collection of clinical trials featuring Actoplus Met, we think they might fit your search criteria.
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