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13 Fisetin Trials Near You
Power is an online platform that helps thousands of patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.
Learn More About PowerFisetin for PAD
Chicago, Illinois
The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutaneous and inter muscular adipose tissue and improve 6-minute walk distance in 34 people with peripheral artery disease (PAD). the investigators will determine whether greater declines in abundance of cells with senescent markers are associated with greater improvement in 6-minute walk distance in people with peripheral artery disease. In exploratory analyses, the investigators will assess whether Fisetin reduces interleukin-6 (IL-6) and novel senescent markers in adipose tissue, muscle, and/or blood.
Trial Details
Trial Status:Recruiting
Trial Phase:Phase 2
Age:50+
Key Eligibility Criteria
Disqualifiers:Amputation, Critical Limb Ischemia, Others
Must Not Be Taking:Warfarin, Others
34 Participants Needed
Fisetin for Fatigue
Winston-Salem, North Carolina
The purpose of this study is to find out if taking a Fisetin supplement can decrease fatigue among older cancer survivors.
Trial Details
Trial Status:Not Yet Recruiting
Trial Phase:Phase 4
Age:65+
Key Eligibility Criteria
Disqualifiers:Hypertension, Heart Failure, Lung Disease, Others
Must Not Be Taking:Warfarin, Steroids, CYP3A4 Drugs
60 Participants Needed
Fisetin for Sepsis
Iowa City, Iowa
The long-term goal is to test the clinical efficacy of senolytic therapies to reduce progression to and severity of sepsis in older patients. The central hypothesis is that a threshold burden of SnCs predisposes to a SASP mediated dysfunctional response to PAMPs, contributing to a disproportionate burden of sepsis in older patients. The study hypothesizes timely treatment with fisetin will interrupt this pathway.
A multicenter, randomized, adaptive allocation clinical trial to identify the most efficacious dose of the senolytic fisetin to reduce the composite cardiovascular, respiratory, and renal sequential organ failure assessment score at 1 week, and predict the probability of success of a definitive phase III clinical trial.
Trial Details
Trial Status:Recruiting
Trial Phase:Phase 2
Age:65+
Key Eligibility Criteria
Disqualifiers:ICU Admission, Cancer, HIV, Others
Must Not Be Taking:Vasopressors, Antivirals, Antifungals, Others
220 Participants Needed
Senolytic Therapy for Frailty
Memphis, Tennessee
This is a first-in survivor pilot study with the goal of establishing preliminary evidence of efficacy, safety, and tolerability of two senolytic regimens to reduce markers of cellular senescence (primary outcome: p16\^INK4a) and improve frailty (primary outcome: walking speed) in adult survivors of childhood cancer. If successful, this pilot would provide the preliminary evidence needed for a phase 2, randomized, placebo-controlled trial to establish efficacy.
Primary Objective
* The primary aim of this proposal is to test the efficacy of two, short duration senolytic regimens: 1) combination of Dasatinib plus Quercetin and 2) Fisetin alone, to improve walking speed and decrease senescent cell abundance in blood (p16\^INKA):
* Primary endpoints of this trial will be change in walking speed and senescent cell abundance in blood (p16\^INK4A) determined at baseline and again at 60 days, within an individual arm. Extended follow up at 150 days will assess the permanence of change after completion of the trial. Secondary endpoints of this trial will be effect of intervention on additional measures of frailty (beyond walking speed; Fried criteria) and on other cell senescence markers, markers of inflammation, insulin resistance, bone resorption, and cognitive function.
Secondary Objectives
The secondary aim is to test the safety and tolerability of two different senolytic therapies.
Exploratory Objectives
* To compare the efficacy of the two senolytic regimens in improving walking speed and decreasing senescent cell abundance
* To evaluate the longitudinal pattern in measures of frailty.
No Placebo Group
Trial Details
Trial Status:Recruiting
Trial Phase:Phase 2
Key Eligibility Criteria
Disqualifiers:HIV, Hepatitis B/C, Anemia, Others
Must Not Be Taking:CYP3A4 Drugs, Anticoagulants
120 Participants Needed
Fisetin for Carpal Tunnel Syndrome
Rochester, Minnesota
This trial is testing Fisetin, a supplement, to see if it can help people with mild to moderate carpal tunnel syndrome. The study will involve 40 participants who show signs of aging cells in their blood. Fisetin aims to reduce these aging cells and inflammation, potentially improving CTS symptoms.
No Placebo Group
Trial Details
Trial Status:Active Not Recruiting
Trial Phase:Phase 2
Age:21 - 80
Key Eligibility Criteria
Disqualifiers:Pregnancy, Liver Disease, Uncontrolled Diabetes, Cancer, Others
Must Not Be Taking:Flavonoids
40 Participants Needed
Fisetin for Frailty
Rochester, Minnesota
This trial tests if Fisetin can reduce inflammation and frailty in elderly adults. Fisetin may help by lowering oxidative stress and improving overall health. The study focuses on older adults because they often face these health issues. Fisetin is a natural flavonoid found in many fruits and vegetables, known for its anti-inflammatory and antioxidant properties.
Trial Details
Trial Status:Enrolling By Invitation
Trial Phase:Phase 2
Age:70+
Key Eligibility Criteria
Disqualifiers:HIV, Hepatitis B/C, Cancer, Others
Must Not Be Taking:Antifungals, Antivirals, Chemotherapy, Quinolones
40 Participants Needed
Fisetin for Frailty
Rochester, Minnesota
This trial aims to see if Fisetin, a natural substance from fruits and vegetables, can help elderly postmenopausal women with walking difficulties by reducing inflammation and protecting cells. Fisetin is a natural flavonoid found in many fruits and vegetables, known for its anti-inflammatory, antioxidant, and anti-carcinogenic properties. The goal is to improve their overall health and physical function.
Trial Details
Trial Status:Enrolling By Invitation
Trial Phase:Phase 2
Age:70+
Sex:Female
Key Eligibility Criteria
Disqualifiers:Liver Disease, Renal Disease, Malignancy, Others
Must Not Be Taking:Sulfonylureas, SGLT2 Inhibitors, Insulin, Others
40 Participants Needed
Fisetin for Immune Deficiency-Related Lung Disease
Rochester, Minnesota
This trial is testing whether a natural supplement called Fisetin can help people with common variable immunodeficiency (CVID). CVID patients often struggle with infections due to a weak immune system. Fisetin might help by reducing inflammation and strengthening their immune response.
Trial Details
Trial Status:Enrolling By Invitation
Trial Phase:Phase 2
Key Eligibility Criteria
Disqualifiers:Pregnancy, Tobacco Use, Excessive Caffeine, Others
20 Participants Needed
Fisetin for Coronavirus
Rochester, Minnesota
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
Trial Details
Trial Status:Active Not Recruiting
Trial Phase:Phase 2
Key Eligibility Criteria
Disqualifiers:HIV, Hepatitis B/C, Invasive Cancer, Others
Must Not Be Taking:Antifungals, CYP3A4 Inhibitors
80 Participants Needed
Fisetin for Improved Vascular Function in Aging
Boulder, Colorado
This trial tests if fisetin, a natural substance from fruits and vegetables, can improve blood vessel health and reduce artery stiffness in older adults. It works by making old cells act younger, reducing cell stress, and lowering inflammation. The study will also check if fisetin is safe and well-tolerated. Fisetin is a natural flavonoid found in various fruits and vegetables, known for its antioxidant, anti-inflammatory, and anti-carcinogenic properties.
Trial Details
Trial Status:Recruiting
Trial Phase:Phase 1, 2
Age:65+
Key Eligibility Criteria
Disqualifiers:Active Malignancy, Unstable CVD, Others
Must Not Be Taking:Senolytics, Cardiovascular-acting, Others
70 Participants Needed
Senolytic + Anti-Fibrotic Agents for Osteoarthritis
Vail, Colorado
This is a prospective, randomized, double-blind, active control clinical trial to evaluate the safety and efficacy of a senolytic agent (Fisetin) and an anti-fibrotic agent (Losartan), used independently and in combination, to improve beneficial effect demonstrated by the active control which is to be injection of autologous bone marrow aspirate concentrate (BMAC) into an osteoarthritic knee.
Trial Details
Trial Status:Active Not Recruiting
Trial Phase:Phase 1, 2
Age:40 - 85
Key Eligibility Criteria
Disqualifiers:Diabetes, Fibromyalgia, Autoimmune Diseases, Others
Must Not Be Taking:Losartan, Warfarin, Lithium, Opioids
100 Participants Needed
Fisetin for Breast Cancer Survivors
Duarte, California
This phase II trial tests whether fisetin works to improve physical function in women who have received chemotherapy for stage I-III breast cancer treatment. Fisetin is a naturally occurring substance that is found in strawberries and other foods. Fisetin eliminates cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that causes inflammation and damages nearby healthy cells. Studies have shown that chemotherapy causes a build-up of these senescent cells. Giving fisetin may eliminate senescent cells and improve physical function in postmenopausal women who have received chemotherapy for breast cancer.
Trial Details
Trial Status:Recruiting
Trial Phase:Phase 2
Age:65+
Sex:Female
Key Eligibility Criteria
Disqualifiers:Active Cancer, Surgery, Radiation, Others
Must Not Be Taking:Senolytics, Anticoagulants, Herbal Supplements
88 Participants Needed
Fisetin + Exercise for Breast Cancer
Pasadena, California
This phase II trial tests how well fisetin and exercise works in preventing frailty in breast cancer survivors. Fisetin is a natural substance found in strawberries and other foods and is available as a nutritional supplement. Nutritional supplements may be useful in eliminating cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that cause inflammation and damage nearby healthy cells. Giving fisetin may eliminate senescent cells in patients with breast cancer undergoing physical activity.
Trial Details
Trial Status:Recruiting
Trial Phase:Phase 2
Sex:Female
Key Eligibility Criteria
Disqualifiers:Active Cancer, Surgery, Radiation, Others
Must Not Be Taking:Senolytics, Anticoagulants, Herbal Supplements
164 Participants Needed
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Frequently Asked Questions
How much do clinical trials pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.How do clinical trials work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length is 12 months.How do I participate in a study as a "healthy volunteer"?
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.Do I need to be insured to participate in a medical study ?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.What are the newest clinical trials ?
Most recently, we added Fisetin for Fatigue, Fisetin for PAD and Fisetin + Exercise for Breast Cancer to the Power online platform.Popular Searches
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