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Antibiotic Duration for Kidney Stone Surgery

N/A

Waitlist Available

Led By Thomas Chi, MD, MBA

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

immunosuppression (such as for transplant recipients, active chemotherapy use)

bowel interposition (such as ileal conduit, neobladder)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 30 days after surgery

Awards & highlights

Study Summary

This trial compares short vs long pre-op antibiotics for patients at risk of infection during ureteroscopy to test if there's any difference in safety and efficacy.

Who is the study for?

This trial is for adults over 18 with kidney stones who are at moderate to high risk of infection and planning to undergo ureteroscopy. They may have a stent, nephrostomy tube, or use catheters like foley or suprapubic. People with asymptomatic bacteriuria, bowel interposition, or immunosuppression can join. Pregnant individuals, those with active infections or recent non-study antibiotics cannot participate.Check my eligibility

What is being tested?

The study compares the effectiveness of taking antibiotics for two days versus seven days before ureteroscopy in preventing post-operative infections. It's a randomized controlled trial aiming to see if a shorter antibiotic course is just as good as a longer one for patients at higher risk of complications.See study design

What are the potential side effects?

Potential side effects from the antibiotics could include allergic reactions, gastrointestinal issues like nausea and diarrhea, yeast infections due to disruption of normal body flora, and possibly increased resistance to antibiotics.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am on immunosuppressants, possibly for a transplant or chemotherapy.

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I have had surgery to create a new way for urine to leave my body.

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I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ obtained during the peri-operative period

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~obtained during the peri-operative period

This trial's timeline: 3 weeks for screening, Varies for treatment, and obtained during the peri-operative period for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

infectious complication rate

Secondary outcome measures

Adverse reaction to antibiotic regimen

Identification of secondary markers of post-operative sepsis

Non-infectious complications including readmission

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Short duration of preoperative antibiotics (2 days)Experimental Treatment1 Intervention

Group II: Long duration of preoperative antibiotics (7 days)Active Control1 Intervention

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor

2,510 Previous Clinical Trials

15,243,635 Total Patients Enrolled

Thomas Chi, MD, MBAPrincipal InvestigatorUniversity of California, San Francisco

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you please confirm if participation in this clinical trial is still available?

"Confirmatively, this clinical trial is not recruiting at the moment. According to records hosted on clinicaltrials.gov, it was originally posted in January 1st 2024 and was last edited November 20th 2023. Despite its nonparticipation status, there are 177 other trials actively seeking patients currently."

Answered by AI

Does the age limit for this trial extend beyond 40 years?

"The lower age limit for enrollment in this study is 18 and the upper bound set by inclusion criteria is 99."

Answered by AI

For whom is the criteria suitable to enter this clinical experiment?

"To be considered for this study, potential participants must have kidney stones and be within the ages of 18 to 99. Currently, 72 individuals are being sought out."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy

Thomas Chi, MD 2024. "Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06149455.

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