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81 Kidney Stone Trials Near You

Power is an online platform that helps thousands of Kidney Stone patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

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No Placebo
Highly Paid
Stay on Current Meds
Pivotal Trials (Near Approval)
Breakthrough Medication

ClearPetra for Kidney Stones

Kansas City, Kansas
Ureteroscopy has been considered the best approach when treating renal stones smaller than 2 cm. This procedure is usually performed together with ureteral access sheaths, which helps protect the ureter mucosa and lowers intrarenal pressure. Recently, a new vacuum-assisted ureteral access sheath called ClearPetra has entered US market and allows for continuous stone fragmentation and aspiration. Because there is little information on comparing this device with traditional approach (no sheath or non-vacuum-assisted sheath) in American population, we aim to compare those devices in terms of their ability to clear the kidney from kidney stones, as well as reduce infection rates postoperatively.
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased

150 Participants Needed

LithoVue Elite Ureteroscope for Kidney Stones

Kansas City, Kansas
The goal of this study is to evaluate the influence of real-time intrarenal pressure measurement availability on surgeons' behavior during ureteroscopy while using the ureteroscope LithoVue Elite.
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased

80 Participants Needed

SOLTIVE Laser vs Ho:YAG Laser for Kidney Stones

Kansas City, Kansas
This trial compares the new SOLTIVE Thulium laser to the traditional Holmium laser for treating kidney stones. The new laser aims to break down stones more efficiently and with less damage to surrounding tissues, potentially improving patient outcomes and reducing costs. The Thulium fibre laser (TFL) has recently been introduced as a new technology and may challenge the Holmium:YAG (Ho:YAG) laser as the preferred option due to its favorable properties.
No Placebo Group

Trial Details

Trial Status:Recruiting

100 Participants Needed

TFL vs MOSES Laser for Kidney Stones

Thunder Bay, Ontario
This study aims to compare the efficacy and safety of both types of lasers, Holmium MOSES and TFL, in management of kidney stones requiring treatment.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased

174 Participants Needed

Antibiotic Prophylaxis for Kidney Stones

Sherbrooke, Quebec
This is a two arm, double blind RCT comparing the use of a single dose ciprofloxacin prior to SWL to saline alone. The multicenter trial will be conducted with a pragmatic emphasis including both high volume and low volume sites internationally.

Trial Details

Trial Status:Recruiting

1500 Participants Needed

Holmium vs Thulium Lasers for Kidney Stones

Portland, Maine
This is a single institution, single surgeon, randomized controlled trial to evaluate the Boston Scientific Lumenis Pulse 120H Moses 2.0 holmium laser versus the Olympus Soltive Superpulsed thulium fiber laser (TFL) for medium-to-large stones in the mini PCNL setting.
No Placebo Group

Trial Details

Trial Status:Enrolling By Invitation
Trial Phase:Unphased
Age:21 - 90

52 Participants Needed

Hydroxycitrate for Kidney Stones

Dallas, Texas
This trial tests whether hydroxycitrate can reduce the recurrence of kidney stones in patients who frequently get them. It compares hydroxycitrate to potassium citrate. The treatment works by preventing the formation of crystals that cause kidney stones. Hydroxycitrate is a derivative of citric acid and has shown the ability to inhibit the formation of calcium oxalate crystals in vitro.

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 4
Age:21 - 99

25 Participants Needed

Pioglitazone + Weight Loss for Kidney Stones

Dallas, Texas
This trial tests the effects of Pioglitazone, weight loss, or both in overweight and obese patients with uric acid kidney stones. Pioglitazone helps the body use insulin better and reduces urine acid, while weight loss improves health and reduces the risk of stones.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 4
Age:21 - 99

54 Participants Needed

Alkalinizing Agents for Kidney Stones

Dallas, Texas
The purpose of this study is to compare over the counter and alternative prescription urinary alkalinizing agents to slow release potassium citrate in their ability to modify urinary parameters associated with stone formation.

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Early Phase 1

15 Participants Needed

Intra-nasal Ketorolac for Stent-Related Pain in Kidney Stones

Dallas, Texas
Objective: To improve quality-of-life and health care delivery to patients receiving ureteral stents. Specific Aims: Evaluate the feasibility, practicality, and qualitative outcomes of utilizing intra-nasal ketorolac in patients with indwelling ureteral stents (Phase I), followed by a randomized trial comparing two non-steroidal anti-inflammatory drugs, intra-nasal Ketorolac versus oral Diclofenac. Hypotheses: Due to its favorable pharmacokinetics in relieving acute pain, investigators expect improved pain scores and a lower rate of unplanned clinical encounters in patients receiving intra-nasal ketorolac compared to those taking oral diclofenac following ureteroscopic surgery for urolithiasis. Study Rationale: Following ureteroscopic management of urolithiasis, patient with indwelling ureter stents have higher levels of discomfort compared to those without a ureter stent. Prior studies showed that intramuscular Ketorolac at time of ureter stent removal decreased the incidence of unplanned clinical encounters. Furthermore, onset of analgesic effect by intra-nasal ketorolac is faster than its oral form, and similar its intramuscular and intravenous counterparts.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 1, 2

80 Participants Needed

Retrograde vs Antegrade Nephrostomy for Kidney Stones

Houston, Texas
The purpose of this study is to compare relevant clinical outcomes in patients requiring percutaneous nephrostomy for urolithiasis treatment between those who undergo an antegrade approach versus a retrograde approach and to determine which clinical characteristics predict success of lithotomy with anterograde or retrograde percutaneous nephrostomy approaches.
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased

50 Participants Needed

Fecal Microbiota Transplantation for Kidney Stones

Park City, Utah
The purpose of this study is to measure the impact of Microbial Transplant Therapy (MTT) on 24-hour urine parameters in recurrent hypercalciuric and hyperoxaluric kidney stone formers.

Trial Details

Trial Status:Recruiting
Trial Phase:Early Phase 1

36 Participants Needed

Laser Systems for Kidney Stones

San Diego, California
This research study is being conducted to assess the ability and efficiency of two laser systems to break up kidney stones during ureteroscopy with laser lithotripsy for kidney stone treatment.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased

50 Participants Needed

Antibiotics for Preventing Infections After Kidney Stone Treatment

San Diego, California
This trial tests if an antibiotic can prevent infections in patients having a ureteral stent removed. The antibiotic works by killing or stopping the growth of bacteria that could cause infections. It has been shown to be effective in preventing infections in various surgical and medical contexts, including urinary tract infections and transurethral surgeries.
No Placebo Group

Trial Details

Trial Status:Recruiting

80 Participants Needed

Antibiotics Before Surgery for Kidney Stones

San Diego, California
This study will be a multi-institutional randomized clinical trial of a short course of pre-operative antibiotic prophylaxis in addition to perioperative antibiotics prior to undergoing percutaneous nephrolithotomy. The select patient population will be those patients deemed to be at a moderately increased risk of postoperative infectious complications. These higher risk patients are those with indwelling urinary drainage tubes and those with a positive preoperative urine culture.
No Placebo Group

Trial Details

Trial Status:Recruiting

330 Participants Needed

Erector Spinae Plane Block for Postoperative Pain After Kidney Stone Surgery

San Diego, California
This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to provide postoperative analgesia following percutaneous nephrolithotomy. Participants will all receive a single-injection nerve block and perineural catheter insertion. Following surgery, participants will be randomly allocated to receive either perineural local anesthetic or normal saline until the second day following surgery.

Trial Details

Trial Status:Enrolling By Invitation
Trial Phase:Phase 4

50 Participants Needed

Ultrasound Imaging Technology for Kidney Stones

Seattle, Washington
The purpose of this study is to determine whether new software processing of ultrasound images can improve detection and size determination of kidney stones.
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased
Age:21+

370 Participants Needed

Antibiotic Duration for Kidney Stone Surgery

San Francisco, California
The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in patients with moderate to high risk of infection undergoing ureteroscopy. The main questions it aims to answer are: 1. Determine the safety and efficacy of a short course (2 days) as compared to a long course (7 days) 2. Identify secondary predictors of post-operative infectious complications
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased

72 Participants Needed

Ureteroscopy for Kidney Stones

San Francisco, California
A prospective, non-blinded, randomized controlled trial studying the management of symptomatic ureteral stones. This study will compare upfront ureteroscopy vs observation and delayed intervention for patients presenting to the emergency department with a symptomatic ureteral stone.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased

100 Participants Needed

Ultrasound for Kidney Stones Detection

San Francisco, California
The purpose of this study is to assess the accuracy of ultrasound and traditional fluoroscopy to find the residual fragments before retrograde intrarenal surgery is complete. This would ultimately limit the need for radiation exposure and improve the quality of clinical care given to patients and healthcare teams.
No Placebo Group

Trial Details

Trial Status:Recruiting

172 Participants Needed

Why Other Patients Applied

"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."

HZ
Arthritis PatientAge: 78

"I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."

WR
Obesity PatientAge: 58

"I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."

AG
Paralysis PatientAge: 50

"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."

IZ
Healthy Volunteer PatientAge: 38

"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."

ZS
Depression PatientAge: 51

Alpha Lipoic Acid for Cystinuria

San Francisco, California
This study evaluates how daily alpha lipoic acid supplementation affects cystine kidney stone recurrence. Half of the subjects will receive 1200 mg alpha lipoic acid orally daily for three years, while the other half will receive a placebo. The funding source for this clinical trial is FDA OOPD.

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Phase 2

50 Participants Needed

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How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?

Frequently Asked Questions

How much do Kidney Stone clinical trials pay?

Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.

How do Kidney Stone clinical trials work?

After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Kidney Stone trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Kidney Stone is 12 months.

How do I participate in a study as a "healthy volunteer"?

Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.

What does the "phase" of a clinical trial mean?

The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.

Do I need to be insured to participate in a Kidney Stone medical study?

Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

What are the newest Kidney Stone clinical trials?

Most recently, we added Ultrasound Imaging Technology for Kidney Stones, Alkalinizing Agents for Kidney Stones and ClearPetra for Kidney Stones to the Power online platform.

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By Trial

Mapping and Biopsy Study for Kidney Stones

Steroids for Kidney Transplant Rejection

DCreg Cell Therapy for Kidney Transplant Recipients

Erector Spinae Plane Block for Postoperative Pain After Kidney Stone Surgery

INCB000928 for Stone Man Syndrome

Oxalobacter Formigenes for Kidney Stones

Extracorporeal Lithotripsy for Kidney Stones

RMC-035 for Acute Kidney Injury

MOx Diet for Enteric Hyperoxaluria

Dietary Oxalate Intake for Kidney Stone Prevention

AT-1501 for Kidney Transplant

Ureteroscopy for Kidney Stones

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