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Norditropin vs Humatrope

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Norditropin Details

Humatrope Details


Norditropin Prescription Information

Humatrope Prescription Information

Norditropin Side Effects

Humatrope Side Effects

Safety Information


Market Information


For patients with growth hormone deficiencies, certain medications can help stimulate growth and development. Norditropin and Humatrope are two such drugs that are often prescribed for this condition. These synthetic hormones work by supplementing or replacing the growth hormone in the body. Norditropin is a biosynthetic human growth hormone used to treat children with growth problems due to inadequate endogenous Growth Hormone secretion, Turner syndrome, Chronic renal insufficiency (CRI), Short stature in small for gestational age (SGA) children, and adults with pronounced GH deficiency. On the other hand, Humatrope is also a human-made form of human growth hormone indicated primarily for children who do not make enough natural substance or those with Prader-Willi syndrome, short stature at birth without catch-up growth, or other causes.

Norditropin vs Humatrope Side By Side

Brand NameNorditropinHumatrope
ContraindicationsAllergy/hypersensitivity to somatropin or its excipients, active tumors/cancers, acute critical illness due to complications following open heart surgery/abdominal surgery/multiple accidental trauma/severe respiratory failureAllergy/hypersensitivity to somatropin or its excipients, active tumors/cancers, acute critical illness due to complications following open heart surgery/abdominal surgery/multiple accidental trauma/severe respiratory failure
CostAround $800 for one Norditropin FlexPro Pen (10 mg/1.5 mL), which works out to $26–$53/day depending on doseAround $420 for one Humatrope Cartridge (6 mg), working out to approximately $14/day
Generic NameSomatropinSomatropin
Most Serious Side EffectIncreased risk of developing diabetes, signs of allergic reactions, changes in eyesight, symptoms of a heart condition, low adrenal gland hormones, increased pressure in the brain, hypothyroidismSigns of allergic reaction, swelling in your hands and feet, changes in behavior or mood swings, persistent nausea or vomiting, vision changes, unusual heartbeat rhythms
Severe Drug InteractionsNot specifically mentioned, but it's important to inform your doctor about all medical conditions and medicines you take due to potential interactionsNot specifically mentioned, but it's important to inform your doctor about all medical conditions and medicines you take due to potential interactions
Typical DoseDosages range from 0.024 to 0.034 mg/kg/day for children and adolescentsBegins with a low dosage, often around 0.006 mg/kg daily, with a maximum dosage usually not exceeding 0.0125 mg/kg per day

What is Norditropin?

Norditropin and Humatrope are two different brands of synthetic human growth hormones, used for treating various conditions such as growth hormone deficiency in both children and adults, Turner's syndrome, chronic renal insufficiency in prepubertal patients, idiopathic short stature, Noonan syndrome among other conditions. Norditropin is a product of Novo Nordisk that was first approved by the FDA in 1995 while Humatrope is made by Eli Lilly and Company and was first approved in 1987. Both these drugs work to stimulate bone growth and improve metabolism but their influence varies slightly due to minor differences in their formulation which can affect their bioavailability. Therefore it is crucial to note that even though they serve similar purposes, they might have different side effects or efficacy rates depending on individual patient's responses.

What conditions is Norditropin approved to treat?

Norditropin is used for the treatment of various growth-related conditions, including:

  • Growth hormone deficiency (GHD) in children and adults
  • Turner syndrome (a genetic disorder affecting girls)
  • Short stature homeobox-containing gene (SHOX) deficiency
  • Children born small for gestational age (SGA) with no catch-up growth by age 2 to 4 years
  • Idiopathic short stature (ISS), a term for short stature that does not have a known cause.

How does Norditropin help with these illnesses?

Norditropin aids in managing growth hormone deficiencies by introducing additional biosynthetic human growth hormone into the body. It performs this role by mimicking the effect of natural human growth hormone, which is produced by the pituitary gland and plays vital roles in cellular repair, metabolism and growth. Growth Hormone Deficiency (GHD) can lead to a variety of physical effects such as decreased muscle mass, low energy levels, and abnormal fat accumulation. Therefore, Norditropin works to compensate for lower levels of naturally occurring HGH in individuals with GHD - helping them improve their physique and overall vitality.

On the other hand, Humatrope also serves a similar function. It too is a recombinant form of human growth hormone used to treat children who are growing slowly because they do not make enough growth hormone on their own. Both these medications have similar indications but might differ slightly based on individual patient factors like age, underlying conditions or even preference due to different modes of administration.

What is Humatrope?

Humatrope is a brand name for somatropin, which is a human growth hormone. It functions by stimulating growth in the body's cells and tissues. This makes it an important treatment for children who have certain types of growth disorders (such as Turner syndrome or idiopathic short stature) and adults with growth hormone deficiency.

Somatropin was first approved by the FDA in 1987 under the brand name Humatrope. As somatropin does not affect other hormones such as serotonin, its side-effects differ from those of drugs that do. Common side effects include joint pain, muscle ache, and swelling of hands or feet rather than sedation, weight gain or sexual dysfunction seen with SSRIs like Prozac.

The way Humatrope works to stimulate physical growth can be particularly helpful for patients who don't respond well to more traditional treatments for their particular condition.

What conditions is Humatrope approved to treat?

Humatrope is an FDA-approved prescription medication for the treatment of various growth hormone-related disorders, including:

  • Pediatric patients who have growth failure due to inadequate secretion of endogenous growth hormone (GH)
  • Adults with either childhood-onset or adult-onset GH deficiency

How does Humatrope help with these illnesses?

Human Growth Hormone (HGH) is a hormone that plays an integral role in growth, body composition, cell repair, and metabolism. Low levels of HGH can lead to various health issues including decreased muscle mass and bone density. Humatrope works by supplementing or replacing the naturally produced HGH in the body, thereby helping to maintain normal growth in children who are deficient and improving overall bodily functions in adults with low HGH levels. Its action on cellular regeneration and metabolic processes also play roles in its effectiveness as a treatment for HGH deficiency. Since it does not significantly affect insulin-like growth factors like Norditropin does, it might be prescribed when a patient has certain contraindications or may be combined with other treatments under particular circumstances.

How effective are both Norditropin and Humatrope?

Both Norditropin and Humatrope are synthetic forms of human growth hormone, used to treat conditions associated with growth hormone deficiency. They were introduced by the FDA in 1987 and 1998 respectively, offering a therapeutic option for patients who experience short stature or poor growth due to insufficient endogenous production of this vital hormone.

In comparative clinical trials, both drugs have demonstrated similar efficacy in promoting statural growth as well as overall safety profiles. None of the different metrics studied to measure efficacy in stimulating longitudinal bone development showed significant differences between patients receiving Norditropin versus those receiving Humatrope.

A review of available literature on Norditropin suggests that it is effective from the early stages of treatment, with an acceptable side effect profile comparable to other similar medications. It has become one of the most prescribed brands worldwide among children requiring therapy for idiopathic short stature or other pediatric growth disorders.

Conversely, clinical studies demonstrate that Humatrope seems equally effective compared to placebo groups in treating children with hypopituitarism or Turner's syndrome. However, usage tends towards being a secondary option after initial treatment attempts fail or prove inadequate. Data verifying its effectiveness as a stand-alone therapy is less comprehensive than that for Norditropin; frequently it’s co-prescribed alongside adjunct therapies such as aromatase inhibitors when accelerated epiphyseal maturation threatens final adult height outcome. Nonetheless due to its unique pharmacokinetics and molecular formulation which closely mimics natural human GH structure -Humatrope could be better tailored for certain patient groups who may not respond optimally to first-line treatments or need specific titration requirements.

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At what dose is Norditropin typically prescribed?

Dosages of Norditropin typically range from 0.024 to 0.034 mg/kg/day for treating growth hormone deficiency in children and adolescents, although studies have suggested that a dose as low as 0.017 mg/kg/day can be effective. Similarly with Humatrope, the dosage usually lies between 0.18 - 0.3mg/kg/week administered daily by subcutaneous injection in divided doses; however, it's always important to start at a lower dose and gradually increase based on individual patient requirements under close medical supervision. In either case, if there is no response after several months of therapy, your doctor may consider adjusting the dosage accordingly but exceeding the maximum recommended dosage is not advisable due to potential side effects.

At what dose is Humatrope typically prescribed?

Humatrope therapy typically begins with a low dosage, often around 0.006 mg/kg daily. The dose can then be gradually increased based on individual patient responses to treatment. Maximum dosage usually does not exceed 0.0125 mg/kg per day. Increase in dosages are administered in two to three separate injections throughout the day, spaced evenly apart. If there is no response or inadequate response to treatment at this level after a certain period, your healthcare provider may consider adjusting the dose further until optimal results are achieved.

What are the most common side effects for Norditropin?

Common side effects of Norditropin may include:

  • Injection site reactions (redness, soreness, swelling)
  • Headache
  • Swelling due to fluid retention
  • Joint or muscle pain
  • Numbness and tingling sensations
  • Unusual skin sensations
  • Carpal tunnel syndrome symptoms (numbness/tingling in the hands, weakness in hand grip)

Conversely, Humatrope may lead to:

  • Mild rash at the injection site
  • Swelling (especially of your hands or feet)
  • Muscle pain and joint stiffness or ache
  • Cold symptoms such as stuffy nose, sneezing and a sore throat
  • Upper respiratory infection

It is important to note that both medications can have more serious side effects. If you notice sudden changes in mood or behavior, vision problems, limping or hip/knee pain while using these drugs seek immediate medical attention.

abstract image of a patient experiencing side effect

Are there any potential serious side effects for Norditropin?

When comparing Norditropin to Humatrope, the potential side effects can be quite serious. For both of these growth hormone medications, you should watch for:

  • Signs of allergic reactions: such as hives, difficulty breathing or swallowing, swelling in your face or throat
  • Changes in eyesight: including blurred vision and seeing halos around lights
  • Symptoms of a heart condition: like rapid or pounding heartbeat, chest discomfort, shortness of breath and sudden dizziness; it's worth noting that these drugs may also increase the risk of developing diabetes.
  • Low adrenal gland hormones: which could result in severe fatigue, loss of appetite, weight loss or skin darkening
  • Increased pressure in the brain symptoms - severe headache combined with nausea/vomiting/eye pain/swelling/double vision
  • Hypothyroidism (low thyroid hormone levels) signs - unexplained tiredness/weight gain/hair thinning/cold sensitivity/slow speech/dry skin

In case you experience any such symptoms while on either medication regimen, discontinue use and seek immediate medical attention.

What are the most common side effects for Humatrope?

Humatrope, a synthetic human growth hormone, can potentially cause the following side effects:

  • Swelling of hands and feet due to fluid retention
  • Joint pain or stiffness
  • Muscular discomfort or myalgia
  • Itching or skin rashes at the injection site
  • Headaches and dizziness
  • Unusual tiredness or weakness
  • Nausea, vomiting, stomach discomfort
  • Changes in appetite
  • Sleep problems such as insomnia Increased frequency of urination.

It is important to note that these side effects may not occur in all individuals taking Humatrope but it's always prudent to consult your healthcare provider if you experience any unusual symptoms after starting this medication.

Are there any potential serious side effects for Humatrope?

Humatrope is generally safe when used appropriately, but it can cause some serious side effects in rare cases. These may include:

  • Signs of allergic reaction, such as hives, itching, rash or difficulty breathing
  • Swelling in your hands and feet
  • Changes in behavior or mood swings
  • Persistent nausea or vomiting
  • Vision changes like blurred vision
  • Unusual heartbeat rhythms; either too fast or too slow.

If you experience any of these symptoms after taking Humatrope, discontinue use and contact a healthcare professional immediately for advice.

Contraindications for Norditropin and Humatrope?

Similar to other growth hormones, Norditropin and Humatrope can occasionally cause undesirable side effects. If you observe symptoms like rapid weight gain, severe pain in the upper stomach spreading to your back with nausea and vomiting, swelling in hands or feet, changes in behavior or mood swings, high blood sugar (increased thirst or hunger), increased pressure inside skull (severe headaches, ringing in ears), vision problems including blurred vision and limping/walking with a limp due to hip/ knee pain after starting on these medications immediately contact your healthcare provider.

Norditropin and Humatrope should not be used by patients who have had an allergy/hypersensitivity to somatropin or any of its excipients. They are also contraindicated for those suffering from active tumors/cancers since they might potentially stimulate their growth. Patients with acute critical illness due to complications following open heart surgery/abdominal surgery/multiple accidental trauma/severe respiratory failure are also advised against using them until they stabilize.

Make sure you inform your doctor about all medical conditions before commencing treatment including diabetes; underactive thyroid; history of tumor/cancer; Prader-Willi syndrome that is complicated by sleep apnea/obesity/severe breathing problems; scoliosis etc., as well as all medicines you take as there could be potential interactions between them.

How much do Norditropin and Humatrope cost?

For the brand name versions of these growth hormone drugs:

  • The price for one Norditropin FlexPro Pen (10 mg/1.5 mL) averages around $800, which works out to $26–$53/day, depending on your dose.
  • The price for one Humatrope Cartridge (6 mg) averages around $420, working out to approximately $14/day.

Thus, if you are in the higher dosage range for Norditropin (i.e., 0.3 mg/kg/week), then brand-name Humatrope is less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which of these drugs is right for you.

It's important to mention that there are no generic versions available for either Norditropin or Humatrope due to their complex structure and production process as biopharmaceuticals; therefore costs remain relatively high compared with small-molecule pharmaceuticals.

Popularity of Norditropin and Humatrope

Norditropin, a brand of somatropin (human growth hormone), was prescribed to approximately 85,000 people in the USA in 2020. Norditropin accounted for just over 35% of the total human growth hormone prescriptions in the US. It is used primarily for treating children with growth failure due to inadequate secretion of endogenous growth hormone and adults with either childhood or adult-onset growth hormone deficiency.

Humatrope, another form of somatropin, had around 75,000 prescriptions filled during that same year. Humatrope accounts for about a third of all human growth hormone prescriptions within the United States market. The prevalence of Humatrope has remained relatively steady over recent years.

Both Norditropin and Humatrope are therapeutically equivalent; thus their choice often comes down to patient preference on delivery device design and cost considerations.


Both Norditropin (somatropin) and Humatrope (somatropin) are synthetic versions of human growth hormone, used for treating growth disorders in children and adults. Backed by extensive clinical studies, these drugs have been shown to be more effective than placebo treatments at promoting growth. While they share the same active ingredient, somatropin, their manufacturing processes differ slightly which could potentially lead to differences in how individual patients respond.

Norditropin may appeal to some patients due to its user-friendly device design which includes a built-in needle guard and dosage dial for ease of administration. On the other hand, Humatrope is also favored by many due to its long-standing reputation and proven efficacy.

Both drugs are available only as brand-name medications, meaning cost considerations can play a significant role when choosing between them. Similarly with Prozac and Wellbutrin comparison above; both Norditropin and Humatrope might require an adjustment period as effects might not be noticeable immediately after starting therapy.

The side effect profile is similar between the two hormones: common side effects include joint pain or stiffness, swelling hands/ankles/feet (peripheral edema), muscle pain/cramps; rare but serious ones including heart disease or cancer must be monitored closely by healthcare provider especially when starting treatment.