This trial will use D20 to track YFV specific CD8+ T cells in human vaccinees who are positive for a specific HLA type, HLA A202. D20 will help us understand how long these cells live and how often they divide to create new cells. This will give us a better understanding of the immune response to live viral infections.
- Yellow Fever
2 Primary · 0 Secondary · Reporting Duration: CD8 T cells will be measured on Day 0, 14, 28 and 3 to 6 months, 1-2 years and >5 years after vaccination.
Awards & Highlights
5 Treatment Groups
Group 2a - Yellow fever vaccine and deuterated water for three weeks
1 of 5
Group 1 - Yellow fever vaccine and deuterated water for two weeks
1 of 5
1 of 5
1 of 5
Group 2b - Yellow fever vaccine and deuterated water for three weeks
1 of 5
40 Total Participants · 5 Treatment Groups
Primary Treatment: Deuterium (70% enriched 2H2O) labeled water · No Placebo Group · Phase 4
Who is running the clinical trial?
Age 18 - 45 · All Participants · 0 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
Is the age range for this research confined to individuals over 45?
"To qualify for this research, participants should be aged 18 to 45. However, there are 26 trials available for minors and 70 clinical studies designed specifically with elderly patients in mind." - Anonymous Online Contributor
Are there any preconditions for enrolling in this trial?
"Prospective members of this trial must have a yellow fever diagnosis and meet the age requirement between 18 to 45. A total of 40 participants are needed for enrolment into the study." - Anonymous Online Contributor
How many subjects are currently receiving treatment through this clinical experiment?
"Affirmative. Clinicaltrials.gov reveals that this clinical investigation is actively looking for participants, having initially been posted on February 1st 2011 and recently updated on May 17th 2022. 40 patients are required from two separate medical centres in order to fill the trial's requirements." - Anonymous Online Contributor
How reliable is Deuterium (70% enriched 2H2O) labeled water for medical applications?
"There is considerable evidence supporting the safety of deuterium (70% enriched 2H2O) labelled water, thus it has been assigned a score of 3 reflecting its approval in Phase 4 trials." - Anonymous Online Contributor
Are enrollees being accepted for this experiment presently?
"According to clinicaltrials.gov, recruitment for this trial is currently taking place. It was initially posted on February 1st 2011 and the information was updated as recently as May 17th 2022." - Anonymous Online Contributor
What past experiments have utilized Deuterium (70% enriched 2H2O) labeled water?
"Presently, 7 studies are being conducted investigating Deuterium (70% enriched 2H2O) labeled water. None of these active investigations have reached Phase 3. The many Madrid, Comunidad De-based trials for this therapy also span 59 clinical sites across the globe." - Anonymous Online Contributor