Liver Disease Clinical Trials
Here are the 6 most popular medical studies for liver disease
Organ Preservation
Cold Preservation vs. Machine Perfusion for Liver Transplants
This trial will compare the outcomes of transplanting livers that have been kept alive with a machine after being rejected by other transplant centers, to the outcomes of using livers that have been kept cold.
Behavioural Intervention
DALC Digital Clinic for Alcoholism
"This trial aims to see if using a digital clinic with multiple specialists can help improve health outcomes, lower costs, increase access to care, and make healthcare providers happier. The main goal is to improve outcomes
Behavioral Intervention
Genomic Medicine Risk Assessment Care for Everyone for Liver Disease
This trial aims to develop a program called "GRACE" to help assess and manage health risks in populations with limited resources. The goal is to improve health outcomes, quality of life, and reduce costs
Behavioral Intervention
ENGAGE-ALD Application (APP) for Alcoholic Liver Disease
"This trial aims to determine if offering personalized alcohol treatment options to patients with alcohol-related liver disease will help them to better engage with treatment and address any misunderstandings they may have."
Popular filter options for liver disease trials
Non-alcoholic Fatty Liver Disease Clinical Trials
View 67 Non-alcoholic Fatty Liver Disease medical studies.
Behavioral Intervention
Stepped Alcohol Intervention for Alcohol-related Liver Disease
This trial is testing a new way to help people with chronic liver disease who have unhealthy alcohol use. The new treatment includes 3 sessions of motivational interviewing, and referral to addiction medicine if necessary. The trial will measure how well the new treatment works at 6 and 12 months.
Fatty Liver Clinical Trials
View 36 Fatty Liver medical studies.
Behavioral Intervention
Stepped Alcohol Intervention for Alcohol-related Liver Disease
This trial is testing a new way to help people with chronic liver disease who have unhealthy alcohol use. The new treatment includes 3 sessions of motivational interviewing, and referral to addiction medicine if necessary. The trial will measure how well the new treatment works at 6 and 12 months.
Phase 3 Liver Disease Clinical Trials
View 98 phase 3 liver disease medical studies.
Noninvasive SHAPE for Portal Hypertension
This trial will study if the SHAPE algorithm can accurately estimate portal pressures in patients with various degrees of liver disease, if it can predict the development of ascites and other liver-related events, and if it can be used to monitor treatment response in patients with portal hypertension.
Antisense Oligonucleotide
Fazirsiran for Alpha-1 Antitrypsin Deficiency
"This trial aims to determine if fazirsiran is safe for long-term use in individuals with liver disease caused by a specific protein. Participants who were part of previous fazirsiran studies can continue in this
Anti-sense oligonucleotide
Fazirsiran +1 More for Alpha-1 Antitrypsin Deficiency
This trial is studying a medication called fazirsiran in people with a liver disease caused by an abnormal protein called Z-AAT. The medication aims to reduce the build-up of this abnormal protein in the
Liver Disease Clinical Trials With No Placebo
View 98 liver disease medical studies that do not have a placebo group.
Noninvasive SHAPE for Portal Hypertension
This trial will study if the SHAPE algorithm can accurately estimate portal pressures in patients with various degrees of liver disease, if it can predict the development of ascites and other liver-related events, and if it can be used to monitor treatment response in patients with portal hypertension.
Procedure
BI 685509 + Empagliflozin for Portal Hypertension
This trial is for adults with liver cirrhosis caused by hepatitis B, hepatitis C, or nonalcoholic steatohepatitis. The study is testing whether BI 685509, taken alone or with empagliflozin, helps people with this condition by checking the pressure in a liver vein.
Paid Liver Disease Clinical Trials
View 98 liver disease medical studies that offer remuneration.
Opioid Analgesic
Nalbuphine ER for Nalbuphine
This research study will evaluate the effect of liver disease on the pharmacokinetics (the breakdown of the drug in the body) of parallel-group, multiple oral doses nalbuphine extended release (NAL ER), tablets in people with liver disease (mild, moderate and severe), compared to people with normal liver function. The study will also test the safety and tolerability of the NAL ER, when it is given to subjects with mild, moderate and severe liver disease, compared to subjects with normal liver function. This protocol will also study the effects of this drug on itching in liver disease subjects if they report some itching prior to taking part in this study.
View More Liver Disease Trials
See another 72 medical studies focused on liver disease.
Frequently Asked Questions
Introduction to liver disease
What are the top hospitals conducting liver disease research?
In the realm of liver disease research, several hospitals are making significant strides in understanding and treating this complex condition. Massachusetts General Hospital, located in the vibrant city of Boston, leads the pack with four active clinical trials focused on liver disease. With a total of 22 studies conducted to date since their first recorded trial in 2010, this institution is dedicated to uncovering innovative interventions for patients suffering from liver-related ailments. Meanwhile, across the country in Tustin, California, Orange County Research Center is also playing a crucial role by conducting three ongoing liver disease trials and contributing to 15 previous investigations since initiating their inaugural study in 2015.
Moving further south to Gainesville, Florida, we find the University of Florida at the forefront of liver disease research as well. This esteemed institution currently has three active clinical trials dedicated to studying and developing treatments for various types of liver diseases. Since embarking on its first recorded trial back in 1999, they have completed nine studies that have significantly contributed to our understanding of these conditions.
Notably renowned for its healthcare excellence nationwide,Mayo Clinic's Rochester branch too contributes remarkably within this field; demonstrating dedication with having three concurrent active experiments focusing specifically upon diverse aspects concerning different forms associated with Liver Disease cases.Substantial contributions made yielding reliable results derived from previously held nine incrementally accumulated experiments dating all way back until it's initial pioneering investigation efforts initiated around year ,2012.
Lastly yet assuredly not lacking significance,Tampa's Genesis Clinical Research comes forward showcasing commendable effort where two current underway clinical tests concentrate squarely upon investigating ways potentially helping those affected by Liver Diseases.At present theirs seems minimal but not forgetting that they had begun delving into these areas just recently -in early2022- thereby holding traceable culmination limited unto four times so far through smaller-scale projects under taken aimed towards wider communities'
Collectively,the unwavering commitment demonstrated by these institutions emphasizes an encouraging message: medical professionals and researchers are actively working towards a future where liver diseases will be better understood, diagnosed, and treated. Through these pioneering clinical trials conducted nationwide, the hope for improved therapies and ultimately better outcomes is steadily becoming a reality for countless individuals affected by liver disease.
Which are the best cities for liver disease clinical trials?
When it comes to liver disease clinical trials, several cities stand out as leaders in research and development. San Antonio, Texas leads the way with 15 active trials focused on studying interventions like Resmetirom and BI 456906. New york, New York follows closely behind with 11 ongoing studies exploring treatments such as Fazirsiran and TIPS with Scorpion Portal Vein Access Kit. Philadelphia, Pennsylvania is also a key player with 9 active trials investigating innovative approaches like SHAPE measurement and Transitional Liver Clinic (TLC). These cities offer individuals affected by liver disease access to cutting-edge clinical trials that hold promise for better treatment options and improved outcomes.
Which are the top treatments for liver disease being explored in clinical trials?
Liver disease continues to be a focus of intensive research, with several promising treatments making their mark in clinical trials. The Transitional Liver Clinic (TLC) emerges as a top contender, currently being explored in one active trial for liver disease. This innovative approach brings new hope to patients since its first listing in 2023, representing the cutting edge of medical advancements. Another notable player is the GATT-Patch, which has garnered attention with one active and two all-time liver disease trials since its introduction in 2022. As researchers delve deeper into these treatments, they pave the way for potential breakthroughs that could transform the lives of individuals affected by liver diseases worldwide.
What are the most recent clinical trials for liver disease?
The field of liver disease research is making significant strides with recent clinical trials offering hope for patients. One such trial, LY3885125 (Part A), has entered Phase 1 and holds promise as a potential treatment option. Another Phase 1 trial, BI 3006337 dose group 4, aims to evaluate its efficacy in combating liver disease. Additionally, a Phase 2 study offers the opportunity for individuals to receive targeted treatment specifically developed for liver disease. Notably, a Phase 3 trial focusing on Fazirsiran showcases the progress being made in advancing therapeutic options for this complex condition. These groundbreaking trials signify an exciting era of innovation and improved outcomes for those affected by liver disease.
What liver disease clinical trials were recently completed?
In the field of liver disease, numerous clinical trials have recently concluded, offering hope for improved treatments. Some notable trials include Insmed Incorporated's trial on Brensocatib, completed in October 2022; Pfizer's trial on PF-07081532, completed in August 2022; and Merck Sharp & Dohme LLC's trial on Molnupiravir, completed in June 2022. Other noteworthy studies encompassed Concert Pharmaceuticals' CTP-543 trial (June 2022), Cerevel Therapeutics' Tavapadon trial (April 2022), EQRx Inc.'s aumolertinib trial (March 2022), and Hutchison Medipharma Limited's Fruquintinib trial (March 2022). These diverse investigations contribute to advancing our understanding and treatment options for liver diseases.