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USC / Norris Comprehensive Cancer Center

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Los Angeles, California 90033

Global Leader in Cancer

Global Leader in Lung Cancer

Conducts research for Breast Cancer

Conducts research for Colorectal Cancer

Conducts research for Prostate Cancer

960 reported clinical trials

64 medical researchers

Photo of USC / Norris Comprehensive Cancer Center in Los AngelesPhoto of USC / Norris Comprehensive Cancer Center in Los AngelesPhoto of USC / Norris Comprehensive Cancer Center in Los Angeles

Summary

USC / Norris Comprehensive Cancer Center is a medical facility located in Los Angeles, California. This center is recognized for care of Cancer, Lung Cancer, Breast Cancer, Colorectal Cancer, Prostate Cancer and other specialties. USC / Norris Comprehensive Cancer Center is involved with conducting 960 clinical trials across 787 conditions. There are 64 research doctors associated with this hospital, such as Anthony El-Khoueiry, MD, Heinz-Josef Lenz, David Hong, MD, and Jacob Thomas, MD.

Area of expertise

1

Cancer

Global Leader

USC / Norris Comprehensive Cancer Center has run 309 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage III
HER2 positive
2

Lung Cancer

Global Leader

USC / Norris Comprehensive Cancer Center has run 156 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
EGFR positive

Top PIs

Clinical Trials running at USC / Norris Comprehensive Cancer Center

Cancer

Skin Cancer

Prostate Cancer

Lung Cancer

Bladder Cancer

Breast Cancer

Esophageal cancer

Colorectal Cancer

Kidney Cancer

Testicular cancer

Image of trial facility.

Immunotherapy + Chemotherapy

for Sarcoma

This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with dedifferentiated liposarcoma (DDLPS), undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (unresectable). Doxorubicin is in a class of medications called anthracyclines. Doxorubicin damages the cell's deoxyribonucleic acid (DNA) and may kill tumor cells. It also blocks a certain enzyme needed for cell division and DNA repair. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Adding immunotherapy (pembrolizumab) to the standard chemotherapy (doxorubicin) may help patients with metastatic or unresectable DDLPS, UPS or a related poorly differentiated sarcoma live longer without having disease progression.

Recruiting

2 awards

Phase 3

10 criteria

Image of trial facility.

Carvedilol

for Preventing Heart Problems in HER2 Positive Breast Cancer

This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment. Both cohorts are being observed for cardiac toxicity. The largest cohort (currently open to accrual) is observational, and contains patients who are taking a beta blocker, ACE inhibitor, or ARB as well as their trastuzumab-based treatment. The goal is to understand how common cardiac problems are in this group of patients at high risk. The smaller cohort (currently closed to accrual) is randomized. Patients in this second cohort are randomized to either carvedilol or no treatment, with the goal of seeing whether carvedilol (used to treat heart failure and high blood pressure) may prevent the heart from side effects of chemotherapy.

Recruiting

2 awards

Phase 3

23 criteria

Image of trial facility.

PF-07220060 + Letrozole

for Breast Cancer

The purpose of this study is to determine the safety and efficacy of PF-07220060 with letrozole compared to approved treatments (ie, palbociclib, ribociclib or abemaciclib with letrozole) in people with breast cancer: * HR-positive (breast cancer cells that need estrogen or progesterone to grow) * HER2-negative (cells that have a small amount or none of a protein called HER2 on their surface); * locally advanced (that has spread from where it started to nearby tissue or lymph nodes) or metastatic disease (the spread of cancer to other places in the body) * who have not received any prior systemic anti-cancer treatment for advanced/metastatic disease. Approximately half of the participants will receive PF-07220060 plus letrozole while the other half of participants will receive the investigator's choice of treatment plus letrozole. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.

Recruiting

2 awards

Phase 3

4 criteria

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