Fisetin for Coronavirus
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether Fisetin, a drug that clears out old cells, can slow the worsening of coronavirus symptoms and reduce inflammation-related complications. Participants will receive either Fisetin or a placebo (a harmless pill that does not affect the disease) to compare outcomes. The trial seeks individuals aged 60 or older, or those aged 18-59 with conditions such as diabetes, asthma, or a history of heart issues, who have a confirmed coronavirus infection. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering a chance to contribute to important findings.
Will I have to stop taking my current medications?
You may need to stop taking certain medications before and during the trial. If you are on specific medications like those metabolized by CYP450 enzymes or strong inhibitors of CYP3A4, you will need to pause them immediately before the first dose of the trial drug and for at least 10 hours after the last dose. Check with the trial team to see if your medications are affected.
Is there any evidence suggesting that Fisetin is likely to be safe for humans?
Research shows that fisetin, a drug that helps remove old cells, is usually well-tolerated. Studies have found few, if any, serious side effects directly linked to fisetin. Although human data on fisetin's safety is limited, reported side effects are generally mild. This suggests that the drug might be safe for people, based on earlier trials.12345
Why do researchers think this study treatment might be promising for coronavirus?
Fisetin is unique because it is a plant-derived compound that researchers believe might have anti-inflammatory and antiviral properties, setting it apart from current coronavirus treatments that generally focus on antiviral drugs like remdesivir or monoclonal antibodies. Unlike standard treatments that primarily target the virus itself, fisetin could potentially help reduce inflammation associated with severe COVID-19, a significant cause of complications. Researchers are excited about fisetin because it offers a novel mechanism of action, targeting the body's inflammatory response rather than just the virus, which might lead to better outcomes for patients with severe cases.
What evidence suggests that Fisetin might be an effective treatment for coronavirus?
Research has shown that Fisetin, a natural substance, might help treat COVID-19 by lowering inflammation. In this trial, participants in the treatment group will receive Fisetin to evaluate its effectiveness. Studies suggest that Fisetin could improve outcomes for COVID-19 patients, particularly by reducing severe reactions. This compound targets and removes old and damaged cells, which can help decrease inflammation. Some studies also suggest it might prevent the virus from attaching to cells. While more research is needed, these findings offer hope that Fisetin could help manage COVID-19 symptoms.26789
Who Is on the Research Team?
Paschalis Vergidis, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
Adults aged 18+ with COVID-19 confirmed by a PCR test, especially those over 60 or aged 18-59 with conditions like obesity, diabetes, lung diseases (asthma/COPD), heart issues (past strokes or heart attacks), high blood pressure, history of smoking/vaping, or past chemotherapy/radiation. Must not be pregnant and willing to use contraception.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Fisetin or placebo to assess its effect on disease progression and inflammation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Fisetin
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor