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USC / Norris Comprehensive Cancer Center

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Los Angeles, California 90033

Global Leader in Cancer

Global Leader in Breast Cancer

Conducts research for Lung Cancer

Conducts research for Colorectal Cancer

Conducts research for Pancreatic Cancer

960 reported clinical trials

63 medical researchers

Photo of USC / Norris Comprehensive Cancer Center in Los AngelesPhoto of USC / Norris Comprehensive Cancer Center in Los AngelesPhoto of USC / Norris Comprehensive Cancer Center in Los Angeles

Summary

USC / Norris Comprehensive Cancer Center is a medical facility located in Los Angeles, California. This center is recognized for care of Cancer, Breast Cancer, Lung Cancer, Colorectal Cancer, Pancreatic Cancer and other specialties. USC / Norris Comprehensive Cancer Center is involved with conducting 960 clinical trials across 789 conditions. There are 63 research doctors associated with this hospital, such as Anthony El-Khoueiry, MD, Heinz-Josef Lenz, David Hong, MD, and Jacob Thomas, MD.

Area of expertise

1

Cancer

Global Leader

USC / Norris Comprehensive Cancer Center has run 185 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage III
HER2 positive
2

Breast Cancer

Global Leader

USC / Norris Comprehensive Cancer Center has run 160 trials for Breast Cancer. Some of their research focus areas include:

Stage IV
HER2 positive
HER2 negative

Top PIs

Clinical Trials running at USC / Norris Comprehensive Cancer Center

Breast Cancer

Skin Cancer

Bladder Cancer

Prostate Cancer

Cancer

Esophageal cancer

Colorectal Cancer

Lung Cancer

Kidney Cancer

Testicular cancer

Image of trial facility.

Radiation and HER2-Targeted Therapy

for Breast Cancer

This Phase III trial compares the recurrence-free interval (RFI) among patients with early-stage, low risk HER2+ breast cancer who undergo breast conserving surgery and receive HER2-directed therapy, and are randomized to not receive adjuvant breast radiotherapy versus those who are randomized to receive adjuvant radiotherapy per the standard of care.

Recruiting

2 awards

Phase 3

15 criteria

Image of trial facility.

Carvedilol

for Preventing Heart Problems in HER2 Positive Breast Cancer

This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment. Both cohorts are being observed for cardiac toxicity. The largest cohort (currently open to accrual) is observational, and contains patients who are taking a beta blocker, ACE inhibitor, or ARB as well as their trastuzumab-based treatment. The goal is to understand how common cardiac problems are in this group of patients at high risk. The smaller cohort (currently closed to accrual) is randomized. Patients in this second cohort are randomized to either carvedilol or no treatment, with the goal of seeing whether carvedilol (used to treat heart failure and high blood pressure) may prevent the heart from side effects of chemotherapy.

Recruiting

2 awards

Phase 3

23 criteria

Image of trial facility.

Low Dose Tamoxifen

for Breast Cancer

This phase III trial compares the effect of low dose tamoxifen to usual hormonal therapy, including aromatase inhibitors, in treating post-menopausal women with hormone positive, HER2 negative early stage breast cancer. Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, prevent the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy to treat postmenopausal women with hormone-dependent breast cancer. Giving low dose tamoxifen may be more effective compared to usual hormone therapy in treating post-menopausal women with hormone-positive, HER2 negative early stage breast cancer.

Recruiting

2 awards

Phase 3

8 criteria

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