30 Participants Needed

Simplified Language for Down Syndrome

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Overseen ByJennifer Johnson, M.S.
Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: Michigan State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how different methods of simplifying language can aid young children with Down syndrome in learning and processing language more effectively. Researchers aim to determine whether using single words or short, simple sentences differs from using full, grammatical sentences. The study includes children with Down syndrome who speak English as their primary language and are between 2 and 7 years old. It seeks to identify which type of language input best supports word learning and understanding. Participants will experience all types of linguistic simplification during the trial. As an unphased trial, this study provides a unique opportunity to contribute to understanding language development in children with Down syndrome.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that this linguistic simplification is safe for young children with Down syndrome?

Research shows that using simpler language for children with Down syndrome is generally safe. Similar studies have used language programs without harmful effects. For example, research on language programs for Down syndrome demonstrated improvements in language skills without negative effects. This suggests that simpler language is well-tolerated, especially as it is a non-invasive approach.

In this study, all participants will hear different types of speech, including simpler language. No known risks exist from listening to or learning with simpler language. Based on these findings, the treatment being tested is expected to be safe for participants.12345

Why are researchers excited about this trial?

Researchers are excited about the linguistic simplification approach for Down syndrome because it focuses on altering the way language is presented to enhance understanding and communication. Unlike standard therapies that concentrate on speech production or cognitive training, this method modifies the complexity of language itself, making it more accessible for individuals with Down syndrome. By exposing participants to different types of simplified utterances, this approach aims to directly improve their ability to comprehend and interact using language, potentially leading to more immediate and tangible improvements in communication skills.

What evidence suggests that linguistic simplification is effective for language processing and word learning in children with Down syndrome?

Research has shown that language programs can help children with Down syndrome improve their speaking and understanding skills. A detailed review found that these children benefit from language programs, showing clear progress in their language abilities. Another study pointed out that using simple words and gestures helps children with Down syndrome understand and communicate better. This trial will explore the effects of linguistic simplification, exposing participants to different types of utterances. These findings suggest that using simpler language can help young children with Down syndrome learn words more easily. Overall, the evidence supports that language programs, including using simpler language, can positively affect language development in children with Down syndrome.26789

Who Is on the Research Team?

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Courtney Venker, PhD

Principal Investigator

Michigan State University

Are You a Good Fit for This Trial?

This trial is for young children with Down syndrome. It aims to understand how simplifying language in the form of single words or short phrases affects their ability to process and learn language compared to full sentences.

Inclusion Criteria

I have Down syndrome.
English as primary language
I am between 2 and 7 years old.

Exclusion Criteria

Acquired brain injury
Cerebral palsy
I have vision or hearing problems that haven't been corrected.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Experimental Manipulation

Participants are exposed to all utterance types to evaluate language processing and word learning

Baseline

Teaching Phase

Participants undergo the Teaching Phase of the Fast Mapping task to assess gaze location and word learning

Baseline

Follow-up

Participants are monitored for safety and effectiveness after the experimental manipulation

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Linguistic simplification
Trial Overview The study tests linguistic simplification methods, specifically comparing the effects of single-word utterances, telegraphic (short phrases) speech, and complete grammatical sentences on real-time language processing and word learning in these children.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Utterance TypeExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Michigan State University

Lead Sponsor

Trials
202
Recruited
687,000+

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Trials
377
Recruited
190,000+

Published Research Related to This Trial

Integrating speech and grammatical interventions using recast treatment showed positive effects on speech-comprehensibility in 4 out of 6 children with Down syndrome, indicating a potential benefit of this combined approach.
Five out of 6 participants demonstrated growth in mean length of utterance (MLU) during generalization sessions, suggesting that this method may effectively enhance both speech clarity and grammatical skills in children with Down syndrome.
Simultaneous treatment of grammatical and speech-comprehensibility deficits in children with Down syndrome.Camarata, S., Yoder, P., Camarata, M.[2022]

Citations

Study Details | NCT06951516 | How Simplified Language ...The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with ...
Language Intervention in Down Syndrome: A Systematic ...The results highlight that language intervention improves linguistic levels in people with Down Syndrome. Most of the research focuses on early ...
Early predictors of language outcomes in Down syndromeThe purpose of this study was to systematically explore the evidence for early predictors of language outcomes in infants and toddlers with DS
Simplified Language for Down SyndromeThe research on using plain language and nonverbal communication tools in medical settings shows that these methods can improve understanding and communication ...
Results from a systematic review and meta-analysisThe results from the systematic review and meta-analysis showed that children with Down syndrome can benefit from receiving language intervention. The effect ...
Study Details | NCT06951516 | How Simplified Language ...The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with ...
Early predictors of language outcomes in Down syndromeThe purpose of this study was to systematically explore the evidence for early predictors of language outcomes in infants and toddlers with DS
Language Intervention in Down Syndrome: A Systematic ...The results highlight that language intervention improves linguistic levels in people with Down Syndrome. Most of the research focuses on ...
Digital Comprehensibility Assessment of Simplified Texts ...We conducted an evaluation study of text comprehensibility including participants with and without intellectual disabilities reading ...
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